Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | inositol-1 | 0.0072 | 0.0259 | 0.091 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0044 | 0.0061 | 0.0213 |
Echinococcus granulosus | lamin b receptor | 0.0088 | 0.0372 | 0.0372 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0072 | 0.0259 | 0.0259 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0797 | 0.2802 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.0465 | 0.1635 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.008 | 0.028 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Onchocerca volvulus | 0.0088 | 0.0372 | 0.1307 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0091 | 0.039 | 0.1372 |
Echinococcus multilocularis | geminin | 0.0191 | 0.1101 | 0.1101 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.0797 | 0.2802 |
Loa Loa (eye worm) | serotonin transporter b | 0.0088 | 0.0372 | 0.1307 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0076 | 0.0286 | 0.0286 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0607 | 0.2134 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1101 | 0.1101 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Echinococcus granulosus | geminin | 0.0191 | 0.1101 | 0.1101 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0082 | 0.033 | 0.1159 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.008 | 0.028 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.008 | 0.008 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Leishmania major | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0088 | 0.0372 | 0.1307 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0607 | 0.2134 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.0088 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.2393 | 0.8414 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.008 | 0.008 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.0563 | 0.1979 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.0563 | 0.1979 |
Schistosoma mansoni | inositol monophosphatase | 0.0072 | 0.0259 | 0.0259 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0438 | 0.2844 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0076 | 0.0286 | 0.0286 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0103 | 0.0478 | 0.0478 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.008 | 0.008 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.006 | 0.021 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Loa Loa (eye worm) | glutamate receptor | 0.0036 | 0 | 0.0001 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0088 | 0.0372 | 0.1307 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0088 | 0.0372 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.006 | 0.006 |
Trypanosoma brucei | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0465 | 0.0465 |
Brugia malayi | Inositol-1 | 0.0072 | 0.0259 | 0.091 |
Echinococcus multilocularis | lamin b receptor | 0.0088 | 0.0372 | 0.0372 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0065 | 0.0205 | 0.1507 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.008 | 0.008 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0374 | 0.2393 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0088 | 0.0372 | 0.0372 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.008 | 0.008 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.008 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0539 | 0.1894 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0044 | 0.0061 | 0.0061 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0072 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.008 | 0.028 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Leishmania major | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.0797 | 0.2802 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.2844 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0072 | 0.0259 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.145 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0465 | 0.1635 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0072 | 0.0259 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.006 | 0.021 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.2844 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0374 | 0.2393 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0065 | 0.0205 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.008 | 0.008 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.0563 | 0.1979 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0805 | 0.5437 | 0.5437 |
Schistosoma mansoni | microtubule-associated protein tau | 0.145 | 1 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0072 | 0.0259 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0072 | 0.0259 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0112 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0088 | 0.0372 | 0.1307 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1101 | 0.1101 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Echinococcus granulosus | serotonin transporter | 0.0088 | 0.0372 | 0.0372 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0374 | 0.2393 | 0.8414 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0112 | 0.0539 | 0.0539 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.0797 | 0.2802 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Echinococcus multilocularis | serotonin transporter | 0.0088 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.1361 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0091 | 0.039 | 0.1372 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0072 | 0.0253 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0374 | 0.2393 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0088 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Schistosoma mansoni | inositol monophosphatase | 0.0072 | 0.0259 | 0.0259 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0076 | 0.0286 | 0.0286 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 6 mm | Antituberculosis activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 21429744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.