Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.2691 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0042 | 0.3378 | 0.5 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0042 | 0.3378 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0042 | 0.3378 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0042 | 0.3378 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0035 | 0.2691 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0042 | 0.3378 | 0.3378 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0042 | 0.3378 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0042 | 0.3378 | 0.3378 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0042 | 0.3378 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0038 | 0.2966 | 0.8778 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0102 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.3378 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0042 | 0.3378 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0038 | 0.2966 | 0.8778 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0042 | 0.3378 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2414 | 0.2414 |
Echinococcus multilocularis | 0.0042 | 0.3378 | 1 | |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0042 | 0.3378 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.3349 | 0.9914 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0042 | 0.3378 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0041 | 0.3349 | 0.9914 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0038 | 0.2966 | 0.2966 |
Trypanosoma brucei | cytochrome P450, putative | 0.01 | 0.9783 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0042 | 0.3378 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.01 | 0.9783 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.01 | 0.9783 | 0.9783 |
Mycobacterium leprae | putative cytochrome p450 | 0.0042 | 0.3378 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0042 | 0.3378 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.5195 | 0.5195 |
Loa Loa (eye worm) | cytochrome P450 | 0.0042 | 0.3378 | 0.3378 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0042 | 0.3378 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0038 | 0.2966 | 0.2966 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.01 | 0.9783 | 0.9783 |
Brugia malayi | Cytochrome P450 family protein | 0.01 | 0.9783 | 0.9783 |
Loa Loa (eye worm) | CYP4Cod1 | 0.01 | 0.9783 | 0.9783 |
Trypanosoma cruzi | cytochrome P450, putative | 0.01 | 0.9783 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.01 | 0.9783 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0042 | 0.3378 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.01 | 0.9783 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0042 | 0.3378 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0042 | 0.3378 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.01 | 0.9783 | 0.9783 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 28 nM | Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cells | ChEMBL. | 11133072 |
Ki (binding) | = 28 nM | Displacement of [3H]-ketanserin from human 5-hydroxytryptamine 2A receptor expressed in CHO cells | ChEMBL. | 11133072 |
Ratio (binding) | = 2 | Selectivity as ratio of Ki against human dopamine D2 and 5-HT2A receptors | ChEMBL. | 11133072 |
Ratio (binding) | = 30 | Selectivity as ratio of Ki against human 5-HT2C and 5-HT2A receptors | ChEMBL. | 11133072 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.