Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0.0282 | 0.9555 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0242 | 0.0553 |
Onchocerca volvulus | 0.0099 | 0.1075 | 0.7933 | |
Trypanosoma brucei | cytochrome P450, putative | 0.0039 | 0.0293 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0088 | 0.1864 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0137 | 0.1561 | 0.2441 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.0282 | 0.6317 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0096 | 0.1029 | 0.283 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0088 | 0.2102 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.3505 | 0.5586 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0048 | 0.0417 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0726 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.0321 | 0.7379 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0427 | 0.1187 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0282 | 0.6317 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0048 | 0.0417 | 0.0591 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.0293 | 0.0804 |
Schistosoma mansoni | gliotactin | 0.0048 | 0.0417 | 0.1059 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0048 | 0.0417 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0427 | 0.1087 |
Schistosoma mansoni | acetylcholinesterase | 0.0048 | 0.0417 | 0.1059 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0096 | 0.1029 | 0.1581 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0427 | 0.0377 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.0293 | 0.0804 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0088 | 0.1864 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0282 | 0.2364 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.0321 | 0.0781 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.0282 | 0.0773 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.1332 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0255 | 0.3085 | 0.8798 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.0321 | 0.0781 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.3505 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0088 | 0.0372 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0282 | 0.9555 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0242 | 0.0553 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0242 | 0.0553 |
Onchocerca volvulus | 0.0052 | 0.0461 | 0.3004 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0048 | 0.0417 | 0.0368 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0051 | 0.0965 |
Echinococcus multilocularis | neuroligin | 0.0048 | 0.0417 | 0.0368 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.1702 | 0.478 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.3505 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0282 | 0.2364 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0417 | 0.1159 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0.0282 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1953 |
Brugia malayi | hypothetical protein | 0.0119 | 0.1332 | 0.3707 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0417 | 0.1059 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0051 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0051 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0242 | 0.0309 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0105 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.1505 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.1864 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0039 | 0.0293 | 0.0804 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.0321 | 0.0436 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.0282 | 0.0232 |
Schistosoma mansoni | survival motor neuron protein | 0.0052 | 0.0461 | 0.1188 |
Brugia malayi | hypothetical protein | 0.0048 | 0.0417 | 0.1059 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1332 | 0.3778 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.0282 | 0.6317 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0039 | 0.0293 | 0.6939 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0148 | 0.0389 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0726 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0417 | 0.1059 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0048 | 0.0417 | 0.0591 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0726 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0498 | 0.6235 | 0.6215 |
Brugia malayi | Carboxylesterase family protein | 0.0287 | 0.3505 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0148 | 0.1702 | 0.478 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1029 | 0.2911 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0427 | 0.0377 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0048 | 0.0417 | 0.0591 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0.0417 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.1332 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0088 | 0.0372 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0302 | 0.0726 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0287 | 0.3505 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0088 | 0.1864 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0242 | 0.0192 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0051 | 0.1229 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0427 | 0.1087 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0088 | 0.0372 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0048 | 0.0417 | 0.0368 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0427 | 0.1087 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.0396 | 0.0347 |
Echinococcus granulosus | carboxylesterase 5A | 0.0287 | 0.3505 | 0.5586 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0051 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0498 | 0.6235 | 0.6215 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1953 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.0293 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0051 | 0.5 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.0282 | 0.0669 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.2012 | 0.1971 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0096 | 0.1029 | 0.0983 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0088 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0048 | 0.0417 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.3505 | 0.3472 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.1864 |
Loa Loa (eye worm) | carboxylesterase | 0.0287 | 0.3505 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0216 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.1505 |
Brugia malayi | hypothetical protein | 0.0255 | 0.3085 | 0.8784 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0417 | 0.1059 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.0282 | 0.0374 |
Echinococcus granulosus | neuroligin | 0.0048 | 0.0417 | 0.0591 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0172 | 0.2012 | 0.1971 |
Brugia malayi | Carboxylesterase family protein | 0.0048 | 0.0417 | 0.1059 |
Loa Loa (eye worm) | carboxylesterase | 0.0048 | 0.0417 | 0.1159 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.0321 | 0.0436 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0096 | 0.1029 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0427 | 0.0607 |
Echinococcus granulosus | acetylcholinesterase | 0.0287 | 0.3505 | 0.5586 |
Schistosoma mansoni | hypothetical protein | 0.0052 | 0.0461 | 0.1188 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0088 | 0.1864 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.0293 | 0.07 |
Leishmania major | cytochrome p450-like protein | 0.0039 | 0.0293 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0321 | 0.0884 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.0293 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0287 | 0.3505 | 0.3472 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0255 | 0.3085 | 0.305 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0216 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0172 | 0.2012 | 0.3171 |
Echinococcus granulosus | neuropeptide s receptor | 0.0498 | 0.6235 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0172 | 0.2012 | 0.5676 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.0282 | 0.9555 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0282 | 0.9555 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0441 | 0.1227 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0088 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0282 | 0.6317 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0048 | 0.0417 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0048 | 0.0417 | 1 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.0954 | 0.1459 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0012 | 0.0292 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0051 | 0.0112 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0255 | 0.3085 | 0.4906 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0012 | 0.5 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0088 | 0.1864 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0287 | 0.3505 | 0.3472 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0088 | 0.2102 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0427 | 0.0607 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.0321 | 0.0271 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.0321 | 0.0271 |
Onchocerca volvulus | 0.0048 | 0.0417 | 0.2647 | |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.1864 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.0282 | 0.0669 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0105 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0137 | 0.1561 | 0.1517 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0216 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0172 | 0.2012 | 0.5725 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0417 | 0.1159 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.1048 | 0.2886 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0498 | 0.6235 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0287 | 0.3505 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.0954 | 0.0907 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0105 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.0321 | 0.0884 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0051 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0427 | 0.1087 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.0293 | 0.07 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0048 | 0.0417 | 0.1059 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0282 | 0.6317 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0052 | 0.0461 | 0.1188 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.1505 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1953 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0242 | 0.1953 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1332 | 0.3778 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0048 | 0.0417 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0287 | 0.3505 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 0.5 % | Cytotoxicity against human MRC5 cells assessed as cell viability at 100 uM after 72 hrs by XTT assay | ChEMBL. | 21429630 |
Activity (ADMET) | = 56.09 % | Cytotoxicity against human MRC5 cells assessed as cell viability at 30 uM after 72 hrs by XTT assay | ChEMBL. | 21429630 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.