TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 307.346 | Formula: C18H17N3O2
H donors: 0 H acceptors: 2 LogP: 3.8 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1ncnc2c1cc(cc2)c1ccc2c(c1)OCO2)C
InChi: 1S/C18H17N3O2/c1-3-21(2)18-14-8-12(4-6-15(14)19-10-20-18)13-5-7-16-17(9-13)23-11-22-16/h4-10H,3,11H2,1-2H3
InChiKey: QQMMDWIXEPHCHM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	Starlite/ChEMBL	No references
Homo sapiens	CDC-like kinase 4	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus granulosus	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 19	Get druggable targets OG5_126990	All targets in OG5_126990
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Theileria parva	serine/threonine protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Neospora caninum	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase minibrain, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Candida albicans	Serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium berghei	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium vivax	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania mexicana		Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus granulosus	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Giardia lamblia	Kinase, CMGC CLK	Get druggable targets OG5_126990	All targets in OG5_126990
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Cryptosporidium parvum	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	CMGC/CLK protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Cryptosporidium hominis	serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis		Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	kinetoplastid kinetochore protein, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium yoelii	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Echinococcus multilocularis	dual specificity protein kinase clk2	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	Serine/threonine-protein kinase Doa, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Babesia bovis	protein serine/threonine kinase 1	Get druggable targets OG5_126990	All targets in OG5_126990
Plasmodium falciparum	protein serine/threonine kinase-1	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma brucei	kinetoplastid kinetochore protein 10	Get druggable targets OG5_126990	All targets in OG5_126990
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Plasmodium knowlesi	serine/threonine kinase-1, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania donovani	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania major	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	ko:K08823 CDC-like kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_126990	All targets in OG5_126990
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	Get druggable targets OG5_127901	All targets in OG5_127901
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127901	All targets in OG5_127901
Echinococcus multilocularis	dual specificity	Get druggable targets OG5_127901	All targets in OG5_127901
Trypanosoma congolense	serine/threonine-protein kinase, putative	Get druggable targets OG5_127901	All targets in OG5_127901
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127901	All targets in OG5_127901

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	unspecified product	0.0037	0.0275	0.0621
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0211	0.0211
Plasmodium vivax	serine/threonine kinase-1, putative	0.0074	0.0771	0.2655
Trypanosoma brucei	DNA topoisomerase type IB small subunit	0.0051	0.046	0.1057
Brugia malayi	glutathione reductase	0.0041	0.033	0.0927
Entamoeba histolytica	protein kinase, putative	0.0108	0.1244	0.1826
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.1888	0.4259
Plasmodium vivax	thioredoxin reductase, putative	0.0041	0.033	0.0803
Plasmodium falciparum	glutathione reductase	0.0041	0.033	0.0803
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0211	0.0307
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0398	0.0633
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0195	0.0195
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0074	0.0771	0.1539
Toxoplasma gondii	DNA topoisomerase I, putative	0.0202	0.252	1
Entamoeba histolytica	hypothetical protein	0.0079	0.0839	0.0667
Loa Loa (eye worm)	Ras protein let-60	0.0061	0.0606	0.1704
Brugia malayi	hypothetical protein	0.0079	0.0839	0.236
Treponema pallidum	fructose-bisphosphate aldolase	0.0318	0.4102	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3555	0.8533
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0094	0.1048	0.4733
Schistosoma mansoni	transcription factor LCR-F1	0.0079	0.0839	0.0839
Giardia lamblia	Fructose-bisphosphate aldolase	0.0318	0.4102	1
Plasmodium falciparum	thioredoxin reductase	0.0041	0.033	0.0803
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0225	0.0503
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0104	0.1191	0.543
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0155	0.1886	0.8675
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0104	0.1191	0.1705
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0074	0.0771	0.2655
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0318	0.4102	1
Trichomonas vaginalis	dexras1, putative	0.0061	0.0606	0.0626
Trypanosoma cruzi	trypanothione reductase, putative	0.0041	0.033	0.0466
Schistosoma mansoni	hypothetical protein	0.0037	0.0268	0.0268
Onchocerca volvulus	Glucosylceramidase homolog	0.0182	0.2253	0.6651
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0079	0.0839	0.0839
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.0372	0.085
Echinococcus multilocularis	transfer RNA-Lys	0.0039	0.0303	0.0303
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0225	0.0634
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0074	0.0771	0.1791
Echinococcus multilocularis		0.0072	0.0755	0.0755
Echinococcus granulosus	dna polymerase kappa	0.0044	0.0372	0.0372
Brugia malayi	Ras-related protein R-Ras2	0.0061	0.0606	0.1704
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0318	0.4102	1
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0074	0.0771	0.2168
Trichomonas vaginalis	GTP-binding protein rit, putative	0.0061	0.0606	0.0626
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0074	0.0771	0.1791
Plasmodium falciparum	topoisomerase I	0.0202	0.252	1
Trypanosoma cruzi	DNA topoisomerase type IB small subunit, putative	0.0051	0.046	0.0783
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Entamoeba histolytica	protein kinase, putative	0.0108	0.1244	0.1826
Trichomonas vaginalis	set domain proteins, putative	0.0258	0.3281	0.7798
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0046	0.0398	0.0912
Echinococcus multilocularis	dna polymerase kappa	0.0044	0.0372	0.0372
Brugia malayi	hypoxia-induced factor 1	0.0164	0.2001	0.5629
Mycobacterium tuberculosis	Probable dehydrogenase	0.0094	0.1048	0.4733
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0138	0.0297
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2387	0.5401
Schistosoma mansoni	serine/threonine protein kinase	0.0108	0.1244	0.1244
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0268	0.0755
Toxoplasma gondii	hypothetical protein	0.0053	0.0491	0.1481
Schistosoma mansoni	hypothetical protein	0.0079	0.0839	0.0839
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0046	0.0398	0.0633
Giardia lamblia	Kinase, CMGC CLK	0.0074	0.0771	0.1721
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1229	0.3457
Trichomonas vaginalis	CMGC family protein kinase	0.0074	0.0771	0.1069
Brugia malayi	hypothetical protein	0.0027	0.0138	0.0389
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0318	0.4102	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0318	0.4102	1
Entamoeba histolytica	hypothetical protein	0.0079	0.0839	0.0667
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0211	0.0211
Mycobacterium ulcerans	hypothetical protein	0.0173	0.2127	1
Toxoplasma gondii	thioredoxin reductase	0.0041	0.033	0.0803
Leishmania major	DNA topoisomerase type IB small subunit	0.0051	0.046	0.0916
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.05	0.1405
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0074	0.0771	0.1539
Schistosoma mansoni	DNA topoisomerase type I	0.0202	0.252	0.252
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0372	0.0569
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0104	0.1191	0.543
Brugia malayi	Pre-SET motif family protein	0.0033	0.0211	0.0595
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0108	0.1244	0.2691
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0164	0.2001	0.5629
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2253	0.5042
Plasmodium vivax	SET domain protein, putative	0.0033	0.0211	0.0307
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0156	0.1888	0.443
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0046	0.0398	0.0633
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0108	0.1244	0.2796
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0041	0.033	0.1226
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0074	0.0771	0.1539
Loa Loa (eye worm)	hypothetical protein	0.0178	0.2188	0.6157
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0318	0.4102	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.05	0.1405
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0211	0.0211
Loa Loa (eye worm)	thioredoxin reductase	0.0041	0.033	0.0927
Brugia malayi	Pre-SET motif family protein	0.0227	0.2854	0.803
Trypanosoma brucei	DNA polymerase IV, putative	0.0037	0.0275	0.0621
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0074	0.0771	0.0771
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0079	0.0839	0.0839
Echinococcus granulosus	DNA topoisomerase 1	0.0202	0.252	0.252
Loa Loa (eye worm)	glutathione reductase	0.0041	0.033	0.0927
Mycobacterium ulcerans	DNA polymerase IV	0.0044	0.0372	0.0381
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.05	0.1405
Echinococcus multilocularis	ras gtpase	0.0061	0.0606	0.0606
Echinococcus granulosus	dual specificity	0.0108	0.1244	0.1244
Brugia malayi	Protein kinase domain containing protein	0.0108	0.1244	0.3499
Onchocerca volvulus		0.0039	0.0303	0.0297
Echinococcus granulosus	dual specificity protein kinase clk2	0.0074	0.0771	0.0771
Brugia malayi	PAS domain containing protein	0.0053	0.049	0.1378
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0771	0.0771
Mycobacterium tuberculosis	Probable oxidoreductase	0.0104	0.1191	0.543
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0227	0.2854	0.803
Plasmodium falciparum	protein serine/threonine kinase-1	0.0074	0.0771	0.2655
Leishmania major	trypanothione reductase	0.0041	0.033	0.0603
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2253	0.5042
Entamoeba histolytica	protein kinase domain containing protein	0.0108	0.1244	0.1826
Echinococcus granulosus	single minded 2	0.0039	0.0303	0.0303
Brugia malayi	polk-prov protein	0.0034	0.0225	0.0634
Entamoeba histolytica	hypothetical protein	0.0079	0.0839	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0606	0.1704
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0372	0.0569
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0108	0.1244	0.3499
Entamoeba histolytica	hypothetical protein	0.0108	0.1244	0.1826
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0211	0.0211
Trichomonas vaginalis	rap1 and, putative	0.0061	0.0606	0.0626
Loa Loa (eye worm)	hypothetical protein	0.0072	0.0755	0.2125
Leishmania major	protein kinase, putative	0.0074	0.0771	0.1661
Loa Loa (eye worm)	DNA topoisomerase I	0.0202	0.252	0.7088
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0329	0.4246	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0056	0.0536	0.0968
Trichomonas vaginalis	rheb, putative	0.0061	0.0606	0.0626
Plasmodium vivax	glutathione reductase, putative	0.0041	0.033	0.0803
Schistosoma mansoni	aryl hydrocarbon receptor	0.0053	0.049	0.049
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0108	0.1244	0.2691
Trichomonas vaginalis	ral, putative	0.0061	0.0606	0.0626
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0156	0.1888	0.4341
Trypanosoma cruzi	DNA topoisomerase IB, large subunit, putative	0.0151	0.1829	0.4114
Schistosoma mansoni	DNA topoisomerase type I	0.0151	0.1829	0.1829
Leishmania major	hypothetical protein, conserved	0.0027	0.0138	0.0144
Leishmania major	DNA topoisomerase IB, large subunit	0.0151	0.1829	0.4199
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0042	0.0337	0.0337
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2253	0.5042
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3555	0.8533
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.0372	0.085
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0278	0.3555	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2253	0.5042
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0108	0.1244	0.2909
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Schistosoma mansoni	microtubule-associated protein tau	0.0751	1	1
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0155	0.1886	0.882
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0278	0.3555	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3555	0.8533
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2253	0.5042
Schistosoma mansoni	single-minded	0.0053	0.049	0.049
Brugia malayi	hypothetical protein	0.0018	0.0007	0.0021
Trichomonas vaginalis	glucosylceramidase, putative	0.0192	0.2387	0.5401
Echinococcus multilocularis	dual specificity	0.0108	0.1244	0.1244
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0094	0.1048	0.4733
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0372	0.0569
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3555	0.8533
Brugia malayi	hypothetical protein	0.0178	0.2188	0.6157
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1229	0.3457
Echinococcus granulosus	ras gtpase	0.0061	0.0606	0.0606
Onchocerca volvulus		0.0258	0.3281	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0318	0.4102	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.05	0.1405
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0211	0.0211
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0318	0.4102	1
Mycobacterium ulcerans	DNA polymerase IV	0.0044	0.0372	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0268	0.0755
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3555	0.8533
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0173	0.2127	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Trypanosoma brucei	DNA polymerase kappa, putative	0.0034	0.0225	0.0503
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0211	0.0211
Entamoeba histolytica	hypothetical protein	0.0079	0.0839	0.0667
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0211	0.0211
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0078	0.0156
Brugia malayi	Thioredoxin reductase	0.0041	0.033	0.0927
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0771	0.0771
Trypanosoma brucei	trypanothione reductase	0.0041	0.033	0.0749
Trichomonas vaginalis	ras-dva small GTPase, putative	0.0061	0.0606	0.0626
Leishmania major	mitochondrial DNA polymerase beta	0.0329	0.4246	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Schistosoma mansoni	DNA topoisomerase type I	0.0151	0.1829	0.1829
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0138	0.0389
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0318	0.4102	1
Echinococcus multilocularis	microtubule associated protein 2	0.0751	1	1
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0074	0.0771	0.1539
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.0372	0.0569
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0211	0.0595
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0318	0.4102	1
Brugia malayi	Protein kinase domain containing protein	0.0074	0.0771	0.2168
Echinococcus granulosus	hypothetical protein	0.0072	0.0755	0.0755
Brugia malayi	Ras protein let-60	0.0061	0.0606	0.1704
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0318	0.4102	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0094	0.1048	0.4733
Echinococcus multilocularis	DNA topoisomerase 1	0.0202	0.252	0.252
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0329	0.4246	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2253	0.5042
Leishmania major	protein kinase, putative	0.0074	0.0771	0.1661
Trypanosoma brucei	DNA topoisomerase IB, large subunit	0.0151	0.1829	0.4289
Brugia malayi	bHLH-PAS transcription factor	0.0039	0.0303	0.0851
Brugia malayi	DNA topoisomerase I	0.0202	0.252	0.7088
Echinococcus granulosus	thioredoxin glutathione reductase	0.0042	0.0337	0.0337
Mycobacterium tuberculosis	Probable reductase	0.0094	0.1048	0.4733
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.0372	0.085
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0155	0.1886	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0182	0.2253	0.5042
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0329	0.4246	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0094	0.1048	0.4733
Plasmodium vivax	topoisomerase I, putative	0.0202	0.252	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0278	0.3555	0.8533

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0463 uM	PUBCHEM_BIOASSAY: Confirmation Assay for Inhibitors of CDC-like Kinase 4 (Kinase-Glo Assay): SAR round 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1379, AID1770, AID1983, AID1997, AID2710, AID488872, AID488883, AID488887, AID504421, AID504424, AID504427, AID504428, AID504429, AID504430]	ChEMBL.	No reference
Potency (functional)	0.4627 uM	PUBCHEM_BIOASSAY: Assay for Inhibitors of Dual-Specificity Tyrosine-(Y)-Phosphorylation Regulated Kinase 1A (Kinase-Glo assay): round 2 SAR. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1770, AID1970, AID2705, AID488872]	ChEMBL.	No reference
Potency_Clk2_uM (functional)	1.557 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of CDC-like Kinase 2 (Reaction Biology data). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference
Potency_Clk3_uM (functional)	37.4 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of CDC-like Kinase 3 (Reaction Biology data). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference
Potency_Clk4_uM (functional)	0.122 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of CDC-like Kinase 4 (Reaction Biology data): SAR round 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference
Potency_Dyrk1a_uM (functional)	0.427 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of Dyrk1a (Reaction Biology data). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference
Potency_Dyrk1b_uM (functional)	2.142 uM	PUBCHEM_BIOASSAY: Kinase Inhibition Study on Inhibitors of Dyrk1b (Reaction Biology data). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1459, AID1487, AID1498, AID1770, AID1970, AID1997, AID488872, AID488883, AID488887, AID493204]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1705397

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1520792