Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | 0.0024 | 0.0394 | 0.5 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0024 | 0.0394 | 0.1603 |
Trypanosoma brucei | beta tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1622 | 0.6603 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2456 | 1 |
Trypanosoma brucei | epsilon tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1622 | 0.1622 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.2456 | 1 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0024 | 0.0394 | 0.1603 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0024 | 0.0394 | 0.5 |
Plasmodium falciparum | ornithine aminotransferase | 0.0024 | 0.0394 | 1 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0024 | 0.0394 | 1 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | tubulin gamma chain | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2456 | 1 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0014 | 0 | 0.5 |
Giardia lamblia | Alpha-tubulin | 0.0014 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0014 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0076 | 0.2456 | 0.2456 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1622 | 0.6603 |
Trypanosoma cruzi | beta tubulin, putative | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Giardia lamblia | Alpha-tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | tubulin gamma chain | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2456 | 1 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0024 | 0.0394 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2456 | 1 |
Trypanosoma brucei | alpha tubulin | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0024 | 0.0394 | 0.1603 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.2456 | 1 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0014 | 0 | 0.5 |
Giardia lamblia | Gamma tubulin | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1622 | 0.6603 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0269 | 1 | 1 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | ornithine aminotransferase | 0.0024 | 0.0394 | 0.1603 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.2456 | 1 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0014 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | epsilon tubulin, putative | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.2456 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1622 | 0.6603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.2456 | 1 |
Echinococcus granulosus | Aminotransferase class III | 0.0024 | 0.0394 | 0.1603 |
Entamoeba histolytica | tubulin family protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1622 | 0.6603 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1622 | 0.6603 |
Trypanosoma cruzi | tubulin gamma chain | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1622 | 0.6603 |
Mycobacterium leprae | Probable Acetylornithine aminotransferase ArgD | 0.0024 | 0.0394 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0014 | 0 | 0.5 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.2456 | 0.2456 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0024 | 0.0394 | 0.5 |
Mycobacterium leprae | PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) | 0.0024 | 0.0394 | 0.5 |
Leishmania major | gamma-tubulin | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1622 | 0.6603 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.2456 | 1 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.2456 | 0.2456 |
Leishmania major | alpha tubulin | 0.0014 | 0 | 0.5 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0024 | 0.0394 | 1 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0024 | 0.0394 | 1 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0014 | 0 | 0.5 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0269 | 1 | 1 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | Aminotransferase class III | 0.0024 | 0.0394 | 0.1603 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.