Detailed information for compound 1516915

Basic information

Technical information
  • TDR Targets ID: 1516915
  • Name: 4-(2-ethylbutanoyl)-N-(2-pyridin-2-ylethyl)-1 H-pyrrole-2-carboxamide
  • MW: 313.394 | Formula: C18H23N3O2
  • H donors: 2 H acceptors: 3 LogP: 2.68 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(C(=O)c1c[nH]c(c1)C(=O)NCCc1ccccn1)CC
  • InChi: 1S/C18H23N3O2/c1-3-13(4-2)17(22)14-11-16(21-12-14)18(23)20-10-8-15-7-5-6-9-19-15/h5-7,9,11-13,21H,3-4,8,10H2,1-2H3,(H,20,23)
  • InChiKey: PQJGJICEZJKAOL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-(2-ethylbutanoyl)-N-[2-(2-pyridyl)ethyl]-1H-pyrrole-2-carboxamide
  • 4-(2-ethyl-1-oxobutyl)-N-[2-(2-pyridyl)ethyl]-1H-pyrrole-2-carboxamide
  • Oprea1_501147
  • 4-(2-ethylbutanoyl)-N-[2-(2-pyridinyl)ethyl]-1H-pyrrole-2-carboxamide
  • MLS000546575
  • SMR000179973
  • ZINC01403948
  • 9R-0215

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0146 0.0146
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0015 0.0552
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0034 0.2687
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0015 0.0552
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Brugia malayi hypothetical protein 0.0024 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0058 0.0123 0.0113
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0101 0.1377
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0034 0.3158
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0113 0.1557
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0024 0.0015 0.0076
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0121 0.5717
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0015 0.2056
Loa Loa (eye worm) cytochrome P450 family protein 0.0036 0.0052 0.0042
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0015 1
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0088 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0121 0.1671
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0479 0.7058
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.001 0.5
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0146 0.1291
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0088 1
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0494 0.7293
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0012 0.0002
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0146 0.2052
Mycobacterium tuberculosis Possible exported protein 0.0913 0.2841 1
Brugia malayi mbt repeat family protein 0.0058 0.0121 0.0121
Brugia malayi mbt repeat family protein 0.0058 0.0121 0.0121
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0034 0.2687
Schistosoma mansoni hypothetical protein 0.0355 0.1066 1
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0012 0.0893
Loa Loa (eye worm) hypothetical protein 0.0058 0.0121 0.0111
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0121 0.1051
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.0015 0.0048
Loa Loa (eye worm) hypothetical protein 0.0066 0.0146 0.0136
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0012 0.0893
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0012 0.0002
Loa Loa (eye worm) peptidase family M1 containing protein 0.0067 0.015 0.014
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.001 0.001
Entamoeba histolytica aminopeptidase, putative 0.0024 0.0015 0.0649
Onchocerca volvulus 0.0058 0.0121 0.5717
Brugia malayi Peptidase family M1 containing protein 0.0083 0.02 0.02
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0088 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0121 0.1671
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0034 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0012 0.4344
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0101 1
Echinococcus multilocularis aminopeptidase N 0.0083 0.02 0.2865
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0015 0.2056
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0101 1
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0034 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0101 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0015 0.2056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0113 0.098
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0034 1
Brugia malayi Cytochrome P450 family protein 0.0023 0.0012 0.0012
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0121 0.1671
Leishmania major hypothetical protein, conserved 0.003 0.0034 1
Brugia malayi Cytochrome P450 family protein 0.0023 0.0012 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0113 0.098
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0015 0.2056
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0121 0.0111
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0494 0.0494
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0146 0.2052
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0012 0.0002
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0121 0.1051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0113 0.1557
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0146 0.2052
Loa Loa (eye worm) aminopeptidase N 0.0024 0.0015 0.0005
Echinococcus granulosus aminopeptidase N 0.0083 0.02 0.2865
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.001 0.5
Brugia malayi hypothetical protein 0.003 0.0034 0.0034
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0113 0.0113
Brugia malayi Cytochrome P450 family protein 0.0036 0.0052 0.0052
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0012 0.0893
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0015 0.2056
Loa Loa (eye worm) hypothetical protein 0.0074 0.0173 0.0163
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0146 0.2052
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0113 0.0104
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0121 0.1051
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0232 0.0674 1
Leishmania major cytochrome p450-like protein 0.0023 0.0012 0.0893
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0113 0.098
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0494 0.4587
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0113 0.1557
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0232 0.0674 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.0025
Onchocerca volvulus 0.0083 0.02 1
Loa Loa (eye worm) MBCTL1 0.0066 0.0146 0.0136
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0121 0.1671
Loa Loa (eye worm) acetyltransferase 0.0175 0.0494 0.0485
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0015 0.0076
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0101 1
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0024 0.0015 0.0048
Trypanosoma cruzi Aminopeptidase M1, putative 0.0024 0.0015 0.2056
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0015 0.0015
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0101 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0015 0.2056
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0015 0.2056
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0034 0.3158
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0113 0.1557

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 39.81071706 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 2.9362 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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