Detailed information for compound 157065

Basic information

Technical information
  • TDR Targets ID: 157065
  • Name: 6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]isoq uinoline
  • MW: 309.359 | Formula: C19H19NO3
  • H donors: 0 H acceptors: 1 LogP: 3.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Cc1nccc2c1cc(OC)c(c2)OC
  • InChi: 1S/C19H19NO3/c1-21-15-6-4-13(5-7-15)10-17-16-12-19(23-3)18(22-2)11-14(16)8-9-20-17/h4-9,11-12H,10H2,1-3H3
  • InChiKey: RVTQRSDLGBOKCF-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 6,7-dimethoxy-1-p-anisyl-isoquinoline
  • 6,7-dimethoxy-1-(4-methoxybenzyl)isoquinoline
  • NW8180000
  • 6,7-Dimethoxy-1-(4-methoxybenzyl)isoquinoline hydrochloride
  • AIDS-157565
  • AIDS157565
  • NSC645240 (HYDROCHLORIDE SALT)
  • 6,7-Dimethoxy-1-(p-methoxybenzyl)isoquinoline
  • Isoquinoline, 6,7-dimethoxy-1-(p-methoxybenzyl)-
  • NCI60_015393

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) phosphatidylinositol 3 0.162 0.3276 0.3276
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.091 0.1735 0.1735
Entamoeba histolytica hypothetical protein 0.0314 0.0442 0.0324
Entamoeba histolytica hypothetical protein 0.0314 0.0442 0.0324
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.091 0.1735 0.1633
Trichomonas vaginalis PIKK family atypical protein kinase 0.161 0.3253 0.317
Schistosoma mansoni hypothetical protein 0.0314 0.0442 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.3762 0.7923 0.7897
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0314 0.0442 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.2567 0.533 0.5273
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0167 0.0122 0.0122
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0314 0.0442 0.042
Trichomonas vaginalis conserved hypothetical protein 0.0596 0.1053 0.0943
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0314 0.0442 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.2563 0.5322 0.5264
Loa Loa (eye worm) phosphatidylinositol 3 0.0314 0.0442 0.0442
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4719 1 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0167 0.0122 0.0122
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0501 0.0847 0.0735
Plasmodium vivax hypothetical protein 0.0314 0.0442 0.8837
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0402 0.0631 0.0516
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0167 0.0122 0.0122
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0167 0.0122 0.0122
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0433 0.07 0.07
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.091 0.1735 0.1735
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0334 0.0484 0.0463
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0566 0.0988 0.0988
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.1735 0.1633
Trichomonas vaginalis PIKK family atypical protein kinase 0.352 0.7399 0.7367
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0167 0.0122 0.01
Echinococcus multilocularis Zinc finger, PHD finger 0.0334 0.0484 0.0484
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0334 0.0484 0.0367
Mycobacterium tuberculosis Conserved hypothetical protein 0.0314 0.0442 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4719 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.161 0.3253 0.317
Loa Loa (eye worm) phosphatidylinositol 3 0.0632 0.113 0.113
Leishmania major phosphatidylinositol kinase, putative 0.0314 0.0442 0.0324
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0334 0.0484 0.0367
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0699 0.1277 0.1277
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0921 0.1758 0.1657
Trichomonas vaginalis PIKK family atypical protein kinase 0.161 0.3253 0.317
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0314 0.0442 0.0324
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1971 0.4037 0.3963
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0441 0.0716 0.0602
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0334 0.0484 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4719 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0373 0.0569 0.0453
Loa Loa (eye worm) phosphatidylinositol kinase 0.0314 0.0442 0.0442
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.017 0.0128 0.0128
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0501 0.0847 0.0735
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.0442 0.0442
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0501 0.0847 0.0735
Entamoeba histolytica protein kinase rad3, putative 0.091 0.1735 0.1633
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0671 0.1216 0.1216
Onchocerca volvulus 0.0314 0.0442 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1014 0.196 0.2182
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3765 0.7931 0.7906
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4719 1 1
Schistosoma mansoni immunophilin 0.0144 0.0072 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.352 0.7399 0.7367
Giardia lamblia Phosphatidylinositol 4-kinase 0.0314 0.0442 0.0324
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0314 0.0442 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.2563 0.5322 0.5264
Echinococcus multilocularis 0.0314 0.0442 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.352 0.7399 0.7367
Trichomonas vaginalis PIKK family atypical protein kinase 0.2821 0.5881 0.583
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0334 0.0484 0.0061
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1659 0.3361 0.3279
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0314 0.0442 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.352 0.7399 0.7367
Trichomonas vaginalis PIKK family atypical protein kinase 0.091 0.1735 0.1633
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0314 0.0442 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0334 0.0484 0.0463
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0314 0.0442 0.0442
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0334 0.0484 0.0484
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0334 0.0484 0.0367
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0314 0.0442 0.8837
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.0442 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.352 0.7399 0.7367
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0167 0.0122 0.5
Toxoplasma gondii FATC domain-containing protein 0.091 0.1735 0.1859
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0314 0.0442 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.3165 0.6629 0.6588
Trichomonas vaginalis PIKK family atypical protein kinase 0.352 0.7399 0.7367
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0314 0.0442 0.0442
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3765 0.7931 0.7906
Schistosoma mansoni hypothetical protein 0.0699 0.1277 0.1258
Loa Loa (eye worm) hypothetical protein 0.0144 0.0072 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0921 0.1758 0.1657
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0314 0.0442 0.042
Leishmania major hypothetical protein, unknown function 0.0314 0.0442 0.0324
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0847 0.0847
Loa Loa (eye worm) hypothetical protein 0.0699 0.1277 0.1277
Giardia lamblia Hypothetical protein 0.0314 0.0442 0.0324
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4719 1 1
Schistosoma mansoni immunophilin 0.0167 0.0122 0.01
Loa Loa (eye worm) hypothetical protein 0.1014 0.196 0.196
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4719 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 1 1
Loa Loa (eye worm) hypothetical protein 0.0433 0.07 0.07
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0373 0.0569 0.0453
Loa Loa (eye worm) hypothetical protein 0.0314 0.0442 0.0442
Leishmania major phosphatidylinositol kinase related protein, putative 0.0314 0.0442 0.0324
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0462 0.0762 0.0648
Loa Loa (eye worm) hypothetical protein 0.0596 0.1053 0.1053
Loa Loa (eye worm) FKBP5 protein 0.0167 0.0122 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.2563 0.5322 0.5264
Loa Loa (eye worm) phosphatidylinositol 3 0.0314 0.0442 0.0442
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0314 0.0442 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.2808 0.5854 0.5803
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0167 0.0122 0.0122
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0373 0.0569 0.0453
Trypanosoma cruzi target of rapamycin kinase 3 0.3765 0.7931 0.7906
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0501 0.0847 0.0735
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0334 0.0484 0.0484
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0671 0.1216 0.1196
Trichomonas vaginalis PIKK family atypical protein kinase 0.2821 0.5881 0.583
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0699 0.1277 0.1277
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0334 0.0484 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0442 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0314 0.0442 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.3762 0.7923 0.7897
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0501 0.0847 0.0735
Echinococcus granulosus serine protein kinase ATM 0.091 0.1735 0.1735
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0373 0.0569 0.0453
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0314 0.0442 0.8837
Onchocerca volvulus 0.0314 0.0442 0.5
Loa Loa (eye worm) hypothetical protein 0.091 0.1735 0.1735
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4719 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.352 0.7399 0.7367
Entamoeba histolytica hypothetical protein 0.0462 0.0762 0.0648
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0144 0.0072 0.0072
Plasmodium vivax hypothetical protein, conserved 0.0314 0.0442 0.8837
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0334 0.0484 0.0061
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0566 0.0988 0.0988
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0314 0.0442 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.2567 0.533 0.5273
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.091 0.1735 0.1735
Echinococcus multilocularis serine protein kinase ATM 0.091 0.1735 0.1735
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1659 0.3361 0.3361
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0314 0.0442 0.042
Echinococcus granulosus serine:threonine protein kinase SMG1 0.091 0.1735 0.1735
Trichomonas vaginalis PIKK family atypical protein kinase 0.3762 0.7923 0.7897
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0314 0.0442 0.0324
Leishmania major phosphatidylinositol 3-kinase, putative 0.161 0.3253 0.317
Trichomonas vaginalis PIKK family atypical protein kinase 0.4719 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1659 0.3361 0.3346
Trichomonas vaginalis conserved hypothetical protein 0.0699 0.1277 0.117
Leishmania major hypothetical protein, conserved 0.0404 0.0635 0.052
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1659 0.3361 0.3279
Loa Loa (eye worm) phosphatidylinositol 3 0.0314 0.0442 0.0442
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0334 0.0484 0.0367
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0187 0.0165 0.0044
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4719 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1014 0.196 0.1861
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0314 0.0442 0.0324
Schistosoma mansoni immunophilin 0.0167 0.0122 0.01
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0394 0.0615 0.0499
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0433 0.07 0.07
Giardia lamblia GTOR 0.4719 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0373 0.0569 0.0569
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.091 0.1735 0.1633
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0373 0.0569 0.0453
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1659 0.3361 0.3361
Trichomonas vaginalis PIKK family atypical protein kinase 0.2821 0.5881 0.583
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.161 0.3253 0.317
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1659 0.3361 0.3361
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0167 0.0122 0.0122
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.091 0.1735 0.1717
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4719 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0373 0.0569 0.0453
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.162 0.3276 0.3193
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0354 0.0527 0.041
Loa Loa (eye worm) phosphatidylinositol 3 0.4719 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0144 0.0072 0.0072
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0314 0.0442 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.2808 0.5854 0.5803
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0334 0.0484 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.1267 0.251 0.2418
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0441 0.0716 0.0602
Trichomonas vaginalis PIKK family atypical protein kinase 0.161 0.3253 0.317
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0167 0.0122 0.5
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0671 0.1216 0.1216
Loa Loa (eye worm) hypothetical protein 0.0953 0.1828 0.1828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0596 0.1053 0.0943
Trichomonas vaginalis PIKK family atypical protein kinase 0.3062 0.6405 0.6361
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0314 0.0442 0.0324
Echinococcus multilocularis fk506 binding protein 0.0167 0.0122 0.0122
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0334 0.0484 0.0367
Mycobacterium leprae conserved hypothetical protein 0.0314 0.0442 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0373 0.0569 0.0453
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4719 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0334 0.0484 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2567 0.533 0.5273
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0596 0.1053 0.0943
Toxoplasma gondii target of rapamycin (TOR), putative 0.352 0.7399 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.091 0.1735 0.1717
Entamoeba histolytica hypothetical protein 0.091 0.1735 0.1633
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0314 0.0442 0.0442
Loa Loa (eye worm) phosphatidylinositol 3 0.0314 0.0442 0.0442
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0314 0.0442 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.2567 0.533 0.5273
Brugia malayi FAT domain containing protein 0.0699 0.1277 0.1277
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0334 0.0484 0.0367
Trichomonas vaginalis PIKK family atypical protein kinase 0.3762 0.7923 0.7897
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0373 0.0569 0.0548
Entamoeba histolytica hypothetical protein 0.0314 0.0442 0.0324
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.091 0.1735 0.1633
Trichomonas vaginalis PIKK family atypical protein kinase 0.162 0.3276 0.3193
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0334 0.0484 0.0367
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0334 0.0484 0.0367
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0314 0.0442 0.0442
Trichomonas vaginalis PIKK family atypical protein kinase 0.4019 0.8482 0.8463
Leishmania major phosphatidylinositol 3-kinase, putative 0.0334 0.0484 0.0367
Leishmania major phosphatidylinositol 3-related kinase, putative 0.162 0.3276 0.3193
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4719 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0334 0.0484 0.0484
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0433 0.07 0.07
Leishmania major phosphatidylinositol 4-kinase, putative 0.0314 0.0442 0.0324
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0501 0.0847 0.0735
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0314 0.0442 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.3762 0.7923 0.7897
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2225 0.4587 0.4521
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0334 0.0484 0.0367

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 36.7 uM In vitro inhibition of Collagen (10 ug/mL) induced platelet aggregatory activity. ChEMBL. 12873516
IC50 (functional) = 59.2 uM Inhibitory concentration required against Archidonic acid (100 uM) induced platelet aggregatory activity ChEMBL. 12873516
Inhibition (functional) = 26 % Percentage inhibition against thrombin induced platelet aggregatory activity ChEMBL. 12873516
Inhibition (functional) = 52 % Percentage inhibition against platelet activating factor (2 ng/mL) induced platelet aggregatory activity ChEMBL. 12873516

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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