Detailed information for compound 1562311

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 292.332 | Formula: C18H16N2O2
  • H donors: 3 H acceptors: 2 LogP: 3.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc2c1cc(O)cc2)Nc1cccc(c1)C
  • InChi: 1S/C18H16N2O2/c1-12-4-2-6-14(10-12)19-18(22)20-17-7-3-5-13-8-9-15(21)11-16(13)17/h2-11,21H,1H3,(H2,19,20,22)
  • InChiKey: JCBUZWRPLCATEB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens transient receptor potential cation channel, subfamily V, member 1 Starlite/ChEMBL References
Rattus norvegicus Vanilloid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.1005 0.0995
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0018 0.0011
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0023 0.0121 0.0249
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1005 0.3173
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0722 0.0768
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0541 0.0806
Brugia malayi intermediate filament protein 0.0057 0.0835 0.0887
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0769
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0541 0.0576
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0112 0.012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0023 0.0112 0.0102
Brugia malayi hypothetical protein 0.0253 0.4977 0.5293
Echinococcus granulosus Aminotransferase class III 0.0023 0.0121 0.011
Echinococcus granulosus aryl hydrocarbon receptor 0.0027 0.0196 0.0185
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0159 0.2991 0.2984
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0027 0.0196 0.0268
Loa Loa (eye worm) CYP4Cod1 0.002 0.0063 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Brugia malayi Glutamate receptor 2 precursor 0.0144 0.2676 0.2846
Schistosoma mansoni importin beta-1 0.0031 0.0284 0.0415
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0202 0.6999
Echinococcus granulosus glutamate receptor 2 0.0106 0.1865 0.1856
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0023 0.0121 0.0249
Schistosoma mansoni ATP-binding cassette transporter 0.0144 0.2676 0.4052
Schistosoma mansoni nuclear receptor 0.002 0.0061 0.0077
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0112 0.0645
Brugia malayi conserved hypotetical protein 0.002 0.0061 0.0065
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0212 0.0202
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.063 0.0942
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0161 0.0491
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0121 0.0249
Onchocerca volvulus 0.0027 0.0196 0.151
Schistosoma mansoni aryl hydrocarbon receptor 0.0103 0.1801 0.2721
Trichomonas vaginalis ran, putative 0.0023 0.0112 0.0331
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0043 0.0541 0.0531
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0159 0.2991 0.2984
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0053 0.0759 0.0749
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0061 0.0073
Schistosoma mansoni glutamate receptor kainate 0.0144 0.2676 0.4052
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0769
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0043 0.0541 0.0576
Echinococcus granulosus lamin 0.0057 0.0835 0.0825
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0769
Brugia malayi Cathepsin L-like precursor 0.0018 0.0011 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0112 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0202 0.0277
Loa Loa (eye worm) hypothetical protein 0.0027 0.0196 0.0268
Echinococcus multilocularis ecdysone induced protein 78C 0.0043 0.0541 0.0531
Echinococcus granulosus voltage gated potassium channel 0.0018 0.0018 0.0008
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0061 0.005
Schistosoma mansoni retinoic acid receptor RXR 0.0043 0.0541 0.0806
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.1005 0.9347
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0023 0.0121 0.0249
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0027 0.0196 0.0606
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0196 0.0606
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0541 0.0531
Echinococcus multilocularis musashi 0.0057 0.0835 0.0825
Loa Loa (eye worm) hypothetical protein 0.0039 0.0459 0.0651
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0541 0.0531
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0063 0.0076
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0043 0.0541 0.0806
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0061 0.005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0112 0.0952
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0044 0.056 0.055
Loa Loa (eye worm) hypothetical protein 0.0027 0.0212 0.0292
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0202 0.1799
Loa Loa (eye worm) hypothetical protein 0.0026 0.019 0.0261
Brugia malayi steroid hormone receptor 0.0043 0.0541 0.0576
Onchocerca volvulus 0.0043 0.0541 0.4325
Loa Loa (eye worm) DR-78 0.002 0.0061 0.0073
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1074 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0196 0.0606
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0212 0.0202
Brugia malayi ecdysteroid receptor 0.0043 0.0541 0.0576
Brugia malayi Glutamate receptor 1 precursor 0.0144 0.2676 0.2846
Brugia malayi nuclear receptor NHR-88 0.002 0.0061 0.0065
Leishmania major cytochrome p450-like protein 0.002 0.0063 0.0496
Schistosoma mansoni ap endonuclease 0.002 0.0046 0.0053
Entamoeba histolytica hypothetical protein 0.0039 0.0445 1
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.063 0.0942
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Onchocerca volvulus 0.002 0.0061 0.041
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0023 0.0121 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Echinococcus multilocularis FTZ F1 alpha 0.0043 0.0541 0.0531
Schistosoma mansoni survival motor neuron protein 0.0052 0.0722 0.1082
Echinococcus multilocularis Aminotransferase class III 0.0023 0.0121 0.011
Schistosoma mansoni glutamate receptor AMPA 0.0144 0.2676 0.4052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0043 0.0541 0.0531
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0061 0.005
Echinococcus granulosus survival motor neuron protein 1 0.0253 0.4977 0.4972
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0053 0.0759 0.0749
Echinococcus granulosus glutamate receptor NMDA 0.0077 0.1263 0.1254
Schistosoma mansoni hypothetical protein 0.0052 0.0722 0.1082
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0046 0.0035
Brugia malayi nuclear receptor NHR-88 0.0043 0.0541 0.0576
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Brugia malayi hypothetical protein 0.0023 0.0112 0.012
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0163 0.3068 1
Brugia malayi RNA, U transporter 1 0.0088 0.1486 0.158
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0345 0.1093
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Schistosoma mansoni ap endonuclease 0.002 0.0046 0.0053
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0046 0.1277
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0196 0.0606
Echinococcus granulosus FTZ F1 alpha 0.0043 0.0541 0.0531
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0766 0.7098
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0061 0.0077
Schistosoma mansoni single-minded 0.0103 0.1801 0.2721
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0063 0.0076
Mycobacterium ulcerans acetylornithine aminotransferase 0.0023 0.0121 0.0249
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0196 0.0606
Brugia malayi Cytochrome P450 family protein 0.002 0.0063 0.0067
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0046 0.0114
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1074 1
Loa Loa (eye worm) steroid hormone receptor 0.0043 0.0541 0.0769
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0835 0.0887
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0112 0.0101
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0027 0.0196 0.0185
Loa Loa (eye worm) glutamate receptor 2 0.0144 0.2676 0.3864
Entamoeba histolytica hypothetical protein 0.0039 0.0445 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0061 0.0077
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0023 0.0112 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0018 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0043 0.0541 0.0531
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0121 0.011
Echinococcus multilocularis aryl hydrocarbon receptor 0.0027 0.0196 0.0185
Echinococcus multilocularis glutamate receptor 2 0.0159 0.2991 0.2984
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0148
Echinococcus granulosus neuropeptide receptor A26 0.0491 1 1
Leishmania major cathepsin L-like protease 0.0068 0.1074 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0061 0.0077
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0027 0.0196 0.0185
Leishmania major cathepsin L-like protease 0.0068 0.1074 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.0011 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0061 0.005
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0196 0.0606
Plasmodium vivax ornithine aminotransferase, putative 0.0023 0.0121 0.4026
Schistosoma mansoni ran 0.0023 0.0112 0.0154
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0196 0.0606
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0769
Leishmania major protein kinase, putative 0.0031 0.0297 0.2689
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0044 0.056 0.0797
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0053 0.0759 0.0749
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0043 0.0541 0.0531
Brugia malayi Cytochrome P450 family protein 0.002 0.0063 0.0067
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0043 0.0541 0.0769
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0053 0.0759 0.0749
Brugia malayi nuclear receptor RXR 0.0023 0.0112 0.012
Schistosoma mansoni lamin 0.0057 0.0835 0.1252
Brugia malayi hypoxia-induced factor 1 0.0318 0.6345 0.6748
Leishmania major importin beta-1 subunit, putative 0.0025 0.0161 0.1411
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0161 0.1411
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0043 0.0541 0.0576
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0043 0.0541 0.0806
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0061 0.005
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0043 0.0541 0.0576
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0445 0.0661
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0043 0.0541 0.0576
Echinococcus granulosus ecdysone induced protein 78C 0.0043 0.0541 0.0531
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0023 0.0121 0.1107
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0148
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0159 0.2991 0.2984
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0202 0.1924
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0196 0.1741
Schistosoma mansoni intermediate filament proteins 0.0057 0.0835 0.1252
Schistosoma mansoni glutamate receptor AMPA 0.0144 0.2676 0.4052
Mycobacterium leprae Possible regulatory protein 0.0027 0.0196 0.0255
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0061 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0043 0.0541 0.0769
Echinococcus granulosus nmda type glutamate receptor 0.0131 0.239 0.2382
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0276 0.0385
Echinococcus granulosus intermediate filament protein 0.0057 0.0835 0.0825
Echinococcus multilocularis neuropeptide s receptor 0.0491 1 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0043 0.0541 0.0806
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0046 0.0035
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0061 0.041
Brugia malayi Serotonin receptor 0.0463 0.9403 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0196 0.1741
Plasmodium falciparum importin beta, putative 0.0031 0.0284 1
Brugia malayi bHLH-PAS transcription factor 0.0076 0.1237 0.1316
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0769
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0018 0.0018 0.0008
Echinococcus multilocularis lamin 0.0057 0.0835 0.0825
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0043 0.0541 0.0576
Schistosoma mansoni zinc finger protein 0.002 0.0061 0.0077
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Toxoplasma gondii exonuclease III APE 0.002 0.0046 0.0351
Brugia malayi nuclear hormone receptor 0.0043 0.0541 0.0576
Schistosoma mansoni coup transcription factor 0.0043 0.0541 0.0806
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0023 0.0112 0.0155
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0769
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0044 0.056 0.0596
Brugia malayi Steroid receptor seven-up type 2 0.0043 0.0541 0.0576
Schistosoma mansoni glutamate receptor kainate 0.0144 0.2676 0.4052
Brugia malayi Cathepsin L-like precursor 0.0018 0.0011 0.0011
Echinococcus granulosus glutamate receptor 2 0.0159 0.2991 0.2984
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0061 0.005
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.1074 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0284 0.0396
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.1005 0.3173
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0061 0.0077
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0046 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Echinococcus granulosus geminin 0.0176 0.3357 0.335
Leishmania major protein kinase, putative 0.0027 0.0196 0.1741
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0148
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0023 0.0121 0.0249
Mycobacterium ulcerans hypothetical protein 0.0163 0.3068 1
Echinococcus multilocularis survival motor neuron protein 1 0.0253 0.4977 0.4972
Entamoeba histolytica hypothetical protein 0.0039 0.0445 1
Schistosoma mansoni RAR-like nuclear receptor 0.0043 0.0541 0.0806
Mycobacterium ulcerans L-lysine aminotransferase 0.0023 0.0121 0.0249
Brugia malayi Cathepsin L-like precursor 0.0018 0.0011 0.0011
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0835 0.1194
Brugia malayi Cathepsin L-like precursor 0.0018 0.0011 0.0011
Echinococcus multilocularis glutamate receptor NMDA 0.0077 0.1263 0.1254
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0046 0.0114
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0018 0.0018 0.0008
Entamoeba histolytica hypothetical protein 0.0039 0.0445 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0061 0.005
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0046 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0044 0.056 0.055
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0112 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.4977 0.72
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0027 0.0196 0.1741
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0023 0.0112 0.0148
Brugia malayi hypothetical protein 0.0039 0.0445 0.0474
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0027 0.0196 0.0606
Onchocerca volvulus Bile acid receptor homolog 0.0043 0.0541 0.4325
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1005 0.3173
Brugia malayi hypothetical protein 0.0023 0.0112 0.012
Schistosoma mansoni hypothetical protein 0.0039 0.0445 0.0661
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0061 0.005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0112 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0541 0.0576
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0023 0.0121 0.0249
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0063 0.0496
Echinococcus multilocularis voltage gated potassium channel 0.0018 0.0018 0.0008
Echinococcus multilocularis lamin dm0 0.0057 0.0835 0.0825
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0284 0.2318
Echinococcus granulosus glutamate receptor subunit protein glur 0.0053 0.0759 0.0749
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1005 0.1511
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0112 0.0101
Echinococcus granulosus lamin dm0 0.0057 0.0835 0.0825
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0835 0.1194
Brugia malayi hypothetical protein 0.002 0.0061 0.0065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0541 0.0531
Trypanosoma brucei cytochrome P450, putative 0.002 0.0063 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0043 0.0541 0.0576
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0445 0.0435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0043 0.0541 0.0576
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0056 0.0813 0.1162
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Loa Loa (eye worm) hypoxia-induced factor 1 0.0318 0.6345 0.9183
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0541 0.0806
Trichomonas vaginalis guanylate cyclase, putative 0.0027 0.0196 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0161 0.0491
Onchocerca volvulus Protein ultraspiracle homolog 0.0043 0.0541 0.4325
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.1005 0.0995
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.033 0.659 0.9538
Echinococcus granulosus glutamate NMDA receptor subunit 0.0306 0.6102 0.6098
Echinococcus multilocularis glutamate receptor 2 0.0106 0.1865 0.1856
Entamoeba histolytica hypothetical protein 0.0025 0.0161 0.3451
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0061 0.0073
Loa Loa (eye worm) hypothetical protein 0.0345 0.6909 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0345 0.1093
Brugia malayi nuclear receptor RXR 0.002 0.0061 0.0065
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0053 0.0759 0.0749
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0053 0.0759 0.0749
Schistosoma mansoni nuclear receptor 0.002 0.0061 0.0077
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0046 0.0803
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0159 0.2991 0.2984
Onchocerca volvulus 0.0076 0.1237 1
Echinococcus multilocularis geminin 0.0176 0.3357 0.335
Loa Loa (eye worm) hypothetical protein 0.0026 0.019 0.0261
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0541 0.0576
Echinococcus multilocularis NMDA receptor 0.0053 0.0759 0.0749
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0148
Schistosoma mansoni hypothetical protein 0.0176 0.3357 0.5086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0043 0.0541 0.0769
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0061 0.005
Brugia malayi hypothetical protein 0.0027 0.0202 0.0215
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0023 0.0121 0.0249
Brugia malayi tailless protein 0.002 0.0061 0.0065
Brugia malayi Nuclear hormone receptor E75 0.002 0.0061 0.0065
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0276 0.0294
Brugia malayi Importin beta-1 subunit 0.0031 0.0284 0.0302
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0023 0.0121 0.0128
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0284 0.0274
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0159 0.2991 0.2984
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0541 0.0576
Echinococcus granulosus nmda type glutamate receptor 0.0092 0.1578 0.157
Echinococcus multilocularis thyroid hormone receptor alpha 0.0043 0.0541 0.0531
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0043 0.0541 0.0531
Schistosoma mansoni thyroid hormone receptor 0.0043 0.0541 0.0806
Plasmodium vivax importin-beta 2, putative 0.0031 0.0284 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0046 0.0328
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0043 0.0541 0.0531
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0284 0.2318
Echinococcus multilocularis transfer RNA-Lys 0.0076 0.1237 0.1228
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0046 0.0328
Loa Loa (eye worm) hypothetical protein 0.0023 0.0112 0.0148
Brugia malayi nuclear hormone receptor 0.002 0.0061 0.0065
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0053 0.0759 0.0749
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0011 0.0011
Mycobacterium tuberculosis Probable aminotransferase 0.0163 0.3068 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0061 0.0065
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0202 0.6999
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0202 0.152
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0202 0.6999
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Schistosoma mansoni nuclear hormone receptor 0.002 0.0061 0.0077
Leishmania major cathepsin L-like protease 0.0068 0.1074 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0043 0.0541 0.0576
Schistosoma mansoni ran 0.0023 0.0112 0.0154
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0163 0.3068 1
Echinococcus multilocularis glutamate receptor 2 0.0144 0.2676 0.2669
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0043 0.0541 0.0806
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0043 0.0541 0.0576
Echinococcus granulosus importin subunit beta 1 0.0031 0.0284 0.0274
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0196 0.1741
Schistosoma mansoni steroid hormone receptor ad4bp 0.0043 0.0541 0.0806
Echinococcus granulosus snurportin 1 0.033 0.659 0.6587
Echinococcus granulosus single minded 2 0.0079 0.1308 0.1298
Loa Loa (eye worm) glutamate receptor 1 0.0144 0.2676 0.3864
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0769
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0043 0.0541 0.0769
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0112 0.3703
Brugia malayi nuclear receptor NHR-67 0.002 0.0061 0.0065
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.1074 1
Schistosoma mansoni glutamate receptor kainate 0.0144 0.2676 0.4052
Schistosoma mansoni hypothetical protein 0.0053 0.0759 0.1137
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0043 0.0541 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0043 0.0541 0.0576
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0541 0.0806
Schistosoma mansoni lamin 0.0057 0.0835 0.1252
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Schistosoma mansoni glutamate receptor NMDA 0.0236 0.4623 0.701
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0163 0.3068 1
Schistosoma mansoni hypothetical protein 0.033 0.659 1
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0112 0.3703
Trichomonas vaginalis adenylate cyclase, putative 0.0027 0.0196 0.0606
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0196 0.1741
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0949 0.8824
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0163 0.3068 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0284 0.2749
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0043 0.0541 0.0531
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0023 0.0121 0.0167
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0043 0.0541 0.0531
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0061 0.005
Brugia malayi ecdysone receptor 0.002 0.0061 0.0065
Onchocerca volvulus 0.002 0.0061 0.041
Echinococcus multilocularis nmda type glutamate receptor 0.0131 0.239 0.2382
Echinococcus multilocularis nmda type glutamate receptor 0.0092 0.1578 0.157
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0061 0.005
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0306 0.6102 0.6098
Echinococcus granulosus ornithine aminotransferase 0.0023 0.0121 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0159 0.2991 0.2984
Brugia malayi PAS domain containing protein 0.0103 0.1801 0.1915
Schistosoma mansoni hypothetical protein 0.0176 0.3357 0.5086
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0027 0.0196 0.0606
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0541 0.0531
Schistosoma mansoni voltage-gated potassium channel 0.0018 0.0018 0.0011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0061 0.005
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0159 0.2991 0.2984
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0043 0.0541 0.0806
Loa Loa (eye worm) hypothetical protein 0.0043 0.0541 0.0769
Brugia malayi hypothetical protein 0.0345 0.6909 0.7347
Leishmania major hypothetical protein, conserved 0.0027 0.0202 0.1799
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0445 0.0435
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0063 0.0496
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0161 0.0491
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0112 0.0155
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0159 0.2991 0.2984
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0112 0.0952
Leishmania major GTP-binding protein, putative 0.0023 0.0112 0.0952
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0023 0.0121 0.0249
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0196 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0046 0.0328
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0046 0.1277
Brugia malayi hypothetical protein 0.002 0.0061 0.0065
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0112 0.1018
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0018 0.0018 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0043 0.0541 0.0769
Entamoeba histolytica Ran family GTPase 0.0023 0.0112 0.2328
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.002 0.0061 0.041
Mycobacterium ulcerans putative regulatory protein 0.0076 0.1237 0.3943
Loa Loa (eye worm) hypothetical protein 0.002 0.0061 0.0073
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0196 0.1741
Echinococcus multilocularis snurportin 1 0.033 0.659 0.6587
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0196 0.1741
Loa Loa (eye worm) hypothetical protein 0.0057 0.0835 0.1194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0043 0.0541 0.0769
Onchocerca volvulus 0.0057 0.0835 0.6716
Plasmodium falciparum ornithine aminotransferase 0.0023 0.0121 0.4026
Onchocerca volvulus 0.0052 0.0722 0.5802
Schistosoma mansoni glutamate receptor NMDA 0.0306 0.6102 0.9258
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0063 0.0059
Brugia malayi photoreceptor-specific nuclear receptor 0.0043 0.0541 0.0576
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1005 0.1511
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0112 0.0147
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0043 0.0541 0.0769
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0043 0.0541 0.4325
Onchocerca volvulus 0.0057 0.0835 0.6716
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0202 0.1799
Echinococcus multilocularis ornithine aminotransferase 0.0023 0.0121 0.011
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0046 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.1074 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.1005 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1005 0.3173
Brugia malayi Nuclear hormone receptor E75 0.002 0.0061 0.0065
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0061 0.0073
Brugia malayi Cathepsin L-like precursor 0.0018 0.0011 0.0011
Echinococcus multilocularis neuropeptide receptor A26 0.0491 1 1
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0061 0.0065

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 11 nM Antagonist activity at human TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-induced calcium flux ChEMBL. 21531136
IC50 (functional) = 19 nM Antagonist activity at rat TRPV1 expressed in CHO cells co-expressing aequorin and CRE-luciferase reporter gene assessed as inhibition of capsaicin-induced calcium flux ChEMBL. 21531136

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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