Detailed information for compound 1491464

Basic information

Technical information
  • TDR Targets ID: 1491464
  • Name: 2-[(4-fluorophenyl)methyl]-4-[(5-methyl-1H-py razol-3-yl)amino]phthalazin-1-one
  • MW: 349.362 | Formula: C19H16FN5O
  • H donors: 2 H acceptors: 2 LogP: 2.88 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)Cn1nc(Nc2n[nH]c(c2)C)c2c(c1=O)cccc2
  • InChi: 1S/C19H16FN5O/c1-12-10-17(23-22-12)21-18-15-4-2-3-5-16(15)19(26)25(24-18)11-13-6-8-14(20)9-7-13/h2-10H,11H2,1H3,(H2,21,22,23,24)
  • InChiKey: AQQWXMKDEBTQIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-fluorophenyl)methyl]-4-[(5-methyl-1H-pyrazol-3-yl)amino]-1-phthalazinone
  • 2-(4-fluorobenzyl)-4-[(5-methyl-1H-pyrazol-3-yl)amino]phthalazin-1-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Wolbachia endosymbiont of Brugia malayi ankyrin repeat-containing protein 0.0012 0.0678 0.5
Echinococcus multilocularis voltage dependent calcium channel 0.0002 0.0094 0.0219
Loa Loa (eye worm) hypothetical protein 0.0165 1 1
Schistosoma mansoni mucolipin 0.0065 0.3934 0.9138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0678 0.0589
Echinococcus multilocularis potassium voltage gated channel protein 0.0002 0.0094 0.0219
Brugia malayi serine/threonine protein kinase 6 0.0068 0.41 0.41
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.1559 0.3658
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Echinococcus multilocularis aurora kinase A 0.0068 0.41 0.9544
Giardia lamblia Protein 21.1 0.0012 0.0678 0.1653
Onchocerca volvulus 0.0012 0.0678 0.0589
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0068 0.41 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0021 0.1224 0.2689
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.1366 0.3062
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0002 0.0094 0.0094
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0002 0.0094 0.0219
Toxoplasma gondii aurora kinase 0.0068 0.41 1
Echinococcus granulosus calcium activated potassium channel 0.0003 0.0128 0.008
Onchocerca volvulus 0.0012 0.0678 0.0589
Loa Loa (eye worm) hypothetical protein 0.0012 0.0678 0.0589
Loa Loa (eye worm) hypothetical protein 0.0012 0.0678 0.0589
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0678 0.0589
Echinococcus multilocularis transient receptor potential cation channel 0.0002 0.0094 0.0219
Echinococcus multilocularis voltage gated potassium channel 0.0002 0.0094 0.0219
Brugia malayi Coelomocyte uptake defective protein 5 0.0071 0.4296 0.4296
Echinococcus multilocularis ryanodine receptor 44f 0.0002 0.0094 0.0219
Echinococcus multilocularis sodium leak channel non selective protein 0.0002 0.0094 0.0219
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0002 0.0094 0.0094
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0301 0.0515
Plasmodium vivax exosome complex exonuclease RRP6, putative 0.0003 0.0175 0.0042
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0068 0.41 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0678 0.0589
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0623 0.1451
Loa Loa (eye worm) 3'-5' exonuclease 0.0003 0.0175 0.0082
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0002 0.0094 0.0219
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0002 0.0094 0.0094
Echinococcus multilocularis transient receptor potential cation channel 0.0002 0.0094 0.0219
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.1559 0.1559
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0327 0.0582
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0623 0.152
Echinococcus granulosus transient receptor potential cation channel 0.0002 0.0104 0.0023
Brugia malayi olfactory channel protein osm-9 0.0002 0.0104 0.0104
Leishmania major exosome subunit rrp6p homologue, putative 0.0003 0.0175 0.0202
Schistosoma mansoni transient receptor potential channel 0.0002 0.0094 0.0000001581
Mycobacterium leprae conserved hypothetical protein 0.0003 0.0175 0.5
Trichomonas vaginalis AGC family protein kinase 0.0068 0.41 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0011 0.0623 0.1179
Loa Loa (eye worm) hypothetical protein 0.0012 0.0678 0.0589
Echinococcus multilocularis transient receptor potential cation channel 0.0002 0.0094 0.0219
Trichomonas vaginalis AGC family protein kinase 0.0068 0.41 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0002 0.0094 0.0094
Echinococcus multilocularis polycystic kidney disease protein 2 0.0006 0.0327 0.0762
Loa Loa (eye worm) hypothetical protein 0.0132 0.799 0.7971
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0301 0.0515
Loa Loa (eye worm) AUR protein kinase 0.0068 0.41 0.4044
Entamoeba histolytica protein kinase, putative 0.0068 0.41 1
Loa Loa (eye worm) RecQ helicase 0.0026 0.1559 0.1479
Echinococcus granulosus bloom syndrome protein 0.0026 0.1559 0.3487
Echinococcus granulosus mucolipin 3 0.0071 0.4296 1
Giardia lamblia Aurora kinase 0.0068 0.41 1
Leishmania major hypothetical protein, conserved 0.0006 0.0327 0.0582
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0002 0.0094 0.0094
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0301 0.0491
Loa Loa (eye worm) hypothetical protein 0.0012 0.0678 0.0589
Echinococcus multilocularis potassium voltage gated channel protein 0.0002 0.0094 0.0219
Schistosoma mansoni polymyositis/scleroderma autoantigen-related 0.0003 0.0175 0.0193
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0068 0.41 1
Schistosoma mansoni hypothetical protein 0.0006 0.0327 0.0555
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0002 0.0094 0.0219
Schistosoma mansoni protein kinase 0.0068 0.41 0.9534
Loa Loa (eye worm) mucolipin 1 0.0071 0.4296 0.4242
Onchocerca volvulus 0.0165 1 1
Echinococcus multilocularis sodium channel protein 0.0002 0.0094 0.0219
Schistosoma mansoni mucolipin 0.0071 0.4296 1
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Onchocerca volvulus 0.0012 0.0678 0.0589
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Trypanosoma brucei ribosomal RNA processing protein 6 0.0003 0.0175 0.0202
Echinococcus multilocularis transient receptor potential cation channel 0.0002 0.0104 0.0242
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Loa Loa (eye worm) hypothetical protein 0.0002 0.0094 0.000000067059
Echinococcus multilocularis calcium activated potassium channel 0.0003 0.0128 0.0298
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0002 0.0094 0.0094
Echinococcus granulosus Helicase RNase D C terminal HRDC domain 0.0003 0.0175 0.0193
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Brugia malayi cation channel family protein 0.0002 0.0094 0.0094
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0817 0.1804
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0002 0.0094 0.0219
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0002 0.0094 0.0219
Brugia malayi Transient-receptor-potential like protein 0.0002 0.0094 0.0094
Loa Loa (eye worm) AUR protein kinase 0.0068 0.41 0.4044
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0301 0.0515
Echinococcus granulosus transient receptor potential cation channel 0.0002 0.0094 0.0000001581
Loa Loa (eye worm) hypothetical protein 0.0002 0.0094 0.000000067059
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0002 0.0094 0.0219
Loa Loa (eye worm) hypothetical protein 0.0002 0.0104 0.001
Leishmania major protein kinase, putative 0.0068 0.41 1
Entamoeba histolytica protein kinase , putative 0.0068 0.41 1
Echinococcus multilocularis voltage gated potassium channel 0.0002 0.0094 0.0219
Brugia malayi serine/threonine kinase 12 0.0068 0.41 0.41
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0301 0.032
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0002 0.0094 0.0219
Brugia malayi serine/threonine-protein kinase 6 0.0068 0.41 0.41
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0018 0.103 0.2337
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0623 0.0534
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0002 0.0094 0.0219
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0002 0.0094 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0159 0.0161
Trichomonas vaginalis AGC family protein kinase 0.0068 0.41 1
Entamoeba histolytica recQ family helicase, putative 0.0005 0.0288 0.0287
Echinococcus multilocularis voltage dependent calcium channel 0.0002 0.0094 0.0219
Giardia lamblia Kinase, NEK 0.0001 0.001 0.0024
Toxoplasma gondii hypothetical protein 0.0008 0.0456 0.0904
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0817 0.1804
Echinococcus multilocularis short transient receptor potential channel 6 0.0002 0.0094 0.0219
Trypanosoma brucei aurora B kinase 0.0068 0.41 1
Echinococcus multilocularis shaker cognate 0.0002 0.0094 0.0219
Loa Loa (eye worm) hypothetical protein 0.0011 0.0623 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0003 0.0175 0.0202
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0002 0.0094 0.0094
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0002 0.0094 0.0219
Echinococcus multilocularis two pore calcium channel protein 2 0.0002 0.0094 0.0219
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0068 0.41 0.9534
Toxoplasma gondii hypothetical protein 0.0006 0.0327 0.0582
Echinococcus multilocularis short transient receptor potential channel 6 0.0002 0.0104 0.0242
Mycobacterium tuberculosis Conserved hypothetical alanine rich protein 0.0003 0.0175 1
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0002 0.0094 0.0094
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0002 0.0094 0.0219
Entamoeba histolytica protein kinase, putative 0.0068 0.41 1
Schistosoma mansoni transient receptor potential channel 0.0002 0.0105 0.0026
Brugia malayi hypothetical protein 0.0002 0.0094 0.0094
Trypanosoma cruzi Polycystin cation channel, putative 0.0006 0.0327 0.0582
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.1559 0.3658
Toxoplasma gondii 3'-5' exonuclease domain-containing protein 0.0003 0.0175 0.0202
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0623 0.1321
Schistosoma mansoni transient receptor potential channel 0.0002 0.0094 0.0000001581
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0623 0.0623
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0002 0.0094 0.0219
Trypanosoma brucei Polycystin cation channel, putative 0.0006 0.0327 0.0582
Trypanosoma cruzi Polycystin cation channel, putative 0.0006 0.0327 0.0582
Entamoeba histolytica protein kinase domain containing protein 0.0068 0.41 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0678 0.0589
Mycobacterium ulcerans hypothetical protein 0.0003 0.0175 1
Echinococcus granulosus aurora kinase A 0.0068 0.41 0.9534
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0068 0.41 0.9544
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0327 0.0582
Loa Loa (eye worm) AUR protein kinase 0.0068 0.41 0.4044
Treponema pallidum ATP-dependent DNA helicase 0.0006 0.0301 0.5
Brugia malayi 3'-5' exonuclease family protein 0.0003 0.0175 0.0175
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0623 0.1259
Echinococcus granulosus short transient receptor potential channel 6 0.0002 0.0104 0.0023
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0002 0.0094 0.0094
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Echinococcus multilocularis transient receptor potential gamma protein 0.0002 0.0094 0.0219
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0817 0.1804
Trypanosoma cruzi ribosomal RNA processing protein 6, putative 0.0003 0.0175 0.0202
Echinococcus multilocularis conserved hypothetical protein 0.0002 0.0094 0.0219
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0002 0.0094 0.0094
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0002 0.0094 0.0094
Brugia malayi ion channel NompC 0.0012 0.0689 0.0689
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0002 0.0094 0.0219
Echinococcus multilocularis transient receptor potential cation channel 0.0002 0.0094 0.0219
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Schistosoma mansoni DNA helicase recq1 0.0011 0.0623 0.1259
Echinococcus multilocularis transient receptor potential cation channel 0.0002 0.0104 0.0242
Echinococcus granulosus polycystin 2 0.0006 0.0327 0.0555
Brugia malayi voltage-dependent calcium channel 0.0002 0.0094 0.0094
Echinococcus multilocularis Polycystic kidney disease protein 0.0006 0.0327 0.0762
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0002 0.0094 0.0094
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0002 0.0094 0.0219
Plasmodium falciparum serine/threonine protein kinase, putative 0.0068 0.41 1
Echinococcus multilocularis Helicase RNase D C terminal, HRDC domain 0.0003 0.0175 0.0408
Brugia malayi ion channel NompC 0.0014 0.0807 0.0807
Echinococcus multilocularis potassium voltage gated channel protein 0.0002 0.0094 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0068 0.41 0.9534
Echinococcus granulosus transient receptor potential cation channel 0.0002 0.0094 0.0000001581
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0005 0.0288 0.0327
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0002 0.0094 0.0094
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0002 0.0094 0.0094
Trichomonas vaginalis AGC family protein kinase 0.0068 0.41 1
Echinococcus multilocularis transfer RNA-Gly 0.0002 0.0094 0.0219
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0817 0.1635
Brugia malayi cation channel family protein 0.0002 0.0094 0.0094
Schistosoma mansoni DNA helicase recq5 0.0011 0.0623 0.1259
Echinococcus multilocularis potassium large conductance calcium activated 0.0002 0.0094 0.0219
Trypanosoma cruzi aurora B kinase, putative 0.0068 0.41 1
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0623 0.0623
Echinococcus multilocularis two pore calcium channel protein 1 0.0002 0.0094 0.0219
Schistosoma mansoni hypothetical protein 0.0006 0.0327 0.0555
Loa Loa (eye worm) ion channel NompC 0.0014 0.0807 0.0719
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0623 0.1451
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0002 0.0094 0.0219
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0018 0.1043 0.2244
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0068 0.41 1
Echinococcus granulosus Polycystic kidney disease protein 0.0006 0.0327 0.0555
Echinococcus multilocularis hyperpolarization activated cyclic 0.0002 0.0094 0.0219
Schistosoma mansoni polycystin 1-related 0.0006 0.0327 0.0555
Giardia lamblia Kinase, NEK 0.0001 0.0009 0.0021
Echinococcus multilocularis mucolipin 3 0.0071 0.4296 1
Brugia malayi Cyclic-nucleotide gated cation channel 0.0002 0.0094 0.0094
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0817 0.1804
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0002 0.0094 0.0219
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0623 0.1321
Echinococcus granulosus polycystic kidney disease protein 2 0.0006 0.0327 0.0555
Loa Loa (eye worm) hypothetical protein 0.0006 0.0301 0.0208
Echinococcus multilocularis potassium voltage gated channel protein 0.0002 0.0094 0.0219
Echinococcus multilocularis hyperpolarization activated cyclic 0.0002 0.0094 0.0219
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0623 0.1259
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0002 0.0094 0.0094
Echinococcus multilocularis bloom syndrome protein 0.0026 0.1559 0.363
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0002 0.0094 0.0219

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.014 uM Inhibition of Aurora A by ELISA ChEMBL. 21128645
IC50 (functional) = 1.4 uM Cytotoxicity against human HCT116 cells after 5 days by celltiter-glo assay ChEMBL. 21128645
IC50 (functional) = 17 uM Cytotoxicity against human COLO205 cells ChEMBL. 21128645
IC50 (functional) > 30 uM Cytotoxicity against human MCF7 cells ChEMBL. 21128645
IC50 (binding) = 69 uM Inhibition of Aurora B by ELISA ChEMBL. 21128645

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 21128645

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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