TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 685.852 | Formula: C39H51N5O6
H donors: 2 H acceptors: 3 LogP: 3.01 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: O=C(C[C@H]1C[C@H](C(=O)N2CCOCC2)[C@@]2(N(C1=O)CCc1c2[nH]c2c1ccc(c2)c1ccco1)CCC1CCCC1)NCCN1CCOCC1
InChi: 1S/C39H51N5O6/c45-35(40-12-14-42-15-20-48-21-16-42)26-29-24-32(38(47)43-17-22-49-23-18-43)39(11-9-27-4-1-2-5-27)36-31(10-13-44(39)37(29)46)30-8-7-28(25-33(30)41-36)34-6-3-19-50-34/h3,6-8,19,25,27,29,32,41H,1-2,4-5,9-18,20-24,26H2,(H,40,45)/t29-,32-,39+/m1/s1
InChiKey: QUUWGVAZRPBGHS-AIKCQAODSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fatty acid synthase	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks12	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	Get druggable targets OG5_126633	All targets in OG5_126633
Onchocerca volvulus	Fatty acid synthase homolog	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks3	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Onchocerca volvulus		Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	KR domain domain-containing protein, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	type I fatty acid synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Polyketide synthase Pks2	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	Type I modular polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Short-chain dehydrogenase/reductase SDR, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	Get druggable targets OG5_126633	All targets in OG5_126633
Neospora caninum	Soraphen polyketide synthase A, related	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Polyketide synthase Pks13	Get druggable targets OG5_126633	All targets in OG5_126633
Cryptosporidium parvum	polyketide synthase	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	acyl carrier protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide beta-ketoacyl synthase Pks4	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	Get druggable targets OG5_126633	All targets in OG5_126633
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	Get druggable targets OG5_126633	All targets in OG5_126633
Toxoplasma gondii	type I fatty acid synthase, putative	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsE	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	Get druggable targets OG5_126633	All targets in OG5_126633
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	Get druggable targets OG5_126633	All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0335	0.4065
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0057	0.0838	0.0718
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0197	0.346	0.5
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0024	0.0225	0.172
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.0369	0.481
Mycobacterium ulcerans	polyketide synthase Pks13	0.0045	0.0612	1
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0032	0.0369	0.481
Echinococcus granulosus	stromal cell derived factor 2	0.0037	0.0458	0.0415
Loa Loa (eye worm)	ryanodine receptor	0.0204	0.3593	0.5744
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.003	0.0335	0.4065
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.0335	0.4065
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.003	0.0335	0.5463
Schistosoma mansoni	ryanodine receptor related	0.0547	1	1
Brugia malayi	MH2 domain containing protein	0.0144	0.2467	0.2368
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0898	0.0779
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0045	0.0612	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0167	0.29	0.2807
Echinococcus multilocularis	ryanodine receptor 44f	0.0443	0.8054	1
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0045	0.0612	1
Schistosoma mansoni	ryanodine receptor 1 skeletal muscle	0.0063	0.0953	0.0835
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.2467	0.3928
Loa Loa (eye worm)	fatty acid synthase	0.003	0.0327	0.0477
Loa Loa (eye worm)	MIR domain-containing protein	0.0037	0.0458	0.0688
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0032	0.0369	0.481
Onchocerca volvulus	Fatty acid synthase homolog	0.0054	0.0785	1
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0298	0.0171
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0024	0.0225	0.172
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0032	0.0369	0.481
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.003	0.0335	0.4065
Mycobacterium ulcerans	polyketide synthase	0.0032	0.0369	0.481
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0335	0.4065
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0029	0.0317	0.5182
Schistosoma mansoni	hypothetical protein	0.0135	0.2295	0.2195
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0032	0.0369	0.6033
Brugia malayi	cation channel family protein	0.0234	0.4145	0.4069
Schistosoma mansoni	hypothetical protein	0.0205	0.3596	0.3513
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0898	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0088	0.0091
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.003	0.0335	0.5463
Toxoplasma gondii	type I fatty acid synthase, putative	0.0021	0.0173	0.3708
Leishmania major	hypothetical protein, conserved	0.0134	0.228	0.5
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0022	0.0176	0.288
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0129	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0716	0.1105
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0025	0.0241	0.3934
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0025	0.0241	0.2064
Brugia malayi	MIR domain containing protein	0.0037	0.0458	0.0333
Mycobacterium ulcerans	thioesterase	0.0025	0.0241	0.2064
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0024	0.0225	0.172
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0898	0.0779
Loa Loa (eye worm)	hypothetical protein	0.01	0.1639	0.2592
Mycobacterium ulcerans	Type I modular polyketide synthase	0.003	0.0335	0.4065
Schistosoma mansoni	hypothetical protein	0.0205	0.3596	0.3513
Echinococcus multilocularis	geminin	0.0205	0.3596	0.4375
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.003	0.0335	0.0208
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0025	0.0232	0.3792
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0032	0.0369	0.6033
Schistosoma mansoni	stromal cell-derived factor 2 precursor-like protein	0.0037	0.0458	0.0333
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0129	0.0157
Echinococcus multilocularis	stromal cell derived factor 2	0.0037	0.0458	0.0415
Mycobacterium ulcerans	thioesterase TesA	0.0025	0.0241	0.2064
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0197	0.346	0.5
Loa Loa (eye worm)	ryanodine receptor	0.0129	0.2187	0.3476
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0032	0.0369	0.6033
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0028	0.0298	0.043
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0017	0.0092	0.1505
Onchocerca volvulus		0.0037	0.0458	0.3286
Echinococcus multilocularis	ryanodine receptor 44f	0.0346	0.6232	0.7701
Mycobacterium leprae	Polyketide synthase Pks13	0.0045	0.0612	1
Loa Loa (eye worm)	hypothetical protein	0.0346	0.6232	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0542	0.0418
Echinococcus granulosus	ryanodine receptor 44f	0.0443	0.8054	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0067	0.1019	0.0901
Loa Loa (eye worm)	hypothetical protein	0.006	0.0898	0.1397
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0542	0.0823
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.002	0.0137	0.2574
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1719	0.2722
Toxoplasma gondii	type I fatty acid synthase, putative	0.0032	0.0369	1
Entamoeba histolytica	MIR domain protein	0.0037	0.0458	0.5
Echinococcus granulosus	geminin	0.0205	0.3596	0.4375
Loa Loa (eye worm)	hypothetical protein	0.0067	0.1019	0.1592
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0032	0.0369	0.481
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0029	0.0317	0.5182
Trichomonas vaginalis	mannosyltransferase 1, putative	0.0037	0.0458	0.5
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.003	0.0335	0.5463
Schistosoma mansoni	hypothetical protein	0.0041	0.0542	0.0418
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0028	0.0298	0.4861
Echinococcus granulosus	ryanodine receptor 44f	0.0346	0.6232	0.7701
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.2467	0.3928
Onchocerca volvulus		0.0052	0.0751	0.9285
Mycobacterium ulcerans	polyketide synthase	0.003	0.0335	0.4065

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	3.76 uM	PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	6.62 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1714150

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1487516