Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Neuronal acetylcholine receptor protein alpha-7 subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0372 | 0.094 | 0.094 |
Brugia malayi | Choline O-acetyltransferase | 0.0372 | 0.094 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0023 | 0.0023 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1714 | 0.5458 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0372 | 0.094 | 1 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0604 | 0.1721 | 0.1729 |
Loa Loa (eye worm) | hypothetical protein | 0.3062 | 1 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0372 | 0.094 | 0.0918 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0604 | 0.1721 | 0.1702 |
Schistosoma mansoni | choline o-acyltransferase | 0.0372 | 0.094 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0372 | 0.094 | 0.0918 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0023 | 0.0023 |
Onchocerca volvulus | 0.0372 | 0.094 | 1 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0604 | 0.1721 | 1 |
Onchocerca volvulus | 0.0372 | 0.094 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1714 | 0.5458 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0372 | 0.094 | 0.094 |
Onchocerca volvulus | 0.0372 | 0.094 | 1 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0604 | 0.1721 | 0.1729 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0604 | 0.1721 | 0.1729 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0604 | 0.1721 | 0.1729 |
Onchocerca volvulus | 0.0372 | 0.094 | 1 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1714 | 0.5458 | 1 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1714 | 0.5458 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0604 | 0.1721 | 0.1721 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1714 | 0.5458 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0372 | 0.094 | 0.094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 15 % | Displacement of [3H]-epibatidine from alpha1betagammadelta nAChR in human TE671 cellular membranes at 5 uM after 2 hrs by liquid scintillation counting | ChEMBL. | 21986237 |
Inhibition (binding) | = 15 % | Displacement of [3H]epibatidine from human alpha1betagammadelta nAchR expressed in TE-671 cell membrane at 5 uM | ChEMBL. | 22177081 |
Inhibition (binding) | = 32 % | Displacement of [3H]-epibatidine from alpha4beta2 nAChR in rat cortical membranes at 5 uM after 2 hrs by liquid scintillation counting | ChEMBL. | 21986237 |
Inhibition (binding) | = 32 % | Displacement of [3H]epibatidine from human alpha4beta2 nAchR expressed in SH-EP1 cells at 5 uM | ChEMBL. | 22177081 |
Inhibition (binding) | = 55 % | Displacement of [3H]-epibatidine from alpha3beta4 nAChR in human SH-SY5Y cellular membranes at 5 uM after 2 hrs by liquid scintillation counting | ChEMBL. | 21986237 |
Inhibition (binding) | = 55 % | Displacement of [3H]epibatidine from human alpha3beta4 nAchR expressed in SH-SY5Y cells at 5 uM | ChEMBL. | 22177081 |
Inhibition (binding) | = 93 % | Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes at 5 uM after 2 hrs by liquid scintillation counting | ChEMBL. | 21986237 |
Ki (binding) | = 7.2 nM | Displacement of [3H]-methyllycaconitine from alpha7 nAChR in rat hippocampal membranes after 2 hrs by liquid scintillation counting | ChEMBL. | 21986237 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.