Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Serotonin 1a (5-HT1a) receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Dopamine D2 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrixin family protein | 0.0298 | 0.0396 | 0.1493 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0525 | 0.242 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0525 | 0.242 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0363 | 0.0974 | 0.3672 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.1376 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0661 | 0.3628 | 1 |
Plasmodium falciparum | peptide deformylase | 0.1376 | 1 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0298 | 0.0396 | 0.1092 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0525 | 0.242 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0298 | 0.0396 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0661 | 0.3628 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.0974 | 0.1789 |
Loa Loa (eye worm) | matrixin family protein | 0.0551 | 0.2654 | 0.6985 |
Treponema pallidum | polypeptide deformylase (def) | 0.1376 | 1 | 0.5 |
Onchocerca volvulus | 0.0298 | 0.0396 | 0.1092 | |
Plasmodium vivax | peptide deformylase, putative | 0.1376 | 1 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0525 | 0.242 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0298 | 0.0396 | 0.1493 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0525 | 0.242 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0525 | 0.242 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0914 | 0.5885 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0551 | 0.2654 | 1 |
Brugia malayi | Matrixin family protein | 0.0298 | 0.0396 | 0.1493 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0661 | 0.3628 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0914 | 0.5885 | 1 |
Brugia malayi | Matrixin family protein | 0.0298 | 0.0396 | 0.1493 |
Toxoplasma gondii | hypothetical protein | 0.1376 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.1376 | 1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0525 | 0.242 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.1376 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.1376 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 11 nM | Binding affinity was determined against 5-hydroxytryptamine 1A receptor using [3H]-WB-4101 | ChEMBL. | 7473547 |
Ki (binding) | > 1000 nM | Binding affinity was determined against Dopamine receptor D2 using [3H]-spiperone | ChEMBL. | 7473547 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.