Detailed information for compound 151686

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 411.536 | Formula: C21H37N3O5
  • H donors: 2 H acceptors: 5 LogP: 2.52 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC[C@@H](C(=O)N[C@@H](C(C)(C)C)C(=O)N1CCC(CC1)C(=O)C)CN(C=O)O
  • InChi: 1S/C21H37N3O5/c1-6-7-8-17(13-24(29)14-25)19(27)22-18(21(3,4)5)20(28)23-11-9-16(10-12-23)15(2)26/h14,16-18,29H,6-13H2,1-5H3,(H,22,27)/t17-,18-/m1/s1
  • InChiKey: NIQSBYDEZPZESQ-QZTJIDSGSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli peptide deformylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium yoelii polypeptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium falciparum peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium ulcerans peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) Get druggable targets OG5_128237 All targets in OG5_128237
Wolbachia endosymbiont of Brugia malayi peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium berghei peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Plasmodium vivax peptide deformylase, putative Get druggable targets OG5_128237 All targets in OG5_128237
Chlamydia trachomatis peptide deformylase Get druggable targets OG5_128237 All targets in OG5_128237
Treponema pallidum polypeptide deformylase (def) Get druggable targets OG5_128237 All targets in OG5_128237
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128237 All targets in OG5_128237
Neospora caninum Peptide deformylase, related Get druggable targets OG5_128237 All targets in OG5_128237
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.2024 0.3828
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0095 0.018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0095 0.018
Schistosoma mansoni endoplasmin 0.0037 0.0302 0.0631
Trichomonas vaginalis superoxide dismutase, putative 0.0067 0.0714 0.0619
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0106 0.02
Brugia malayi hypothetical protein 0.0084 0.0943 0.1076
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0095 0.018
Trichomonas vaginalis set domain proteins, putative 0.074 1 1
Echinococcus multilocularis heat shock protein 90 0.003 0.0196 0.0371
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0095 0.0109
Entamoeba histolytica iron-containing superoxide dismutase 0.0067 0.0714 0.4009
Trypanosoma brucei heat shock protein, putative 0.0037 0.0302 0.2408
Echinococcus multilocularis RUN 0.0023 0.0106 0.02
Loa Loa (eye worm) inositol-1 0.0036 0.0288 0.0329
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.1253 1
Echinococcus multilocularis manganese superoxide dismutase 0.0067 0.0714 0.1351
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0095 0.018
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0095 0.0109
Plasmodium falciparum endoplasmin, putative 0.0023 0.0102 0.028
Onchocerca volvulus 0.0023 0.0106 0.001
Loa Loa (eye worm) hypothetical protein 0.0299 0.3907 0.446
Loa Loa (eye worm) hypothetical protein 0.006 0.0608 0.0694
Schistosoma mansoni heat shock protein 0.0037 0.0302 0.0631
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Loa Loa (eye worm) hypothetical protein 0.0049 0.0457 0.0522
Schistosoma mansoni hypothetical protein 0.0047 0.0433 0.0905
Brugia malayi nuclear receptor NHR-88 0.0023 0.0095 0.0109
Schistosoma mansoni survival motor neuron protein 0.0056 0.0552 0.1155
Trypanosoma brucei heat shock protein, putative 0.0037 0.0302 0.2408
Trypanosoma cruzi Iron/manganese superoxide dismutases, C-terminal domain containing protein, putative 0.0017 0.0017 0.0133
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.003 0.0196 0.0371
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0095 0.018
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0236 0.0114
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0095 0.018
Echinococcus granulosus endoplasmin 0.003 0.0196 0.0371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0095 0.0109
Giardia lamblia Heat shock protein HSP 90-alpha 0.0037 0.0302 1
Schistosoma mansoni hypothetical protein 0.0023 0.0106 0.0221
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0095 0.0199
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.2024 0.3828
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.1351 0.2556
Schistosoma mansoni polycystin 1-related 0.0023 0.0106 0.0221
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0067 0.0714 0.0619
Echinococcus granulosus heat shock protein 90 0.0037 0.0302 0.0571
Leishmania major superoxide dismutase, putative 0.0038 0.0312 0.2489
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0095 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0109
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Loa Loa (eye worm) heat shock protein 90 0.0037 0.0302 0.0344
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0288 0.0793
Schistosoma mansoni lipoxygenase 0.0139 0.1705 0.3567
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.1351 0.1543
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Schistosoma mansoni hypothetical protein 0.0047 0.0433 0.0905
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0214 0.0244
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.0943 0.1972
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Wolbachia endosymbiont of Brugia malayi superoxide dismutase, SodA 0.0067 0.0714 0.1507
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0302 0.0126
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0109
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Loa Loa (eye worm) hypothetical protein 0.0031 0.0206 0.0235
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.009 0.1025 0.1938
Trypanosoma cruzi superoxide dismutase, putative 0.0038 0.0312 0.2489
Brugia malayi Endoplasmin precursor 0.0037 0.0302 0.0344
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.065 0.876 1
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0067 0.0714 0.5701
Trypanosoma brucei Polypeptide deformylase 1 0.0106 0.1253 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.021 0.024
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0106 0.02
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0014 0.0016
Echinococcus granulosus tumor protein p63 0.0399 0.5287 1
Trypanosoma cruzi superoxide dismutase, putative 0.0017 0.0017 0.0133
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0095 0.0109
Trypanosoma cruzi Peptide deformylase 2, putative 0.0106 0.1253 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0109
Leishmania major polypeptide deformylase-like protein, putative 0.0106 0.1253 1
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0095 0.0199
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0457 0.0864
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0095 0.0109
Echinococcus multilocularis muscleblind protein 1 0.0172 0.2162 0.4089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0095 0.0199
Echinococcus granulosus heat shock protein 90 0.003 0.0196 0.0371
Plasmodium vivax peptide deformylase, putative 0.0279 0.3634 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0095 0.0109
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0106 0.02
Schistosoma mansoni lamin 0.0031 0.0214 0.0447
Onchocerca volvulus 0.0031 0.0214 0.012
Entamoeba histolytica hypothetical protein 0.0084 0.0943 0.6158
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.1351 0.2556
Trypanosoma cruzi Heat shock protein 83, putative 0.0037 0.0302 0.2408
Echinococcus multilocularis heat shock protein 90 0.0037 0.0302 0.0571
Mycobacterium leprae Probable superoxide dismutase SodA 0.0067 0.0714 0.1507
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0095 0.0109
Loa Loa (eye worm) hypothetical protein 0.0023 0.0106 0.0121
Mycobacterium tuberculosis Superoxide dismutase [FE] SodA 0.0067 0.0714 0.1966
Trypanosoma cruzi iron superoxide dismutase A, mitochondrial 0.0067 0.0714 0.5701
Trypanosoma cruzi superoxide dismutase, putative 0.0038 0.0312 0.2489
Brugia malayi CHE-14 protein 0.0049 0.0457 0.0522
Trypanosoma brucei iron superoxide dismutase A, mitochondrial 0.0067 0.0714 0.5701
Trypanosoma cruzi iron superoxide dismutase, putative 0.0046 0.0419 0.3345
Trypanosoma cruzi superoxide dismutase, putative 0.0038 0.0312 0.2489
Trichomonas vaginalis heat shock protein, putative 0.003 0.0196 0.0096
Trichomonas vaginalis heat shock protein, putative 0.003 0.0196 0.0096
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0109
Trichomonas vaginalis iron superoxide dismutase A, putative 0.0067 0.0714 0.0619
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.003 0.0196 0.0541
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0095 0.0109
Schistosoma mansoni coup transcription factor 0.0023 0.0095 0.0199
Schistosoma mansoni hypothetical protein 0.0051 0.0486 0.1017
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0302 0.2408
Brugia malayi Superoxide dismutase, mitochondrial precursor, putative 0.0067 0.0714 0.0816
Leishmania major superoxide dismutase, putative 0.0038 0.0312 0.2489
Echinococcus multilocularis heat shock protein 0.0037 0.0302 0.0571
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.1253 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0093 0.1072 0.2242
Brugia malayi Cytochrome P450 family protein 0.0031 0.021 0.024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0095 0.018
Echinococcus granulosus muscleblind protein 0.0172 0.2162 0.4089
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Toxoplasma gondii superoxide dismutase SOD2 0.0067 0.0714 0.1966
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0109
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.0943 0.1783
Loa Loa (eye worm) hypothetical protein 0.0113 0.1351 0.1543
Schistosoma mansoni heat shock protein 0.0037 0.0302 0.0631
Schistosoma mansoni rab6-interacting 0.0023 0.0106 0.0221
Echinococcus granulosus intermediate filament protein 0.0031 0.0214 0.0404
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0095 0.0199
Trypanosoma brucei heat shock protein, putative 0.0037 0.0302 0.2408
Loa Loa (eye worm) endoplasmin 0.0037 0.0302 0.0344
Plasmodium falciparum superoxide dismutase [Fe] 0.0038 0.0312 0.0858
Brugia malayi hypothetical protein 0.0023 0.0106 0.0121
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0095 0.0199
Schistosoma mansoni hypothetical protein 0.0047 0.0433 0.0905
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0095 0.0109
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0067 0.0714 0.0619
Toxoplasma gondii heat shock protein HSP90 0.0037 0.0302 0.083
Schistosoma mansoni inositol monophosphatase 0.0036 0.0288 0.0603
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Echinococcus multilocularis endoplasmin 0.003 0.0196 0.0371
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Echinococcus granulosus histone lysine methyltransferase setb 0.0093 0.1072 0.2027
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0236 0.0648
Brugia malayi Pre-SET motif family protein 0.0093 0.1072 0.1224
Onchocerca volvulus 0.0058 0.059 0.0499
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Treponema pallidum polypeptide deformylase (def) 0.0279 0.3634 1
Echinococcus multilocularis protein patched 0.0049 0.0457 0.0864
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0552 0.063
Onchocerca volvulus 0.0093 0.1072 0.0986
Toxoplasma gondii thioredoxin domain-containing protein 0.0217 0.2783 0.766
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0095 0.018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0095 0.0199
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0457 0.0522
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0106 0.0121
Trypanosoma brucei heat shock protein, putative 0.0037 0.0302 0.2408
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.1351 1
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0457 0.0359
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0095 0.018
Entamoeba histolytica heat shock protein 90, putative 0.0037 0.0302 0.0126
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0288 0.2301
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0288 0.0188
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0109
Trypanosoma brucei heat shock protein, putative 0.0037 0.0302 0.2408
Echinococcus granulosus expressed conserved protein 0.0107 0.1256 0.2376
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.1072 0.2242
Schistosoma mansoni endoplasmin 0.0037 0.0302 0.0631
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0106 0.1253 1
Onchocerca volvulus 0.0056 0.0552 0.0461
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.0943 0.1783
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0095 0.0199
Schistosoma mansoni lamin 0.0031 0.0214 0.0447
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0046 0.0419 0.0327
Echinococcus multilocularis geminin 0.0362 0.4781 0.9043
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0067 0.0714 0.0625
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.003 0.0196 0.1567
Echinococcus multilocularis expressed conserved protein 0.0107 0.1256 0.2376
Echinococcus multilocularis muscleblind protein 0.0172 0.2162 0.4089
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0095 0.0199
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Schistosoma mansoni cellular tumor antigen P53 0.0058 0.059 0.1234
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0095 0.018
Schistosoma mansoni loxhd1 0.0023 0.0106 0.0221
Loa Loa (eye worm) hypothetical protein 0.0023 0.0106 0.0121
Plasmodium vivax thioredoxin 3, putative 0.0217 0.2783 0.766
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.009 0.0717
Plasmodium vivax SET domain protein, putative 0.0093 0.1072 0.295
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0095 0.0109
Trypanosoma brucei Peptide deformylase 2 0.0106 0.1253 1
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.3548 0.671
Loa Loa (eye worm) hypothetical protein 0.0067 0.0714 0.0816
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0095 0.0109
Trypanosoma brucei heat shock protein, putative 0.0037 0.0302 0.2408
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0095 0.0109
Leishmania major iron superoxide dismutase, putative 0.0067 0.0714 0.5701
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0214 0.0244
Plasmodium vivax endoplasmin, putative 0.0037 0.0302 0.083
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0214 0.0244
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0095 0.0109
Plasmodium falciparum thioredoxin 3 0.0217 0.2783 0.766
Schistosoma mansoni hypothetical protein 0.0362 0.4781 1
Trypanosoma cruzi iron superoxide dismutase, putative 0.0067 0.0714 0.5701
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0288 0.0188
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0302 0.2408
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0279 0.3634 1
Trypanosoma cruzi Iron/manganese superoxide dismutases, C-terminal domain containing protein, putative 0.0017 0.0017 0.0133
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0014 0.0016
Echinococcus granulosus RUN 0.0023 0.0106 0.02
Trypanosoma cruzi heat shock protein 85, putative 0.003 0.0196 0.1567
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0095 0.0109
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0095 0.0109
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0139 0.1705 0.3225
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0095 0.018
Loa Loa (eye worm) hypothetical protein 0.0023 0.0095 0.0109
Echinococcus multilocularis tumor protein p63 0.0399 0.5287 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0288 0.0188
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Loa Loa (eye worm) hypothetical protein 0.0172 0.2162 0.2468
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0095 0.0109
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0106 0.0291
Trypanosoma cruzi heat shock protein 90, putative 0.003 0.0196 0.1567
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0288 0.0267
Loa Loa (eye worm) hypothetical protein 0.0273 0.3548 0.405
Echinococcus granulosus lamin 0.0031 0.0214 0.0404
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.1072 0.2242
Loa Loa (eye worm) hypothetical protein 0.0172 0.2162 0.2468
Schistosoma mansoni superoxide dismutase [mn] 0.0067 0.0714 0.1494
Brugia malayi Doublecortin family protein 0.0023 0.0106 0.0121
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0279 0.3634 1
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Plasmodium falciparum superoxide dismutase [Fe] 0.0067 0.0714 0.1966
Entamoeba histolytica hypothetical protein 0.0084 0.0943 0.6158
Schistosoma mansoni hypothetical protein 0.0084 0.0943 0.1972
Trypanosoma brucei Mitochondrial SSU ribosomal protein, putative 0.0017 0.0017 0.0133
Brugia malayi Pre-SET motif family protein 0.065 0.876 1
Toxoplasma gondii superoxide dismutase SOD3 0.0067 0.0714 0.1966
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0095 0.018
Onchocerca volvulus Superoxide dismutase [Mn], mitochondrial homolog 0.0067 0.0714 0.0625
Leishmania major iron superoxide dismutase 0.0067 0.0714 0.5701
Trichomonas vaginalis heat shock protein, putative 0.0037 0.0302 0.0202
Trypanosoma brucei heat shock protein, putative 0.0037 0.0302 0.2408
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0095 0.0199
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0106 0.02
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0095 0.0199
Echinococcus granulosus heat shock protein 0.0037 0.0302 0.0571
Trichomonas vaginalis superoxide dismutase [mn], putative 0.0067 0.0714 0.0619
Brugia malayi steroid hormone receptor 0.0023 0.0095 0.0109
Toxoplasma gondii superoxide dismutase 0.0067 0.0714 0.1966
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0457 0.0864
Brugia malayi nuclear hormone receptor 0.0023 0.0095 0.0109
Toxoplasma gondii hypothetical protein 0.0279 0.3634 1
Plasmodium vivax heat shock protein 86, putative 0.0037 0.0302 0.083
Trypanosoma cruzi iron superoxide dismutase, putative 0.0067 0.0714 0.5701
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0095 0.0109
Trypanosoma brucei superoxide dismutase, putative 0.0038 0.0312 0.2489
Brugia malayi hypothetical protein 0.0023 0.0106 0.0121
Schistosoma mansoni hypothetical protein 0.0362 0.4781 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.1072 0.1224
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0095 0.018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0095 0.018
Plasmodium falciparum peptide deformylase 0.0279 0.3634 1
Schistosoma mansoni hypothetical protein 0.0047 0.0433 0.0905
Trypanosoma cruzi superoxide dismutase, putative 0.0038 0.0312 0.2489
Trichomonas vaginalis heat shock protein, putative 0.003 0.0196 0.0096
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0288 0.0545
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0095 0.0109
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.1072 0.295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0095 0.0109
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0288 0.2301
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0288 0.2301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0095 0.0109
Chlamydia trachomatis peptide deformylase 0.0279 0.3634 1
Schistosoma mansoni inositol monophosphatase 0.0036 0.0288 0.0603
Trichomonas vaginalis superoxide dismutase [fe], putative 0.0067 0.0714 0.0619
Brugia malayi hypothetical protein 0.0273 0.3548 0.405
Entamoeba histolytica hypothetical protein 0.0084 0.0943 0.6158
Echinococcus granulosus manganese superoxide dismutase 0.0067 0.0714 0.1351
Brugia malayi Muscleblind-like protein 0.0172 0.2162 0.2468
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0095 0.0109
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0095 0.018
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0095 0.0199
Toxoplasma gondii heat shock protein 90, putative 0.0037 0.0302 0.083
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0288 0.0267
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0302 0.2408
Leishmania major heat shock protein 83-1 0.0037 0.0302 0.2408
Brugia malayi hypothetical protein 0.0299 0.3907 0.446
Loa Loa (eye worm) hypothetical protein 0.0058 0.059 0.0673
Trypanosoma brucei iron superoxide dismutase 0.0067 0.0714 0.5701
Echinococcus multilocularis protein dispatched 1 0.0056 0.0552 0.1044
Plasmodium vivax superoxide dismutase [Fe], putative 0.0038 0.0312 0.0858
Trypanosoma cruzi iron superoxide dismutase, putative 0.0067 0.0714 0.5701
Leishmania major iron superoxide dismutase, putative 0.0067 0.0714 0.5701
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0095 0.018
Onchocerca volvulus 0.0031 0.0214 0.012
Trichomonas vaginalis superoxide dismutase, putative 0.0067 0.0714 0.0619
Trypanosoma brucei Heat shock protein 83, putative 0.0037 0.0302 0.2408
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0106 0.02
Brugia malayi Inositol-1 0.0036 0.0288 0.0329
Mycobacterium ulcerans superoxide dismutase [Fe] SodA 0.0067 0.0714 0.1507
Brugia malayi ecdysteroid receptor 0.0023 0.0095 0.0109
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0095 0.018
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.1376 0.2877
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0093 0.1072 0.2027
Brugia malayi heat shock protein 90 0.0037 0.0302 0.0344
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0457 0.0864
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0279 0.3634 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0095 0.0199
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0095 0.018
Schistosoma mansoni patched 1 0.0049 0.0457 0.0956
Schistosoma mansoni hypothetical protein 0.0056 0.0552 0.1155
Schistosoma mansoni lipoxygenase 0.0097 0.1127 0.2358
Mycobacterium ulcerans peptide deformylase 0.0279 0.3634 1
Echinococcus granulosus geminin 0.0362 0.4781 0.9043
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0288 0.0545
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0106 0.0291
Echinococcus granulosus lamin dm0 0.0031 0.0214 0.0404
Onchocerca volvulus 0.0299 0.3907 0.3848
Plasmodium vivax superoxide dismutase [Fe], putative 0.0067 0.0714 0.1966
Onchocerca volvulus 0.0023 0.0106 0.001
Trypanosoma brucei iron superoxide dismutase C, mitochondrial 0.0038 0.0312 0.2489
Entamoeba histolytica hypothetical protein 0.0084 0.0943 0.6158
Trypanosoma cruzi heat shock protein 85, putative 0.0037 0.0302 0.2408
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0095 0.0109
Loa Loa (eye worm) hypothetical protein 0.0031 0.0214 0.0244
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.1072 0.2027
Trypanosoma cruzi heat shock protein 90, putative 0.0037 0.0302 0.2408
Echinococcus multilocularis lamin 0.0031 0.0214 0.0404
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0139 0.1705 0.3225
Echinococcus multilocularis lamin dm0 0.0031 0.0214 0.0404
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0106 0.02
Trypanosoma brucei heat shock protein 90, putative 0.0037 0.0302 0.2408
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.1072 0.2242
Plasmodium falciparum heat shock protein 90 0.0037 0.0302 0.083
Trypanosoma brucei heat shock protein, putative 0.0037 0.0302 0.2408
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0095 0.0109
Brugia malayi intermediate filament protein 0.0031 0.0214 0.0244
Schistosoma mansoni intermediate filament proteins 0.0031 0.0214 0.0447
Echinococcus multilocularis musashi 0.0031 0.0214 0.0404
Trypanosoma brucei iron superoxide dismutase 0.0067 0.0714 0.5701
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.3548 0.671
Schistosoma mansoni rab6-interacting 0.0023 0.0106 0.0221
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0288 0.2301

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 10 nM Inhibition concentration against Escherichia coli peptide deformylase. ChEMBL. 12873500
IC50 (binding) = 10 nM Inhibition concentration against Escherichia coli peptide deformylase. ChEMBL. 12873500
MIC (functional) = 25 uM Antibacterial activity against Staphylococcus capitis. ChEMBL. 12873500
MIC (functional) = 100 uM Antibacterial activity against Escherichia coli. ChEMBL. 12873500
MIC (functional) = 100 uM Antibacterial activity against Escherichia coli. ChEMBL. 12873500

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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