TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 251.321 | Formula: C14H21NO3
H donors: 4 H acceptors: 3 LogP: 0.43 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC1C(NCc2ccccc2)CC(C(C1O)O)C
InChi: 1S/C14H21NO3/c1-9-7-11(13(17)14(18)12(9)16)15-8-10-5-3-2-4-6-10/h2-6,9,11-18H,7-8H2,1H3
InChiKey: CWMJMLDDWUSQAN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fucosidase, alpha-L- 1, tissue	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Alpha-L-fucosidase family protein	Get druggable targets OG5_129683	All targets in OG5_129683
Schistosoma japonicum	ko:K01206 alpha-L-fucosidase [EC3.2.1.51], putative	Get druggable targets OG5_129683	All targets in OG5_129683
Echinococcus granulosus	fucosidase alpha L 1 tissue	Get druggable targets OG5_129683	All targets in OG5_129683
Mycobacterium ulcerans	alpha-L-fucosidase	Get druggable targets OG5_129683	All targets in OG5_129683
Loa Loa (eye worm)	alpha-L-fucosidase	Get druggable targets OG5_129683	All targets in OG5_129683
Schistosoma mansoni	alpha-l-fucosidase	Get druggable targets OG5_129683	All targets in OG5_129683
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	Get druggable targets OG5_129683	All targets in OG5_129683

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lamin	0.0027	0.0248	0.0291
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0427	0.072
Schistosoma mansoni	peptidase Clp (S14 family)	0.0084	0.1394	0.2248
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0036	0.0421	0.2604
Echinococcus multilocularis	geminin	0.0169	0.3074	0.3019
Loa Loa (eye worm)	alpha-L-fucosidase	0.0313	0.5933	1
Schistosoma mansoni	hypothetical protein	0.0037	0.046	0.0652
Echinococcus granulosus	tumor protein p63	0.0365	0.6976	0.6952
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1394	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0187	0.2857
Loa Loa (eye worm)	MH2 domain-containing protein	0.0126	0.2214	0.3731
Onchocerca volvulus		0.0027	0.0248	0.1041
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0421	0.0709
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0421	0.0346
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0024	0.0187	0.0315
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1394	0.101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0084	0.1394	0.1327
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Toxoplasma gondii	cathepsin CPL	0.0036	0.0421	0.1162
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0421	0.0709
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0187	0.0315
Brugia malayi	cathepsin L-like precursor	0.0024	0.0187	0.0315
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0421	0.145
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0427	0.072
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0427	0.1479
Echinococcus multilocularis	GPCR, family 2	0.0033	0.0371	0.0295
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0137	0.2442	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0033	0.0371	0.0295
Echinococcus multilocularis	fucosidase, alpha L 1, tissue	0.0517	1	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0071	0.1134	0.1911
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0187	0.0315
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0421	0.0709
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0427	0.1479
Brugia malayi	MH2 domain containing protein	0.0126	0.2214	0.3731
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0036	0.0421	0.2604
Echinococcus granulosus	GPCR family 2	0.0033	0.0371	0.0295
Trypanosoma cruzi	cysteine peptidase, putative	0.0135	0.2408	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0084	0.1394	1
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0248	0.0418
Onchocerca volvulus	Cathepsin F homolog	0.0036	0.0421	0.3965
Echinococcus multilocularis	musashi	0.0027	0.0248	0.0172
Onchocerca volvulus		0.0027	0.0248	0.1041
Loa Loa (eye worm)	transcription factor SMAD2	0.0126	0.2214	0.3731
Onchocerca volvulus		0.0036	0.0421	0.3965
Loa Loa (eye worm)	cysteine protease	0.0036	0.0421	0.0709
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0427	0.0597
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0427	0.072
Onchocerca volvulus		0.0036	0.0421	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0084	0.1394	0.235
Entamoeba histolytica	hypothetical protein	0.0037	0.046	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.0187	0.0186
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0084	0.1394	0.1327
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0036	0.0421	0.0346
Onchocerca volvulus		0.0036	0.0421	0.3965
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0427	0.2656
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0229	0.4275	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0421	0.0346
Brugia malayi	beta-lactamase family protein	0.0036	0.0427	0.072
Leishmania major	cathepsin L-like protease	0.0135	0.2408	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0421	0.0346
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0427	0.0352
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0187	0.0461
Brugia malayi	beta-lactamase family protein	0.0036	0.0427	0.072
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0421	0.0346
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0421	0.8978
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0248	0.0418
Plasmodium vivax	vivapain-2	0.0036	0.0421	0.2604
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0421	0.1472
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0248	0.0418
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0055	0.0815	0.1008
Entamoeba histolytica	hypothetical protein	0.0037	0.046	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.046	0.0385
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0055	0.0815	0.4744
Echinococcus multilocularis	cysteine protease	0.0036	0.0421	0.0346
Echinococcus granulosus	cathepsin l1	0.0036	0.0421	0.0346
Echinococcus multilocularis	lamin dm0	0.0027	0.0248	0.0172
Mycobacterium ulcerans	alpha-L-fucosidase	0.0517	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0124	0.2174	0.8997
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0421	0.0586
Schistosoma mansoni	lamin	0.0027	0.0248	0.0291
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0421	0.3965
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0427	0.072
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0104	0.1791	0.3019
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0421	0.0709
Trypanosoma cruzi	major cysteine proteinase, putative	0.0106	0.1831	0.7525
Onchocerca volvulus		0.0036	0.0421	0.3965
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0055	0.0815	0.0743
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0104	0.1791	0.3019
Trichomonas vaginalis	esterase, putative	0.0036	0.0427	0.1479
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0427	0.1501
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1394	0.101
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0187	0.0315
Schistosoma mansoni	hypothetical protein	0.0071	0.1134	0.1804
Onchocerca volvulus		0.0036	0.0427	0.4081
Echinococcus multilocularis	lamin	0.0027	0.0248	0.0172
Schistosoma mansoni	hypothetical protein	0.0033	0.0371	0.0501
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0187	0.0315
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0421	0.8978
Onchocerca volvulus		0.0036	0.0421	0.3965
Onchocerca volvulus		0.0053	0.0776	1
Toxoplasma gondii	ABC1 family protein	0.0036	0.0427	0.1224
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0029	0.0293	0.1632
Schistosoma mansoni	hypothetical protein	0.0033	0.0371	0.0501
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Schistosoma mansoni	hypothetical protein	0.0169	0.3074	0.5116
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.046	0.0652
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0421	0.0586
Entamoeba histolytica	hypothetical protein	0.0037	0.046	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0427	0.072
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0187	0.0461
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Brugia malayi	Probable ClpP-like protease	0.0084	0.1394	0.235
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0036	0.0421	0.2604
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0427	0.072
Echinococcus granulosus	lamin dm0	0.0027	0.0248	0.0172
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0029	0.0293	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0427	0.072
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0135	0.2408	1
Loa Loa (eye worm)	fibroinase	0.0036	0.0421	0.0709
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0033	0.0371	0.0625
Onchocerca volvulus		0.0036	0.0421	0.3965
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0421	0.0709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Brugia malayi	hypothetical protein	0.0037	0.046	0.0775
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0036	0.0421	0.0346
Trichomonas vaginalis	alpha-L-fucosidase, putative	0.0137	0.2442	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0427	0.0597
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0084	0.1394	1
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0421	0.3965
Echinococcus granulosus	cathepsin l1	0.0024	0.0187	0.011
Onchocerca volvulus		0.0036	0.0421	0.3965
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0427	0.1479
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0033	0.0371	0.0295
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0421	0.8978
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1791	0.3019
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0427	0.0352
Brugia malayi	intermediate filament protein	0.0027	0.0248	0.0418
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0033	0.0371	0.0625
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1394	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0421	0.0709
Schistosoma mansoni	hypothetical protein	0.0169	0.3074	0.5116
Echinococcus multilocularis	tumor protein p63	0.0365	0.6976	0.6952
Brugia malayi	beta-lactamase	0.0036	0.0427	0.072
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0427	0.072
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0033	0.0371	0.0295
Brugia malayi	Latrophilin receptor protein 2	0.0033	0.0371	0.0625
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0421	0.0709
Trypanosoma cruzi	cysteine peptidase, putative	0.0135	0.2408	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0135	0.2408	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0421	0.0709
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Leishmania major	cathepsin L-like protease	0.0135	0.2408	1
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0421	0.0709
Onchocerca volvulus		0.0036	0.0427	0.4081
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0427	0.1479
Loa Loa (eye worm)	hypothetical protein	0.0071	0.1134	0.1911
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0427	0.1479
Echinococcus granulosus	intermediate filament protein	0.0027	0.0248	0.0172
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0421	0.145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Echinococcus granulosus	peptidase Clp S14 family	0.0055	0.0815	0.0743
Echinococcus multilocularis	cysteine protease	0.0036	0.0421	0.0346
Leishmania major	hypothetical protein, conserved	0.0036	0.0427	0.0034
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0078	0.0131
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0427	0.1501
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.1394	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0776	0.1193
Brugia malayi	Papain family cysteine protease containing protein	0.0018	0.0078	0.0131
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0104	0.1791	0.3019
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0084	0.1394	1
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0248	0.0291
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1394	0.5
Plasmodium vivax	vivapain-2	0.0036	0.0421	0.2604
Echinococcus granulosus	lamin	0.0027	0.0248	0.0172
Schistosoma mansoni	hypothetical protein	0.0033	0.0371	0.0501
Echinococcus granulosus	geminin	0.0169	0.3074	0.3019
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0371	0.0625
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0033	0.0371	0.0295
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Brugia malayi	Alpha-L-fucosidase family protein	0.0313	0.5933	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0055	0.0815	0.1008
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0238	0.0402
Onchocerca volvulus		0.0036	0.0427	0.4081
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0187	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0427	0.072
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0427	0.1224
Schistosoma mansoni	alpha-l-fucosidase	0.0313	0.5933	1
Leishmania major	cathepsin L-like protease	0.0135	0.2408	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1394	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0135	0.2408	1
Entamoeba histolytica	hypothetical protein	0.0037	0.046	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0084	0.1394	0.5
Schistosoma mansoni	hypothetical protein	0.0033	0.0371	0.0501
Loa Loa (eye worm)	ctsf protein	0.0036	0.0421	0.0709
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.046	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0776	0.1309
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0427	0.1224
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0421	0.145
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0421	0.145
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0036	0.0421	0.0709
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0427	0.1501
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0248	0.0418

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	uM	Inhibitory activity of the compound against Beta-galactosidase in bovine liver was determined;NT means not tested	ChEMBL.	12270152
IC50 (binding)	0 uM	Inhibitory activity of the compound against Beta-galactosidase in bovine liver was determined;NT means not tested	ChEMBL.	12270152
IC50 (binding)	= 1 uM	Inhibition of bovine kidney alpha-L-fucosidase	ChEMBL.	12270152
IC50 (binding)	= 1 uM	Inhibition of bovine kidney alpha-L-fucosidase	ChEMBL.	12270152
Ki (binding)	= 0.069 uM	Binding affinity of the compound against alpha-L-fucosidase in bovine kidney was determined	ChEMBL.	12270152
Ki (binding)	= 0.069 uM	Binding affinity of the compound against alpha-L-fucosidase in bovine kidney was determined	ChEMBL.	12270152

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL96392

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 155460