TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 524.508 | Formula: C25H28F4N4O4
H donors: 3 H acceptors: 4 LogP: 1.84 Rotable bonds: 7
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)C(F)(F)F.C[C@H](NC(=O)c1ccc(cc1)C)CN1CCC(CC1)n1c(=O)[nH]c2c1cccc2F
InChi: 1S/C23H27FN4O2.C2HF3O2/c1-15-6-8-17(9-7-15)22(29)25-16(2)14-27-12-10-18(11-13-27)28-20-5-3-4-19(24)21(20)26-23(28)30;3-2(4,5)1(6)7/h3-9,16,18H,10-14H2,1-2H3,(H,25,29)(H,26,30);(H,6,7)/t16-;/m0./s1
InChiKey: IIIMFJGQQQJAKE-NTISSMGPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phospholipase D1, phosphatidylcholine-specific	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	ko:K01115 phospholipase D [EC3.1.4.4], putative	Get druggable targets OG5_128363	All targets in OG5_128363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128363	All targets in OG5_128363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128363	All targets in OG5_128363
Echinococcus multilocularis	phospholipase D	Get druggable targets OG5_128363	All targets in OG5_128363
Echinococcus granulosus	phospholipase D	Get druggable targets OG5_128363	All targets in OG5_128363
Schistosoma japonicum	Phospholipase D1, putative	Get druggable targets OG5_128363	All targets in OG5_128363
Candida albicans	Phospholipase D:required for commitment to meiosis	Get druggable targets OG5_128363	All targets in OG5_128363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128363	All targets in OG5_128363
Brugia malayi	Phospholipase d protein 1	Get druggable targets OG5_128363	All targets in OG5_128363
Echinococcus multilocularis	phospholipase D1	Get druggable targets OG5_128363	All targets in OG5_128363
Echinococcus granulosus	phospholipase D1	Get druggable targets OG5_128363	All targets in OG5_128363
Candida albicans	Phospholipase D:required for commitment to meiosis	Get druggable targets OG5_128363	All targets in OG5_128363
Schistosoma mansoni	phospholipase D	Get druggable targets OG5_128363	All targets in OG5_128363
Entamoeba histolytica	phospholipase D, putative	Get druggable targets OG5_128363	All targets in OG5_128363
Schistosoma japonicum	Conserved hypothetical protein	Get druggable targets OG5_128363	All targets in OG5_128363
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128363	All targets in OG5_128363
Entamoeba histolytica	phospholipase D, putative	Get druggable targets OG5_128363	All targets in OG5_128363
Schistosoma japonicum	ko:K01115 phospholipase D [EC3.1.4.4], putative	Get druggable targets OG5_128363	All targets in OG5_128363
Entamoeba histolytica	phospholipase D active site domain-containing protein	Get druggable targets OG5_128363	All targets in OG5_128363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128363	All targets in OG5_128363

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0017	0.0055	0.5
Brugia malayi	Protein kinase domain containing protein	0.0091	0.0678	0.0678
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.0255	0.0255
Giardia lamblia	Serpin 1	0.0017	0.0056	0.5
Echinococcus multilocularis	Estrogen regulated protein EP45	0.0017	0.0056	0.0097
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0019	0.0074	0.0462
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0041	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0674	0.0674
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Brugia malayi	serpin (BmSERPIN)	0.0017	0.0056	0.0056
Schistosoma mansoni	hypothetical protein	0.0173	0.1365	0.2343
Entamoeba histolytica	phospholipase D, putative	0.0055	0.0376	0.5142
Brugia malayi	hypothetical protein	0.0019	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0214	0.0214
Schistosoma mansoni	phospholipase D	0.0055	0.0376	0.0645
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0048	0.0048
Echinococcus granulosus	ecdysone induced protein 78C	0.0041	0.0255	0.0438
Schistosoma mansoni	apoferritin-2	0.0017	0.0055	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0255	0.0255
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0019	0.0074	0.0074
Schistosoma mansoni	ferritin	0.0017	0.0055	0.0094
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.034	0.034
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0022	0.0094	0.0161
Echinococcus granulosus	nuclear receptor nhr 48	0.0019	0.0074	0.0127
Echinococcus granulosus	geminin	0.0173	0.1365	0.2343
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0041	0.0255	0.0438
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0041	0.0255	0.0438
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0041	0.0255	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0255	0.0255
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0041	0.0255	0.1591
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.0214	0.0367
Onchocerca volvulus		0.0017	0.0056	0.0351
Brugia malayi	serpin	0.0017	0.0056	0.0056
Trypanosoma cruzi	squalene monooxygenase, putative	0.0515	0.4233	1
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0017	0.0055	0.5
Schistosoma mansoni	serpin	0.0017	0.0056	0.0097
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0048	0.0082
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.0074	0.0127
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.0074	0.0127
Schistosoma mansoni	nuclear hormone receptor	0.0041	0.0255	0.0438
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0041	0.0255	0.0255
Schistosoma mansoni	serine protease inhibitors serpins	0.0017	0.0056	0.0097
Schistosoma mansoni	serine protease inhibitors serpins	0.0017	0.0056	0.0097
Loa Loa (eye worm)	serpin	0.0017	0.0056	0.0056
Brugia malayi	tailless protein	0.0019	0.0074	0.0074
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0074	0.0127
Brugia malayi	BmSERPIN	0.0017	0.0056	0.0056
Brugia malayi	serpin	0.0017	0.0056	0.0056
Onchocerca volvulus		0.0017	0.0056	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Onchocerca volvulus		0.0017	0.0056	0.0351
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0091	0.0678	0.16
Echinococcus granulosus	Estrogen regulated protein EP45	0.0017	0.0056	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0255	0.0255
Schistosoma mansoni	apoferritin-2	0.0017	0.0055	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0094	0.0094
Brugia malayi	nuclear hormone receptor	0.0041	0.0255	0.0255
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.034	0.034
Echinococcus multilocularis	microtubule associated protein 2	0.0705	0.5826	1
Entamoeba histolytica	hypothetical protein	0.0091	0.0678	1
Entamoeba histolytica	protein kinase, putative	0.0091	0.0678	1
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0091	0.0678	0.1451
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0022	0.0094	0.0161
Echinococcus multilocularis	Estrogen regulated protein EP45	0.0017	0.0056	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0041	0.0255	0.0255
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.034	0.034
Trypanosoma cruzi	squalene monooxygenase, putative	0.0515	0.4233	1
Echinococcus granulosus	dual specificity	0.0091	0.0678	0.1163
Schistosoma mansoni	hypothetical protein	0.0209	0.1662	0.2852
Loa Loa (eye worm)	DR-78	0.0019	0.0074	0.0074
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0017	0.0055	0.5
Echinococcus multilocularis	jun protein	0.0257	0.2065	0.3544
Echinococcus multilocularis	FTZ F1 alpha	0.0041	0.0255	0.0438
Onchocerca volvulus		0.0017	0.0056	0.0351
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0048	0.0048
Schistosoma mansoni	ferritin	0.0017	0.0055	0.0094
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0242	0.0415
Loa Loa (eye worm)	serpin	0.0017	0.0056	0.0056
Brugia malayi	ecdysone receptor	0.0019	0.0074	0.0074
Echinococcus granulosus	microtubule associated protein 2	0.0705	0.5826	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0041	0.0255	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Loa Loa (eye worm)	serpin	0.0017	0.0056	0.0056
Trypanosoma brucei	squalene monooxygenase, putative	0.0515	0.4233	1
Schistosoma mansoni	microtubule-associated protein tau	0.0705	0.5826	1
Onchocerca volvulus		0.0017	0.0056	0.0351
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0041	0.0255	0.0255
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0041	0.0255	0.0255
Schistosoma mansoni	thyroid hormone receptor	0.0041	0.0255	0.0438
Schistosoma mansoni	hypothetical protein	0.0039	0.0244	0.0419
Brugia malayi	conserved hypotetical protein	0.0019	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0255	0.0255
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0048	0.0082
Echinococcus granulosus	serine protease inhibitor	0.0017	0.0056	0.0097
Brugia malayi	serpin	0.0017	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Brugia malayi	nuclear receptor NHR-67	0.0019	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0205	0.0205
Schistosoma mansoni	retinoic acid receptor RXR	0.0041	0.0255	0.0438
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.0091	0.0678	0.1451
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0302	0.0302
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0041	0.0255	0.0438
Brugia malayi	Nuclear hormone receptor E75	0.0019	0.0074	0.0074
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0205	0.0205
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0022	0.0094	0.0094
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0041	0.0255	0.0438
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0048	0.0048
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0041	0.0255	0.0438
Schistosoma mansoni	nuclear receptor	0.0019	0.0074	0.0127
Echinococcus multilocularis	ecdysone induced protein 78C	0.0041	0.0255	0.0438
Brugia malayi	serpin	0.0017	0.0056	0.0056
Schistosoma mansoni	coup transcription factor	0.0041	0.0255	0.0438
Echinococcus multilocularis	serine protease inhibitor	0.0017	0.0056	0.0097
Entamoeba histolytica	phospholipase D active site domain-containing protein	0.0046	0.0302	0.3948
Loa Loa (eye worm)	steroid hormone receptor	0.0041	0.0255	0.0255
Echinococcus granulosus	expressed protein	0.0017	0.0055	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0214	0.0214
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0041	0.0255	0.0255
Entamoeba histolytica	protein kinase, putative	0.0091	0.0678	1
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0017	0.0055	0.5
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0302	0.0302
Onchocerca volvulus		0.0019	0.0074	0.0462
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Echinococcus multilocularis	ferritin	0.0017	0.0055	0.0094
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0019	0.0074	0.0074
Leishmania major	squalene monooxygenase-like protein	0.0515	0.4233	1
Onchocerca volvulus		0.0202	0.1603	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0019	0.0074	0.0074
Brugia malayi	photoreceptor-specific nuclear receptor	0.0041	0.0255	0.0255
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0094	0.0094
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0048	0.0048
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0041	0.0255	0.0438
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0255	0.0438
Mycobacterium ulcerans	bacterioferritin BfrA	0.0017	0.0055	0.5
Echinococcus granulosus	phospholipase D1	0.0055	0.0376	0.0645
Echinococcus granulosus	serine protease inhibitor	0.0017	0.0056	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0214	0.0214
Brugia malayi	serpin (BmSERPIN)	0.0017	0.0056	0.0056
Entamoeba histolytica	hypothetical protein	0.0039	0.0244	0.3021
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0041	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0674	0.0674
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0041	0.0255	0.0438
Toxoplasma gondii	phospholipase D active site domain-containing protein	0.0019	0.0074	1
Schistosoma mansoni	jun-related protein	0.0209	0.1662	0.2852
Brugia malayi	hypothetical protein	0.0039	0.0244	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0194	1
Onchocerca volvulus	Bile acid receptor homolog	0.0041	0.0255	0.1591
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0019	0.0074	0.0127
Echinococcus multilocularis	expressed protein	0.0017	0.0055	0.0094
Entamoeba histolytica	hypothetical protein	0.0039	0.0244	0.3021
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.0255	0.0255
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0022	0.0094	0.0161
Echinococcus granulosus	ferritin	0.0017	0.0055	0.0094
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0041	0.0255	0.0438
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0255	0.0438
Echinococcus granulosus	Estrogen regulated protein EP45	0.0017	0.0056	0.0097
Echinococcus granulosus	GPCR family 2	0.0016	0.0048	0.0082
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0041	0.0255	0.0438
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0074	0.0127
Schistosoma mansoni	hypothetical protein	0.0016	0.0048	0.0082
Echinococcus multilocularis	phospholipase D1	0.0055	0.0376	0.0645
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0041	0.0255	0.0438
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0041	0.0255	0.0255
Schistosoma mansoni	ferritin	0.0017	0.0055	0.0094
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0041	0.0255	0.0255
Schistosoma mansoni	hypothetical protein	0.0173	0.1365	0.2343
Brugia malayi	Serpin protein 6	0.0017	0.0056	0.0056
Loa Loa (eye worm)	serpin protein 6	0.0017	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.1203	1	1
Treponema pallidum	bacterioferrin (TpF1)	0.0017	0.0055	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0091	0.0678	0.1163
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0041	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0051	0.034	0.034
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Brugia malayi	hypothetical protein	0.0017	0.0056	0.0056
Brugia malayi	nuclear hormone receptor	0.0019	0.0074	0.0074
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0041	0.0255	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Schistosoma mansoni	serine protease inhibitors serpins	0.0017	0.0056	0.0097
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0094	0.0161
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0244	0.0419
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0244	0.0419
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.0074	0.0127
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0019	0.0074	0.0127
Schistosoma mansoni	zinc finger protein	0.0019	0.0074	0.0127
Schistosoma mansoni	serine protease inhibitors serpins	0.0017	0.0056	0.0097
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0041	0.0255	0.0255
Entamoeba histolytica	protein kinase domain containing protein	0.0091	0.0678	1
Brugia malayi	Phospholipase D. Active site motif family protein	0.0019	0.0074	0.0074
Echinococcus granulosus	thyroid hormone receptor alpha	0.0019	0.0074	0.0127
Brugia malayi	Cytochrome P450 family protein	0.0047	0.0311	0.0311
Brugia malayi	nuclear receptor RXR	0.0022	0.0094	0.0094
Brugia malayi	hypothetical protein	0.0022	0.0094	0.0094
Brugia malayi	hypothetical protein	0.0202	0.1603	0.1603
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0257	0.2065	0.3544
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.0242	0.0415
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0019	0.0074	0.0074
Echinococcus multilocularis	phospholipase D	0.0049	0.0322	0.0552
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0244	0.0419
Echinococcus granulosus	serine protease inhibitor	0.0017	0.0056	0.0097
Echinococcus multilocularis	geminin	0.0173	0.1365	0.2343
Brugia malayi	serpin	0.0017	0.0056	0.0056
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0041	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0041	0.0255	0.0438
Schistosoma mansoni	RAR-like nuclear receptor	0.0041	0.0255	0.0438
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0041	0.0255	0.0438
Schistosoma mansoni	thyroid hormone receptor	0.0041	0.0255	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Schistosoma mansoni	serine protease inhibitors serpins	0.0017	0.0056	0.0097
Echinococcus granulosus	plasminogen activator inhibitor 2	0.0017	0.0056	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Schistosoma mansoni	ferritin light chain	0.0017	0.0055	0.0094
Onchocerca volvulus		0.0041	0.0255	0.1591
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0094	0.0094
Brugia malayi	Steroid receptor seven-up type 2	0.0041	0.0255	0.0255
Schistosoma mansoni	serine protease inhibitors serpins	0.0017	0.0056	0.0097
Brugia malayi	nuclear receptor RXR	0.0019	0.0074	0.0074
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0019	0.0074	0.0462
Schistosoma mansoni	hypothetical protein	0.0016	0.0048	0.0082
Echinococcus multilocularis	serine protease inhibitor	0.0017	0.0056	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0255	0.0255
Brugia malayi	bZIP transcription factor family protein	0.0257	0.2065	0.2065
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0019	0.0074	0.0127
Schistosoma mansoni	nuclear receptor nhr-48	0.0019	0.0074	0.0127
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0041	0.0255	0.0255
Brugia malayi	Nuclear hormone receptor-like 1	0.0041	0.0255	0.0255
Schistosoma mansoni	hypothetical protein	0.0016	0.0048	0.0082
Loa Loa (eye worm)	hypothetical protein	0.025	0.2006	0.2006
Echinococcus multilocularis	dual specificity	0.0091	0.0678	0.1163
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.0255	0.0255
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.0091	0.0678	0.0678
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0041	0.0255	0.0255
Mycobacterium ulcerans	bacterioferritin BfrB	0.0017	0.0055	0.5
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0048	0.0082
Loa Loa (eye worm)	nuclear hormone receptor	0.0019	0.0074	0.0074
Brugia malayi	nuclear hormone receptor family member odr-7	0.0019	0.0074	0.0074
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0074	0.0127
Brugia malayi	hypothetical protein	0.0017	0.0056	0.0056
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0048	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0041	0.0255	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0194	1
Schistosoma mansoni	serpin	0.0017	0.0056	0.0097
Onchocerca volvulus	Protein ultraspiracle homolog	0.0041	0.0255	0.1591
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0041	0.0255	0.0438
Brugia malayi	Phospholipase d protein 1	0.0055	0.0376	0.0376
Onchocerca volvulus		0.0017	0.0056	0.0351
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0094	0.0094
Entamoeba histolytica	hypothetical protein	0.0039	0.0244	0.3021
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0257	0.2065	0.3544
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0056	0.0056
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0019	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0255	0.0255
Entamoeba histolytica	phospholipase D, putative	0.0055	0.0376	0.5142
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Echinococcus granulosus	jun protein	0.0257	0.2065	0.3544
Entamoeba histolytica	hypothetical protein	0.0039	0.0244	0.3021
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0048	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Echinococcus multilocularis	nuclear receptor nhr 48	0.0019	0.0074	0.0127
Loa Loa (eye worm)	serpin	0.0017	0.0056	0.0056
Brugia malayi	ecdysteroid receptor	0.0041	0.0255	0.0255
Brugia malayi	nuclear receptor NHR-88	0.0019	0.0074	0.0074
Echinococcus granulosus	phospholipase D	0.0049	0.0322	0.0552
Schistosoma mansoni	nuclear receptor	0.0019	0.0074	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0094	0.0094
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.0074	0.0127
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0074	0.0127
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0041	0.0255	0.0255
Schistosoma mansoni	hypothetical protein	0.0035	0.0205	0.0352
Brugia malayi	steroid hormone receptor	0.0041	0.0255	0.0255
Schistosoma mansoni	ferritin light chain	0.0017	0.0055	0.0094
Brugia malayi	nuclear receptor NHR-88	0.0041	0.0255	0.0255
Brugia malayi	BmSERPIN, truncated	0.0017	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0094	0.0094
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0255	0.0255
Brugia malayi	hypothetical protein	0.0019	0.0074	0.0074
Echinococcus granulosus	FTZ F1 alpha	0.0041	0.0255	0.0438
Brugia malayi	serpin	0.0017	0.0056	0.0056
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0041	0.0255	0.0255
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0019	0.0074	0.0127
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.0214	0.0367
Schistosoma mansoni	ferritin	0.0017	0.0055	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0074	0.0074
Brugia malayi	hypothetical protein	0.0022	0.0094	0.0094
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.0091	0.0678	0.1451
Brugia malayi	Nuclear hormone receptor E75	0.0019	0.0074	0.0074
Schistosoma mansoni	hypothetical protein	0.0016	0.0048	0.0082
Onchocerca volvulus		0.0019	0.0074	0.0462
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0041	0.0255	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0255	0.0255
Loa Loa (eye worm)	cytochrome P450 family protein	0.0047	0.0311	0.0311
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0041	0.0255	0.0438
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0019	0.0074	0.0127
Brugia malayi	serpin precursor	0.0017	0.0056	0.0056
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0041	0.0255	0.0438

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	0.222 uM	PUBCHEM_BIOASSAY: Cellular PLD1 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854]	ChEMBL.	No reference
IC50 (functional)	20 uM	PUBCHEM_BIOASSAY: Cellular PLD2 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1897334

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1573085