TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 402.827 | Formula: C19H12ClFN2O3S
H donors: 1 H acceptors: 3 LogP: 4.11 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1cc(=O)oc2c1cccc2C)Nc1sc2c(n1)cc(c(c2)F)Cl
InChi: 1S/C19H12ClFN2O3S/c1-9-3-2-4-11-10(6-17(25)26-18(9)11)5-16(24)23-19-22-14-7-12(20)13(21)8-15(14)27-19/h2-4,6-8H,5H2,1H3,(H,22,23,24)
InChiKey: OUUMALFDHXSEJL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0134	0.0624
Echinococcus granulosus	heat shock protein 90	0.0028	0.0204	0.0221
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0024	0.0026
Trypanosoma cruzi	heat shock protein, putative	0.0015	0.0071	0.033
Mycobacterium ulcerans	FAD-linked oxidoreductase	0.0062	0.0531	0.0701
Mycobacterium ulcerans	hypothetical protein	0.0062	0.0531	0.0701
Echinococcus multilocularis	dna polymerase eta	0.0021	0.0134	0.0145
Toxoplasma gondii	FAD binding domain-containing protein	0.0062	0.0531	0.2447
Loa Loa (eye worm)	heat shock protein 75	0.0015	0.0071	0.0071
Trypanosoma brucei	heat shock protein 84, putative	0.0015	0.0071	0.1337
Entamoeba histolytica	hypothetical protein	0.0078	0.0683	1
Leishmania major	UDP-galactopyranose mutase	0.0228	0.215	1
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0274	0.5164
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0028	0.0204	0.0949
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0134	0.0251
Onchocerca volvulus		0.1036	1	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0071	0.1335
Schistosoma mansoni	DNA polymerase eta	0.0021	0.0134	0.0145
Mycobacterium tuberculosis	Probable oxidoreductase	0.0062	0.0531	0.0992
Leishmania major	DNA polymerase kappa, putative	0.0021	0.0134	0.0624
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0035	0.0274	0.4012
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Loa Loa (eye worm)	heat shock protein 90	0.0035	0.0274	0.0274
Mycobacterium ulcerans	dehydrogenase	0.0228	0.215	0.2841
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Giardia lamblia	hypothetical protein	0.0078	0.0683	1
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0204	0.2986
Giardia lamblia	DINP protein human, muc B family	0.0021	0.0134	0.1965
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Plasmodium vivax	hypothetical protein, conserved	0.0062	0.0531	0.2469
Entamoeba histolytica	90 kDa heat shock protein, putative	0.0015	0.0071	0.1038
Echinococcus multilocularis	heat shock protein 75 kDa, mitochondrial	0.0015	0.0071	0.0077
Plasmodium vivax	heat shock protein, putative	0.0015	0.0071	0.033
Echinococcus granulosus	geminin	0.0185	0.1724	0.1865
Echinococcus granulosus	endoplasmin	0.0028	0.0204	0.0221
Brugia malayi	Hsp90 protein	0.0015	0.0071	0.0071
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0134	0.0624
Entamoeba histolytica	heat shock protein 90, putative	0.0035	0.0274	0.4012
Echinococcus granulosus	heat shock protein	0.0035	0.0274	0.0296
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Schistosoma mansoni	heat shock protein	0.0015	0.0071	0.0077
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0005	0.0006
Mycobacterium ulcerans	FAD-dependent oxidoreductase	0.0062	0.0531	0.0701
Trypanosoma brucei	heat shock protein 90, putative	0.0035	0.0274	0.5164
Trypanosoma cruzi	hypothetical protein, conserved	0.0062	0.0531	0.2469
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0005	0.0006
Trichomonas vaginalis	heat shock protein, putative	0.0035	0.0274	0.4012
Trypanosoma brucei	unspecified product	0.0021	0.0134	0.253
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0228	0.215	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0134	0.0624
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.0134	0.1965
Loa Loa (eye worm)	endoplasmin	0.0035	0.0274	0.0274
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0274	0.5164
Onchocerca volvulus		0.0031	0.0234	0.0234
Plasmodium vivax	hypothetical protein, conserved	0.0228	0.215	1
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.023	0.2169	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0005	0.0006
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0558	0.5349	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0071	0.1335
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Toxoplasma gondii	FAD binding domain-containing protein	0.0062	0.0531	0.2447
Onchocerca volvulus	Heat shock protein 75 kDa, mitochondrial homolog	0.0015	0.0071	0.0071
Echinococcus granulosus	dna polymerase kappa	0.0021	0.0134	0.0145
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0683	1
Schistosoma mansoni	hypothetical protein	0.0185	0.1724	0.1865
Trypanosoma cruzi	DNA polymerase eta, putative	0.0021	0.0134	0.0624
Mycobacterium ulcerans	oxidoreductase	0.0228	0.215	0.2841
Trichomonas vaginalis	heat shock protein, putative	0.0022	0.0141	0.2064
Trypanosoma brucei	Monooxygenase, putative	0.0062	0.0531	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0506	0.2334
Mycobacterium ulcerans	membrane-associated oxidoreductase	0.0062	0.0531	0.0701
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.0228	0.215	0.2841
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0575	0.0622
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.0134	0.0145
Echinococcus granulosus	heat shock protein 90	0.0035	0.0274	0.0296
Schistosoma mansoni	cpg binding protein	0.0031	0.0234	0.0253
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.0134	0.0145
Leishmania major	DNA polymerase eta, putative	0.0021	0.0134	0.0624
Brugia malayi	SWIRM domain containing protein	0.0078	0.0683	0.0683
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0134	0.0177
Toxoplasma gondii	histone lysine-specific demethylase	0.0228	0.215	0.9915
Loa Loa (eye worm)	hypothetical protein	0.0228	0.215	0.215
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0959	0.9247	1
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0228	0.215	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Mycobacterium ulcerans	hypothetical protein	0.0062	0.0531	0.0701
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0228	0.215	0.2325
Echinococcus multilocularis	geminin	0.0185	0.1724	0.1865
Echinococcus multilocularis	ubiquinone biosynthesis monooxygenase COQ6	0.0062	0.0531	0.0574
Schistosoma mansoni	endoplasmin	0.0035	0.0274	0.0296
Echinococcus granulosus	ubiquinone biosynthesis monooxygenase COQ6	0.0062	0.0531	0.0574
Leishmania major	hypothetical protein, conserved	0.0062	0.0531	0.2469
Trypanosoma brucei	Heat shock protein 83, putative	0.0035	0.0274	0.5164
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.0134	0.0145
Mycobacterium ulcerans	oxidoreductase	0.0062	0.0531	0.0701
Treponema pallidum	heat shock protein 90	0.0028	0.0204	1
Echinococcus granulosus	SWI:SNF complex subunit SMARCC2	0.0078	0.0683	0.0739
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0228	0.215	1
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Schistosoma mansoni	heat shock protein	0.0035	0.0274	0.0296
Toxoplasma gondii	heat shock protein 75, putative	0.0015	0.0071	0.0327
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0028	0.0204	0.0949
Plasmodium falciparum	protoporphyrinogen oxidase	0.0228	0.215	1
Schistosoma mansoni	hypothetical protein	0.0062	0.0531	0.0574
Trypanosoma cruzi	heat shock protein 90, putative	0.0035	0.0274	0.1275
Echinococcus granulosus	heat shock protein 75 kDa mitochondrial	0.0015	0.0071	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0683	0.0683
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0024	0.0024
Echinococcus granulosus	cpg binding protein	0.0033	0.0251	0.0272
Schistosoma mansoni	endoplasmin	0.0035	0.0274	0.0296
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.0274	0.1275
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.0134	0.0624
Leishmania major	heat shock protein, putative	0.0015	0.0071	0.033
Loa Loa (eye worm)	hypothetical protein	0.0959	0.9247	0.9247
Entamoeba histolytica	SWIRM domain protein	0.0078	0.0683	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0028	0.0204	0.0949
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.0134	0.0145
Plasmodium vivax	FAD-dependent monooxygenase, putative	0.0062	0.0531	0.2469
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.0134	0.0177
Plasmodium vivax	heat shock protein 86, putative	0.0035	0.0274	0.1275
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.0134	0.1965
Loa Loa (eye worm)	hypothetical protein	0.0959	0.9247	0.9247
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0028	0.0204	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0134	0.0134
Echinococcus multilocularis	heat shock protein 90	0.0028	0.0204	0.0221
Plasmodium falciparum	FAD-dependent monooxygenase, putative	0.0062	0.0531	0.2469
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0274	0.5164
Echinococcus multilocularis	SWI:SNF complex subunit SMARCC2	0.0078	0.0683	0.0739
Toxoplasma gondii	SWIRM domain-containing protein	0.0078	0.0683	0.3151
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Entamoeba histolytica	SWIRM domain protein	0.0078	0.0683	1
Trypanosoma cruzi	Heat shock protein 83, putative	0.0035	0.0274	0.1275
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0023	0.0023
Entamoeba histolytica	heat shock protein 90, putative	0.0035	0.0274	0.4012
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0134	0.253
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Wolbachia endosymbiont of Brugia malayi	2-polyprenyl-6-methoxyphenol 4-hydroxylase	0.0062	0.0531	1
Toxoplasma gondii	Hsp90 domain-containing protein	0.0015	0.0071	0.0327
Mycobacterium leprae	possibleputative FAD-linked oxidoreductase	0.0062	0.0531	0.2469
Trypanosoma brucei	kynurenine 3-monooxygenase, putative	0.0062	0.0531	1
Trichomonas vaginalis	conserved hypothetical protein	0.0078	0.0683	1
Echinococcus multilocularis	cpg binding protein	0.0033	0.0251	0.0272
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0005	0.0006
Plasmodium falciparum	heat shock protein 90	0.0035	0.0274	0.1275
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0228	0.215	0.2325
Trypanosoma cruzi	heat shock protein 85, putative	0.0028	0.0204	0.0949
Echinococcus multilocularis	heat shock protein	0.0035	0.0274	0.0296
Mycobacterium tuberculosis	Possible oxidoreductase	0.0062	0.0531	0.0992
Mycobacterium ulcerans	oxidoreductase GMC-type	0.0062	0.0531	0.0701
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.0274	0.1275
Loa Loa (eye worm)	hypothetical protein	0.1036	1	1
Loa Loa (eye worm)	hypothetical protein	0.0062	0.0531	0.0531
Schistosoma mansoni	SWI/SNF complex-related	0.0078	0.0683	0.0739
Trypanosoma brucei	heat shock protein 90, putative	0.0035	0.0274	0.5164
Chlamydia trachomatis	monooxygenase	0.0062	0.0531	0.2469
Leishmania major	hypothetical protein, conserved	0.0062	0.0531	0.2469
Plasmodium vivax	hypothetical protein, conserved	0.0228	0.215	1
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0204	0.2986
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0028	0.0204	0.0221
Plasmodium falciparum	heat shock protein 90, putative	0.0015	0.0071	0.033
Echinococcus granulosus	protein MICAL 3	0.0062	0.0531	0.0574
Plasmodium falciparum	heat shock protein 90, putative	0.0015	0.0071	0.033
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0786	0.757	1
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Plasmodium vivax	endoplasmin, putative	0.0035	0.0274	0.1275
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0228	0.215	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0035	0.0274	0.1275
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Toxoplasma gondii	heat shock protein HSP90	0.0035	0.0274	0.1264
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.0228	0.215	1
Schistosoma mansoni	hypothetical protein	0.0185	0.1724	0.1865
Giardia lamblia	Grp94/Hsp90	0.0028	0.0204	0.2986
Brugia malayi	hypothetical protein	0.0228	0.215	0.215
Schistosoma mansoni	cpg binding protein	0.0033	0.0251	0.0272
Trypanosoma cruzi	heat shock protein 90, putative	0.0021	0.0133	0.0619
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0959	0.9247	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0024	0.0026
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.0134	0.253
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0959	0.9247	1
Schistosoma mansoni	monoxygenase	0.0062	0.0531	0.0574
Trypanosoma cruzi	Monooxygenase, putative	0.0062	0.0531	0.2469
Brugia malayi	heat shock protein 90	0.0035	0.0274	0.0274
Echinococcus multilocularis	heat shock protein 90	0.0035	0.0274	0.0296
Mycobacterium tuberculosis	Possible oxidoreductase	0.0062	0.0531	0.0992
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0274	0.5164
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0228	0.215	0.402
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.0134	0.0624
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0228	0.215	1
Echinococcus multilocularis	endoplasmin	0.0028	0.0204	0.0221
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0005	0.0006
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Trichomonas vaginalis	heat shock protein, putative	0.0028	0.0204	0.2986
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0228	0.215	1
Mycobacterium ulcerans	heat shock protein 90	0.0028	0.0204	0.027
Brugia malayi	amine oxidase, flavin-containing family protein	0.0306	0.2904	0.2904
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0274	0.5164
Mycobacterium tuberculosis	Possible oxidoreductase	0.0228	0.215	0.402
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.0134	0.0251
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0134	0.0134
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0028	0.0204	0.3844
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0234	0.0234
Schistosoma mansoni	amine oxidase	0.0228	0.215	0.2325
Trypanosoma brucei	unspecified product	0.0015	0.0071	0.1335
Trypanosoma brucei	DNA polymerase kappa, putative	0.0015	0.0071	0.1335
Mycobacterium ulcerans	oxidoreductase	0.0062	0.0531	0.0701
Trypanosoma brucei	DNA polymerase eta, putative	0.0021	0.0134	0.253
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.0134	0.0134
Echinococcus multilocularis		0.0228	0.215	0.2325
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0274	0.5164
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0786	0.757	1
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0274	0.5164
Mycobacterium ulcerans	monoamine oxidase	0.0228	0.215	0.2841
Schistosoma mansoni	amine oxidase	0.0228	0.215	0.2325
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.0134	0.0145
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0134	0.253
Schistosoma mansoni	cpg binding protein	0.0033	0.0251	0.0272
Plasmodium vivax	heat shock protein 90, putative	0.0015	0.0071	0.033
Toxoplasma gondii	heat shock protein 90, putative	0.0035	0.0274	0.1264
Trichomonas vaginalis	endoplasmin, putative	0.0022	0.0141	0.2064
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.0134	0.1965
Brugia malayi	Endoplasmin precursor	0.0035	0.0274	0.0274
Echinococcus granulosus	dna polymerase eta	0.0021	0.0134	0.0145
Mycobacterium tuberculosis	Probable oxidoreductase	0.0062	0.0531	0.0992
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0028	0.0204	0.0381
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0228	0.215	1
Trypanosoma brucei	heat shock protein, putative	0.0035	0.0274	0.5164
Loa Loa (eye worm)	hypothetical protein	0.0228	0.215	0.215
Trypanosoma brucei	unspecified product	0.0015	0.0071	0.1335
Plasmodium falciparum	endoplasmin, putative	0.0022	0.0141	0.0656
Schistosoma mansoni	heat shock protein	0.0035	0.0274	0.0296
Leishmania major	heat shock protein 83-1	0.0035	0.0274	0.1275
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.0134	0.253
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.0134	0.0134
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0234	0.0234
Mycobacterium ulcerans	hypothetical protein	0.0062	0.0531	0.0701
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0228	0.215	0.2325
Mycobacterium tuberculosis	Possible oxidoreductase	0.0062	0.0531	0.0992
Trichomonas vaginalis	heat shock protein, putative	0.0015	0.0071	0.1038
Echinococcus multilocularis	protein MICAL 3	0.0062	0.0531	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0306	0.2904	0.2904

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (ADMET)	> 58 ug ml-1	Cytotoxicity against human mock-infected MT4 cells after 4 days by MTT assay	ChEMBL.	21515046

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1778075

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1527062