Detailed information for compound 157655

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 192.258 | Formula: C11H16N2O
  • H donors: 1 H acceptors: 1 LogP: 1.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cn1)OC[C@@H]1CCN1
  • InChi: 1S/C11H16N2O/c1-2-9-3-4-11(7-13-9)14-8-10-5-6-12-10/h3-4,7,10,12H,2,5-6,8H2,1H3/t10-/m0/s1
  • InChiKey: BGTNWUQBMGHNII-JTQLQIEISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuronal acetylcholine receptor; alpha4/beta2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0704 0.1097 0.1081
Entamoeba histolytica hypothetical protein 0.0532 0.0784 0.0756
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0054 0.0054
Trichomonas vaginalis PIKK family atypical protein kinase 0.3027 0.5343 0.5334
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0371 0.0489 0.046
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.012 0.003 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3318 0.5873 0.5865
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0371 0.0489 0.0489
Echinococcus multilocularis fk506 binding protein 0.012 0.003 0.003
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0435 0.0606 0.0589
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4449 0.7941 0.7934
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0575 0.0863 0.0846
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0392 0.0527 0.051
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0761 0.1202 0.1202
Loa Loa (eye worm) hypothetical protein 0.0826 0.132 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.3333 0.5902 0.5894
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0392 0.0527 0.0499
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0371 0.0489 0.046
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0371 0.0489 0.922
Trichomonas vaginalis PIKK family atypical protein kinase 0.4445 0.7932 0.7928
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0575 0.0863 0.0846
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0435 0.0606 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.1074 0.1774 0.1759
Loa Loa (eye worm) phosphatidylinositol 3 0.0371 0.0489 0.0489
Loa Loa (eye worm) phosphatidylinositol 3 0.0371 0.0489 0.0489
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1074 0.1774 0.175
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5577 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0532 0.0784 0.0756
Trichomonas vaginalis PIKK family atypical protein kinase 0.4159 0.741 0.7406
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.012 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0371 0.0489 0.0471
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0392 0.0527 0.0499
Trichomonas vaginalis PIKK family atypical protein kinase 0.3032 0.5351 0.5342
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0647 0.0993 0.0993
Plasmodium vivax hypothetical protein, conserved 0.0371 0.0489 0.922
Schistosoma mansoni fkbp-rapamycin associated protein 0.1074 0.1774 0.1774
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1074 0.1774 0.175
Giardia lamblia Hypothetical protein 0.0371 0.0489 0.046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1954 0.3382 0.3362
Trichomonas vaginalis PIKK family atypical protein kinase 0.4445 0.7932 0.7928
Entamoeba histolytica hypothetical protein 0.1074 0.1774 0.175
Loa Loa (eye worm) phosphatidylinositol 3 0.0371 0.0489 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.19 0.3283 0.3271
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5577 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1954 0.3382 0.3362
Trichomonas vaginalis conserved hypothetical protein 0.0826 0.132 0.1304
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0371 0.0489 0.922
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1954 0.3382 0.3362
Leishmania major hypothetical protein, conserved 0.0468 0.0667 0.0639
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0392 0.0527 0.0527
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0205 0.0186 0.0156
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5577 1 1
Loa Loa (eye worm) hypothetical protein 0.1196 0.1997 0.1997
Loa Loa (eye worm) hypothetical protein 0.0371 0.0489 0.0489
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0121 0.0033 0.0033
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0458 0.0648 0.062
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0501 0.0727 0.0727
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0435 0.0606 0.0578
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5577 1 1
Entamoeba histolytica protein kinase rad3, putative 0.1074 0.1774 0.175
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0435 0.0606 0.0578
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1954 0.3382 0.3382
Trichomonas vaginalis PIKK family atypical protein kinase 0.3333 0.5902 0.5894
Trichomonas vaginalis PIKK family atypical protein kinase 0.19 0.3283 0.3271
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1954 0.3382 0.3382
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0121 0.0033 0.0033
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1074 0.1774 0.1774
Trichomonas vaginalis PIKK family atypical protein kinase 0.5577 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0435 0.0606 0.0589
Loa Loa (eye worm) phosphatidylinositol 3 0.1912 0.3304 0.3304
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0414 0.0567 0.0539
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5577 1 1
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.012 0.003 0.003
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0371 0.0489 0.0471
Trichomonas vaginalis PIKK family atypical protein kinase 0.3318 0.5873 0.5865
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0392 0.0527 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.1498 0.2548 0.2534
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0509 0.0742 0.0725
Trichomonas vaginalis PIKK family atypical protein kinase 0.19 0.3283 0.3271
Schistosoma mansoni voltage-gated potassium channel 0.0133 0.0054 0.0054
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0761 0.1202 0.1202
Loa Loa (eye worm) hypothetical protein 0.1127 0.1871 0.1871
Trichomonas vaginalis PIKK family atypical protein kinase 0.3619 0.6424 0.6417
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0704 0.1097 0.107
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0392 0.0527 0.0056
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0371 0.0489 0.046
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0121 0.0033 0.0003
Onchocerca volvulus 0.0371 0.0489 0.5
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5577 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0435 0.0606 0.0589
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0392 0.0527 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3032 0.5351 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0704 0.1097 0.1081
Trichomonas vaginalis PIKK family atypical protein kinase 0.4159 0.741 0.7406
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1074 0.1774 0.175
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0371 0.0489 0.046
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1074 0.1774 0.175
Leishmania major hypothetical protein, unknown function 0.0371 0.0489 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0371 0.0489 0.0471
Schistosoma mansoni hypothetical protein 0.0826 0.132 0.132
Trichomonas vaginalis PIKK family atypical protein kinase 0.3032 0.5351 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.4445 0.7932 0.7928
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0392 0.0527 0.0499
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0435 0.0606 0.0578
Entamoeba histolytica hypothetical protein 0.0371 0.0489 0.046
Echinococcus multilocularis serine protein kinase ATM 0.1074 0.1774 0.1774
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1912 0.3304 0.3284
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0392 0.0527 0.0527
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0392 0.0527 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0371 0.0489 0.0489
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.012 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.4751 0.8491 0.8488
Echinococcus multilocularis Zinc finger, PHD finger 0.0392 0.0527 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.1912 0.3304 0.3292
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0392 0.0527 0.0527
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5577 1 1
Loa Loa (eye worm) hypothetical protein 0.0501 0.0727 0.0727
Loa Loa (eye worm) phosphatidylinositol 3 0.0371 0.0489 0.0489
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0575 0.0863 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.4445 0.7932 0.7928
Echinococcus multilocularis 0.0371 0.0489 0.0489
Leishmania major phosphatidylinositol 3-kinase, putative 0.0392 0.0527 0.0499
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.263 0.4616 0.46
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1912 0.3304 0.3284
Trichomonas vaginalis PIKK family atypical protein kinase 0.1074 0.1774 0.1759
Entamoeba histolytica hypothetical protein 0.0371 0.0489 0.046
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1074 0.1774 0.175
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0371 0.0489 0.0471
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.19 0.3283 0.3263
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0371 0.0489 0.922
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0371 0.0489 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.3032 0.5351 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.4445 0.7932 0.7928
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.012 0.003 0.0011
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0371 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0704 0.1097 0.1097
Loa Loa (eye worm) phosphatidylinositol kinase 0.0371 0.0489 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.3027 0.5343 0.5334
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0371 0.0489 0.046
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5577 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0575 0.0863 0.0835
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0121 0.0033 0.0033
Schistosoma mansoni hypothetical protein 0.0371 0.0489 0.0489
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0466 0.0663 0.0635
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.012 0.003 0.0011
Schistosoma mansoni immunophilin 0.012 0.003 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0501 0.0727 0.0699
Loa Loa (eye worm) hypothetical protein 0.1074 0.1774 0.1774
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0392 0.0527 0.0527
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0647 0.0993 0.0993
Trichomonas vaginalis PIKK family atypical protein kinase 0.4159 0.741 0.7406
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1074 0.1774 0.1774
Trichomonas vaginalis immunophilin, putative 0.012 0.003 0.0011
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0392 0.0527 0.0499
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0392 0.0527 0.0527
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0371 0.0489 0.046
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5577 1 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.19 0.3283 0.3263
Loa Loa (eye worm) phosphatidylinositol 3 0.0718 0.1124 0.1124
Leishmania major phosphatidylinositol 4-kinase, putative 0.0371 0.0489 0.046
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.012 0.003 0.003
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0392 0.0527 0.0527
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0826 0.132 0.132
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1086 0.1796 0.1771
Trichomonas vaginalis PIKK family atypical protein kinase 0.19 0.3283 0.3271
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2328 0.4065 0.4047
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0509 0.0742 0.0725
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0371 0.0489 0.0489
Loa Loa (eye worm) hypothetical protein 0.0105 0.0004 0.0004
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0392 0.0527 0.0499
Giardia lamblia GTOR 0.5577 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0435 0.0606 0.0606
Mycobacterium leprae conserved hypothetical protein 0.0371 0.0489 0.5
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0186 0.0151 0.0121
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0575 0.0863 0.0835
Echinococcus granulosus serine protein kinase ATM 0.1074 0.1774 0.1774
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0371 0.0489 0.0489
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0575 0.0863 0.0835
Leishmania major phosphatidylinositol kinase related protein, putative 0.0371 0.0489 0.046
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0761 0.1202 0.1202
Trichomonas vaginalis conserved hypothetical protein 0.1196 0.1997 0.1982
Trypanosoma cruzi target of rapamycin kinase 3 0.4449 0.7941 0.7934
Loa Loa (eye worm) phosphatidylinositol 3 0.5577 1 1
Loa Loa (eye worm) FKBP5 protein 0.012 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.4159 0.741 0.7406
Onchocerca volvulus 0.0371 0.0489 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0371 0.0489 0.922
Trichomonas vaginalis PIKK family atypical protein kinase 0.3027 0.5343 0.5334
Toxoplasma gondii target of rapamycin (TOR), putative 0.4159 0.741 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0371 0.0489 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.3333 0.5902 0.5894
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0392 0.0527 0.051
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1954 0.3382 0.3382
Mycobacterium tuberculosis Conserved hypothetical protein 0.0371 0.0489 0.5
Toxoplasma gondii FATC domain-containing protein 0.1074 0.1774 0.1858
Trichomonas vaginalis PIKK family atypical protein kinase 0.4159 0.741 0.7406
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0392 0.0527 0.051
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0371 0.0489 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.5577 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0371 0.0489 0.0489
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0392 0.0527 0.0499
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0392 0.0527 0.0499
Entamoeba histolytica hypothetical protein 0.0371 0.0489 0.046
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0371 0.0489 0.922
Trichomonas vaginalis PIKK family atypical protein kinase 0.4159 0.741 0.7406
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.012 0.003 0.003
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1074 0.1774 0.1774
Plasmodium vivax hypothetical protein 0.0371 0.0489 0.922
Trichomonas vaginalis PIKK family atypical protein kinase 0.4159 0.741 0.7406
Trichomonas vaginalis PIKK family atypical protein kinase 0.3741 0.6646 0.664
Giardia lamblia Phosphatidylinositol 4-kinase 0.0371 0.0489 0.046
Brugia malayi FAT domain containing protein 0.0826 0.132 0.1294
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4449 0.7941 0.7934
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.012 0.003 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1086 0.1796 0.178
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0371 0.0489 0.046
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0575 0.0863 0.0846
Leishmania major phosphatidylinositol kinase, putative 0.0371 0.0489 0.046
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0826 0.132 0.132
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0371 0.0489 0.0489
Trichomonas vaginalis PIKK family atypical protein kinase 0.5577 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1196 0.1997 0.218
Schistosoma mansoni immunophilin 0.012 0.003 0.003
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5577 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5577 1 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0501 0.0727 0.0727
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0371 0.0489 0.046
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0435 0.0606 0.0578
Trichomonas vaginalis fk506-binding protein, putative 0.012 0.003 0.0011
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0371 0.0489 0.046

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 19 nM Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 in rat brain using [3H]-cytisine as radioligand ChEMBL. 9873625
Ki (binding) = 19 nM Binding affinity towards Nicotinic acetylcholine receptor alpha4-beta2 in rat brain using [3H]-cytisine as radioligand ChEMBL. 9873625
MED (functional) > 6.2 uM kg-1 Analgesic activity in a mouse hot plate assay ChEMBL. 9873625
MED (functional) > 6.2 uM kg-1 Analgesic activity in a mouse hot plate assay ChEMBL. 9873625

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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