Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | survival of motor neuron 2, centromeric | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus granulosus | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Echinococcus multilocularis | survival motor neuron protein 1 | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132873 | All targets in OG5_132873 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Mycobacterium leprae | Probable Acetylornithine aminotransferase ArgD | 0.0024 | 0.0325 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0058 | 0.1593 | 0.1593 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.1593 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) | 0.0024 | 0.0325 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | gamma-tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | epsilon tubulin, putative | 0.0015 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0015 | 0 | 0.5 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0024 | 0.0325 | 1 |
Plasmodium falciparum | ornithine aminotransferase | 0.0024 | 0.0325 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0024 | 0.0325 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0015 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0024 | 0.0325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0015 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0024 | 0.0325 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | tubulin gamma chain | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma cruzi | tubulin gamma chain | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | ornithine aminotransferase | 0.0024 | 0.0325 | 0.0325 |
Trypanosoma brucei | epsilon tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0015 | 0 | 0.5 |
Mycobacterium leprae | Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM | 0.0024 | 0.0325 | 0.5 |
Mycobacterium tuberculosis | Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) | 0.0269 | 0.9377 | 1 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0015 | 0 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | Aminotransferase class III | 0.0024 | 0.0325 | 0.0325 |
Echinococcus granulosus | Aminotransferase class III | 0.0024 | 0.0325 | 0.0325 |
Trypanosoma brucei | alpha tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0024 | 0.0325 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0015 | 0 | 0.5 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0015 | 0 | 0.5 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0286 | 1 | 1 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0024 | 0.0325 | 0.0325 |
Mycobacterium ulcerans | L-lysine aminotransferase | 0.0269 | 0.9377 | 1 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0015 | 0 | 0.5 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0269 | 0.9377 | 0.9377 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | tubulin gamma chain | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0024 | 0.0325 | 0.0325 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0024 | 0.0325 | 0.2039 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Giardia lamblia | Gamma tubulin | 0.0015 | 0 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0058 | 0.1593 | 0.5 | |
Schistosoma mansoni | survival motor neuron protein | 0.0058 | 0.1593 | 1 |
Trypanosoma brucei | beta tubulin | 0.0015 | 0 | 0.5 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0024 | 0.0325 | 0.5 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | alpha tubulin | 0.0015 | 0 | 0.5 |
Leishmania major | beta tubulin | 0.0015 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Activation of SMN expressed in HEK293 cells assessed as concentration required to reach 50% of maximum luciferase signal by SMN2-promotor driven luciferase reporter gene assay | ChEMBL. | 21819082 | |
Potency (functional) | 5.4679 uM | PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Enhancers of SMN2 Splice Variant Expression for Further Probe SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1474] | ChEMBL. | No reference |
Potency (functional) | 89.7249 uM | PUBCHEM_BIOASSAY: Counterscreen Assay for Enhancers of SMN2 Splice Variant Expression: Interaction with Luciferase Reporter for Further Probe SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1474] | ChEMBL. | No reference |
Potency (functional) | 30748.2558 uM | PUBCHEM_BIOASSAY: Counterscreen Assay for Enhancers of SMN2 Splice Variant Expression: Modulation of SMN1 Expression for Further Probe SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1474] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.