Detailed information for compound 1550873

Basic information

Technical information
  • TDR Targets ID: 1550873
  • Name: N-(3-hydroxypropyl)-2-(2,3,4,9-tetramethyl-7- oxopyrano[6,5-g][1]benzoxol-8-yl)acetamide
  • MW: 357.4 | Formula: C20H23NO5
  • H donors: 2 H acceptors: 3 LogP: 2.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCCNC(=O)Cc1c(=O)oc2c(c1C)c1oc(c(c1c(c2)C)C)C
  • InChi: 1S/C20H23NO5/c1-10-8-15-18(19-17(10)11(2)13(4)25-19)12(3)14(20(24)26-15)9-16(23)21-6-5-7-22/h8,22H,5-7,9H2,1-4H3,(H,21,23)
  • InChiKey: TXAAKLARVGOKPE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-hydroxypropyl)-2-(2,3,4,9-tetramethyl-7-oxo-pyrano[6,5-g]benzofuran-8-yl)acetamide
  • N-(3-hydroxypropyl)-2-(2,3,4,9-tetramethyl-7-oxo-8-pyrano[6,5-g]benzofuranyl)acetamide
  • N-(3-hydroxypropyl)-2-(7-keto-2,3,4,9-tetramethyl-pyrano[6,5-g]benzofuran-8-yl)acetamide
  • N-(3-hydroxypropyl)-2-(2,3,4,9-tetramethyl-7-oxo-pyrano[6,5-g][1]benzoxol-8-yl)ethanamide
  • ZINC04089195
  • STOCK1N-63967

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0194 0.3106 0.5066
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Brugia malayi Pre-SET motif family protein 0.0216 0.3476 0.567
Echinococcus granulosus protein tyrosine phosphatase n9 0.0018 0.0135 0.0219
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0135 0.0219
Brugia malayi hypothetical protein 0.0018 0.0135 0.0219
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0981 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0373 0.6132 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0373 0.6132 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Trichomonas vaginalis set domain proteins, putative 0.0246 0.3981 0.3899
Onchocerca volvulus 0.0117 0.181 0.4547
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0194 0.3106 0.5
Entamoeba histolytica rodhanase-like domain containing protein 0.0117 0.181 0.1699
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0373 0.6132 1
Loa Loa (eye worm) acetyltransferase 0.015 0.2367 0.3861
Echinococcus multilocularis 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0347 0.0565
Entamoeba histolytica rodhanase-like domain containing protein 0.0117 0.181 0.1699
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0373 0.6132 1
Brugia malayi Rhodanese-like domain containing protein 0.0117 0.181 0.2952
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0135 0.0219
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0135 0.0219
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.2367 0.3861
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0571 0.0442
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0347 0.0565
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Schistosoma mansoni dual specificity protein phosphatase 0.0012 0.0027 0.0045
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0108 0.1655 0.2699
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0981 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0981 0.1601
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0135 0.0219
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0373 0.6132 1
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0018 0.0135 0.0219
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0018 0.0135 0.0219
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0018 0.0135 0.0219
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0117 0.181 0.1699
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.3106 0.3012
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0981 0.1601
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0117 0.181 0.1699
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0981 0.0858
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.3106 0.3012
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0117 0.181 0.2952
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0981 1
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.2367 0.3861
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0135 0.0219
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0018 0.0135 0.0219
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0117 0.181 0.1699
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Brugia malayi hypothetical protein 0.0018 0.0135 0.0219
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.3106 0.3012
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0135 0.0219
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0018 0.0135 0.0219
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0135 0.0219
Echinococcus multilocularis hypothetical protein 0.0018 0.0135 0.0219
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.006 0.0835 0.071
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0117 0.181 0.2952
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0347 0.0565
Onchocerca volvulus 0.0018 0.0135 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0347 0.0565
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0509 0.1258
Onchocerca volvulus 4.1 G protein, putative homolog 0.0018 0.0135 0.0338
Entamoeba histolytica rodhanase-like domain containing protein 0.0117 0.181 0.1699
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.006 0.0835 0.071
Trichomonas vaginalis cdc25b, putative 0.0117 0.181 0.1699
Onchocerca volvulus 0.0018 0.0135 0.0338
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0135 0.0219
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0018 0.0135 0.0219
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0134 0.2094 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0117 0.181 0.1699
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0135 0.0219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0246 0.3981 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.3106 0.3012
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0327 0.0534
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0018 0.0135 0.0219
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0493 0.0805
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0194 0.3106 0.5066
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0571 0.0931
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0117 0.181 0.4547
Loa Loa (eye worm) hypothetical protein 0.0031 0.0347 0.0565
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0571 1
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0018 0.0135 0.0219
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0031 0.0347 0.0871
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0347 0.0565
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0509 0.5
Onchocerca volvulus 0.0018 0.0135 0.0338
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Onchocerca volvulus 0.0018 0.0135 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Brugia malayi hypothetical protein 0.0018 0.0135 0.0219
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0347 0.0565
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0347 0.0565
Brugia malayi Protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0981 0.1601
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0981 1
Onchocerca volvulus 0.0018 0.0135 0.0338
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0194 0.3106 0.3012
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.3476 0.567
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Trichomonas vaginalis cdc25b, putative 0.0117 0.181 0.1699
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0194 0.3106 0.3012
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0135 0.0219
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Brugia malayi Pre-SET motif family protein 0.0031 0.0347 0.0565
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0194 0.3106 0.3012
Brugia malayi hypothetical protein 0.0018 0.0135 0.0219
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0018 0.0135 0.0219
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0117 0.181 0.1699
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0981 0.1601
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0194 0.3106 0.7803
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Trichomonas vaginalis pps1 dual specificty phosphatase, putative 0.0601 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0018 0.0135 0.0219
Leishmania major hypothetical protein, conserved 0.006 0.0835 0.8269
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0194 0.3106 0.3012
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0117 0.181 0.2952
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase 1 0.0018 0.0135 0.0219
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0571 1
Loa Loa (eye worm) hypothetical protein 0.0117 0.181 0.2952
Echinococcus granulosus transcription factor Dp 1 0.004 0.0493 0.0805
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0571 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0835 0.8269
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.2367 0.3861
Onchocerca volvulus 0.0018 0.0135 0.0338
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0117 0.181 0.4547
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.006 0.0835 0.8269
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Brugia malayi Rhodanese-like domain containing protein 0.0117 0.181 0.2952
Onchocerca volvulus 0.0018 0.0135 0.0338
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0571 0.0442
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0018 0.0135 0.0219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0135 0.0219
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0018 0.0135 0.0219
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0018 0.0135 0.0219
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.006 0.0835 0.8269
Brugia malayi hypothetical protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0117 0.181 0.4547
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0509 0.0379
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Loa Loa (eye worm) protein tyrosine phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0117 0.181 0.2952
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Echinococcus granulosus geminin 0.0205 0.3286 0.5359
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Trichomonas vaginalis cdc25c, putative 0.0117 0.181 0.1699
Onchocerca volvulus 0.0018 0.0135 0.0338
Onchocerca volvulus 0.0018 0.0135 0.0338
Schistosoma mansoni protein tyrosine phosphatase 0.0018 0.0135 0.0219
Schistosoma mansoni hypothetical protein 0.0205 0.3286 0.5359
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0018 0.0135 0.0219
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0108 0.1655 0.2699
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Schistosoma mansoni pcd6 interacting protein-related 0.0018 0.0135 0.0219
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0018 0.0135 0.0219
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0018 0.0135 0.0219
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0219
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0981 0.1601
Echinococcus multilocularis geminin 0.0205 0.3286 0.5359
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0018 0.0135 0.0219
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0018 0.0135 0.0219
Onchocerca volvulus 0.0018 0.0135 0.0338
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0194 0.3106 1
Schistosoma mansoni hypothetical protein 0.0205 0.3286 0.5359
Onchocerca volvulus 0.0018 0.0135 0.0338
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.2296 0.3744
Onchocerca volvulus 0.0018 0.0135 0.0338

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3264 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.