TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 355.318 | Formula: C15H18FN3O6
H donors: 4 H acceptors: 6 LogP: -1 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1O[C@H](OCc2nnn(c2)c2cccc(c2)F)[C@H]([C@H]([C@@H]1O)O)O
InChi: 1S/C15H18FN3O6/c16-8-2-1-3-10(4-8)19-5-9(17-18-19)7-24-15-14(23)13(22)12(21)11(6-20)25-15/h1-5,11-15,20-23H,6-7H2/t11-,12-,13+,14+,15+/m1/s1
InChiKey: INZJAGSIEHLXIY-MRLBHPIUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	minor component of type 1 fimbriae	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0025	0.0385	0.0556
Echinococcus multilocularis	voltage gated potassium channel	0.0012	0.0091	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Echinococcus multilocularis	musashi	0.0063	0.1266	0.1266
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	hypothetical protein	0.0025	0.0385	0.0538
Onchocerca volvulus		0.0025	0.0385	0.0556
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0022	0.031	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Brugia malayi	larval opioid receptor	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Brugia malayi	Pre-SET motif family protein	0.0244	0.5489	0.7667
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.256	0.3575
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0.031	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	DNA helicase recq5	0.001	0.0041	0.0057
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.0327	0.0327
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0385	0.0455
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0022	0.0327	0.0457
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0385	0.0455
Brugia malayi	Serotonin receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Schistosoma mansoni	hypothetical protein	0.0025	0.0385	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0327	0.0457
Trichomonas vaginalis	mucin-desulfating sulfatase, putative	0.001	0.0038	0.0053
Loa Loa (eye worm)	glutaminase	0.0315	0.7159	0.8453
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0327	0.0386
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0385	0.0385
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0091	0.0127
Echinococcus multilocularis	bloom syndrome protein	0.0025	0.0378	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0327	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus granulosus	serotonin receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Schistosoma mansoni	hypothetical protein	0.0198	0.4432	0.6191
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0731	0.1021
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0385	0.0385
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.0385	0.0385
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.0385	0.0538
Loa Loa (eye worm)	glutaminase 2	0.0315	0.7159	0.8453
Echinococcus multilocularis	serotonin receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.256	0.3575
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus multilocularis	Glycoside hydrolase, family 27	0.0118	0.256	0.256
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.0385	0.0385
Brugia malayi	Bloom's syndrome protein homolog	0.0025	0.0378	0.0528
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Echinococcus granulosus	Regulator of G protein signaling 20	0.0022	0.0327	0.0327
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0327	0.0457
Schistosoma mansoni	voltage-gated potassium channel	0.0012	0.0091	0.0127
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.0327	0.0457
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.031	0.031
Onchocerca volvulus		0.0025	0.0385	0.0556
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.0327	0.0327
Giardia lamblia	Sgs1 DNA helicase, putative	0.001	0.0041	0.0094
Brugia malayi	regulator of G-protein signaling egl-10	0.0022	0.0327	0.0457
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0385	0.0385
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0062	0.1239	0.1463
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0327	0.0386
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.0385	0.0538
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.031	0.031
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0327	0.0457
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.031	0.2758
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.0385	0.0385
Onchocerca volvulus		0.0025	0.0385	0.0556
Onchocerca volvulus		0.0025	0.0385	0.0556
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.001	0.0041	0.0041
Schistosoma mansoni	amine GPCR	0.0025	0.0385	0.0538
Echinococcus granulosus	somatostatin receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	lamin dm0	0.0063	0.1266	0.1266
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Onchocerca volvulus		0.0063	0.1266	0.1969
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.0385	0.0385
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	lamin dm0	0.0063	0.1266	0.1266
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0022	0.0327	0.0386
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.0385	0.0385
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.0385	0.0385
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0327	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0665	0.0785
Schistosoma mansoni	histamine h1 receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0385	0.0385
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0022	0.0327	0.0327
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0022	0.0327	0.0327
Echinococcus multilocularis	somatostatin receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	hypothetical protein	0.0198	0.4432	0.6191
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0619	0.0865
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0016	0.0187	0.0582
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0385	0.0455
Loa Loa (eye worm)	intermediate filament protein	0.0063	0.1266	0.1495
Brugia malayi	PXA domain containing protein	0.0022	0.0327	0.0457
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Onchocerca volvulus		0.0025	0.0385	0.0556
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0887	0.1239
Echinococcus multilocularis	regulator of G protein signaling	0.0022	0.0327	0.0327
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0079	0.1642	0.2293
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.0385	0.0385
Schistosoma mansoni	opsin-like receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	DNA helicase recq1	0.001	0.0041	0.0057
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.0385	0.0538
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0385	0.0455
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0045
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.002	0.0262	0.0309
Brugia malayi	neuropeptide F receptor	0.0025	0.0385	0.0538
Brugia malayi	Dopamine receptor	0.0025	0.0385	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.003	0.0509	0.0509
Toxoplasma gondii	Alpha-galactosidase	0.0017	0.0194	0.0608
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0022	0.0327	0.0327
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Brugia malayi	sulfakinin receptor protein	0.0025	0.0385	0.0538
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0.031	1
Brugia malayi	hypothetical protein	0.0022	0.0327	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	intermediate filament protein	0.0063	0.1266	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0327	0.0457
Echinococcus granulosus	lamin	0.0063	0.1266	0.1266
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0043	0.0796	0.0796
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0012	0.0091	0.0127
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0385	0.0385
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0385	0.0385
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0041	0.0057
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0244	0.5489	0.6481
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Schistosoma mansoni	blooms syndrome DNA helicase	0.0019	0.0257	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0371	0.847	1
Brugia malayi	GnHR receptor homolog	0.0025	0.0385	0.0538
Onchocerca volvulus		0.0277	0.6274	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0035	0.0619	0.0619
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.001	0.0041	0.0041
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.0619	0.2296
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0022	0.0327	0.0457
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.0385	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Brugia malayi	Serotonin receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0022	0.031	1
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0022	0.0327	0.0386
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.0385	0.0385
Onchocerca volvulus		0.0025	0.0385	0.0556
Schistosoma mansoni	amine GPCR	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0063	0.1266	0.1495
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0327	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0483	0.057
Echinococcus granulosus	voltage gated potassium channel	0.0012	0.0091	0.0091
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.0327	0.0457
Echinococcus multilocularis	geminin	0.0198	0.4432	0.4432
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0.031	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Trichomonas vaginalis	DNA helicase recq, putative	0.0013	0.011	0.0154
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.003	0.0509	0.0601
Onchocerca volvulus		0.0063	0.1266	0.1969
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	intermediate filament proteins	0.0063	0.1266	0.1768
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Loa Loa (eye worm)	PXA domain-containing protein	0.0022	0.0327	0.0386
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0327	0.0457
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.001	0.0041	0.0041
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.001	0.0041	0.0048
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.256	0.3575
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0385	0.0385
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.0385	0.0538
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.0385	0.0385
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0063	0.1266	0.1495
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.0385	0.0385
Brugia malayi	regulator of G-protein signaling rgs-7	0.0022	0.0327	0.0457
Entamoeba histolytica	hypothetical protein	0.0022	0.0327	1
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0385	0.0385
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.0327	0.0327
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Loa Loa (eye worm)	RecQ helicase	0.0025	0.0378	0.0446
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Schistosoma mansoni	amine GPCR	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0385	0.0455
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0385	0.0455
Echinococcus multilocularis	expressed protein	0.0437	1	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0385	0.0385
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0385	0.0385
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0012	0.0091	0.0091
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.0385	0.0538
Brugia malayi	cytoplasmic intermediate filament protein	0.0034	0.0587	0.082
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0327	0.0386
Onchocerca volvulus		0.0035	0.0619	0.0932
Trichomonas vaginalis	set domain proteins, putative	0.0277	0.6274	0.8764
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.0385	0.0385
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.031	0.0366
Entamoeba histolytica	hypothetical protein	0.0022	0.0327	1
Schistosoma mansoni	glutaminase	0.0315	0.7159	1
Trichomonas vaginalis	DNA helicase recq, putative	0.0025	0.0378	0.0528
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.0385	0.0556
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0327	0.0457
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	ap endonuclease	0.0022	0.031	0.0433
Brugia malayi	ORL1-like opioid receptor	0.0025	0.0385	0.0538
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0385	0.0385
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0483	0.057
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0022	0.0327	0.0457
Schistosoma mansoni	adenoreceptor	0.0025	0.0385	0.0538
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Schistosoma mansoni	amine GPCR	0.0025	0.0385	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0385	0.0455
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0385	0.0385
Brugia malayi	G protein-coupled receptor	0.0025	0.0385	0.0538
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.0385	0.0385
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.0327	0.0327
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0385	0.0385
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0385	0.0385
Onchocerca volvulus		0.0025	0.0385	0.0556
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0619	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1642	0.1938
Echinococcus granulosus	hypothetical protein	0.0025	0.0385	0.0385
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0385	0.0385
Onchocerca volvulus		0.0025	0.0385	0.0556
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0385	0.0455
Brugia malayi	neuropeptide F receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	serotonin receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.003	0.0509	0.0509
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Brugia malayi	Intermediate filament tail domain containing protein	0.0063	0.1266	0.1768
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0022	0.0308	0.994
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0385	0.0385
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0022	0.031	1
Brugia malayi	G-protein coupled receptor	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.0385	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0327	0.0457
Onchocerca volvulus		0.0025	0.0385	0.0556
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0091	0.0108
Echinococcus multilocularis	regulator of G protein signaling 7	0.0022	0.0327	0.0327
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.0385	0.0538
Brugia malayi	intermediate filament protein	0.0063	0.1266	0.1768
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Onchocerca volvulus		0.0025	0.0385	0.0556
Echinococcus multilocularis	lamin	0.0063	0.1266	0.1266
Onchocerca volvulus		0.0025	0.0385	0.0556
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0385	0.0385
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0327	0.0457
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0035	0.0619	0.0865
Onchocerca volvulus		0.0025	0.0385	0.0556
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0043	0.0796	0.0796
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.001	0.0041	0.0048
Trichomonas vaginalis	DNA helicase recq1, putative	0.0025	0.0378	0.0528
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.0327	0.0457
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0022	0.0327	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0385	0.0538
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0012	0.0091	0.0091
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0385	0.0455
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0043	0.0796	0.1112
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.0385	0.0538
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0034	0.0589	0.0589
Toxoplasma gondii	exonuclease III APE	0.0022	0.031	0.1068
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.0327	0.0327
Loa Loa (eye worm)	hypothetical protein	0.001	0.0038	0.0045
Brugia malayi	putative neuropeptide receptor	0.0025	0.0385	0.0538
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0385	0.0385
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0017	0.0194	0.0271
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0385	0.0385
Toxoplasma gondii	melibiase subfamily protein	0.0118	0.256	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0041	0.0000000004285
Echinococcus multilocularis	axis inhibition protein axin	0.0022	0.0327	0.0327
Trichomonas vaginalis	Phosphoglycerol transferase I, putative	0.001	0.0038	0.0053
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.031	0.0433
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0034	0.0587	0.0693
Brugia malayi	G-protein coupled receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	regulator of G protein signaling 3	0.0022	0.0327	0.0327
Trichomonas vaginalis	ap endonuclease, putative	0.0022	0.031	0.0433
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0022	0.031	1
Echinococcus granulosus	Alpha N acetylgalactosaminidase	0.0118	0.256	0.256
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Schistosoma mansoni	hypothetical protein	0.0025	0.0385	0.0538
Echinococcus multilocularis	Alpha N acetylgalactosaminidase	0.0118	0.256	0.256
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.0327	0.0327
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	opsin-like receptor	0.0025	0.0385	0.0538
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.0385	0.0556
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0041	0.0057
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0385	0.0385
Loa Loa (eye worm)	RGS-3 protein	0.0022	0.0327	0.0386
Brugia malayi	Dopamine receptor protein 2	0.0025	0.0385	0.0538
Onchocerca volvulus		0.0025	0.0385	0.0556
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	sex peptide receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0385	0.0385
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	opsin-like receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0385	0.0538
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0385	0.0385
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0022	0.031	0.0381
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0022	0.0327	0.0327
Echinococcus multilocularis	sex peptide receptor	0.0025	0.0385	0.0385
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.0619	0.0619
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Brugia malayi	Melibiase family protein	0.0079	0.1642	0.2293
Onchocerca volvulus		0.0025	0.0385	0.0556
Brugia malayi	glutaminase DH11.1	0.0315	0.7159	1
Echinococcus granulosus	geminin	0.0198	0.4432	0.4432
Schistosoma mansoni	amine GPCR	0.0025	0.0385	0.0538
Schistosoma mansoni	voltage-gated potassium channel	0.0046	0.0887	0.1239
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.004	0.0731	0.1021
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0619	0.0731
Schistosoma mansoni	myosin xvIII	0.0025	0.0385	0.0538
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0.031	0.919
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0385	0.0538
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Onchocerca volvulus		0.0025	0.0385	0.0556
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0385	0.0385
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0.031	1
Schistosoma mansoni	hypothetical protein	0.0025	0.0385	0.0538
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0035	0.0619	0.0619
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0385	0.0385
Trichomonas vaginalis	alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative	0.0079	0.1642	0.2293
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0385	0.0538
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0327	0.0457
Schistosoma mansoni	regulator of G protein signaling	0.0022	0.0327	0.0457
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0035	0.0619	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus granulosus	regulator of G protein signaling 7	0.0022	0.0327	0.0327
Echinococcus granulosus	regulator of G protein signaling 3	0.0022	0.0327	0.0327
Plasmodium vivax	SET domain protein, putative	0.0035	0.0619	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.0385	0.0538
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0385	0.0538
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0022	0.031	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0385	0.0385
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0043	0.0796	0.094
Brugia malayi	hypothetical protein	0.0022	0.0327	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	axis inhibition protein axin	0.0022	0.0327	0.0457
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0385	0.0385
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Schistosoma mansoni	z-protein (S1r protein)	0.0022	0.0327	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0327	0.0386
Trichomonas vaginalis	glutaminase, putative	0.0315	0.7159	1
Brugia malayi	hypothetical protein	0.0143	0.3129	0.437
Brugia malayi	hypothetical protein	0.001	0.0038	0.0053
Brugia malayi	PXA domain containing protein	0.0022	0.0327	0.0457
Echinococcus granulosus	axis inhibition protein axin	0.0022	0.0327	0.0327
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0022	0.0327	0.0457
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Brugia malayi	Pre-SET motif family protein	0.0035	0.0619	0.0865
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0327	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0385	0.0385
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0385	0.0385
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0385	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Brugia malayi	Sulfatase family protein	0.001	0.0038	0.0053
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.0385	0.0538
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.0385	0.0385
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0022	0.0327	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0079	0.1642	0.2293
Schistosoma mansoni	lamin	0.0063	0.1266	0.1768
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0327	0.0457
Brugia malayi	Melatonin receptor type 1A	0.0025	0.0385	0.0538
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.001	0.0041	0.0041
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0022	0.0327	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.0385	0.0538
Brugia malayi	A-kinase anchor protein 10, precursor	0.0022	0.0327	0.0457
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	serine/threonine protein kinase	0.0022	0.0327	0.0457
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Schistosoma mansoni	ap endonuclease	0.0022	0.031	0.0433
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.031	0.0433
Mycobacterium ulcerans	glutaminase	0.0315	0.7159	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0038	0.0053
Echinococcus granulosus	bloom syndrome protein	0.0025	0.0378	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Schistosoma mansoni	lamin	0.0063	0.1266	0.1768
Onchocerca volvulus		0.0025	0.0385	0.0556
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.0385	0.0538
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.0385	0.0385
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0385	0.0538
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Brugia malayi	AKH receptor	0.0025	0.0385	0.0538
Brugia malayi	RE15519p	0.0025	0.0385	0.0538
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0385	0.0385
Brugia malayi	hypothetical protein	0.0025	0.0385	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0385	0.0455
Brugia malayi	Dopamine receptor protein 1	0.0025	0.0385	0.0538
Entamoeba histolytica	hypothetical protein	0.0022	0.0327	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0385	0.0455
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0385	0.0385
Schistosoma mansoni	alpha-galactosidase/alpha-n-acetylgalactosaminidase	0.0118	0.256	0.3575
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.0385	0.0538

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.348 uM	Antagonist activity at Escherichia coli recombinant C-terminal 6His-tagged FimH-CRD with a C-terminal thrombin cleavage site expressed in Escherichia coli HM125 assessed as inhibition of streptavidin-horseradish peroxidase conjugated TM-PAA polymer binding after 3 hrs by spectrophotometry	ChEMBL.	21962988
Ratio IC50 (binding)	= 5.3	Ratio of compound IC50 to n-heptyl alpha-D-mannopyranoside IC50 for Escherichia coli recombinant C-terminal 6His-tagged FimH-CRD with a C-terminal thrombin cleavage site expressed in Escherichia coli HM125 assessed as inhibition of streptavidin-horseradish peroxidase conjugated TM-PAA polymer binding after 3 hrs by spectrophotometry	ChEMBL.	21962988

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1917470

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1564330