TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 382.342 | Formula: C19H13F3N6
H donors: 1 H acceptors: 4 LogP: 3.3 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: FC(c1cc(ccc1n1cncc1)Nc1nccc(n1)c1ccncc1)(F)F
InChi: 1S/C19H13F3N6/c20-19(21,22)15-11-14(1-2-17(15)28-10-9-24-12-28)26-18-25-8-5-16(27-18)13-3-6-23-7-4-13/h1-12H,(H,25,26,27)
InChiKey: AFKWNRCLQDGIPI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0029	0.002
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0011	0.0009	0.0009
Trypanosoma brucei	unspecified product	0.0019	0.0039	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0009	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus granulosus	neuropeptide receptor A26	0.0011	0.0009	0.001
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0009	0.001
Trypanosoma brucei	unspecified product	0.0013	0.0017	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	dna polymerase eta	0.0019	0.0039	0.0046
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0029	0.002
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.2683	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.0039	0.003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Schistosoma mansoni	hypothetical protein	0.0011	0.0009	0.001
Brugia malayi	sulfakinin receptor protein	0.0011	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	bloom syndrome protein	0.0021	0.0047	0.0055
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0039	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0009	0.001
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0011	0.0009	0.001
Brugia malayi	G protein-coupled receptor F59B2.13	0.0011	0.0009	0.0009
Trypanosoma brucei	unspecified product	0.0013	0.0017	0.0007
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0029	0.002
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0037	0.0044
Echinococcus multilocularis	geminin	0.0342	0.1244	0.1471
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0011	0.0009	0.001
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.011	0.0377	0.8837
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0011	0.0009	0.001
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0011	0.0009	0.001
Echinococcus granulosus	serotonin receptor	0.0011	0.0009	0.001
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0009	0.001
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.008	0.0095
Brugia malayi	Pre-SET motif family protein	0.0211	0.0758	0.0758
Schistosoma mansoni	amine GPCR	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0031	0.0031
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0011	0.0009	0.001
Echinococcus granulosus	survival motor neuron protein 1	0.0236	0.0851	0.1006
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0011	0.0009	0.001
Echinococcus granulosus	G protein coupled receptor 139	0.0011	0.0009	0.001
Brugia malayi	follicle stimulating hormone receptor	0.0241	0.0869	0.0869
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0147	0.0147
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0037	0.9377
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus granulosus	neuropeptide s receptor	0.0011	0.0009	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Brugia malayi	Dopamine receptor	0.0011	0.0009	0.0009
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0147	1
Brugia malayi	Serotonin receptor	0.0011	0.0009	0.0009
Echinococcus multilocularis	vesicular acetylcholine transporter	0.2271	0.8458	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Brugia malayi	putative neuropeptide receptor NPR1	0.0011	0.0009	0.0009
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0039	0.0046
Leishmania major	trypanothione reductase	0.0048	0.0147	0.0137
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.011	0.0377	0.8837
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0011	0.0009	0.001
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0011	0.0009	0.0009
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0009	0.001
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Plasmodium vivax	SET domain protein, putative	0.003	0.008	0.473
Loa Loa (eye worm)	hypothetical protein	0.1372	0.5095	0.5095
Echinococcus multilocularis	allatostatin A receptor	0.0011	0.0009	0.001
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0009	0.001
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0029	0.0029
Trypanosoma brucei	trypanothione reductase	0.0048	0.0147	0.0137
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0009	0.001
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0009	0.001
Schistosoma mansoni	hypothetical protein	0.0011	0.0009	0.001
Schistosoma mansoni	histamine h1 receptor	0.0011	0.0009	0.001
Echinococcus granulosus	allatostatin A receptor	0.0011	0.0009	0.001
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.0422	1
Brugia malayi	G protein-coupled receptor	0.0011	0.0009	0.0009
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0011	0.0009	0.0009
Brugia malayi	vesicular acetylcholine transporter unc-17	0.2271	0.8458	0.8458
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0009	0.001
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.2271	0.8458	1
Echinococcus granulosus	somatostatin receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0011	0.0009	0.001
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0342	0.1244	0.1471
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.2271	0.8458	0.8458
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0029	0.002
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0011	0.0009	0.001
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0009	0.001
Trichomonas vaginalis	DNA helicase recq1, putative	0.0021	0.0047	0.0434
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0029	0.002
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.008	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0039	0.0046
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0029	0.1998
Toxoplasma gondii	exonuclease III APE	0.0019	0.0037	0.2549
Schistosoma mansoni	ap endonuclease	0.0019	0.0037	0.0044
Trichomonas vaginalis	set domain proteins, putative	0.0241	0.0867	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0011	0.0009	0.001
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0009	0.001
Loa Loa (eye worm)	TYRA-2 protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	dro:myosuppressin receptor	0.0011	0.0009	0.001
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.011	0.0377	0.8837
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0029	0.002
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0029	0.0035
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0009	0.001
Echinococcus granulosus	7TM GPCR rhodopsin	0.0011	0.0009	0.001
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.008	0.0095
Schistosoma mansoni	opsin-like receptor	0.0011	0.0009	0.001
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.011	0.0377	0.8837
Plasmodium falciparum	glutathione reductase	0.0048	0.0147	1
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0029	0.7471
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0039	0.0345
Echinococcus multilocularis	neuropeptide receptor A26	0.0011	0.0009	0.001
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0147	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0009	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0147	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0011	0.0009	0.001
Echinococcus granulosus	tm gpcr rhodopsin	0.0527	0.1937	0.2291
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Leishmania major	C-8 sterol isomerase-like protein	0.2683	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0011	0.0009	0.001
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0039	0.0046
Echinococcus multilocularis	neuropeptide s receptor	0.0011	0.0009	0.001
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0009	0.001
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0037	0.0028
Echinococcus granulosus	hypothetical protein	0.0011	0.0009	0.001
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0037	0.0044
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0011	0.0009	0.001
Schistosoma mansoni	opsin-like receptor	0.0011	0.0009	0.001
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0029	0.002
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0017	0.0007
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0029	0.002
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0009	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0009	0.001
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0009	0.001
Schistosoma mansoni	adenoreceptor	0.0011	0.0009	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0039	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.0039	0.0252
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0009	0.001
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0029	0.066
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0037	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Echinococcus multilocularis	g-protein coupled receptor	0.0011	0.0009	0.001
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	RecQ helicase	0.0021	0.0047	0.0047
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0009	0.001
Schistosoma mansoni	ap endonuclease	0.0019	0.0037	0.0044
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0014	0.002	0.1389
Schistosoma mansoni	opsin-like receptor	0.0011	0.0009	0.001
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0029	0.002
Mycobacterium tuberculosis	Probable reductase	0.011	0.0377	0.8837
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0009	0.001
Brugia malayi	larval opioid receptor	0.0011	0.0009	0.0009
Schistosoma mansoni	myosin xvIII	0.0011	0.0009	0.001
Echinococcus granulosus	7tm_1 domain containing protein	0.0011	0.0009	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0009	0.001
Echinococcus granulosus	vesicular acetylcholine transporter	0.2271	0.8458	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0011	0.0009	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0017	0.0029	0.002
Loa Loa (eye worm)	melatonin receptor type 1A	0.0011	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.0039	0.0252
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0147	0.2985
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.0422	1
Brugia malayi	putative neuropeptide receptor	0.0011	0.0009	0.0009
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0009	0.001
Brugia malayi	Melatonin receptor type 1A	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0029	0.1998
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0147	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0147	0.0173
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0011	0.0009	0.001
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0011	0.0009	0.0009
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0009	0.001
Schistosoma mansoni	amine GPCR	0.0011	0.0009	0.001
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0039	0.0046
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.0422	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.011	0.0377	0.8837
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.008	0.0095
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0009	0.001
Brugia malayi	G-protein coupled receptor	0.0011	0.0009	0.0009
Brugia malayi	Serotonin receptor	0.0011	0.0009	0.0009
Schistosoma mansoni	hypothetical protein	0.0011	0.0009	0.001
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0009	0.001
Leishmania major	DNA polymerase eta, putative	0.0019	0.0039	0.003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0029	0.0035
Brugia malayi	G-protein coupled receptor	0.0011	0.0009	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0211	0.0758	0.0758
Schistosoma mansoni	vesicular acetylcholine transporter	0.2271	0.8458	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0009	0.0009
Brugia malayi	GnHR receptor homolog	0.0011	0.0009	0.0009
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0029	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.008	0.0095
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0037	0.0323
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	survival motor neuron protein 1	0.0236	0.0851	0.1006
Schistosoma mansoni	neuropeptide f receptor 76f	0.0011	0.0009	0.001
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0037	0.0206
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0037	0.0037
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0009	0.001
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0147	0.0137
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0527	0.1937	0.2291
Schistosoma mansoni	blooms syndrome DNA helicase	0.0017	0.003	0.0036
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Trichomonas vaginalis	DNA helicase recq, putative	0.0021	0.0047	0.0434
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0037	0.0323
Schistosoma mansoni	hypothetical protein	0.0342	0.1244	0.1471
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0009	0.0009
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0009	0.001
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0029	0.0035
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0017	0.0007
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0039	0.003
Schistosoma mansoni	amine GPCR	0.0011	0.0009	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Echinococcus granulosus	geminin	0.0342	0.1244	0.1471
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0241	0.0869	0.0869
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0009	0.0009
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0039	1
Schistosoma mansoni	amine GPCR	0.0011	0.0009	0.001
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0009	0.000000000014999	0.0000000010227
Echinococcus granulosus	neuropeptide FF receptor 2	0.0011	0.0009	0.001
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0009	0.001
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0009	0.001
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.008	0.5485
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0147	0.0147
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0039	0.0039
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0029	0.002
Schistosoma mansoni	amine GPCR	0.0011	0.0009	0.001
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0147	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus granulosus	dro:myosuppressin receptor	0.0011	0.0009	0.001
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0029	0.002
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0147	0.0147
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0011	0.0009	0.0009
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0039	0.003
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0039	0.0046
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0011	0.0009	0.0009
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0029	0.002
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0029	0.002
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.008	0.0095
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0039	0.0345
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Brugia malayi	neuropeptide F receptor	0.0011	0.0009	0.0009
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0029	0.1998
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0011	0.0009	0.0009
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0037	0.1303
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0011	0.0009	0.001
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Schistosoma mansoni	growth hormone secretagogue receptor	0.0011	0.0009	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0037	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0147	0.0174
Echinococcus multilocularis	somatostatin receptor	0.0011	0.0009	0.001
Brugia malayi	ORL1-like opioid receptor	0.0011	0.0009	0.0009
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0011	0.0009	0.0009
Echinococcus granulosus	sex peptide receptor	0.0011	0.0009	0.001
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0011	0.0009	0.001
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0009	0.001
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0037	0.0028
Echinococcus multilocularis	G protein coupled receptor 139	0.0011	0.0009	0.001
Brugia malayi	hypothetical protein	0.0011	0.0009	0.0009
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0037	0.9531
Echinococcus granulosus	orexin receptor type 2	0.0011	0.0009	0.001
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0011	0.0009	0.001
Echinococcus multilocularis	orexin receptor type 2	0.0011	0.0009	0.001
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0019	0.0037	0.2534
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0011	0.0009	0.001
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0011	0.0009	0.0009
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0009	0.001
Echinococcus multilocularis	sex peptide receptor	0.0011	0.0009	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0029	0.0229
Echinococcus granulosus	fmrfamide receptor	0.0011	0.0009	0.001
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.2683	1	1
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0029	0.002
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0009	0.001
Brugia malayi	Dopamine receptor protein 2	0.0011	0.0009	0.0009
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0037	0.0037
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0009	0.001
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Schistosoma mansoni	DNA polymerase eta	0.0019	0.0039	0.0046
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0009	0.001
Echinococcus granulosus	bloom syndrome protein	0.0021	0.0047	0.0055
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0009	0.0009
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0013	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0236	0.0851	0.0851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0009	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Brugia malayi	hypothetical protein	0.0236	0.0851	0.0851
Onchocerca volvulus		0.0048	0.0147	0.0164
Brugia malayi	Dopamine receptor protein 1	0.0011	0.0009	0.0009
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0009	0.001
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Brugia malayi	glutathione reductase	0.0048	0.0147	0.0147
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0009	0.001
Plasmodium falciparum	glutathione reductase	0.0017	0.0029	0.1998
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0009	0.001
Trypanosoma brucei	C-8 sterol isomerase, putative	0.2683	1	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.008	0.0095
Echinococcus granulosus	g-protein coupled receptor	0.0011	0.0009	0.001
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Echinococcus multilocularis	serotonin receptor	0.0011	0.0009	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0017	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0039	0.003
Brugia malayi	AKH receptor	0.0011	0.0009	0.0009
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.003	0.008	0.008
Echinococcus multilocularis	serotonin receptor	0.0011	0.0009	0.001
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0147	0.0174
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0037	0.8146
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0013	0.0013
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0037	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0039	0.0039
Brugia malayi	neuropeptide F receptor	0.0011	0.0009	0.0009
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0009	0.001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0039	0.003
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0029	0.002
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0076	0.009
Onchocerca volvulus		0.0241	0.0867	0.1016
Brugia malayi	Bloom's syndrome protein homolog	0.0021	0.0047	0.0047
Brugia malayi	RE15519p	0.0011	0.0009	0.0009
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0037	0.2549
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0009	0.001
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0009	0.001
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0039	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0029	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0011	0.0009	0.001
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0039	0.003
Echinococcus granulosus	dna polymerase eta	0.0019	0.0039	0.0046
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0029	0.1998
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0039	0.0046
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0039	0.0039
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0009	0.001
Brugia malayi	Pre-SET motif family protein	0.003	0.008	0.008
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0029	0.1998
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0009	0.0009
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0037	0.0028
Brugia malayi	Thioredoxin reductase	0.0048	0.0147	0.0147
Schistosoma mansoni	hypothetical protein	0.0011	0.0009	0.001
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0017	0.0029	0.002
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0011	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0039	0.0039
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.0422	1
Onchocerca volvulus		0.003	0.008	0.0085
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0011	0.0009	0.001
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0009	0.001
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.0039	0.003
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0029	0.066

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.4 uM	In vitro inhibition of histamine release from human basophils	ChEMBL.	8410986
IC50 (functional)	= 0.4 uM	In vitro inhibition of histamine release from human basophils	ChEMBL.	8410986

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	8410986

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 152026