Detailed information for compound 1531165

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.45 | Formula: C19H21F2N3O3S
  • H donors: 1 H acceptors: 3 LogP: 2.72 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(c(c1)F)NC(=O)c1cc(ccc1N1CCCC1)S(=O)(=O)N(C)C
  • InChi: 1S/C19H21F2N3O3S/c1-23(2)28(26,27)14-6-8-18(24-9-3-4-10-24)15(12-14)19(25)22-17-7-5-13(20)11-16(17)21/h5-8,11-12H,3-4,9-10H2,1-2H3,(H,22,25)
  • InChiKey: HTJWIGNKFTYEFI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0215
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0347 0.4181 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0331 0.0736
Treponema pallidum DNA ligase (lig) 0.0011 0.0024 0.5
Entamoeba histolytica hypothetical protein 0.0042 0.0398 0.0899
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0024 0.0038
Echinococcus granulosus geminin 0.0171 0.1998 0.314
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.1896 0.2979
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0041 0.0041
Brugia malayi Pre-SET motif family protein 0.0251 0.2999 0.4714
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0041 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0058 0.2995
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0223 0.035
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0024 0.00000083438
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0136 0.0269
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0223 0.0628
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0136 0.0214
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0347 0.4181 1
Leishmania major macrophage migration inhibitory factor-like protein 0.0347 0.4181 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0331 0.0331
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.4181 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0488 0.0767
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0024 0.00000083438
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0488 0.0767
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.0223 0.0628
Echinococcus multilocularis dna polymerase eta 0.002 0.0136 0.0136
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0038
Brugia malayi hypothetical protein 0.0011 0.0024 0.0038
Echinococcus multilocularis protein patched 0.0049 0.0488 0.0488
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0347 0.4181 1
Leishmania major macrophage migration inhibitory factor-like protein 0.0347 0.4181 1
Schistosoma mansoni patched 1 0.0049 0.0488 0.1535
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0058 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0223 0.0628
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0137 0.0271
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0331 0.104
Brugia malayi hypothetical protein 0.0011 0.0024 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0223 0.0628
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0136 0.0214
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Onchocerca volvulus 0.0026 0.0209 0.0326
Schistosoma mansoni survival motor neuron protein 0.0107 0.1205 0.3791
Echinococcus multilocularis lamin 0.0026 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.002 0.0136 0.0214
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0331 0.052
Loa Loa (eye worm) glutaminase 0.0266 0.3179 0.4996
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0136 0.0269
Echinococcus multilocularis musashi 0.0026 0.0209 0.0209
Plasmodium falciparum macrophage migration inhibitory factor 0.0347 0.4181 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0107 0.1205 0.1894
Loa Loa (eye worm) hypothetical protein 0.0013 0.0041 0.0064
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0148 0.1717 0.2698
Echinococcus multilocularis geminin 0.0171 0.1998 0.1998
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Schistosoma mansoni hypothetical protein 0.0171 0.1998 0.6284
Echinococcus granulosus dna polymerase eta 0.002 0.0136 0.0214
Echinococcus granulosus nibrin 0.0011 0.0024 0.0038
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0136 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0331 0.104
Echinococcus multilocularis lamin dm0 0.0026 0.0209 0.0209
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 1
Giardia lamblia Macrophage migration inhibitory factor 0.0347 0.4181 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0568 0.0893
Schistosoma mansoni lamin 0.0026 0.0209 0.0657
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0215
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Echinococcus granulosus survival motor neuron protein 1 0.0523 0.6363 1
Schistosoma mansoni hypothetical protein 0.0107 0.1205 0.3791
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0136 0.0269
Loa Loa (eye worm) hypothetical protein 0.0027 0.0223 0.035
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0024 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0331 0.104
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0136 0.1337
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0488 0.0767
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0568 0.0893
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0136 0.0429
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0114 0.1292 0.3048
Onchocerca volvulus 0.0468 0.5686 1
Loa Loa (eye worm) glutaminase 2 0.0266 0.3179 0.4996
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0215
Echinococcus multilocularis Niemann Pick C1 protein 0.0114 0.1292 0.1292
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0331 0.104
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0568 0.1788
Trypanosoma brucei unspecified product 0.002 0.0136 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0042 0.0398 0.1253
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Entamoeba histolytica hypothetical protein 0.0042 0.0398 0.0899
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0058 0.2995
Entamoeba histolytica hypothetical protein 0.0042 0.0398 0.0899
Schistosoma mansoni hypothetical protein 0.0171 0.1998 0.6284
Schistosoma mansoni DNA ligase IV 0.0011 0.0024 0.0077
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0136 1
Onchocerca volvulus 0.0026 0.0209 0.0326
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0223 0.0477
Schistosoma mansoni hypothetical protein 0.0047 0.0466 0.1466
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0223 0.0213
Toxoplasma gondii ATPase, AAA family protein 0.0011 0.0024 0.00000083438
Trypanosoma brucei unspecified product 0.0014 0.0058 0.2995
Onchocerca volvulus 0.0027 0.0223 0.035
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0024 0.00000083438
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0038
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0223 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0398 0.0626
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0568 0.1788
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0114 0.1292 0.203
Onchocerca volvulus 0.0286 0.343 0.6015
Brugia malayi Pre-SET motif family protein 0.0036 0.0331 0.052
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0209 0.0328
Schistosoma mansoni hypothetical protein 0.0047 0.0466 0.1466
Brugia malayi CHE-14 protein 0.0049 0.0488 0.0767
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 1
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0137 0.0271
Brugia malayi hypothetical protein 0.0468 0.5686 0.8936
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0209 0.0328
Brugia malayi intermediate filament protein 0.0026 0.0209 0.0328
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.1313 0.4132
Trichomonas vaginalis glutaminase, putative 0.0266 0.3179 0.7589
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0314 0.0494
Brugia malayi glutaminase DH11.1 0.0266 0.3179 0.4996
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0137 0.139
Echinococcus granulosus expressed conserved protein 0.0107 0.1206 0.1896
Echinococcus granulosus intermediate filament protein 0.0026 0.0209 0.0328
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0223 1
Giardia lamblia DINP protein human, muc B family 0.002 0.0136 0.0269
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0223 0.0477
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0209 0.0328
Echinococcus multilocularis protein dispatched 1 0.0056 0.0573 0.0573
Loa Loa (eye worm) hypothetical protein 0.0468 0.5686 0.8936
Echinococcus granulosus lamin 0.0026 0.0209 0.0328
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0137 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Echinococcus multilocularis nibrin 0.0011 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0137 0.0215
Brugia malayi Bm-MIF-1, identical 0.0347 0.4181 0.6571
Schistosoma mansoni intermediate filament proteins 0.0026 0.0209 0.0657
Echinococcus multilocularis survival motor neuron protein 1 0.0523 0.6363 0.6363
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0223 0.0213
Loa Loa (eye worm) runx1 0.0059 0.0611 0.0961
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0488 0.1115
Loa Loa (eye worm) hypothetical protein 0.0468 0.5686 0.8936
Plasmodium vivax SET domain protein, putative 0.0036 0.0331 0.0736
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.1896 0.1896
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0223 0.0213
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0488 0.0488
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0136 1
Schistosoma mansoni topbp1 0.0011 0.0024 0.0077
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0136 0.0355
Loa Loa (eye worm) hypothetical protein 0.0027 0.0223 0.035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0568 0.1788
Brugia malayi DKFZp564C0469 protein 0.0011 0.0024 0.0038
Trypanosoma brucei unspecified product 0.0014 0.0058 0.2995
Loa Loa (eye worm) transcription factor SMAD2 0.0138 0.1591 0.25
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0136 0.1337
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0568 0.0893
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0038
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0136 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0223 0.035
Loa Loa (eye worm) hypothetical protein 0.006 0.0624 0.098
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0136 0.0136
Onchocerca volvulus 0.0107 0.1205 0.2086
Loa Loa (eye worm) hypothetical protein 0.0036 0.0331 0.052
Schistosoma mansoni hypothetical protein 0.0047 0.0466 0.1466
Mycobacterium ulcerans glutaminase 0.0266 0.3179 1
Echinococcus multilocularis dna polymerase kappa 0.002 0.0136 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0568 0.0568
Loa Loa (eye worm) hypothetical protein 0.0523 0.6363 1
Entamoeba histolytica hypothetical protein 0.0042 0.0398 0.0899
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Echinococcus multilocularis Protein lozenge 0.0059 0.0611 0.0611
Schistosoma mansoni lozenge 0.0059 0.0611 0.1924
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0148 0.1717 0.2698
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0568 0.0893
Echinococcus multilocularis expressed conserved protein 0.0107 0.1206 0.1206
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0038
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0024 0.0038
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0347 0.4181 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0209 0.0328
Schistosoma mansoni hypothetical protein 0.0047 0.0466 0.1466
Loa Loa (eye worm) hypothetical protein 0.0026 0.0203 0.0319
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0136 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0223 0.035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0024 0.0038
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0223 1
Schistosoma mansoni topbp1 0.0011 0.0024 0.0077
Brugia malayi hypothetical protein 0.0523 0.6363 1
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0488 0.0767
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0331 0.0331
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0136 0.0355
Loa Loa (eye worm) MH2 domain-containing protein 0.0138 0.1591 0.25
Onchocerca volvulus 0.0036 0.0331 0.0541
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0136 1
Trichomonas vaginalis set domain proteins, putative 0.0286 0.343 0.8193
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0223 0.035
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0137 1
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0024 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0136 0.0214
Brugia malayi MH2 domain containing protein 0.0138 0.1591 0.25
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0024 0.00000083438
Schistosoma mansoni lamin 0.0026 0.0209 0.0657
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0024 0.0077
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0223 0.0628
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0223 0.0628
Brugia malayi topoisomerase 0.0011 0.0024 0.0038
Echinococcus granulosus Niemann Pick C1 protein 0.0114 0.1292 0.203
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0223 0.0628
Brugia malayi Niemann-Pick C1 protein precursor 0.0114 0.1292 0.203
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0058 0.2995
Brugia malayi hypothetical protein 0.0042 0.0398 0.0626
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0347 0.4181 0.6571
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0024 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0223 0.0628
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2999 0.4714
Echinococcus granulosus lamin dm0 0.0026 0.0209 0.0328
Schistosoma mansoni DNA polymerase eta 0.002 0.0136 0.0429
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0136 0.0429
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0398 0.0398
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0058 0.0091
Echinococcus granulosus dna polymerase kappa 0.002 0.0136 0.0214
Schistosoma mansoni glutaminase 0.0266 0.3179 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0223 0.0477
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0223 1
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0398 0.1253

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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