Detailed information for compound 1539861

Basic information

Technical information
  • TDR Targets ID: 1539861
  • Name: [2-[(4-carbamoylphenyl)amino]-2-oxoethyl] 5-m ethylthiophene-2-carboxylate
  • MW: 318.348 | Formula: C15H14N2O4S
  • H donors: 2 H acceptors: 3 LogP: 1.97 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)C(=O)N)COC(=O)c1ccc(s1)C
  • InChi: 1S/C15H14N2O4S/c1-9-2-7-12(22-9)15(20)21-8-13(18)17-11-5-3-10(4-6-11)14(16)19/h2-7H,8H2,1H3,(H2,16,19)(H,17,18)
  • InChiKey: ZEIPZRCDCMJSLN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [2-[(4-carbamoylphenyl)amino]-2-oxo-ethyl] 5-methylthiophene-2-carboxylate
  • 5-methyl-2-thiophenecarboxylic acid [2-[(4-carbamoylphenyl)amino]-2-oxoethyl] ester
  • 5-methylthiophene-2-carboxylic acid [2-[(4-carbamoylphenyl)amino]-2-keto-ethyl] ester
  • [2-[(4-aminocarbonylphenyl)amino]-2-oxo-ethyl] 5-methylthiophene-2-carboxylate
  • ZINC03384831
  • T5401613

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0063 0.0445 0.9253
Plasmodium vivax hexose transporter 0.021 0.1781 0.2094
Onchocerca volvulus 0.0029 0.0141 0.0018
Brugia malayi intermediate filament protein 0.0029 0.0137 0.0484
Echinococcus granulosus solute carrier family 22 0.0029 0.0141 0.0141
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0037 0.0211 0.0211
Plasmodium falciparum proline--tRNA ligase 0.0073 0.054 0.051
Loa Loa (eye worm) glutaminase 0.0295 0.2556 1
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0457 0.0404
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0141 0.0498
Plasmodium falciparum protein kinase 7 0.0592 0.5266 0.6542
Plasmodium falciparum protein kinase 6 0.0889 0.7975 1
Onchocerca volvulus 0.0163 0.1355 0.6098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0747 0.0747
Loa Loa (eye worm) hypothetical protein 0.0163 0.1355 0.53
Loa Loa (eye worm) hypothetical protein 0.0031 0.0157 0.0615
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.0185
Loa Loa (eye worm) sugar transporter 0.021 0.1781 0.697
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0039 0.0039
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.054 1
Loa Loa (eye worm) transcription factor SMAD2 0.0268 0.2313 0.905
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0339 0.2957 0.3595
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0014 0.0055
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0141 0.0159
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.1781 0.1781
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0211 0.1751
Schistosoma mansoni sugar transporter 0.0029 0.0141 0.0159
Brugia malayi lysyl-tRNA synthetase 0.0047 0.0298 0.1118
Onchocerca volvulus 0.0029 0.0141 0.0018
Echinococcus multilocularis lamin dm0 0.0029 0.0137 0.0137
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0457 0.1742
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0464 0.134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Leishmania major lysyl-tRNA synthetase, putative 0.0047 0.0298 0.395
Onchocerca volvulus 0.0029 0.0141 0.0018
Plasmodium vivax proline--tRNA ligase, putative 0.0073 0.054 0.051
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.0464 0.8107
Loa Loa (eye worm) glutaminase 2 0.0295 0.2556 1
Schistosoma mansoni sugar transporter 0.0029 0.0141 0.0159
Giardia lamblia Lysyl-tRNA synthetase 0.0047 0.0298 0.5182
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0747 0.2921
Trypanosoma brucei glucose transporter, putative 0.0065 0.0464 0.8107
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0457 0.0404
Leishmania major hypothetical protein, conserved 0.0037 0.0211 0.1751
Onchocerca volvulus 0.0029 0.0141 0.0018
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.054 1
Mycobacterium ulcerans glutaminase 0.0295 0.2556 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0445 0.0633
Echinococcus granulosus solute carrier family 22 0.0029 0.0141 0.0141
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0041 0.0246 0.0435
Onchocerca volvulus 0.0029 0.0141 0.0018
Entamoeba histolytica protein kinase, putative 0.0064 0.0457 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0457 0.0457
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0298 0.0405
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1227 0.4774
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0457 0.0404
Loa Loa (eye worm) MH2 domain-containing protein 0.0268 0.2313 0.905
Brugia malayi MH1 domain containing protein 0.0018 0.0039 0.0096
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0039 0.0039
Onchocerca volvulus 0.0248 0.2134 1
Echinococcus granulosus lamin 0.0029 0.0137 0.0137
Toxoplasma gondii protein kinase, putative 0.0592 0.5266 1
Schistosoma mansoni cellular tumor antigen P53 0.0163 0.1355 0.2049
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0029 0.0132 0.0517
Echinococcus granulosus solute carrier family 22 0.0029 0.0141 0.0141
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0301 0.0301
Echinococcus multilocularis smad 0.0018 0.0039 0.0039
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0457 0.0404
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0457 0.0457
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0464 0.134
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0747 0.0747
Brugia malayi Sugar transporter family protein 0.021 0.1781 0.6953
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0457 0.0457
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0457 0.0457
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0464 0.8107
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0464 0.8107
Trypanosoma brucei glucose transporter, putative 0.0065 0.0464 0.8107
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0073 0.054 1
Brugia malayi Pre-SET motif family protein 0.0218 0.1859 0.726
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0063 0.0445 0.1695
Echinococcus multilocularis solute carrier family 22 0.0029 0.0141 0.0141
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.004 0.0234 1
Loa Loa (eye worm) sugar transporter 0.0029 0.0141 0.055
Schistosoma mansoni glucose transport protein 0.021 0.1781 0.2713
Onchocerca volvulus 0.0029 0.0141 0.0018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0747 0.0747
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.054 1
Plasmodium vivax SET domain protein, putative 0.0031 0.0157 0.0021
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Onchocerca volvulus 0.0029 0.0141 0.0018
Brugia malayi Sugar transporter family protein 0.0029 0.0141 0.0498
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0457 0.0457
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.1781 0.1781
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0157 0.0157
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0037 0.0211 0.1751
Schistosoma mansoni sugar transporter 0.0029 0.0141 0.0159
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0141 0.0498
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.1781 0.1781
Echinococcus granulosus intermediate filament protein 0.0029 0.0137 0.0137
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0457 0.0404
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Brugia malayi Smad1 0.0018 0.0039 0.0096
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0457 0.1787
Schistosoma mansoni hypothetical protein 0.0102 0.0799 0.1184
Brugia malayi hypothetical protein 0.0029 0.0141 0.0498
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Schistosoma mansoni lamin 0.0029 0.0137 0.0153
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0457 0.0404
Schistosoma mansoni intermediate filament proteins 0.0029 0.0137 0.0153
Echinococcus granulosus lysyl tRNA synthetase 0.0047 0.0298 0.0298
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Onchocerca volvulus 0.0029 0.0141 0.0018
Loa Loa (eye worm) Smad1 0.0018 0.0039 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Schistosoma mansoni lysyl-tRNA synthetase 0.0047 0.0298 0.0405
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0747 0.2882
Onchocerca volvulus 0.0029 0.0141 0.0018
Loa Loa (eye worm) hepatopoietin HPO2 0.0037 0.0211 0.0824
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0799 0.3087
Brugia malayi MH2 domain containing protein 0.0018 0.0039 0.0096
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0457 0.7919
Loa Loa (eye worm) hypothetical protein 0.0102 0.0799 0.3125
Echinococcus granulosus General substrate transporter 0.018 0.1513 0.1513
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.1859 0.7275
Loa Loa (eye worm) hypothetical protein 0.0047 0.0298 0.1167
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0298 0.0902
Schistosoma mansoni glucose transporter 0.0029 0.0141 0.0159
Chlamydia trachomatis lysine--tRNA ligase 0.0047 0.0298 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.0445 0.1741
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0464 0.134
Onchocerca volvulus 0.0029 0.0141 0.0018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Schistosoma mansoni protein kinase 0.0064 0.0457 0.0651
Trypanosoma brucei glucose transporter, putative 0.0065 0.0464 0.8107
Schistosoma mansoni hypothetical protein 0.0047 0.0301 0.0409
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0063 0.0445 0.126
Schistosoma mansoni protein kinase 0.0064 0.0457 0.0651
Schistosoma mansoni lamin 0.0029 0.0137 0.0153
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0457 0.1309
Echinococcus multilocularis solute carrier family 22 0.0029 0.0141 0.0141
Giardia lamblia Prolyl-tRNA synthetase 0.0063 0.0445 1
Echinococcus multilocularis Smad4 0.0018 0.0039 0.0039
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0457 0.0404
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0063 0.0445 0.1695
Schistosoma mansoni protein kinase 0.0064 0.0457 0.0651
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0141 0.0141
Mycobacterium ulcerans sugar transporter 0.0029 0.0141 0.0266
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.0185
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0141 0.055
Echinococcus multilocularis General substrate transporter 0.018 0.1513 0.1513
Loa Loa (eye worm) hypothetical protein 0.0047 0.0301 0.1178
Schistosoma mansoni sugar transporter 0.0029 0.0141 0.0159
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0073 0.054 0.0779
Schistosoma mansoni hypothetical protein 0.0047 0.0301 0.0409
Brugia malayi MH1 domain containing protein 0.0018 0.0039 0.0096
Echinococcus multilocularis lamin 0.0029 0.0137 0.0137
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0301 0.1129
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0464 0.8107
Schistosoma mansoni glutaminase 0.0295 0.2556 0.3919
Leishmania major glucose transporter, lmgt3 0.0065 0.0464 0.8107
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0211 0.0136
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0047 0.0298 0.395
Onchocerca volvulus 0.0029 0.0141 0.0018
Loa Loa (eye worm) hypothetical protein 0.0051 0.0338 0.1321
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0157 0.0157
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0457 0.0457
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0039 0.0151
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0039 0.0039
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0157 0.0185
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0457 0.0617
Leishmania major protein kinase, putative 0.0064 0.0457 0.7919
Schistosoma mansoni hypothetical protein 0.0047 0.0301 0.0409
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0039 0.0039
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0141 0.5
Echinococcus granulosus calcium dependent protein kinase 0.006 0.0421 0.0421
Trichomonas vaginalis set domain proteins, putative 0.0248 0.2134 0.8253
Onchocerca volvulus 0.0031 0.0157 0.0102
Brugia malayi major facilitator superfamily protein 0.0029 0.0141 0.0498
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0211 0.0089
Echinococcus multilocularis microtubule associated protein 2 0.0723 0.6461 0.6461
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0464 0.134
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.021 0.1781 0.1781
Echinococcus granulosus Smad4 0.0018 0.0039 0.0039
Trypanosoma brucei glucose transporter 2A 0.0065 0.0464 0.8107
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0339 0.2957 0.5495
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.004 0.0234 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0301 0.1178
Schistosoma mansoni hypothetical protein 0.0047 0.0301 0.0409
Plasmodium falciparum hexose transporter 0.021 0.1781 0.2094
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0063 0.0445 1
Brugia malayi major facilitator superfamily protein 0.0029 0.0141 0.0498
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0211 0.1751
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.1781 0.1781
Plasmodium vivax CDK-related protein kinase 6, putative 0.0889 0.7975 1
Leishmania major glucose transporter, lmgt2 0.0065 0.0464 0.8107
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0464 0.134
Brugia malayi hypothetical protein 0.0029 0.0141 0.0498
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0047 0.0298 0.0653
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0464 0.8107
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0301 0.1129
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0063 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Trichomonas vaginalis conserved hypothetical protein 0.021 0.1781 0.6793
Loa Loa (eye worm) hypothetical protein 0.0149 0.1227 0.4803
Trypanosoma cruzi hexose transporter 0.0065 0.0464 0.8107
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0141 0.0266
Echinococcus granulosus microtubule associated protein 2 0.0723 0.6461 0.6461
Toxoplasma gondii lysine-tRNA ligase 0.0047 0.0298 0.0308
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Brugia malayi MH2 domain containing protein 0.0268 0.2313 0.9045
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0141 0.0141
Leishmania major glucose transporter, lmgt1 0.0065 0.0464 0.8107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Loa Loa (eye worm) hypothetical protein 0.0029 0.0137 0.0536
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0457 0.0404
Brugia malayi Cam kinase protein 1 0.0064 0.0457 0.1742
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0137 0.0536
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0457 0.1787
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.1781 0.1781
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.021 0.1781 0.1781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0747 0.1102
Echinococcus multilocularis GPCR, family 2 0.0047 0.0301 0.0301
Onchocerca volvulus 0.0029 0.0141 0.0018
Echinococcus multilocularis lysyl tRNA synthetase 0.0047 0.0298 0.0298
Echinococcus granulosus solute carrier family 22 0.0029 0.0141 0.0141
Schistosoma mansoni glucose transport protein 0.021 0.1781 0.2713
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0137 0.0536
Trypanosoma brucei glucose transporter 1E 0.0065 0.0464 0.8107
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Brugia malayi hypothetical protein 0.0029 0.0141 0.0498
Onchocerca volvulus Putative transporter 0.0029 0.0141 0.0018
Trichomonas vaginalis glutaminase, putative 0.0295 0.2556 1
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.021 0.1781 0.1781
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0157 0.0157
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0141 0.0266
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0047 0.0298 0.3046
Echinococcus multilocularis tumor protein p63 0.1112 1 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0157 0.0563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0747 0.1102
Schistosoma mansoni hypothetical protein 0.021 0.1781 0.2713
Plasmodium falciparum mitogen-activated protein kinase 2 0.0339 0.2957 0.3595
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0137 0.0484
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0141 0.0141
Onchocerca volvulus 0.0029 0.0141 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.0185
Echinococcus granulosus lamin dm0 0.0029 0.0137 0.0137
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0457 0.0651
Entamoeba histolytica protein kinase, putative 0.0064 0.0457 1
Onchocerca volvulus 0.0029 0.0141 0.0018
Onchocerca volvulus 0.0029 0.0141 0.0018
Plasmodium falciparum lysine--tRNA ligase 0.0047 0.0298 0.0201
Echinococcus granulosus GPCR family 2 0.0047 0.0301 0.0301
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0157 0.0032
Onchocerca volvulus 0.0029 0.0141 0.0018
Schistosoma mansoni microtubule-associated protein tau 0.0723 0.6461 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0063 0.0445 0.0633
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0301 0.0301
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0039 0.0151
Trichomonas vaginalis glucose transporter, putative 0.0065 0.0464 0.134
Brugia malayi MH2 domain containing protein 0.0018 0.0039 0.0096
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.0464 0.8107
Brugia malayi Sugar transporter family protein 0.0029 0.0141 0.0498
Trypanosoma cruzi hexose transporter, putative 0.0065 0.0464 0.8107
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0141 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0747 0.1102
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0301 0.0301
Brugia malayi glutaminase DH11.1 0.0295 0.2556 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0141 0.0141
Trypanosoma brucei glucose transporter, putative 0.0065 0.0464 0.8107
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0141 0.0266
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0457 0.0404
Trypanosoma brucei glucose transporter, putative 0.0065 0.0464 0.8107
Trypanosoma brucei glucose transporter, putative 0.0065 0.0464 0.8107
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0047 0.0298 0.395
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0026 0.0107 0.042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0301 0.0301
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0037 0.0211 0.0089
Trichomonas vaginalis sugar transporter, putative 0.0065 0.0464 0.134
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0141 0.0141
Toxoplasma gondii facilitative glucose transporter GT1 0.021 0.1781 0.3201
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0141 0.055
Trypanosoma brucei glucose transporter, putative 0.0065 0.0464 0.8107
Brugia malayi Augmenter of liver regeneration 0.0037 0.0211 0.0773
Schistosoma mansoni glucose transport protein 0.021 0.1781 0.2713
Loa Loa (eye worm) hypothetical protein 0.0063 0.0445 0.1741
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1227 0.4774
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0047 0.0298 0.0902
Treponema pallidum prolyl-tRNA synthetase 0.0022 0.0075 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1227 0.4803
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0747 0.0747
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0037 0.0211 0.1751
Echinococcus multilocularis calcium dependent protein kinase 0.006 0.0421 0.0421
Loa Loa (eye worm) hypothetical protein 0.0029 0.0141 0.055
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0037 0.0211 0.0211
Trypanosoma cruzi hexose transporter, putative 0.0036 0.0196 0.1383
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0457 0.0617
Echinococcus multilocularis musashi 0.0029 0.0137 0.0137
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0063 0.0445 0.0445
Echinococcus granulosus smad 0.0018 0.0039 0.0039
Trypanosoma brucei glucose transporter, putative 0.0065 0.0464 0.8107
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0457 0.0617
Loa Loa (eye worm) hypothetical protein 0.0064 0.0457 0.1787
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0073 0.054 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0141 0.0141
Plasmodium vivax lysine--tRNA ligase, putative 0.0047 0.0298 0.0201
Toxoplasma gondii Erv1 / Alr family protein 0.0037 0.0211 0.0136

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.