Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Bos taurus | Trypsin I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Membrane-associated serine protease | Trypsin I | 246 aa | 203 aa | 20.7 % |
Echinococcus multilocularis | Mastin | Trypsin I | 246 aa | 306 aa | 23.2 % |
Drosophila melanogaster | CG4914 gene product from transcript CG4914-RA | Trypsin I | 246 aa | 246 aa | 38.2 % |
Drosophila melanogaster | CG33458 gene product from transcript CG33458-RA | Trypsin I | 246 aa | 248 aa | 28.2 % |
Echinococcus granulosus | enteropeptidase | Trypsin I | 246 aa | 230 aa | 27.0 % |
Drosophila melanogaster | Jonah 99Ci | Trypsin I | 246 aa | 237 aa | 32.9 % |
Schistosoma japonicum | Cercarial protease precursor (EC 3.4.21.-) (Cercarial elastase), putative | Trypsin I | 246 aa | 207 aa | 24.6 % |
Drosophila melanogaster | CG10405 gene product from transcript CG10405-RB | Trypsin I | 246 aa | 251 aa | 33.9 % |
Drosophila melanogaster | CG30288 gene product from transcript CG30288-RC | Trypsin I | 246 aa | 250 aa | 29.6 % |
Schistosoma japonicum | Transmembrane protease, serine 9, putative | Trypsin I | 246 aa | 250 aa | 23.6 % |
Drosophila melanogaster | Spatzle-Processing Enzyme | Trypsin I | 246 aa | 272 aa | 31.6 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 241 aa | 27.0 % |
Drosophila melanogaster | CG14990 gene product from transcript CG14990-RA | Trypsin I | 246 aa | 238 aa | 28.6 % |
Drosophila melanogaster | CG9673 gene product from transcript CG9673-RB | Trypsin I | 246 aa | 260 aa | 27.7 % |
Drosophila melanogaster | CG4815 gene product from transcript CG4815-RA | Trypsin I | 246 aa | 205 aa | 27.8 % |
Echinococcus granulosus | transmembrane protease serine 3 | Trypsin I | 246 aa | 233 aa | 33.5 % |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 241 aa | 27.0 % |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 287 aa | 27.9 % |
Drosophila melanogaster | CG18180 gene product from transcript CG18180-RA | Trypsin I | 246 aa | 233 aa | 30.0 % |
Echinococcus multilocularis | glycoprotein Antigen 5 | Trypsin I | 246 aa | 299 aa | 21.7 % |
Echinococcus multilocularis | enteropeptidase | Trypsin I | 246 aa | 230 aa | 27.0 % |
Drosophila melanogaster | CG5909 gene product from transcript CG5909-RA | Trypsin I | 246 aa | 261 aa | 28.0 % |
Echinococcus granulosus | glycoprotein Antigen 5 | Trypsin I | 246 aa | 299 aa | 23.4 % |
Drosophila melanogaster | CG11313 gene product from transcript CG11313-RC | Trypsin I | 246 aa | 223 aa | 31.8 % |
Drosophila melanogaster | Jonah 65Aiii | Trypsin I | 246 aa | 235 aa | 34.9 % |
Drosophila melanogaster | CG33465 gene product from transcript CG33465-RC | Trypsin I | 246 aa | 235 aa | 25.1 % |
Drosophila melanogaster | CG31267 gene product from transcript CG31267-RA | Trypsin I | 246 aa | 234 aa | 32.5 % |
Drosophila melanogaster | CG9733 gene product from transcript CG9733-RB | Trypsin I | 246 aa | 262 aa | 30.1 % |
Drosophila melanogaster | CG31220 gene product from transcript CG31220-RB | Trypsin I | 246 aa | 227 aa | 29.5 % |
Schistosoma japonicum | Enteropeptidase, putative | Trypsin I | 246 aa | 264 aa | 24.6 % |
Onchocerca volvulus | Trypsin I | 246 aa | 210 aa | 21.0 % | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 262 aa | 34.0 % |
Loa Loa (eye worm) | hypothetical protein | Trypsin I | 246 aa | 217 aa | 24.0 % |
Schistosoma japonicum | ko:K09637 transmembrane protease, serine 6, putative | Trypsin I | 246 aa | 242 aa | 30.6 % |
Drosophila melanogaster | CG13744 gene product from transcript CG13744-RA | Trypsin I | 246 aa | 249 aa | 31.3 % |
Echinococcus multilocularis | transmembrane protease serine 3 | Trypsin I | 246 aa | 233 aa | 33.9 % |
Echinococcus granulosus | Mastin | Trypsin I | 246 aa | 306 aa | 23.2 % |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | Trypsin I | 246 aa | 287 aa | 27.5 % |
Drosophila melanogaster | CG34436 gene product from transcript CG34436-RA | Trypsin I | 246 aa | 208 aa | 24.0 % |
Drosophila melanogaster | CG3505 gene product from transcript CG3505-RA | Trypsin I | 246 aa | 235 aa | 29.8 % |
Brugia malayi | Trypsin family protein | Trypsin I | 246 aa | 270 aa | 23.3 % |
Schistosoma japonicum | ko:K01346 pancreatic elastase II [EC3.4.21.71], putative | Trypsin I | 246 aa | 305 aa | 23.9 % |
Onchocerca volvulus | Trypsin I | 246 aa | 247 aa | 21.1 % | |
Drosophila melanogaster | Jonah 65Aii | Trypsin I | 246 aa | 265 aa | 34.3 % |
Drosophila melanogaster | CG17239 gene product from transcript CG17239-RB | Trypsin I | 246 aa | 223 aa | 34.5 % |
Drosophila melanogaster | CG18420 gene product from transcript CG18420-RA | Trypsin I | 246 aa | 243 aa | 28.8 % |
Drosophila melanogaster | CG30287 gene product from transcript CG30287-RA | Trypsin I | 246 aa | 259 aa | 26.6 % |
Drosophila melanogaster | CG30083 gene product from transcript CG30083-RB | Trypsin I | 246 aa | 209 aa | 31.1 % |
Onchocerca volvulus | Trypsin I | 246 aa | 266 aa | 22.2 % | |
Schistosoma mansoni | cercarial elastase (S01 family) | Trypsin I | 246 aa | 234 aa | 26.9 % |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | Trypsin I | 246 aa | 304 aa | 24.0 % |
Drosophila melanogaster | CG3916 gene product from transcript CG3916-RA | Trypsin I | 246 aa | 269 aa | 31.6 % |
Drosophila melanogaster | Jonah 66Ci | Trypsin I | 246 aa | 272 aa | 30.5 % |
Neospora caninum | glycine cleavage T-protein domain containing protein, putative | Trypsin I | 246 aa | 203 aa | 21.7 % |
Drosophila melanogaster | CG32277 gene product from transcript CG32277-RA | Trypsin I | 246 aa | 267 aa | 29.2 % |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | Trypsin I | 246 aa | 301 aa | 23.9 % |
Drosophila melanogaster | CG31326 gene product from transcript CG31326-RA | Trypsin I | 246 aa | 249 aa | 24.5 % |
Drosophila melanogaster | CG30323 gene product from transcript CG30323-RB | Trypsin I | 246 aa | 208 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0169 | 0.1975 | 0.1975 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0149 | 0.0149 |
Onchocerca volvulus | 0.0117 | 0.1189 | 0.0312 | |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | protein will die slowly | 0.0704 | 1 | 1 |
Onchocerca volvulus | 0.0704 | 1 | 1 | |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0149 | 0.0149 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0149 | 0.0149 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0149 | 0.0149 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0 | 0.5 |
Trichomonas vaginalis | WD repeat domain, putative | 0.0704 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.1975 | 0.1975 |
Schistosoma mansoni | hypothetical protein | 0.0704 | 1 | 1 |
Loa Loa (eye worm) | WD40 repeat protein | 0.0704 | 1 | 1 |
Echinococcus granulosus | protein will die slowly | 0.0704 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.1189 | 0.1189 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0149 | 0.0149 |
Schistosoma mansoni | alpha-glucosidase | 0.0146 | 0.1622 | 0.1622 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1189 | 0.1189 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0169 | 0.1975 | 0.1975 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.1189 | 0.1189 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0149 | 0.0149 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0117 | 0.1189 | 0.1189 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0149 | 0.0149 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0169 | 0.1975 | 0.1975 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0038 | 0 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0038 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0146 | 0.1622 | 0.1622 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0038 | 0 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.1033 | 0.0141 | |
Brugia malayi | Trypsin family protein | 0.0117 | 0.1189 | 0.1189 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0169 | 0.1975 | 0.1975 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0149 | 0.0149 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Concentration (functional) | = 1.2 ug ml-1 | Concentration of inhibitor in human plasma required to double the activated partial thromboplastin time (aPTT) | ChEMBL. | 11133089 |
Ki (binding) | = 2.6 nM | In vitro inhibition of human thrombin. | ChEMBL. | 11133089 |
Ki (binding) | = 2.6 nM | In vitro inhibition of human thrombin. | ChEMBL. | 11133089 |
Ki (binding) | = 14 nM | Inhibitory activity of the compound against Bovine Trypsin | ChEMBL. | 11133089 |
Ki (binding) | = 14 nM | Inhibitory activity of the compound against Bovine Trypsin | ChEMBL. | 11133089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.