Detailed information for compound 1561264

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 258.233 | Formula: C12H10N4O3
  • H donors: 2 H acceptors: 4 LogP: 2.28 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccccc1C=NNc1ccc(cn1)[N+](=O)[O-]
  • InChi: 1S/C12H10N4O3/c17-11-4-2-1-3-9(11)7-14-15-12-6-5-10(8-13-12)16(18)19/h1-8,17H,(H,13,15)
  • InChiKey: WBHPJBOSCFRQFT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Homo sapiens snurportin 1 No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.003 0.0595 0.124
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0595 0.0136
Schistosoma mansoni protein kinase C 0.001 0.0043 0.0029
Echinococcus granulosus protein kinase c iota type 0.0086 0.2088 0.2129
Schistosoma mansoni vav2 0.001 0.0043 0.0029
Echinococcus multilocularis unc 13 (munc13) 0.001 0.0043 0.0044
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0031 0.0613 0.0611
Brugia malayi RNA, U transporter 1 0.0099 0.2447 0.5191
Echinococcus granulosus Diacylglycerol kinase theta 0.0009 0.0015 0.0015
Echinococcus granulosus myotubularin protein 13 0.001 0.0043 0.0043
Brugia malayi Pleckstrin Homology Domain 0.001 0.0043 0.006
Echinococcus granulosus N chimaerin 0.0009 0.0015 0.0015
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.001 0.0043 0.0044
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0536 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0288 0.0279
Brugia malayi hypothetical protein 0.002 0.0304 0.0618
Entamoeba histolytica Ran family GTPase 0.0026 0.0466 0.865
Schistosoma mansoni hypothetical protein 0.0019 0.0288 0.0279
Schistosoma mansoni protein kinase C mu 0.004 0.0854 0.0857
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0595 0.5234
Onchocerca volvulus 0.0182 0.4699 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0009 0.0015 0.0015
Trypanosoma cruzi squalene monooxygenase, putative 0.0379 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0288 0.0294
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0009 0.0015 0.0015
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1399 0.2955
Loa Loa (eye worm) hypothetical protein 0.003 0.0595 0.0593
Echinococcus granulosus protein kinase c eta type 0.0009 0.0015 0.0015
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0466 0.0963
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0714 0.026
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0026 0.0466 0.645
Schistosoma mansoni hypothetical protein 0.0014 0.0142 0.013
Echinococcus multilocularis protein kinase c epsilon type 0.0017 0.0241 0.0246
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0022 0.0008
Schistosoma mansoni hypothetical protein 0.0019 0.0288 0.0279
Echinococcus multilocularis snurportin 1 0.0372 0.9808 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0714 0.0728
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0288 0.0294
Loa Loa (eye worm) hypothetical protein 0.0182 0.4699 0.4784
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0288 0.0584
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0595 0.5234
Echinococcus multilocularis N chimaerin 0.0009 0.0015 0.0015
Echinococcus multilocularis protein kinase c eta type 0.0009 0.0015 0.0015
Schistosoma mansoni unc-13 (munc13) 0.001 0.0043 0.0029
Brugia malayi protein kinase C II. 0.0017 0.0241 0.0483
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0288 0.0294
Leishmania major hypothetical protein, conserved 0.003 0.0595 0.0136
Plasmodium falciparum importin beta, putative 0.0035 0.0714 1
Loa Loa (eye worm) CAMK/PKD protein kinase 0.004 0.0854 0.0857
Schistosoma mansoni hypothetical protein 0.0205 0.5297 0.5394
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0142 0.0145
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0536 0.0074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0536 1
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0241 0.0231
Echinococcus granulosus protein kinase c epsilon type 0.0017 0.0241 0.0246
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0009 0.0022 0.0022
Leishmania major importin beta-1 subunit, putative 0.0028 0.0536 0.0074
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0885 0.1857
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.004 0.0854 0.1792
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0241 0.0231
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0017 0.0241 0.0231
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0009 0.0022 0.0022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0288 0.0294
Echinococcus granulosus snurportin 1 0.0372 0.9808 1
Onchocerca volvulus 0.0031 0.0606 0.1208
Echinococcus granulosus importin subunit beta 1 0.0035 0.0714 0.0728
Brugia malayi hypothetical protein 0.0182 0.4699 1
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0536 1
Onchocerca volvulus 0.004 0.0846 0.1725
Trypanosoma cruzi squalene monooxygenase, putative 0.0379 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0595 0.5234
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0022 0.0008
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0084 0.2035 0.2064
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0142 0.0145
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1399 0.1413
Schistosoma mansoni unc-13 (munc13) 0.001 0.0043 0.0029
Echinococcus granulosus C2 calcium dependent membrane targeting 0.001 0.0043 0.0044
Schistosoma mansoni ran 0.0026 0.0466 0.046
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0029
Loa Loa (eye worm) hypothetical protein 0.0041 0.0885 0.0888
Schistosoma mansoni hypothetical protein 0.0019 0.0288 0.0279
Echinococcus multilocularis geminin 0.0205 0.5297 0.5401
Loa Loa (eye worm) hypothetical protein 0.0035 0.0714 0.0714
Plasmodium vivax importin-beta 2, putative 0.0035 0.0714 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0875 0.0878
Trypanosoma brucei squalene monooxygenase, putative 0.0379 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0606 0.0604
Schistosoma mansoni hypothetical protein 0.0205 0.5297 0.5394
Brugia malayi Protein kinase domain containing protein 0.0009 0.0022 0.0016
Echinococcus granulosus raf serine:threonine protein kinase 0.0009 0.0015 0.0015
Echinococcus multilocularis Diacylglycerol kinase theta 0.0009 0.0015 0.0015
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0288 0.0584
Schistosoma mansoni hypothetical protein 0.0372 0.9808 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0606 0.0604
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.9808 1
Brugia malayi Protein kinase c protein 2 0.001 0.005 0.0077
Brugia malayi C1-like domain containing protein 0.004 0.0854 0.1792
Loa Loa (eye worm) hypothetical protein 0.006 0.1399 0.1413
Echinococcus multilocularis Rac GTPase activating protein 1 0.0009 0.0015 0.0015
Echinococcus multilocularis myotubularin protein 13 0.001 0.0043 0.0043
Echinococcus granulosus Rac GTPase activating protein 1 0.0009 0.0015 0.0015
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0595 0.0136
Loa Loa (eye worm) hypothetical protein 0.004 0.0846 0.085
Brugia malayi Importin beta-1 subunit 0.0035 0.0714 0.1492
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0241 0.0231
Echinococcus multilocularis protein kinase c iota type 0.0086 0.2088 0.2129
Echinococcus granulosus geminin 0.0205 0.5297 0.5401
Echinococcus multilocularis GPCR, family 2 0.0019 0.0288 0.0294
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0595 0.0136
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0017 0.0241 0.0246
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0595 0.8308
Schistosoma mansoni hypothetical protein 0.0019 0.0288 0.0279
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0026 0.0466 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0009 0.0015 0.0015
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0714 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0288 0.0279
Brugia malayi protein kinase C3,putative 0.0079 0.1898 0.402
Echinococcus granulosus unc 13 munc13 0.001 0.0043 0.0044
Schistosoma mansoni importin beta-1 0.0035 0.0714 0.0714
Echinococcus granulosus GPCR family 2 0.0019 0.0288 0.0294
Loa Loa (eye worm) hypothetical protein 0.001 0.0043 0.0029
Schistosoma mansoni atypical protein kinase C 0.0091 0.2226 0.2258
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0714 0.026
Schistosoma mansoni ran 0.0026 0.0466 0.046
Schistosoma mansoni hypothetical protein 0.0041 0.0885 0.0888
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0466 0.0475
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0466 0.0475
Onchocerca volvulus 0.0041 0.0875 0.1786
Echinococcus granulosus Protein kinase C brain isozyme 0.0017 0.0241 0.0246
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0466 0.046
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1399 0.2955
Entamoeba histolytica hypothetical protein 0.0028 0.0536 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 30 uM PUBCHEM_BIOASSAY: Dose Response confirmation of small molecule antagonists of the CCR6 receptor: a luminescent beta-arrestin assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159] ChEMBL. No reference
IC50 (functional) = 46 uM PUBCHEM_BIOASSAY: HTS Dose response counterscreen for assays utilizing the enzyme, beta-galactosidase - Set 3. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493098, AID493121, AID493159] ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.0596 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) 2.5929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 67.4555 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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