Detailed information for compound 1487482

Basic information

Technical information
  • TDR Targets ID: 1487482
  • Name: 2-chloro-N-(2-morpholin-4-yl-5-morpholin-4-yl sulfonylphenyl)benzamide
  • MW: 465.95 | Formula: C21H24ClN3O5S
  • H donors: 1 H acceptors: 3 LogP: 1.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1Cl)Nc1cc(ccc1N1CCOCC1)S(=O)(=O)N1CCOCC1
  • InChi: 1S/C21H24ClN3O5S/c22-18-4-2-1-3-17(18)21(26)23-19-15-16(31(27,28)25-9-13-30-14-10-25)5-6-20(19)24-7-11-29-12-8-24/h1-6,15H,7-14H2,(H,23,26)
  • InChiKey: ITHNGPYZQMWQOR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-chloro-N-(2-morpholino-5-morpholinosulfonyl-phenyl)benzamide
  • 2-chloro-N-(2-morpholino-5-morpholinosulfonylphenyl)benzamide
  • 2-chloro-N-(2-morpholin-4-yl-5-morpholin-4-ylsulfonyl-phenyl)benzamide
  • T0511-2455

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0084 0.0126
Echinococcus multilocularis orexin receptor type 2 0.001 0.0074 0.0112
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni biogenic amine receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.1038 0.156
Plasmodium falciparum phd finger protein, putative 0.0032 0.0776 0.9649
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0798 0.1199
Brugia malayi Melatonin receptor type 1A 0.001 0.0074 0.0112
Trichomonas vaginalis esterase, putative 0.0041 0.1038 0.1038
Schistosoma mansoni hypothetical protein 0.001 0.0074 0.0112
Echinococcus granulosus biogenic amine 5HT receptor 0.001 0.0074 0.0112
Schistosoma mansoni amine GPCR 0.001 0.0074 0.0112
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0084 0.0126
Echinococcus multilocularis dro:myosuppressin receptor 0.001 0.0074 0.0112
Brugia malayi jmjC domain containing protein 0.001 0.0084 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0916 0.0916
Loa Loa (eye worm) TYRA-2 protein 0.001 0.0074 0.0112
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.1038 0.1038
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0074 0.0112
Echinococcus granulosus tachykinin peptides receptor 99D 0.001 0.0074 0.0112
Echinococcus granulosus bloom syndrome protein 0.0029 0.0668 0.1004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0032 0.0776 0.1166
Onchocerca volvulus 0.0041 0.1038 0.1465
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.001 0.0074 0.0112
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0798 0.1199
Loa Loa (eye worm) hypothetical protein 0.0041 0.1038 0.156
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0074 0.0112
Schistosoma mansoni histamine h1 receptor 0.001 0.0074 0.0112
Echinococcus granulosus 7tm_1 domain containing protein 0.001 0.0074 0.0112
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0074 0.0112
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0997 0.1499
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0074 0.0112
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0114 0.0172
Brugia malayi Serotonin receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0123 0.363 0.3075
Echinococcus granulosus GPCR family 2 0.0033 0.0798 0.1199
Echinococcus multilocularis 6 phosphofructokinase 0.0123 0.363 0.5457
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus granulosus g protein coupled receptor 0.001 0.0074 0.0112
Echinococcus multilocularis alpha 1A adrenergic receptor 0.001 0.0074 0.0112
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0131 0.0197
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0159 0.4759 0.5378
Echinococcus multilocularis voltage gated potassium channel 0.0011 0.0114 0.0172
Echinococcus granulosus alpha 1A adrenergic receptor 0.001 0.0074 0.0112
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0798 0.1199
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0991 0.149
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Schistosoma mansoni adenoreceptor 0.001 0.0074 0.0112
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0074 0.0112
Schistosoma mansoni phosphatidylserine receptor 0.001 0.0084 0.0126
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.001 0.0074 0.0112
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0033 0.0801 0.7519
Echinococcus multilocularis g protein coupled receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.014 0.418 0.6283
Echinococcus granulosus serotonin receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Onchocerca volvulus Alhambra homolog 0.0032 0.0776 0.1066
Echinococcus granulosus JmjC domain containing protein 4 0.001 0.0084 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.1112 0.1671
Echinococcus multilocularis JmjC domain containing protein 4 0.001 0.0084 0.0126
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.1332 0.2003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.001 0.0074 0.0112
Schistosoma mansoni hypothetical protein 0.001 0.0074 0.0112
Echinococcus multilocularis serotonin receptor 0.014 0.418 0.6283
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.1038 0.269
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0074 0.0112
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0991 0.149
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0088 0.0058
Schistosoma mansoni hypothetical protein 0.0033 0.0798 0.1199
Schistosoma mansoni hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni hypothetical protein 0.001 0.0074 0.0112
Brugia malayi neuropeptide F receptor 0.001 0.0074 0.0112
Brugia malayi jmjC domain containing protein 0.001 0.0084 0.0126
Schistosoma mansoni myosin xvIII 0.001 0.0074 0.0112
Schistosoma mansoni hypothetical protein 0.0033 0.0798 0.1199
Brugia malayi beta-lactamase family protein 0.0041 0.1038 0.156
Echinococcus granulosus geminin 0.0188 0.5694 0.856
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1332 0.2003
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0131 0.0197
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.3052 0.4588
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0242 0.0447
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.1038 0.269
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0801 0.0801
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.1864 0.2802
Schistosoma mansoni hypothetical protein 0.0033 0.0798 0.1199
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0801 0.0801
Giardia lamblia Fructose-bisphosphate aldolase 0.0325 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0011 0.0114 0.0172
Schistosoma mansoni vesicular acetylcholine transporter 0.0219 0.6653 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.001 0.0074 0.0112
Brugia malayi AF-10 protein 0.0011 0.0088 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.1038 0.156
Echinococcus multilocularis neuropeptide receptor A26 0.001 0.0074 0.0112
Onchocerca volvulus 0.0041 0.1038 0.1465
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.363 0.363
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.7957 1
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0088 0.0012
Schistosoma mansoni neuropeptide F-like receptor 0.001 0.0074 0.0112
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Brugia malayi Dopamine receptor protein 1 0.001 0.0074 0.0112
Brugia malayi jmjC domain containing protein 0.0039 0.0991 0.149
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Brugia malayi 6-phosphofructokinase 0.0123 0.363 0.5457
Giardia lamblia PHD finger protein 15 0.0032 0.0776 0.0653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0123 0.363 0.3747
Loa Loa (eye worm) hypothetical protein 0.014 0.418 0.6283
Echinococcus granulosus peptide allatostatin:somatostatin 0.001 0.0074 0.0112
Toxoplasma gondii phosphofructokinase PFKII 0.0033 0.0801 0.7519
Loa Loa (eye worm) hypothetical protein 0.0105 0.3052 0.4588
Echinococcus granulosus neuropeptide receptor 0.001 0.0074 0.0112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0074 0.0112
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0776 0.1166
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.001 0.0074 0.0112
Leishmania major hypothetical protein, conserved 0.0041 0.1038 0.269
Treponema pallidum fructose-bisphosphate aldolase 0.0325 1 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.1038 0.156
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.001 0.0074 0.0112
Schistosoma mansoni protein phosphatase 2C 0.001 0.0084 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0074 0.0112
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.363 0.5457
Echinococcus multilocularis G-protein coupled receptor, putative 0.001 0.0074 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus multilocularis g protein coupled receptor 0.001 0.0074 0.0112
Echinococcus multilocularis geminin 0.0188 0.5694 0.856
Schistosoma mansoni phd/f-box containing protein 0.001 0.0084 0.0126
Loa Loa (eye worm) beta-lactamase 0.0041 0.1038 0.156
Schistosoma mansoni amine GPCR 0.001 0.0074 0.0112
Schistosoma mansoni amine GPCR 0.001 0.0074 0.0112
Echinococcus multilocularis allatostatin A receptor 0.001 0.0074 0.0112
Brugia malayi Serotonin receptor 0.001 0.0074 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.363 0.363
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni hypothetical protein 0.0188 0.5694 0.856
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Echinococcus multilocularis tachykinin peptides receptor 99D 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0033 0.0798 0.1199
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0106 0.3101 0.4662
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0159 0.4759 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0131 0.0497
Echinococcus granulosus G protein coupled receptor 139 0.001 0.0074 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0088 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Echinococcus granulosus 7TM GPCR rhodopsin 0.001 0.0074 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Echinococcus granulosus voltage gated potassium channel 0.0011 0.0114 0.0172
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus multilocularis neuropeptide receptor 0.001 0.0074 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0074 0.0112
Schistosoma mansoni biogenic amine (5HT) receptor 0.014 0.418 0.6283
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus granulosus neuropeptide s receptor 0.001 0.0074 0.0112
Echinococcus granulosus neuropeptide receptor 0.001 0.0074 0.0112
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0074 0.0112
Brugia malayi GnHR receptor homolog 0.001 0.0074 0.0112
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.001 0.0074 0.0112
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Echinococcus multilocularis GPCR, family 2 0.0033 0.0798 0.1199
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.363 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.001 0.0074 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0074 0.0112
Brugia malayi 6-phosphofructokinase 0.0123 0.363 0.5457
Leishmania major ATP-dependent phosphofructokinase 0.0123 0.363 1
Echinococcus multilocularis g protein coupled receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) phosphofructokinase 0.0123 0.363 0.5457
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0074 0.0112
Schistosoma mansoni biogenic amine receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Brugia malayi gonadotropin-releasing hormone receptor 2 0.001 0.0074 0.0112
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Brugia malayi G-protein coupled receptor 0.001 0.0074 0.0112
Echinococcus granulosus somatostatin receptor 0.001 0.0074 0.0112
Schistosoma mansoni hypothetical protein 0.0011 0.0088 0.0132
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1332 0.2003
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0991 0.149
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) jmjC domain-containing protein 0.001 0.0084 0.0126
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0776 0.1166
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.1038 0.1038
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.001 0.0084 0.0126
Schistosoma mansoni voltage-gated potassium channel 0.0011 0.0114 0.0172
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0668 0.0668
Echinococcus granulosus allatostatin A receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni neuropeptide receptor 0.001 0.0074 0.0112
Brugia malayi G protein-coupled receptor 0.001 0.0074 0.0112
Schistosoma mansoni opsin-like receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0074 0.0112
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0088 0.0012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0916 0.0916
Brugia malayi Dopamine receptor 0.001 0.0074 0.0112
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0074 0.0112
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0776 0.7255
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.001 0.0074 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0074 0.0112
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0074 0.0112
Schistosoma mansoni DNA helicase recq5 0.0012 0.0131 0.0197
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0088 0.0044
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0088 0.0044
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Echinococcus granulosus biogenic amine 5HT receptor 0.014 0.418 0.6283
Echinococcus granulosus neuropeptide FF receptor 2 0.001 0.0074 0.0112
Echinococcus multilocularis vesicular acetylcholine transporter 0.0219 0.6653 1
Loa Loa (eye worm) melatonin receptor type 1A 0.001 0.0074 0.0112
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0991 0.149
Echinococcus granulosus neuropeptide Y receptor 0.001 0.0074 0.0112
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0033 0.0801 0.0679
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0801 1
Loa Loa (eye worm) RecQ helicase 0.0029 0.0668 0.1004
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0074 0.0112
Echinococcus multilocularis sex peptide receptor 0.001 0.0074 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1332 0.2003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.1332 0.2003
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0242 0.0242
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0011 0.0114 0.0172
Brugia malayi G protein-coupled receptor F59B2.13 0.001 0.0074 0.0112
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0476 0.0715
Schistosoma mansoni amine GPCR 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus multilocularis neuropeptide Y receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) G-protein coupled receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0126
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0776 0.1166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.1332 0.2003
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.2009 0.3019
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0033 0.0801 0.0573
Echinococcus multilocularis somatostatin receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0072 0.2009 0.3019
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0776 0.7255
Brugia malayi beta-lactamase family protein 0.0041 0.1038 0.156
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0131 0.0197
Schistosoma mansoni hypothetical protein 0.0188 0.5694 0.856
Echinococcus multilocularis biogenic amine (5HT) receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0798 0.1199
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.001 0.0074 0.0112
Brugia malayi PHD-finger family protein 0.0011 0.0088 0.0132
Toxoplasma gondii ABC1 family protein 0.0041 0.1038 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0123 0.363 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0991 0.149
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0557 0.6597
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus multilocularis fmrfamide receptor 0.001 0.0074 0.0112
Brugia malayi neuropeptide F receptor 0.001 0.0074 0.0112
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0106 0.3101 0.4662
Schistosoma mansoni growth hormone secretagogue receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) neuropeptide F receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0041 0.1038 0.156
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0801 0.0801
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0074 0.0112
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.1038 0.1038
Echinococcus granulosus jumonji domain containing 1A 0.001 0.0084 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.3052 0.4588
Echinococcus granulosus g protein coupled receptor 0.001 0.0074 0.0112
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0801 0.5
Loa Loa (eye worm) hypothetical protein 0.0146 0.4355 0.6547
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.1038 0.156
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.1038 0.156
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0033 0.0801 0.5
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.363 0.363
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.001 0.0074 0.0112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0041 0.1038 0.156
Schistosoma mansoni hypothetical protein 0.0072 0.2009 0.3019
Echinococcus multilocularis neuropeptide FF receptor 2 0.001 0.0074 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.1038 0.269
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0776 0.1166
Echinococcus granulosus jumonji domain containing protein 0.0045 0.1176 0.1768
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.1038 0.1038
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0074 0.0112
Brugia malayi AKH receptor 0.001 0.0074 0.0112
Echinococcus multilocularis g-protein coupled receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0056 0.1506 0.2264
Echinococcus multilocularis lysine specific demethylase 6a 0.001 0.0084 0.0126
Brugia malayi jmjC domain containing protein 0.001 0.0084 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Plasmodium vivax hypothetical protein, conserved 0.0041 0.1038 1
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1332 0.2003
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.001 0.0074 0.0112
Echinococcus granulosus g-protein coupled receptor 0.001 0.0074 0.0112
Schistosoma mansoni hypothetical protein 0.0033 0.0798 0.1199
Brugia malayi PHD-finger family protein 0.0032 0.0776 0.1166
Schistosoma mansoni biogenic amine (5HT) receptor 0.001 0.0074 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0074 0.0112
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.001 0.0074 0.0112
Schistosoma mansoni neuropeptide f receptor 76f 0.001 0.0074 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0074 0.0112
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.001 0.0074 0.0112
Brugia malayi larval opioid receptor 0.001 0.0074 0.0112
Echinococcus multilocularis fmrfamide receptor 0.001 0.0074 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0074 0.0112
Echinococcus granulosus hypothetical protein 0.001 0.0074 0.0112
Brugia malayi ORL1-like opioid receptor 0.001 0.0074 0.0112
Brugia malayi G-protein coupled receptor 0.001 0.0074 0.0112
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0033 0.0801 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.001 0.0074 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0074 0.0112
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0088 0.0132
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0997 0.1499
Echinococcus granulosus thyrotropin releasing hormone receptor 0.001 0.0074 0.0112
Schistosoma mansoni jumonji domain containing protein 0.001 0.0084 0.0126
Echinococcus granulosus dro:myosuppressin receptor 0.001 0.0074 0.0112
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.1176 0.1768
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0088 0.0132
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0668 0.1004
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0325 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.3052 0.4588
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Mycobacterium ulcerans 6-phosphofructokinase 0.0123 0.363 0.6966
Echinococcus multilocularis peregrin 0.0032 0.0776 0.1166
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.001 0.0074 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0074 0.0112
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0242 0.0447
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.363 0.5457
Onchocerca volvulus 0.0171 0.5143 0.7705
Echinococcus multilocularis phd:f box containing protein 0.001 0.0084 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.1038 0.156
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0668 0.0668
Loa Loa (eye worm) hypothetical protein 0.0171 0.5143 0.773
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Echinococcus granulosus neuropeptides capa receptor 0.001 0.0074 0.0112
Schistosoma mansoni amine GPCR 0.001 0.0074 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0801 0.0801
Echinococcus granulosus neuropeptide receptor A26 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0372 0.3021
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.363 0.3472
Echinococcus granulosus 6 phosphofructokinase 0.0123 0.363 0.5457
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0776 0.7255
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0074 0.0112
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.363 0.3472
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0033 0.0801 0.0801
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Schistosoma mansoni opsin-like receptor 0.001 0.0074 0.0112
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.001 0.0074 0.0112
Schistosoma mansoni neuropeptide receptor 0.001 0.0074 0.0112
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0074 0.0112
Brugia malayi Dopamine receptor protein 2 0.001 0.0074 0.0112
Echinococcus granulosus lysine specific demethylase 6a 0.001 0.0084 0.0126
Loa Loa (eye worm) hypothetical protein 0.0041 0.1038 0.156
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0131 0.0197
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0668 0.1004
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0011 0.0114 0.0172
Brugia malayi vesicular acetylcholine transporter unc-17 0.0219 0.6653 1
Echinococcus granulosus vesicular acetylcholine transporter 0.0219 0.6653 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.001 0.0074 0.0112
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0798 0.1199
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.001 0.0074 0.0112
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Brugia malayi sulfakinin receptor protein 0.001 0.0074 0.0112
Brugia malayi beta-lactamase 0.0041 0.1038 0.156
Brugia malayi putative neuropeptide receptor NPR1 0.001 0.0074 0.0112
Loa Loa (eye worm) 6-phosphofructokinase 0.0123 0.363 0.5457
Schistosoma mansoni biogenic amine receptor 0.001 0.0074 0.0112
Brugia malayi RE15519p 0.001 0.0074 0.0112
Echinococcus multilocularis rhodopsin orphan GPCR 0.001 0.0074 0.0112
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Brugia malayi hypothetical protein 0.001 0.0074 0.0112
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0801 0.7519
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.1332 0.2003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.001 0.0074 0.0112
Entamoeba histolytica phosphofructokinase, putative 0.0123 0.363 0.3472
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0801 0.0801
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0365 0.2944
Schistosoma mansoni neuropeptide receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0034 0.0833 0.1252
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.001 0.0074 0.0112
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.001 0.0074 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.0033 0.0801 0.0801
Schistosoma mansoni DNA helicase recq1 0.0012 0.0131 0.0197
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0798 0.1199
Echinococcus multilocularis neuropeptides capa receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.0114 0.0172
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0997 0.1499
Loa Loa (eye worm) hypothetical protein 0.001 0.0084 0.0126
Schistosoma mansoni 6-phosphofructokinase 0.0123 0.363 0.5457
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.1112 0.1671
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0131 0.0662
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.001 0.0074 0.0112
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.001 0.0074 0.0112
Brugia malayi Tachykinin-like peptides receptor 99D 0.001 0.0074 0.0112
Echinococcus multilocularis G protein coupled receptor 139 0.001 0.0074 0.0112
Echinococcus granulosus peregrin 0.0032 0.0776 0.1166
Echinococcus granulosus sex peptide receptor 0.001 0.0074 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0325 1 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0159 0.4759 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0033 0.0801 0.7519
Echinococcus multilocularis jumonji domain containing 1A 0.001 0.0084 0.0126
Brugia malayi Serotonin/octopamine receptor family protein 7 0.001 0.0074 0.0112
Brugia malayi phosphofructokinase 0.0123 0.363 0.5457
Schistosoma mansoni jumonji domain containing protein 0.0084 0.2413 0.3628
Echinococcus granulosus phd:f box containing protein 0.001 0.0084 0.0126
Echinococcus multilocularis neuropeptide receptor 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0041 0.1038 0.156
Schistosoma mansoni opsin-like receptor 0.001 0.0074 0.0112
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.001 0.0074 0.0112
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.001 0.0084 0.0126
Echinococcus multilocularis neuropeptide s receptor 0.001 0.0074 0.0112
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.001 0.0074 0.0112
Echinococcus multilocularis serotonin receptor 0.014 0.418 0.6283
Loa Loa (eye worm) hypothetical protein 0.0041 0.1038 0.156
Echinococcus granulosus g protein coupled receptor 0.001 0.0074 0.0112
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0798 0.1199
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0123 0.363 0.6966
Brugia malayi jmjC domain containing protein 0.001 0.0084 0.0126
Echinococcus granulosus tm gpcr rhodopsin 0.001 0.0074 0.0112
Schistosoma mansoni hypothetical protein 0.0032 0.0776 0.1166
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0131 0.0197
Brugia malayi follicle stimulating hormone receptor 0.001 0.0074 0.0112
Schistosoma mansoni rhodopsin-like orphan GPCR 0.001 0.0074 0.0112
Loa Loa (eye worm) hypothetical protein 0.0011 0.0088 0.0132
Toxoplasma gondii 6-phosphofructokinase 0.0033 0.0801 0.7519
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0219 0.6653 1
Schistosoma mansoni neuropeptide receptor 0.001 0.0074 0.0112
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0131 0.0197
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0131 0.0197
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0242 0.0447
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.1332 0.2003
Trichomonas vaginalis phosphofructokinase, putative 0.0123 0.363 0.363
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0219 0.6653 1
Echinococcus granulosus fmrfamide receptor 0.001 0.0074 0.0112
Onchocerca volvulus 0.0041 0.1038 0.1465
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0997 0.1499
Brugia malayi Bromodomain containing protein 0.0032 0.0776 0.1166
Loa Loa (eye worm) hypothetical protein 0.0012 0.0131 0.0197
Echinococcus granulosus orexin receptor type 2 0.001 0.0074 0.0112
Brugia malayi hypothetical protein 0.0171 0.5143 0.773
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.001 0.0084 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.1038 0.1038
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0131 0.0497
Brugia malayi jmjC domain containing protein 0.0106 0.3101 0.4662
Loa Loa (eye worm) hypothetical protein 0.001 0.0074 0.0112
Brugia malayi putative neuropeptide receptor 0.001 0.0074 0.0112

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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