Detailed information for compound 15487

Basic information

Technical information
  • TDR Targets ID: 15487
  • Name: (Z)-N,N-bis(2-hydroxyethyl)octadec-9-enamide
  • MW: 369.582 | Formula: C22H43NO3
  • H donors: 2 H acceptors: 3 LogP: 5.83 Rotable bonds: 20
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)N(CCO)CCO
  • InChi: 1S/C22H43NO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(26)23(18-20-24)19-21-25/h9-10,24-25H,2-8,11-21H2,1H3/b10-9-
  • InChiKey: LPMBTLLQQJBUOO-KTKRTIGZSA-N  


Substructure search Similarity search

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Synonyms

  • (Z)-N,N-bis(2-hydroxyethyl)-9-octadecenamide
  • NCGC00091445-01
  • (9Z)-N,N-bis(2-hydroxyethyl)octadec-9-enamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Trypanosoma cruzi cysteine peptidase, putative Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens jun proto-oncogene Starlite/ChEMBL No references
Homo sapiens androgen receptor Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens thyroid hormone receptor, beta Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi bZIP transcription factor family protein Get druggable targets OG5_131442 All targets in OG5_131442
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K08362 nuclear receptor, subfamily 1, group A, member 2, putative Get druggable targets OG5_134830 All targets in OG5_134830
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Basic leucine zipper bZIP transcription factor Get druggable targets OG5_131442 All targets in OG5_131442
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131442 All targets in OG5_131442
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis jun protein Get druggable targets OG5_131442 All targets in OG5_131442
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis thyroid hormone receptor alpha Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134830 All targets in OG5_134830
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus jun protein Get druggable targets OG5_131442 All targets in OG5_131442
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Thyroid hormone receptor alpha, putative Get druggable targets OG5_134830 All targets in OG5_134830
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni thyroid hormone receptor Get druggable targets OG5_134830 All targets in OG5_134830
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor Get druggable targets OG5_131442 All targets in OG5_131442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi photoreceptor-specific nuclear receptor thyroid hormone receptor, beta 461 aa 414 aa 24.6 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0017 0.0017
Onchocerca volvulus 0.008 0.2459 1
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.022 0.0863
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0608 0.0959
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0101 0.328 0.6322
Schistosoma mansoni hypothetical protein 0.0024 0.0355 0.056
Onchocerca volvulus Cathepsin L homolog 0.002 0.022 0.0893
Onchocerca volvulus Cathepsin L homolog 0.002 0.022 0.0893
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0355 0.0355
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0065 0.0103
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0065
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.022 0.022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0608 0.1171
Echinococcus multilocularis thyroid hormone receptor alpha 0.0183 0.6338 1
Echinococcus granulosus jun protein 0.0101 0.328 0.6322
Schistosoma mansoni thyroid hormone receptor 0.0183 0.6338 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0608 0.0959
Schistosoma mansoni thyroid hormone receptor 0.0183 0.6338 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0608 0.2471
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Brugia malayi ecdysteroid receptor 0.0031 0.0608 0.0608
Onchocerca volvulus 0.002 0.022 0.0893
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0608 0.0608
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0608 0.0959
Loa Loa (eye worm) hypothetical protein 0.0031 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Onchocerca volvulus 0.0031 0.0608 0.2471
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.2109 0.8925
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0608 0.0608
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.5188 0.8185
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2361 1
Onchocerca volvulus Cathepsin F homolog 0.002 0.022 0.0893
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0101 0.328 0.5175
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.022 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0608 0.0959
Brugia malayi nuclear hormone receptor 0.0031 0.0608 0.0608
Schistosoma mansoni polycystin 1-related 0.0024 0.0355 0.056
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0608 0.0959
Onchocerca volvulus 0.002 0.022 0.0893
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2361 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0017 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Brugia malayi hypothetical protein 0.0024 0.0355 0.0355
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Brugia malayi Doublecortin family protein 0.0024 0.0355 0.0355
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.022 0.0423
Brugia malayi hypothetical protein 0.0016 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.022 0.0347
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0608 0.0959
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0608 0.1171
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0065 0.0065
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.022 0.0347
Brugia malayi Cathepsin L-like precursor 0.002 0.022 0.022
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0608 0.1171
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0608 0.0959
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0608 0.1171
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0065 0.0125
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0608 0.0959
Echinococcus granulosus RUN 0.0024 0.0355 0.0684
Brugia malayi Papain family cysteine protease containing protein 0.002 0.022 0.022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Leishmania major cathepsin L-like protease 0.002 0.022 0.0863
Schistosoma mansoni hypothetical protein 0.0152 0.5188 0.8185
Loa Loa (eye worm) hypothetical protein 0.002 0.022 0.022
Schistosoma mansoni lipoxygenase 0.0024 0.0355 0.056
Loa Loa (eye worm) fibroinase 0.002 0.022 0.022
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0608 0.0959
Brugia malayi nuclear receptor RXR 0.0016 0.0065 0.0065
Leishmania major cathepsin L-like protease 0.0077 0.2361 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Schistosoma mansoni lipoxygenase 0.0067 0.197 0.3109
Brugia malayi Cytochrome P450 family protein 0.0015 0.0017 0.0017
Schistosoma mansoni coup transcription factor 0.0031 0.0608 0.0959
Leishmania major cathepsin L-like protease 0.002 0.022 0.0863
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 1 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0608 0.1171
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.022 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0608 0.0959
Trypanosoma cruzi cruzipain precursor, putative 0.0077 0.2361 1
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0017 0.0017
Leishmania major cathepsin L-like protease 0.002 0.022 0.0863
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0608 0.0608
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0608 0.0959
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0608 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0031 0.0608 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0355 0.056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0355 0.056
Leishmania major cathepsin L-like protease 0.0077 0.2361 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0355 0.0684
Brugia malayi steroid hormone receptor 0.0031 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Schistosoma mansoni rab6-interacting 0.0024 0.0355 0.056
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0355 1
Echinococcus multilocularis cysteine protease 0.002 0.022 0.0347
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0608 0.1171
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0608 0.0608
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Loa Loa (eye worm) cysteine protease 0.002 0.022 0.022
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0608 0.0608
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0608 0.0959
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0355 0.056
Echinococcus multilocularis cysteine protease 0.002 0.022 0.0347
Schistosoma mansoni hypothetical protein 0.0082 0.2564 0.4045
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Brugia malayi Cathepsin L-like precursor 0.002 0.022 0.022
Loa Loa (eye worm) hypothetical protein 0.0031 0.0608 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0608 0.0608
Onchocerca volvulus 0.002 0.022 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0065
Brugia malayi Cathepsin L-like precursor 0.002 0.022 0.022
Schistosoma mansoni loxhd1 0.0024 0.0355 0.056
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0608 0.1171
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.197 0.3109
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.002 0.022 0.5
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.022 0.0347
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0608 0.0608
Brugia malayi Cathepsin L-like precursor 0.002 0.022 0.022
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0608 0.0608
Leishmania major cysteine peptidase A (CPA) 0.002 0.022 0.0863
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0608 0.0959
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0608 0.0608
Loa Loa (eye worm) ctsf protein 0.002 0.022 0.022
Trypanosoma cruzi major cysteine proteinase, putative 0.0061 0.174 0.7348
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0608 0.2471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0065
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0031 0.0608 0.0608
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0608 0.0959
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.022 0.0423
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.022 0.0347
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0608 0.0608
Leishmania major cathepsin L-like protease 0.002 0.022 0.0863
Trypanosoma cruzi cysteine peptidase, putative 0.0077 0.2361 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0608 0.0959
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0017 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Brugia malayi Cytochrome P450 family protein 0.0015 0.0017 0.0017
Brugia malayi Cathepsin L-like precursor 0.002 0.022 0.022
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0065 0.0103
Loa Loa (eye worm) hypothetical protein 0.0031 0.0608 0.0608
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.5188 1
Brugia malayi hypothetical protein 0.008 0.2459 0.2459
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.022 0.022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0608 0.0608
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0608 0.0959
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0608 0.0608
Entamoeba histolytica cysteine proteinase, putative 0.002 0.022 0.5
Loa Loa (eye worm) hypothetical protein 0.0099 0.3175 0.3175
Schistosoma mansoni rab6-interacting 0.0024 0.0355 0.056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0608 0.0608
Loa Loa (eye worm) hypothetical protein 0.0024 0.0355 0.0355
Onchocerca volvulus 0.002 0.022 0.0893
Brugia malayi nuclear receptor NHR-88 0.0031 0.0608 0.0608
Leishmania major cathepsin L-like protease 0.002 0.022 0.0863
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0608 0.1171
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0608 0.0959
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0065 0.0065
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0355 0.0684
Brugia malayi Cathepsin L-like precursor 0.002 0.022 0.022
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.197 0.3798
Onchocerca volvulus 0.0024 0.0355 0.1443
Onchocerca volvulus 0.002 0.022 0.0893
Onchocerca volvulus 0.002 0.022 0.0893
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0355 0.0684
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0355 1
Echinococcus multilocularis jun protein 0.0101 0.328 0.5175
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0608 0.0608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.022 0.0347
Loa Loa (eye worm) hypothetical protein 0.0024 0.0355 0.0355
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0608 0.1171
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0065 0.0103
Entamoeba histolytica cysteine proteinase, putative 0.002 0.022 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Onchocerca volvulus 0.002 0.022 0.0893
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0608 0.0959
Entamoeba histolytica cysteine protease, putative 0.002 0.022 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0065 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.022 0.5
Echinococcus multilocularis RUN 0.0024 0.0355 0.056
Toxoplasma gondii cathepsin CPL 0.002 0.022 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0608 0.0608
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0608 0.2471
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0608 0.0608
Brugia malayi bZIP transcription factor family protein 0.0101 0.328 0.328
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.002 0.022 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0608 0.0608
Echinococcus granulosus cathepsin l1 0.002 0.022 0.0423
Loa Loa (eye worm) hypothetical protein 0.0031 0.0608 0.0608
Brugia malayi hypothetical protein 0.0024 0.0355 0.0355
Schistosoma mansoni jun-related protein 0.0082 0.2564 0.4045
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0608 0.0608
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0077 0.2361 1
Brugia malayi hypothetical protein 0.0016 0.0065 0.0065
Leishmania major cathepsin L-like protease 0.0077 0.2361 1
Onchocerca volvulus 0.0024 0.0355 0.1443

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % Tested for inhibition of rat glial cell gap junction at the concentration of 20 microM ChEMBL. 10328303
Inhibition (functional) = 8 % Inhibition of rat glial cell gap junction at the concentration of 50 microM ChEMBL. 10328303
Potency (functional) 0.0035 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule agonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0316 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0316 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.9233 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of glucocorticoid receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.4247 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of retinoid X receptor alpha signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.5133 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of vitamin D receptor signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: Cell Viability - LYMP2-019. CellTiter-Glo luminescent cell viability assay (Promega), as a homogeneous method to measure the number of viable cells in culture was used. The end point readout of this assay is based on quantitation of intracellular ATP, an indicator of metabolic activity, using the luciferase reaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.1632 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 42.1632 uM PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of peroxisome proliferator-activated receptor gamma signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of thyroid hormone receptor beta signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS assay for small molecule antagonists of estrogen receptor alpha signaling. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 54.7461 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 54.7461 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.1267 uM PubChem BioAssay. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway measured by Nrf2-dependant transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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