Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0065 | 0.0205 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0374 | 0.2393 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.0563 | 0.1979 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.008 | 0.008 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0465 | 0.1635 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0072 | 0.0259 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.2844 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.006 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.008 | 0.028 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0438 | 0.2844 | 1 |
Leishmania major | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.0797 | 0.2802 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.145 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0072 | 0.0259 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.008 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0539 | 0.1894 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0044 | 0.0061 | 0.0061 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0072 | 0.0259 | 0.0259 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0088 | 0.0372 | 0.0372 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Schistosoma mansoni | inositol monophosphatase | 0.0072 | 0.0259 | 0.0259 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0076 | 0.0286 | 0.0286 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0072 | 0.0259 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.0088 | 0.0372 | 0.0372 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.0797 | 0.2802 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0112 | 0.0539 | 0.0539 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0607 | 0.2134 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0072 | 0.0253 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0374 | 0.2393 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0228 | 0.1361 | 1 |
Loa Loa (eye worm) | glutamate receptor | 0.0091 | 0.039 | 0.1372 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0112 | 0.0539 | 0.0539 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0072 | 0.0259 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0088 | 0.0372 | 0.0372 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0088 | 0.0372 | 0.1307 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1101 | 0.1101 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0374 | 0.2393 | 0.8414 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0805 | 0.5437 | 0.5437 |
Schistosoma mansoni | microtubule-associated protein tau | 0.145 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0072 | 0.0259 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0076 | 0.0286 | 0.0286 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1101 | 0.1101 |
Echinococcus granulosus | geminin | 0.0191 | 0.1101 | 0.1101 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0607 | 0.2134 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.008 | 0.028 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.008 | 0.008 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0082 | 0.033 | 0.1159 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.0797 | 0.2802 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Loa Loa (eye worm) | serotonin transporter b | 0.0088 | 0.0372 | 0.1307 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.006 | 0.006 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0797 | 0.2802 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.008 | 0.028 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.0465 | 0.1635 |
Onchocerca volvulus | 0.0088 | 0.0372 | 0.1307 | |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.008 | 0.008 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.006 | 0.006 |
Echinococcus multilocularis | geminin | 0.0191 | 0.1101 | 0.1101 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0091 | 0.039 | 0.1372 |
Trypanosoma cruzi | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.0044 | 0.0061 | 0.0213 |
Loa Loa (eye worm) | inositol-1 | 0.0072 | 0.0259 | 0.091 |
Echinococcus granulosus | lamin b receptor | 0.0088 | 0.0372 | 0.0372 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.006 | 0.006 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0072 | 0.0259 | 0.0259 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.006 | 0.006 |
Trypanosoma brucei | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Brugia malayi | Inositol-1 | 0.0072 | 0.0259 | 0.091 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.0465 | 0.0465 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.008 | 0.008 |
Echinococcus multilocularis | lamin b receptor | 0.0088 | 0.0372 | 0.0372 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0065 | 0.0205 | 0.1507 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.008 | 0.008 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0374 | 0.2393 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0088 | 0.0372 | 0.0372 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.008 | 0.008 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0103 | 0.0478 | 0.0478 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0072 | 0.0259 | 0.1082 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0372 | 0.1307 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.006 | 0.021 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0088 | 0.0372 | 0.1307 |
Loa Loa (eye worm) | glutamate receptor | 0.0036 | 0 | 0.0001 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0088 | 0.0372 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0374 | 0.2393 | 0.8414 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.0563 | 0.1979 |
Schistosoma mansoni | inositol monophosphatase | 0.0072 | 0.0259 | 0.0259 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.0563 | 0.1979 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.008 | 0.008 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0438 | 0.2844 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0076 | 0.0286 | 0.0286 |
Leishmania major | C-14 sterol reductase, putative | 0.0088 | 0.0372 | 0.1556 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0438 | 0.2844 | 0.2844 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.006 | 0.006 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0088 | 0.0372 | 0.1307 |
Trypanosoma cruzi | sterol C-24 reductase, putative | 0.0046 | 0.0072 | 0.0301 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0607 | 0.2134 |
Schistosoma mansoni | Lamin B receptor (ERG24) | 0.0088 | 0.0372 | 0.0372 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | = 6 mm | Antituberculosis activity against Mycobacterium tuberculosis H37Rv | ChEMBL. | 21429744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.