TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 254.284 | Formula: C15H14N2O2
H donors: 3 H acceptors: 2 LogP: 2.62 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccccc1[C@H]1NN=C(C1)c1ccccc1O
InChi: 1S/C15H14N2O2/c18-14-7-3-1-5-10(14)12-9-13(17-16-12)11-6-2-4-8-15(11)19/h1-8,12,16,18-19H,9H2/t12-/m0/s1
InChiKey: INFGLUYMRONKHY-LBPRGKRZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0118753	0.0794158	0.0794158
Trichomonas vaginalis	tubulin gamma chain, putative	0.0151711	0.146323	0.332598
Echinococcus multilocularis	glycine receptor subunit beta	0.0118753	0.0794158	0.0794158
Schistosoma mansoni	tubulin subunit alpha	0.0209675	0.263993	0.333887
Trichomonas vaginalis	tubulin gamma chain, putative	0.0151711	0.146323	0.332598
Echinococcus multilocularis	serotonin receptor	0.0117271	0.0764066	0.0764066
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Echinococcus granulosus	peroxisome assembly protein 26	0.0209675	0.263993	0.263993
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Echinococcus multilocularis	tubulin subunit TubB	0.0209675	0.263993	0.263993
Echinococcus multilocularis	hypothetical protein	0.0209675	0.263993	0.263993
Brugia malayi	Cation transporter family protein	0.0118753	0.0794158	0.100442
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0118753	0.0794158	0.0794158
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0118753	0.0794158	0.100442
Schistosoma mansoni	nAChR subunit	0.0118753	0.0794158	0.100442
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Plasmodium vivax	tubulin alpha chain, putative	0.0209675	0.263993	0.34267
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Toxoplasma gondii	alpha-tubulin I, putative	0.0209675	0.263993	0.636658
Echinococcus granulosus	tubulin alpha chain	0.0209675	0.263993	0.263993
Schistosoma mansoni	tubulin subunit beta	0.028389	0.414654	0.524437
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Echinococcus multilocularis	serotonin receptor	0.0117271	0.0764066	0.0764066
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0118753	0.0794158	0.0794158
Echinococcus granulosus	tubulin alpha 1C chain	0.0209675	0.263993	0.263993
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Echinococcus granulosus	alpha tubulin	0.0209675	0.263993	0.263993
Onchocerca volvulus		0.0118753	0.0794158	0.100442
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0118753	0.0794158	0.0794158
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0118753	0.0794158	0.100442
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0118753	0.0794158	0.0794158
Giardia lamblia	Beta tubulin	0.028389	0.414654	1
Echinococcus multilocularis	tubulin beta 1 chain	0.028389	0.414654	0.414654
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0118753	0.0794158	0.100442
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Plasmodium falciparum	tubulin gamma chain	0.0151711	0.146323	0.352879
Echinococcus multilocularis	tubulin alpha chain	0.0209675	0.263993	0.263993
Echinococcus multilocularis	tubulin alpha chain	0.0209675	0.263993	0.263993
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0123835	0.0897327	0.191846
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0118753	0.0794158	0.0895556
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Schistosoma mansoni	hypothetical protein	0.0241724	0.329055	0.416175
Echinococcus granulosus	tubulin beta 4A class IVa	0.028389	0.414654	0.414654
Loa Loa (eye worm)	tubulin alpha chain	0.0209675	0.263993	0.297699
Echinococcus granulosus	beta tubulin	0.028389	0.414654	0.414654
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0209675	0.263993	0.625271
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0118753	0.0794158	0.100442
Trichomonas vaginalis	tubulin, putative	0.028389	0.414654	1
Loa Loa (eye worm)	BEN-1 protein	0.028389	0.414654	0.467597
Loa Loa (eye worm)	norepinephrine transporter	0.0469111	0.790664	0.891615
Loa Loa (eye worm)	LGC-31 protein	0.0118753	0.0794158	0.0895556
Echinococcus multilocularis	beta tubulin	0.028389	0.414654	0.414654
Echinococcus multilocularis	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Schistosoma mansoni	tubulin subunit beta	0.028389	0.414654	0.524437
Trypanosoma brucei	alpha tubulin	0.0209675	0.263993	0.625271
Trypanosoma brucei	alpha tubulin	0.0209675	0.263993	0.625271
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0118753	0.0794158	0.0794158
Brugia malayi	tubulin alpha chain - mouse	0.0209675	0.263993	0.333887
Brugia malayi	Tubulin alpha chain	0.0209675	0.263993	0.333887
Brugia malayi	thymidylate synthase	0.0106376	0.0542901	0.068664
Trichomonas vaginalis	tubulin beta chain, putative	0.0209675	0.263993	0.625271
Trypanosoma brucei	beta tubulin	0.0151711	0.146323	0.332598
Brugia malayi	indoleamine 2,3-dioxygenase	0.0241724	0.329055	0.416175
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0118753	0.0794158	0.0895556
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Echinococcus multilocularis	indoleamine 2,3 dioxygenase 2	0.0241724	0.329055	0.329055
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0209675	0.263993	0.625271
Trichomonas vaginalis	tubulin gamma chain, putative	0.028389	0.414654	1
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Plasmodium falciparum	alpha tubulin 1	0.0209675	0.263993	0.636658
Loa Loa (eye worm)	hypothetical protein	0.0469111	0.790664	0.891615
Brugia malayi	Cation transporter family protein	0.0118753	0.0794158	0.100442
Echinococcus multilocularis	peroxisome assembly protein 26	0.0209675	0.263993	0.263993
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0118753	0.0794158	0.0895556
Echinococcus granulosus	tubulin alpha	0.0151711	0.146323	0.146323
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.0106376	0.0542901	0.068664
Brugia malayi	Tubulin alpha-2 chain	0.0209675	0.263993	0.333887
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.00796331	0	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0118753	0.0794158	0.0794158
Echinococcus granulosus	tubulin alpha chain	0.0209675	0.263993	0.263993
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0118753	0.0794158	0.0794158
Loa Loa (eye worm)	hypothetical protein	0.0516456	0.886777	1
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Loa Loa (eye worm)	thymidylate synthase	0.0106376	0.0542901	0.0612218
Trypanosoma brucei	epsilon tubulin	0.0151711	0.146323	0.332598
Schistosoma mansoni	alpha tubulin	0.0209675	0.263993	0.333887
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118753	0.0794158	0.100442
Echinococcus granulosus	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0118753	0.0794158	0.100442
Trichomonas vaginalis	tubulin epsilon chain, putative	0.028389	0.414654	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118753	0.0794158	0.100442
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0118753	0.0794158	0.0794158
Echinococcus granulosus	tubulin alpha chain	0.0209675	0.263993	0.263993
Brugia malayi	alpha-tubulin	0.0209675	0.263993	0.333887
Schistosoma mansoni	tubulin subunit beta	0.028389	0.414654	0.524437
Echinococcus multilocularis	tubulin alpha 1C chain	0.0209675	0.263993	0.263993
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Echinococcus multilocularis	tubulin epsilon chain	0.0151711	0.146323	0.146323
Plasmodium falciparum	tubulin epsilon chain, putative	0.0151711	0.146323	0.352879
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0118753	0.0794158	0.100442
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0209675	0.263993	0.263993
Echinococcus granulosus	tubulin alpha 3 chain	0.0209675	0.263993	0.263993
Loa Loa (eye worm)	hypothetical protein	0.0376785	0.603236	0.680257
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Schistosoma mansoni	nAChR subunit	0.0118753	0.0794158	0.100442
Loa Loa (eye worm)	indoleamine 2,3-dioxygenase	0.0241724	0.329055	0.371068
Plasmodium vivax	tryptophan-rich antigen (Pv-fam-a)	0.0459129	0.7704	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.028389	0.414654	0.467597
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0118753	0.0794158	0.0794158
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0118753	0.0794158	0.0895556
Trypanosoma brucei	alpha tubulin	0.0209675	0.263993	0.625271
Echinococcus granulosus	tubulin alpha 3 chain	0.0209675	0.263993	0.263993
Onchocerca volvulus		0.0106376	0.0542901	0.068664
Toxoplasma gondii	beta-tubulin, putative	0.028389	0.414654	1
Loa Loa (eye worm)	tubulin beta chain	0.028389	0.414654	0.467597
Echinococcus multilocularis	sodium channel protein	0.0572229	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0143804	0.13027	0.292673
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0469111	0.790664	1
Loa Loa (eye worm)	hypothetical protein	0.0143804	0.13027	0.146903
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0118753	0.0794158	0.100442
Brugia malayi	Tubulin beta chain	0.00858399	0.0126002	0.0159363
Echinococcus multilocularis	tubulin alpha 3 chain	0.0209675	0.263993	0.263993
Echinococcus multilocularis	serotonin transporter	0.0469111	0.790664	0.790664
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0209675	0.263993	0.263993
Plasmodium vivax	tubulin alpha chain, putative	0.0209675	0.263993	0.34267
Brugia malayi	Tubulin gamma chain	0.0151711	0.146323	0.185063
Trypanosoma cruzi	beta tubulin, putative	0.028389	0.414654	1
Loa Loa (eye worm)	hypothetical protein	0.0209675	0.263993	0.297699
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0118753	0.0794158	0.0794158
Echinococcus multilocularis	tubulin alpha chain	0.0209675	0.263993	0.263993
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0123835	0.0897327	0.10119
Schistosoma mansoni	nAChR subunit	0.0118753	0.0794158	0.100442
Echinococcus multilocularis	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Echinococcus granulosus	thymidylate synthase	0.0106376	0.0542901	0.0542901
Echinococcus granulosus	tubulin epsilon chain	0.0151711	0.146323	0.146323
Trypanosoma brucei	epsilon tubulin	0.0151711	0.146323	0.332598
Toxoplasma gondii	beta tubulin	0.028389	0.414654	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.028389	0.414654	1
Trypanosoma cruzi	alpha tubulin, putative	0.0209675	0.263993	0.446723
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0118753	0.0794158	0.0794158
Echinococcus granulosus	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Trichomonas vaginalis	tubulin beta chain, putative	0.0209675	0.263993	0.625271
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0118753	0.0794158	0.0794158
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0118753	0.0794158	0.100442
Entamoeba histolytica	tubulin family protein	0.028389	0.414654	1
Giardia lamblia	Alpha-tubulin	0.0209675	0.263993	0.438526
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0118753	0.0794158	0.100442
Brugia malayi	Tubulin beta-1 chain	0.028389	0.414654	0.524437
Echinococcus granulosus	glycine receptor subunit beta	0.0118753	0.0794158	0.0794158
Echinococcus granulosus	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Brugia malayi	Tubulin alpha-2 chain	0.0209675	0.263993	0.333887
Onchocerca volvulus		0.0469111	0.790664	1
Leishmania major	epsilon tubulin, putative	0.0151711	0.146323	0.00463488
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0118753	0.0794158	0.0794158
Trypanosoma brucei	beta tubulin	0.028389	0.414654	1
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0118753	0.0794158	0.0794158
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0117271	0.0764066	0.096636
Trichomonas vaginalis	tubulin beta chain, putative	0.0209675	0.263993	0.625271
Echinococcus multilocularis	tubulin alpha chain	0.0209675	0.263993	0.263993
Echinococcus multilocularis	tubulin alpha 1C chain	0.0209675	0.263993	0.263993
Entamoeba histolytica	tubulin alpha chain, putative	0.0209675	0.263993	0.438526
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0118753	0.0794158	0.0895556
Loa Loa (eye worm)	serotonin transporter b	0.0469111	0.790664	0.891615
Schistosoma mansoni	tubulin subunit beta	0.028389	0.414654	0.524437
Echinococcus multilocularis	nAChR subunit	0.0118753	0.0794158	0.0794158
Echinococcus granulosus	indoleamine 23 dioxygenase 2	0.0241724	0.329055	0.329055
Treponema pallidum	sodium- and chloride- dependent transporter	0.0469111	0.790664	0.5
Echinococcus multilocularis	tubulin alpha chain	0.0209675	0.263993	0.263993
Echinococcus granulosus	Tubulin alpha 1 chain	0.0209675	0.263993	0.263993
Toxoplasma gondii	beta-1 tubulin, putative	0.028389	0.414654	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.028389	0.414654	1
Loa Loa (eye worm)	tubulin gamma chain	0.0151711	0.146323	0.165005
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0118753	0.0794158	0.0794158
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118753	0.0794158	0.100442
Onchocerca volvulus	Putative nachr subunit	0.0118753	0.0794158	0.100442
Loa Loa (eye worm)	hypothetical protein	0.0469111	0.790664	0.891615
Schistosoma mansoni	tubulin subunit alpha	0.0209675	0.263993	0.333887
Loa Loa (eye worm)	tubulin alpha 2	0.0143804	0.13027	0.146903
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0118753	0.0794158	0.0794158
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Loa Loa (eye worm)	hypothetical protein	0.0117271	0.0764066	0.0861621
Loa Loa (eye worm)	hypothetical protein	0.0469111	0.790664	0.891615
Echinococcus granulosus	nAChR subunit	0.0118753	0.0794158	0.0794158
Plasmodium falciparum	tubulin beta chain	0.028389	0.414654	1
Trypanosoma brucei	tubulin gamma chain	0.0151711	0.146323	0.332598
Echinococcus multilocularis	tubulin alpha	0.0151711	0.146323	0.146323
Trypanosoma brucei	beta tubulin	0.028389	0.414654	1
Echinococcus granulosus	sodium channel protein	0.0572229	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.028389	0.414654	0.414654
Schistosoma mansoni	nAChR subunit	0.0118753	0.0794158	0.100442
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0118753	0.0794158	0.0794158
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0118753	0.0794158	0.100442
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Mycobacterium ulcerans	thymidylate synthase	0.0106376	0.0542901	0.5
Echinococcus multilocularis	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Trypanosoma cruzi	tubulin gamma chain	0.0151711	0.146323	0.0145979
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0149753	0.142347	0.322711
Echinococcus granulosus	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.0106376	0.0542901	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0117271	0.0764066	0.0764066
Echinococcus granulosus	serotonin transporter	0.0469111	0.790664	0.790664
Loa Loa (eye worm)	tubulin beta-2A chain	0.028389	0.414654	0.467597
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0209675	0.263993	0.263993
Loa Loa (eye worm)	tubulin beta-1 chain	0.028389	0.414654	0.467597
Loa Loa (eye worm)	BEN-1 protein	0.028389	0.414654	0.467597
Plasmodium falciparum	alpha tubulin 2	0.0209675	0.263993	0.636658
Trichomonas vaginalis	tubulin beta chain, putative	0.0209675	0.263993	0.625271
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0572229	1	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0151711	0.146323	0.0145979
Echinococcus granulosus	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Loa Loa (eye worm)	ACC-1 protein	0.0118753	0.0794158	0.0895556
Trypanosoma brucei	beta tubulin	0.028389	0.414654	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118753	0.0794158	0.100442
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Brugia malayi	Cation transporter family protein	0.0118753	0.0794158	0.100442
Echinococcus granulosus	beta tubulin	0.028389	0.414654	0.414654
Giardia lamblia	Beta tubulin	0.028389	0.414654	1
Loa Loa (eye worm)	ACC-1 protein	0.0118753	0.0794158	0.0895556
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118753	0.0794158	0.100442
Loa Loa (eye worm)	hypothetical protein	0.0123835	0.0897327	0.10119
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Echinococcus granulosus	tubulin gamma 1 chain	0.0151711	0.146323	0.146323
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0143804	0.13027	0.146903
Loa Loa (eye worm)	beta-tubulin	0.028389	0.414654	0.467597
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0118753	0.0794158	0.100442
Loa Loa (eye worm)	tubulin alpha 2	0.0143804	0.13027	0.146903
Echinococcus multilocularis	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0209675	0.263993	0.625271
Brugia malayi	beta-tubulin, identical	0.028389	0.414654	0.524437
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Echinococcus multilocularis	glycine receptor subunit beta	0.0118753	0.0794158	0.0794158
Onchocerca volvulus		0.0118753	0.0794158	0.100442
Echinococcus multilocularis	tubulin subunit beta	0.028389	0.414654	0.414654
Onchocerca volvulus		0.00858399	0.0126002	0.0159363
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0149753	0.142347	0.343292
Giardia lamblia	Beta tubulin	0.028389	0.414654	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0469111	0.790664	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0118753	0.0794158	0.100442
Echinococcus granulosus	tubulin alpha chain	0.0209675	0.263993	0.263993
Schistosoma mansoni	tubulin subunit gamma	0.0151711	0.146323	0.185063
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0118753	0.0794158	0.0895556
Onchocerca volvulus		0.0118753	0.0794158	0.100442
Trichomonas vaginalis	tubulin alpha chain, putative	0.0151711	0.146323	0.332598
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0149753	0.142347	0.343292
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0209675	0.263993	0.297699
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0118753	0.0794158	0.100442
Trypanosoma cruzi	epsilon tubulin, putative	0.0151711	0.146323	0.0145979
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0118753	0.0794158	0.0794158
Entamoeba histolytica	tubulin alpha-1 chain	0.0209675	0.263993	0.438526
Trichomonas vaginalis	tubulin beta chain, putative	0.0209675	0.263993	0.625271
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0118753	0.0794158	0.100442
Schistosoma mansoni	tubulin subunit beta	0.028389	0.414654	0.524437
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0118753	0.0794158	0.0794158
Loa Loa (eye worm)	alpha-tubulin	0.0209675	0.263993	0.297699
Echinococcus granulosus	Tubulin alpha 1 chain	0.0209675	0.263993	0.263993
Echinococcus granulosus	glycine receptor subunit beta	0.0118753	0.0794158	0.0794158
Echinococcus granulosus	Tubulin alpha 1 chain	0.0209675	0.263993	0.263993
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0118753	0.0794158	0.100442
Plasmodium vivax	tubulin gamma chain, putative	0.0151711	0.146323	0.189931
Entamoeba histolytica	tubulin family protein	0.028389	0.414654	1
Loa Loa (eye worm)	tubulin alpha chain	0.0209675	0.263993	0.297699
Schistosoma mansoni	tubulin subunit alpha	0.0209675	0.263993	0.333887
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0151711	0.146323	0.352879
Trichomonas vaginalis	tubulin beta chain, putative	0.0209675	0.263993	0.625271
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0572229	1	1
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0149753	0.142347	0.184771
Toxoplasma gondii	alpha tubulin TUBA1	0.0209675	0.263993	0.636658
Schistosoma mansoni	tubulin subunit beta	0.028389	0.414654	0.524437
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.0106376	0.0542901	0.5
Echinococcus granulosus	tubulin alpha chain	0.0209675	0.263993	0.263993
Echinococcus granulosus	tubulin subunit beta	0.028389	0.414654	0.414654
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0434576	0.720556	0.91133
Echinococcus granulosus	tubulin alpha 1C chain	0.0209675	0.263993	0.263993
Loa Loa (eye worm)	hypothetical protein	0.0117271	0.0764066	0.0861621
Echinococcus granulosus	tubulin subunit TubB	0.0209675	0.263993	0.263993
Schistosoma mansoni	nAChR subunit	0.0118753	0.0794158	0.100442
Schistosoma mansoni	nAChR subunit	0.0118753	0.0794158	0.100442
Trichomonas vaginalis	tubulin beta chain, putative	0.028389	0.414654	1
Onchocerca volvulus		0.0118753	0.0794158	0.100442
Trypanosoma brucei	epsilon tubulin	0.0151711	0.146323	0.332598
Schistosoma mansoni	alpha tubulin	0.0209675	0.263993	0.333887
Echinococcus multilocularis	tubulin alpha 3 chain	0.0209675	0.263993	0.263993
Schistosoma mansoni	alpha tubulin	0.0209675	0.263993	0.333887
Trypanosoma brucei	alpha tubulin	0.0209675	0.263993	0.625271
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Echinococcus multilocularis	beta tubulin	0.028389	0.414654	0.414654
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0469111	0.790664	0.891615
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0469111	0.790664	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.028389	0.414654	0.414654
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Schistosoma mansoni	hypothetical protein	0.0241724	0.329055	0.416175
Leishmania major	gamma-tubulin	0.0151711	0.146323	0.00463488
Schistosoma mansoni	tubulin subunit epsilon	0.0151711	0.146323	0.185063
Echinococcus multilocularis	tubulin gamma 1 chain	0.0151711	0.146323	0.146323
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0118753	0.0794158	0.0794158
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Loa Loa (eye worm)	hypothetical protein	0.0434576	0.720556	0.812556
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Brugia malayi	tubulin alpha-2 chain	0.0209675	0.263993	0.333887
Leishmania major	beta tubulin	0.028389	0.414654	0.317502
Loa Loa (eye worm)	hypothetical protein	0.0118753	0.0794158	0.0895556
Plasmodium vivax	tubulin epsilon chain, putative	0.0151711	0.146323	0.189931
Brugia malayi	excitatory GABA receptor EXP-1A	0.0118753	0.0794158	0.100442
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0118753	0.0794158	0.100442
Echinococcus multilocularis	thymidylate synthase	0.0106376	0.0542901	0.0542901
Trypanosoma brucei	beta tubulin	0.028389	0.414654	1
Onchocerca volvulus		0.0118753	0.0794158	0.100442
Giardia lamblia	Alpha-tubulin	0.0209675	0.263993	0.438526
Echinococcus multilocularis	Tubulin beta 2C chain	0.028389	0.414654	0.414654
Plasmodium vivax	tubulin beta chain, putative	0.028389	0.414654	0.538232
Schistosoma mansoni	nAChR subunit	0.0118753	0.0794158	0.100442
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Loa Loa (eye worm)	alpha-tubulin	0.0209675	0.263993	0.297699
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835
Onchocerca volvulus		0.0118753	0.0794158	0.100442
Leishmania major	alpha tubulin	0.0209675	0.263993	0.141835

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)		Bactericidal activity against Mycobacterium tuberculosis H37Rv in GASTD medium at 2 times MIC after 30 days by colony counting	ChEMBL.	21940166
IC50 (functional)	= 18 uM	Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 after 10 days by spectrophotometric analysis	ChEMBL.	21940166
IC50 (functional)	= 25 uM	Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium after 10 days by spectrophotometric analysis	ChEMBL.	21940166
MIC90 (functional)	= 59 uM	Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 after 10 days by spectrophotometric analysis	ChEMBL.	21940166
MIC90 (functional)	= 66 uM	Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium after 10 days by spectrophotometric analysis	ChEMBL.	21940166
Ratio (functional)	= 1	Ratio of MIC90 for Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 to MIC90 for Mycobacterium tuberculosis H37Rv in Fe-deficient GASTD medium	ChEMBL.	21940166
Ratio IC50 (functional)	= 1	Ratio of IC50 for Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 to IC50 for Mycobacterium tuberculosis H37Rv in Fe-deficient GASTD medium	ChEMBL.	21940166

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mycobacterium tuberculosis		21940166

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1916841

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1578621