Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin 2 (5-HT2) receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0025 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0489 | 1 | 1 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0032 | 0.0219 | 0.0219 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.0032 | 0.0219 | 0.0767 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0219 | 0.0219 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0025 | 0.0068 | 0.5 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0025 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0219 | 0.0219 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.0032 | 0.0219 | 0.0767 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0025 | 0.0068 | 0.309 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.0032 | 0.0219 | 0.0767 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0025 | 0.0068 | 0.0068 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0156 | 0.2859 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.2859 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0025 | 0.0068 | 0.5 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0025 | 0.0068 | 0.5 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0025 | 0.0068 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.0219 | 0.0219 | |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0025 | 0.0068 | 0.0237 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0219 | 0.0219 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0025 | 0.0068 | 0.0237 |
Onchocerca volvulus | 0.0032 | 0.0219 | 0.0219 | |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.0032 | 0.0219 | 0.0219 |
Onchocerca volvulus | 0.0032 | 0.0219 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0219 | 0.0219 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0025 | 0.0068 | 0.0237 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0219 | 0.0219 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0025 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.0032 | 0.0219 | 0.0219 | |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2859 | 0.2859 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.2859 | 0.2859 |
Onchocerca volvulus | Putative organic anion transporter | 0.0489 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0025 | 0.0068 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0156 | 0.2859 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0219 | 0.0219 |
Schistosoma mansoni | organic anion transporter | 0.0032 | 0.0219 | 0.0767 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0025 | 0.0068 | 0.0237 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0032 | 0.0219 | 0.0219 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0025 | 0.0068 | 0.5 |
Echinococcus multilocularis | serotonin receptor | 0.0156 | 0.2859 | 1 |
Schistosoma mansoni | organic anion transporter | 0.0032 | 0.0219 | 0.0767 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0025 | 0.0068 | 0.0237 |
Trypanosoma cruzi | MFS transporter, putative | 0.0032 | 0.0219 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.0032 | 0.0219 | 0.0219 |
Plasmodium vivax | RNA helicase-1, putative | 0.0025 | 0.0068 | 0.5 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.0032 | 0.0219 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0219 | 0.0219 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0025 | 0.0068 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0219 | 0.0219 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.0032 | 0.0219 | 0.0219 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0025 | 0.0068 | 0.0068 |
Onchocerca volvulus | 0.0032 | 0.0219 | 0.0219 | |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0025 | 0.0068 | 0.0237 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.0032 | 0.0219 | 0.0767 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0025 | 0.0068 | 0.5 |
Onchocerca volvulus | Putative organic anion transporter | 0.0032 | 0.0219 | 0.0219 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 10000 nM | Binding affinity against 5-hydroxytryptamine 2 receptor using [3H]-ketanserin as radioligand | ChEMBL. | 2213830 |
Ki (binding) | > 10000 nM | Binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand | ChEMBL. | 2213830 |
Ki (binding) | > 10000 nM | Binding affinity against 5-hydroxytryptamine 2 receptor using [3H]-ketanserin as radioligand | ChEMBL. | 2213830 |
Ki (binding) | > 10000 nM | Binding affinity against 5-hydroxytryptamine 1A receptor using [3H]-8-OH-DPAT as radioligand | ChEMBL. | 2213830 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.