Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0088 | 0.0372 | 0.0372 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.0563 | 0.1979 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0072 | 0.0253 |
Echinococcus multilocularis | serotonin transporter | 0.0088 | 0.0372 | 0.0372 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.006 | 0.006 |
Echinococcus granulosus | lamin b receptor | 0.0088 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.2393 | 0.8414 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.008 | 0.028 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.0563 | 0.1979 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0112 | 0.0539 | 0.0539 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0374 | 0.2393 | 0.8414 |
Loa Loa (eye worm) | inositol-1 | 0.0072 | 0.0259 | 0.091 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.008 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0465 | 0.1635 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0088 | 0.0372 | 0.1307 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.006 | 0.021 |
Brugia malayi | Inositol-1 | 0.0072 | 0.0259 | 0.091 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0082 | 0.033 | 0.1159 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0088 | 0.0372 | 0.5 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0465 | 0.0465 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Leishmania major | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.008 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.008 | 0.028 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0374 | 0.2393 | 1 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.0088 | 0.0372 | 0.0372 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.008 | 0.008 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0072 | 0.0259 | 0.0259 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Echinococcus granulosus | serotonin transporter | 0.0088 | 0.0372 | 0.0372 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0438 | 0.2844 | 1 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0044 | 0.0061 | 0.0213 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0072 | 0.0259 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.006 | 0.006 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.0797 | 0.2802 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0091 | 0.039 | 0.1372 |
Leishmania major | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0072 | 0.0259 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0088 | 0.0372 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Trypanosoma brucei | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.0797 | 0.2802 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Loa Loa (eye worm) | serotonin transporter b | 0.0088 | 0.0372 | 0.1307 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.008 | 0.028 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0076 | 0.0286 | 0.0286 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0797 | 0.2802 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1101 | 0.1101 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0076 | 0.0286 | 0.0286 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.008 | 0.008 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.2844 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.008 | 0.008 |
Schistosoma mansoni | inositol monophosphatase | 0.0072 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0539 | 0.1894 |
Onchocerca volvulus | 0.0088 | 0.0372 | 0.1307 | |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1101 | 0.1101 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.006 | 0.006 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0374 | 0.2393 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.0465 | 0.1635 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0607 | 0.2134 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0088 | 0.0372 | 0.1307 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.1361 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Echinococcus granulosus | geminin | 0.0191 | 0.1101 | 0.1101 |
Echinococcus multilocularis | lamin b receptor | 0.0088 | 0.0372 | 0.0372 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0076 | 0.0286 | 0.0286 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0607 | 0.2134 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0044 | 0.0061 | 0.0061 |
Schistosoma mansoni | inositol monophosphatase | 0.0072 | 0.0259 | 0.0259 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.006 | 0.021 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0103 | 0.0478 | 0.0478 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.008 | 0.008 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.0563 | 0.1979 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0065 | 0.0205 | 1 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.2844 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.0797 | 0.2802 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0072 | 0.0259 | 0.0259 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0065 | 0.0205 | 0.1507 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0805 | 0.5437 | 0.5437 |
Loa Loa (eye worm) | glutamate receptor | 0.0091 | 0.039 | 0.1372 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0072 | 0.0259 | 0.5 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0072 | 0.0259 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0088 | 0.0372 | 0.1307 |
Echinococcus multilocularis | geminin | 0.0191 | 0.1101 | 0.1101 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.008 | 0.008 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0374 | 0.2393 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0112 | 0.0539 | 0.0539 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 0 mm | Antituberculosis activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 21429744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.