Detailed information for compound 1547487

Basic information

Technical information
  • TDR Targets ID: 1547487
  • Name: [3-[(3,4-dimethoxyphenyl)amino]piperidin-1-yl ]-quinoxalin-6-ylmethanone
  • MW: 392.451 | Formula: C22H24N4O3
  • H donors: 1 H acceptors: 3 LogP: 2.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1OC)NC1CCCN(C1)C(=O)c1ccc2c(c1)nccn2
  • InChi: 1S/C22H24N4O3/c1-28-20-8-6-16(13-21(20)29-2)25-17-4-3-11-26(14-17)22(27)15-5-7-18-19(12-15)24-10-9-23-18/h5-10,12-13,17,25H,3-4,11,14H2,1-2H3
  • InChiKey: KTVMVXPUAOAZRS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-[(3,4-dimethoxyphenyl)amino]-1-piperidyl]-quinoxalin-6-yl-methanone
  • [3-[(3,4-dimethoxyphenyl)amino]-1-piperidinyl]-(6-quinoxalinyl)methanone
  • [3-[(3,4-dimethoxyphenyl)amino]piperidin-1-yl]-quinoxalin-6-yl-methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cathepsin B 0.0581 0.3856 0.3856
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Brugia malayi Cation transporter family protein 0.0036 0.0146 0.0146
Schistosoma mansoni cathepsin F (C01 family) 0.0763 0.5091 0.5091
Giardia lamblia Cathepsin L-like protease 0.0176 0.1104 0.1501
Entamoeba histolytica cysteine proteinase 1, putative 0.042 0.2761 0.5416
Leishmania major cysteine peptidase A (CPA) 0.0763 0.5091 1
Entamoeba histolytica cysteine proteinase, putative 0.042 0.2761 0.5416
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0165 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0044 0.0206 0.0206
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0176 0.1104 0.2159
Loa Loa (eye worm) hypothetical protein 0.0044 0.0206 0.0206
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0581 0.3856 0.7286
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0176 0.1104 0.1244
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0763 0.5091 0.7496
Plasmodium falciparum cysteine proteinase falcipain 3 0.0763 0.5091 0.7496
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.5091 0.4812
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0146
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0176 0.1104 0.1104
Toxoplasma gondii cathepsin B 0.0581 0.3856 0.5897
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Brugia malayi cathepsin L-like precursor 0.0519 0.3435 0.3435
Plasmodium vivax vivapain-2 0.0763 0.5091 0.7496
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0176 0.1104 0.1104
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0959 0.6423 1
Brugia malayi Papain family cysteine protease containing protein 0.0763 0.5091 0.5091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0176 0.1104 0.1244
Entamoeba histolytica cysteine proteinase, putative 0.0519 0.3435 0.6742
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.042 0.2761 0.2761
Echinococcus multilocularis cathepsin L cysteine protease 0.0763 0.5091 0.5091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0176 0.1104 0.1244
Brugia malayi Papain family cysteine protease containing protein 0.042 0.2761 0.2761
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0176 0.1104 0.1501
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0244 0.1561 0.1561
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0581 0.3856 0.7286
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0015 0.0007 0.0007
Brugia malayi Cathepsin L-like cysteine proteinase 0.0519 0.3435 0.3435
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.013
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0038 0.0165 0.0165
Onchocerca volvulus 0.0176 0.1104 0.1938
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Brugia malayi cathepsin F-like cysteine proteinase 0.0244 0.1561 0.1561
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0038 0.0165 0.0165
Trypanosoma cruzi cysteine proteinase, putative 0.042 0.2761 0.2349
Giardia lamblia Encystation-specific protease 0.0473 0.3123 0.4726
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0146
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0959 0.6423 1
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0176 0.1104 0.1244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1485 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0176 0.1104 0.1244
Giardia lamblia Cathepsin B precursor 0.0581 0.3856 0.5897
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.042 0.2761 0.2349
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0244 0.1561 0.1561
Trypanosoma cruzi major cysteine proteinase, putative 0.0176 0.1104 0.0599
Echinococcus granulosus cathepsin L cysteine protease 0.042 0.2761 0.2761
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Loa Loa (eye worm) cysteine protease 0.0763 0.5091 0.5091
Loa Loa (eye worm) hypothetical protein 0.0763 0.5091 0.5091
Echinococcus multilocularis geminin 0.009 0.0519 0.0519
Echinococcus multilocularis cathepsin L 0.042 0.2761 0.2761
Plasmodium vivax unspecified product 0.042 0.2761 0.3114
Plasmodium vivax vivapain-1 0.042 0.2761 0.3114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0519 0.3435 0.6362
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0015 0.0007 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0176 0.1104 0.1244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Onchocerca volvulus 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Entamoeba histolytica cysteine proteinase, putative 0.042 0.2761 0.5416
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0007
Echinococcus granulosus cathepsin L 0.042 0.2761 0.2761
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.042 0.2761 0.4882
Echinococcus granulosus cathepsin L 0.0176 0.1104 0.1104
Echinococcus granulosus cathepsin l1 0.0763 0.5091 0.5091
Giardia lamblia Cathepsin B precursor 0.0581 0.3856 0.5897
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0176 0.1104 0.1104
Echinococcus granulosus cathepsin b 0.1485 1 1
Loa Loa (eye worm) hypothetical protein 0.1485 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0038 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.0519 0.3435 0.3435
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1485 1 1
Loa Loa (eye worm) hypothetical protein 0.0519 0.3435 0.3435
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0034 0.0133 0.0133
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0034 0.0133 0.0133
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0034 0.0133 0.0133
Entamoeba histolytica cysteine proteinase, putative 0.042 0.2761 0.5416
Trypanosoma cruzi cysteine proteinase, putative 0.042 0.2761 0.2349
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.1104 0.1244
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0473 0.3123 0.3794
Trypanosoma cruzi cysteine peptidase, putative 0.042 0.2761 0.2349
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Onchocerca volvulus Cathepsin L homolog 0.0763 0.5091 1
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0093 0.0538 0.0538
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Onchocerca volvulus 0.0763 0.5091 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0176 0.1104 0.1104
Entamoeba histolytica cysteine proteinase, putative 0.0763 0.5091 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0044 0.0206 0.0206
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0763 0.5091 0.7496
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.042 0.2761 0.4882
Toxoplasma gondii cathepsin CPC2 0.0473 0.3123 0.4726
Onchocerca volvulus 0.0763 0.5091 1
Entamoeba histolytica cysteine proteinase, putative 0.0763 0.5091 1
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0093 0.0538 0.0596
Mycobacterium ulcerans hypothetical protein 0.0093 0.0538 0.5
Onchocerca volvulus 0.0763 0.5091 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Giardia lamblia Cysteine protease 0.0176 0.1104 0.1501
Toxoplasma gondii cathepsin CPL 0.0763 0.5091 0.7872
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0959 0.6423 1
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Giardia lamblia Hypothetical protein 0.0176 0.1104 0.1501
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0176 0.1104 0.1104
Onchocerca volvulus Cathepsin F homolog 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0176 0.1104 0.1244
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Giardia lamblia Cysteine protease 0.0176 0.1104 0.1501
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.042 0.2761 0.4882
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0176 0.1104 0.1244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0763 0.5091 1
Schistosoma mansoni hypothetical protein 0.003 0.0111 0.0111
Schistosoma mansoni cathepsin F (C01 family) 0.0763 0.5091 0.5091
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0176 0.1104 0.2159
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0763 0.5091 0.5091
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0038 0.0165 0.0165
Schistosoma mansoni hypothetical protein 0.009 0.0519 0.0519
Trypanosoma cruzi cysteine protease, putative 0.042 0.2761 0.2349
Brugia malayi Papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Entamoeba histolytica cysteine proteinase, putative 0.042 0.2761 0.5416
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0959 0.6423 1
Brugia malayi cathepsin L precursor 0.0176 0.1104 0.1104
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1485 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.5091 0.4812
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.5091 0.4812
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Loa Loa (eye worm) hypothetical protein 0.0244 0.1561 0.1561
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0763 0.5091 1
Echinococcus granulosus cathepsin b 0.1485 1 1
Entamoeba histolytica hypothetical protein 0.0176 0.1104 0.2159
Schistosoma mansoni hypothetical protein 0.009 0.0519 0.0519
Onchocerca volvulus 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Echinococcus granulosus cysteine protease 0.042 0.2761 0.2761
Loa Loa (eye worm) hypothetical protein 0.0077 0.0429 0.0429
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0519 0.3435 0.6362
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0581 0.3856 0.3506
Echinococcus multilocularis cathepsin L cysteine protease 0.0763 0.5091 0.5091
Toxoplasma gondii preprocathepsin c precursor, putative 0.0959 0.6423 1
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0034 0.0133 0.0133
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0473 0.3123 0.3794
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0763 0.5091 0.5091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Giardia lamblia Cathepsin B precursor 0.0581 0.3856 0.5897
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0959 0.6423 1
Giardia lamblia Cathepsin L-like protease 0.0176 0.1104 0.1501
Plasmodium vivax unspecified product 0.0244 0.1561 0.0859
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1485 1 1
Schistosoma mansoni cathepsin C 0.0176 0.1104 0.1104
Schistosoma mansoni cathepsin S (C01 family) 0.0176 0.1104 0.1104
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0157 0.0974 0.0974
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Echinococcus granulosus tm gpcr rhodopsin 0.0157 0.0974 0.0974
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Brugia malayi cathepsin Z-like cysteine proteinase 0.0176 0.1104 0.1104
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0036 0.0146 0.0146
Echinococcus multilocularis cathepsin L 0.0176 0.1104 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0176 0.1104 0.1244
Schistosoma mansoni transcription factor LCR-F1 0.0015 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Loa Loa (eye worm) hypothetical protein 0.0093 0.0538 0.0538
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Brugia malayi fibroinase precursor 0.0176 0.1104 0.1104
Echinococcus multilocularis cysteine protease 0.0763 0.5091 0.5091
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Onchocerca volvulus Cathepsin L homolog 0.0763 0.5091 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0763 0.5091 0.5091
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0959 0.6423 0.6423
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Trypanosoma cruzi cysteine peptidase, putative 0.0763 0.5091 0.4812
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Loa Loa (eye worm) hypothetical protein 0.0519 0.3435 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Brugia malayi latrophilin 2 splice variant baaae 0.003 0.0111 0.0111
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0473 0.3123 0.4726
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Schistosoma mansoni cathepsin F (C01 family) 0.0519 0.3435 0.3435
Giardia lamblia Hypothetical protein 0.0176 0.1104 0.1501
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0662 0.4405 0.8493
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Entamoeba histolytica cysteine protease, putative 0.0176 0.1104 0.2159
Onchocerca volvulus Cathepsin L homolog 0.0176 0.1104 0.1938
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Trypanosoma cruzi cruzipain precursor, putative 0.0763 0.5091 0.4812
Loa Loa (eye worm) hypothetical protein 0.0244 0.1561 0.1561
Echinococcus granulosus cathepsin l1 0.0519 0.3435 0.3435
Brugia malayi Cathepsin L-like precursor 0.0244 0.1561 0.1561
Brugia malayi Cathepsin L-like precursor 0.0519 0.3435 0.3435
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0176 0.1104 0.1104
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.042 0.2761 0.2761
Echinococcus multilocularis cathepsin b 0.1485 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0763 0.5091 0.5091
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0519 0.3435 0.3062
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0038 0.0165 0.0165
Loa Loa (eye worm) hypothetical protein 0.003 0.0111 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0176 0.1104 0.1244
Trichomonas vaginalis conserved hypothetical protein 0.0176 0.1104 0.1244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1485 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0763 0.5091 1
Brugia malayi Papain family cysteine protease containing protein 0.0176 0.1104 0.1104
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Trypanosoma cruzi cruzipain precursor, putative 0.0244 0.1561 0.1081
Onchocerca volvulus 0.0763 0.5091 1
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0093 0.0538 0.1044
Schistosoma mansoni cathepsin B (C01 family) 0.0176 0.1104 0.1104
Trypanosoma cruzi cysteine peptidase, putative 0.0244 0.1561 0.1081
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Brugia malayi hypothetical protein 0.0015 0.0007 0.0007
Brugia malayi cathepsin F-like cysteine proteinase 0.0176 0.1104 0.1104
Brugia malayi Cathepsin L-like precursor 0.0519 0.3435 0.3435
Loa Loa (eye worm) fibroinase 0.0763 0.5091 0.5091
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.042 0.2761 0.2761
Plasmodium vivax vivapain-2 0.0763 0.5091 0.7496
Giardia lamblia Cathepsin L precursor 0.0176 0.1104 0.1501
Loa Loa (eye worm) hypothetical protein 0.0244 0.1561 0.1561
Brugia malayi cathepsin Z-like cysteine proteinase 0.0176 0.1104 0.1104
Trypanosoma cruzi major cysteine proteinase, putative 0.0176 0.1104 0.0599
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Giardia lamblia Cysteine protease 0.0176 0.1104 0.1501
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0763 0.5091 0.5091
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0036 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.042 0.2761 0.4882
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0473 0.3123 0.4726
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0763 0.5091 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.1104 0.1104
Trypanosoma brucei cysteine peptidase C (CPC) 0.0581 0.3856 0.7286
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Brugia malayi Papain family cysteine protease containing protein 0.042 0.2761 0.2761
Giardia lamblia Cysteine protease 0.0176 0.1104 0.1501
Entamoeba histolytica cysteine protease, putative 0.0763 0.5091 1
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Brugia malayi Cathepsin L-like precursor 0.0763 0.5091 0.5091
Onchocerca volvulus 0.0519 0.3435 0.665
Giardia lamblia Cathepsin B precursor 0.0176 0.1104 0.1501
Echinococcus granulosus cathepsin L cysteine proteinase 0.0763 0.5091 0.5091
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0044 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0176 0.1104 0.1104
Echinococcus granulosus geminin 0.009 0.0519 0.0519
Entamoeba histolytica cysteine proteinase 2 0.042 0.2761 0.5416
Entamoeba histolytica cysteine protease, putative 0.042 0.2761 0.5416
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0581 0.3856 0.3856
Schistosoma mansoni cathepsin s 0.0244 0.1561 0.1561
Plasmodium vivax vivapain-3 0.042 0.2761 0.3114
Onchocerca volvulus 0.0763 0.5091 1
Loa Loa (eye worm) ctsf protein 0.0763 0.5091 0.5091
Toxoplasma gondii cathepsin CPC1 0.0959 0.6423 1
Echinococcus multilocularis cathepsin b 0.1485 1 1
Leishmania major cathepsin L-like protease 0.0763 0.5091 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0176 0.1104 0.1244
Plasmodium falciparum cysteine proteinase falcipain 1 0.042 0.2761 0.3114
Echinococcus multilocularis cysteine protease 0.0763 0.5091 0.5091

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.2512 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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