TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 373.383 | Formula: C17H15N3O5S
H donors: 4 H acceptors: 5 LogP: 1.92 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)/C(=N/NC(=O)C1=C(O)c2c(S(=O)(=O)N1)cccc2)/C
InChi: 1S/C17H15N3O5S/c1-10(11-6-8-12(21)9-7-11)18-19-17(23)15-16(22)13-4-2-3-5-14(13)26(24,25)20-15/h2-9,20-22H,1H3,(H,19,23)/b18-10+
InChiKey: NFWXRGJKHXYRMV-VCHYOVAHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Endoplasmin precursor	0.0033	0.0326	0.0326
Toxoplasma gondii	FAD binding domain-containing protein	0.0062	0.0699	0.3059
Mycobacterium ulcerans	heat shock protein 90	0.0026	0.0242	0.0251
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Brugia malayi	hypothetical protein	0.0187	0.2262	0.2262
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.0326	0.4662
Echinococcus granulosus	protein MICAL 3	0.0062	0.0699	0.0755
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.016	0.0705
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0019	0.016	0.0218
Leishmania major	DNA polymerase eta, putative	0.0019	0.016	0.0705
Onchocerca volvulus		0.0803	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0084	0.1205
Loa Loa (eye worm)	hypothetical protein	0.0187	0.2262	0.2262
Echinococcus granulosus	heat shock protein 90	0.0033	0.0326	0.0352
Echinococcus multilocularis	heat shock protein 90	0.0026	0.0242	0.0262
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0013	0.0084	0.0091
Mycobacterium tuberculosis	Probable oxidoreductase	0.0062	0.0699	0.0954
Plasmodium falciparum	heat shock protein 90, putative	0.0013	0.0084	0.0373
Trypanosoma cruzi	heat shock protein 90, putative	0.0033	0.0326	0.144
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0027	0.0027
Trypanosoma cruzi	heat shock protein, putative	0.0013	0.0084	0.0373
Mycobacterium tuberculosis	Possible oxidoreductase	0.0062	0.0699	0.0954
Leishmania major	hypothetical protein, conserved	0.0062	0.0699	0.3089
Mycobacterium ulcerans	oxidoreductase	0.0062	0.0699	0.0723
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.016	0.016
Treponema pallidum	heat shock protein 90	0.0026	0.0242	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.016	0.2419
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0006	0.0007
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0189	0.2284	1
Onchocerca volvulus		0.0029	0.0278	0.0278
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0187	0.2262	1
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0033	0.0326	0.4939
Trypanosoma cruzi	Heat shock protein 83, putative	0.0033	0.0326	0.144
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.0326	0.4939
Echinococcus granulosus	dna polymerase kappa	0.0019	0.016	0.0172
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0187	0.2262	0.2443
Leishmania major	DNA polymerase kappa, putative	0.0019	0.016	0.0705
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.016	0.0705
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0006	0.0007
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0659	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0326	0.144
Toxoplasma gondii	Hsp90 domain-containing protein	0.0013	0.0084	0.0369
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0006	0.0007
Plasmodium vivax	hypothetical protein, conserved	0.0062	0.0699	0.3089
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Plasmodium falciparum	heat shock protein 90, putative	0.0013	0.0084	0.0373
Trypanosoma brucei	heat shock protein 84, putative	0.0013	0.0084	0.1207
Echinococcus multilocularis	geminin	0.017	0.2049	0.2213
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0013	0.0084	0.0084
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0026	0.0242	0.0331
Loa Loa (eye worm)	heat shock protein 90	0.0033	0.0326	0.0326
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.016	0.2284
Trypanosoma brucei	unspecified product	0.0019	0.016	0.2284
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0084	0.1205
Mycobacterium leprae	possibleputative FAD-linked oxidoreductase	0.0062	0.0699	0.3089
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0699	0.0699
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Schistosoma mansoni	DNA polymerase eta	0.0019	0.016	0.0172
Trypanosoma cruzi	heat shock protein 85, putative	0.0026	0.0242	0.1072
Brugia malayi	heat shock protein 90	0.0033	0.0326	0.0326
Echinococcus granulosus	ubiquinone biosynthesis monooxygenase COQ6	0.0062	0.0699	0.0755
Entamoeba histolytica	SWIRM domain protein	0.0059	0.0659	1
Leishmania major	hypothetical protein, conserved	0.0062	0.0699	0.3089
Plasmodium vivax	FAD-dependent monooxygenase, putative	0.0062	0.0699	0.3089
Plasmodium vivax	hypothetical protein, conserved	0.0187	0.2262	1
Echinococcus granulosus	geminin	0.017	0.2049	0.2213
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.016	0.0165
Plasmodium falciparum	FAD-dependent monooxygenase, putative	0.0062	0.0699	0.3089
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.016	0.2284
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0187	0.2262	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0187	0.2262	1
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0776	0.9664	1
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0187	0.2262	0.2443
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.016	0.2284
Echinococcus granulosus	dna polymerase eta	0.0019	0.016	0.0172
Entamoeba histolytica	heat shock protein 90, putative	0.0033	0.0326	0.4939
Schistosoma mansoni	cpg binding protein	0.0029	0.0278	0.03
Trichomonas vaginalis	heat shock protein, putative	0.002	0.0168	0.2541
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.016	0.2419
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0187	0.2262	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0601	0.2633
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0683	0.0738
Schistosoma mansoni	SWI/SNF complex-related	0.0059	0.0659	0.0712
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0187	0.2262	0.309
Toxoplasma gondii	FAD binding domain-containing protein	0.0062	0.0699	0.3059
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.016	0.0172
Mycobacterium ulcerans	membrane-associated oxidoreductase	0.0062	0.0699	0.0723
Trypanosoma brucei	unspecified product	0.0013	0.0084	0.1205
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Schistosoma mansoni	monoxygenase	0.0062	0.0699	0.0755
Schistosoma mansoni	hypothetical protein	0.017	0.2049	0.2213
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0084	0.1205
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.059	0.7319	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0776	0.9664	1
Echinococcus multilocularis	protein MICAL 3	0.0062	0.0699	0.0755
Giardia lamblia	Grp94/Hsp90	0.0026	0.0242	0.3676
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.016	0.0172
Mycobacterium tuberculosis	Probable oxidoreductase	0.0062	0.0699	0.0954
Loa Loa (eye worm)	endoplasmin	0.0033	0.0326	0.0326
Schistosoma mansoni	heat shock protein	0.0013	0.0084	0.0091
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Toxoplasma gondii	heat shock protein HSP90	0.0033	0.0326	0.1426
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Schistosoma mansoni	cpg binding protein	0.003	0.0299	0.0323
Schistosoma mansoni	endoplasmin	0.0033	0.0326	0.0352
Brugia malayi	Hsp90 protein	0.0013	0.0084	0.0084
Trypanosoma brucei	kynurenine 3-monooxygenase, putative	0.0062	0.0699	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0029	0.0031
Schistosoma mansoni	amine oxidase	0.0187	0.2262	0.2443
Mycobacterium ulcerans	FAD-dependent oxidoreductase	0.0062	0.0699	0.0723
Trichomonas vaginalis	heat shock protein, putative	0.0033	0.0326	0.4939
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Plasmodium vivax	heat shock protein 90, putative	0.0013	0.0084	0.0373
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0026	0.0242	0.347
Echinococcus multilocularis	ubiquinone biosynthesis monooxygenase COQ6	0.0062	0.0699	0.0755
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0187	0.2262	0.2443
Loa Loa (eye worm)	hypothetical protein	0.0803	1	1
Wolbachia endosymbiont of Brugia malayi	2-polyprenyl-6-methoxyphenol 4-hydroxylase	0.0062	0.0699	1
Entamoeba histolytica	SWIRM domain protein	0.0059	0.0659	1
Plasmodium vivax	heat shock protein 86, putative	0.0033	0.0326	0.144
Echinococcus granulosus	SWI:SNF complex subunit SMARCC2	0.0059	0.0659	0.0712
Mycobacterium ulcerans	oxidoreductase	0.0062	0.0699	0.0723
Mycobacterium ulcerans	monoamine oxidase	0.0187	0.2262	0.234
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0026	0.0242	0.1072
Echinococcus multilocularis	endoplasmin	0.0026	0.0242	0.0262
Mycobacterium ulcerans	oxidoreductase	0.0187	0.2262	0.234
Echinococcus granulosus	heat shock protein 90	0.0026	0.0242	0.0262
Mycobacterium ulcerans	hypothetical protein	0.0062	0.0699	0.0723
Mycobacterium tuberculosis	Possible oxidoreductase	0.0062	0.0699	0.0954
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0326	0.4662
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0326	0.4662
Trypanosoma cruzi	Monooxygenase, putative	0.0062	0.0699	0.3089
Echinococcus granulosus	cpg binding protein	0.003	0.0299	0.0323
Entamoeba histolytica	hypothetical protein	0.0059	0.0659	1
Schistosoma mansoni	hypothetical protein	0.0062	0.0699	0.0755
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Schistosoma mansoni	heat shock protein	0.0033	0.0326	0.0352
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0006	0.0007
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0029	0.0031
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.016	0.0172
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Trichomonas vaginalis	conserved hypothetical protein	0.0059	0.0659	1
Trypanosoma brucei	unspecified product	0.0013	0.0084	0.1205
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.0699	0.3089
Schistosoma mansoni	heat shock protein	0.0033	0.0326	0.0352
Echinococcus multilocularis	heat shock protein 90	0.0033	0.0326	0.0352
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Chlamydia trachomatis	monooxygenase	0.0062	0.0699	0.3089
Trypanosoma brucei	Monooxygenase, putative	0.0062	0.0699	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.016	0.2284
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0026	0.0242	0.0262
Echinococcus granulosus	endoplasmin	0.0026	0.0242	0.0262
Giardia lamblia	hypothetical protein	0.0059	0.0659	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0019	0.016	0.0218
Trypanosoma cruzi	heat shock protein 90, putative	0.0019	0.0158	0.0699
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0744	0.9257	1
Echinococcus multilocularis	SWI:SNF complex subunit SMARCC2	0.0059	0.0659	0.0712
Loa Loa (eye worm)	hypothetical protein	0.0019	0.016	0.016
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0744	0.9257	1
Mycobacterium ulcerans	FAD-linked oxidoreductase	0.0062	0.0699	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0744	0.9257	0.9257
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0029	0.0029
Schistosoma mansoni	cpg binding protein	0.003	0.0299	0.0323
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.016	0.0172
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0242	0.3676
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0187	0.2262	1
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Trypanosoma brucei	heat shock protein 90, putative	0.0033	0.0326	0.4662
Echinococcus multilocularis	dna polymerase eta	0.0019	0.016	0.0172
Leishmania major	UDP-galactopyranose mutase	0.0187	0.2262	1
Schistosoma mansoni	hypothetical protein	0.017	0.2049	0.2213
Echinococcus multilocularis	heat shock protein	0.0033	0.0326	0.0352
Plasmodium vivax	endoplasmin, putative	0.0033	0.0326	0.144
Toxoplasma gondii	histone lysine-specific demethylase	0.0187	0.2262	0.9904
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0326	0.4662
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0013	0.0084	0.0091
Mycobacterium ulcerans	hypothetical protein	0.0062	0.0699	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0744	0.9257	0.9257
Leishmania major	heat shock protein, putative	0.0013	0.0084	0.0373
Giardia lamblia	DINP protein human, muc B family	0.0019	0.016	0.2419
Plasmodium falciparum	protoporphyrinogen oxidase	0.0187	0.2262	1
Plasmodium vivax	hypothetical protein, conserved	0.0187	0.2262	1
Echinococcus multilocularis		0.0187	0.2262	0.2443
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0744	0.9257	1
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0326	0.144
Plasmodium falciparum	heat shock protein 90	0.0033	0.0326	0.144
Trichomonas vaginalis	heat shock protein, putative	0.0013	0.0084	0.1278
Toxoplasma gondii	SWIRM domain-containing protein	0.0059	0.0659	0.2888
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.016	0.016
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.016	0.016
Mycobacterium tuberculosis	Possible oxidoreductase	0.0187	0.2262	0.309
Trypanosoma brucei	DNA polymerase eta, putative	0.0019	0.016	0.2284
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0026	0.0242	0.3676
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.016	0.0705
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0278	0.0278
Toxoplasma gondii	heat shock protein 75, putative	0.0013	0.0084	0.0369
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0187	0.2262	0.234
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0326	0.4662
Trypanosoma cruzi	heat shock protein 90, putative	0.0026	0.0242	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0187	0.2262	0.2262
Leishmania major	heat shock protein 83-1	0.0033	0.0326	0.144
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0242	0.3676
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0006	0.0007
Schistosoma mansoni	amine oxidase	0.0187	0.2262	0.2443
Trichomonas vaginalis	heat shock protein, putative	0.0026	0.0242	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0246	0.3004	0.3004
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0187	0.2262	1
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.016	0.2419
Schistosoma mansoni	endoplasmin	0.0033	0.0326	0.0352
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0326	0.4662
Mycobacterium ulcerans	hypothetical protein	0.0062	0.0699	0.0723
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0326	0.4662
Brugia malayi	SWIRM domain containing protein	0.0059	0.0659	0.0659
Loa Loa (eye worm)	heat shock protein 75	0.0013	0.0084	0.0084
Mycobacterium ulcerans	oxidoreductase GMC-type	0.0062	0.0699	0.0723
Brugia malayi	amine oxidase, flavin-containing family protein	0.0246	0.3004	0.3004
Mycobacterium tuberculosis	Possible oxidoreductase	0.0062	0.0699	0.0954
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0278	0.0278
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0187	0.2262	1
Plasmodium vivax	heat shock protein, putative	0.0013	0.0084	0.0373
Trichomonas vaginalis	endoplasmin, putative	0.002	0.0168	0.2541
Trypanosoma brucei	Heat shock protein 83, putative	0.0033	0.0326	0.4662
Toxoplasma gondii	heat shock protein 90, putative	0.0033	0.0326	0.1426
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.016	0.0172
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.016	0.0165
Trypanosoma cruzi	DNA polymerase eta, putative	0.0019	0.016	0.0705
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0659	0.0659
Echinococcus granulosus	heat shock protein	0.0033	0.0326	0.0352
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0187	0.2262	1
Mycobacterium ulcerans	dehydrogenase	0.0187	0.2262	0.234
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0026	0.0242	0.1072
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.016	0.0705
Trypanosoma cruzi	heat shock protein 85, putative	0.0033	0.0326	0.144
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0326	0.4662
Plasmodium falciparum	endoplasmin, putative	0.002	0.0168	0.0741
Trypanosoma brucei	heat shock protein, putative	0.0033	0.0326	0.4662
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0013	0.0084	0.1278
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.016	0.0705
Echinococcus multilocularis	cpg binding protein	0.003	0.0299	0.0323

Activities

Activity type	Activity value	Assay description	Source	Reference
MBC (functional)	= 42.6 10'-2umol	Antibacterial activity against Escherichia coli assessed as 99.5% bacterial killing using 1 x 10'4 CFU/ml inoculum after 72 hrs by microdilution method	ChEMBL.	21470723
MIC (functional)	= 21.3 10'-2umol	Antibacterial activity against Escherichia coli using 1 x 10'4 CFU/ml inoculum after 24 hrs by microdilution method	ChEMBL.	21470723

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1782824

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1527045