TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 245.363 | Formula: C15H23N3
H donors: 0 H acceptors: 0 LogP: 2.17 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Cc1cccc(c1)CCN1[C@@H](C)CN=C1N(C)C
InChi: 1S/C15H23N3/c1-12-6-5-7-14(10-12)8-9-18-13(2)11-16-15(18)17(3)4/h5-7,10,13H,8-9,11H2,1-4H3/t13-/m0/s1
InChiKey: XCRACYKSNWKJHL-ZDUSSCGKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0436
Schistosoma mansoni	hypothetical protein	0.0101	0.2253	0.603
Brugia malayi	cytoplasmic intermediate filament protein	0.0014	0.0196	0.0424
Trypanosoma cruzi	hexose transporter, putative	0.0017	0.027	0.386
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0152	0.0328
Schistosoma mansoni	hypothetical protein	0.0164	0.3737	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3279	0.7095
Brugia malayi	Sugar transporter family protein	0.0101	0.2253	0.4877
Leishmania major	glucose transporter, lmgt3	0.0031	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0163	0.0353
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0436
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0911	0.2437
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0701	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0911	0.2437
Toxoplasma gondii	protein kinase, putative	0.0285	0.6612	1
Echinococcus granulosus	geminin	0.0164	0.3737	1
Trypanosoma cruzi	sugar transporter, putative	0.0014	0.0201	0.2874
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0163	0.3724	0.3724
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0597	0.1292
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0031	0.0597	0.0597
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1067
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0436
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Schistosoma mansoni	glucose transporter	0.0014	0.0201	0.0539
Schistosoma mansoni	glucose transport protein	0.0101	0.2253	0.603
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0548	0.1466
Plasmodium vivax	SET domain protein, putative	0.0029	0.0548	0.0548
Echinococcus multilocularis	muscleblind protein 1	0.0144	0.3279	0.8773
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0606	0.1149
Plasmodium vivax	sugar transporter, putative	0.0014	0.0201	0.0201
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	0.5469
Loa Loa (eye worm)	hypothetical protein	0.003	0.0582	0.126
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0031	0.0597	0.1292
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0035	0.0701	0.106
Echinococcus multilocularis	lamin	0.0026	0.0482	0.1289
Leishmania major	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.2874
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0163	0.3724	0.3724
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0606	0.8651
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.1597
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0014	0.0201	0.0539
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0482	0.1043
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Leishmania major	protein kinase, putative	0.0031	0.0597	0.8517
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0031	0.0597	0.0597
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0539
Giardia lamblia	Sugar-proton symporter	0.0014	0.0201	0.346
Brugia malayi	intermediate filament protein	0.0026	0.0482	0.1043
Toxoplasma gondii	sugar transporter ST3	0.0014	0.0201	0.0305
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Leishmania major	glucose transporter, lmgt1	0.0031	0.0606	0.8651
Echinococcus multilocularis	General substrate transporter	0.0087	0.1918	0.5131
Brugia malayi	Pre-SET motif family protein	0.0201	0.4621	1
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0436
Onchocerca volvulus	Huntingtin homolog	0.0118	0.2665	0.4853
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0382
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0013	0.0163	0.0436
Echinococcus multilocularis	muscleblind protein	0.0144	0.3279	0.8773
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0606	0.1149
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0911	0.1971
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0482	0.1043
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0606	0.1149
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0031	0.0597	0.0597
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0539
Schistosoma mansoni	lysyl-tRNA synthetase	0.0023	0.0399	0.1067
Trichomonas vaginalis	sugar transport protein, putative	0.0014	0.0201	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0.2253	0.427
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0382
Onchocerca volvulus		0.0029	0.0548	0.0682
Onchocerca volvulus	Huntingtin homolog	0.0118	0.2665	0.4853
Leishmania major	glucose transporter, lmgt2	0.0031	0.0606	0.8651
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0031	0.0606	0.8651
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0606	0.8651
Trypanosoma cruzi	hexose transporter	0.0031	0.0606	0.8651
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.1597
Brugia malayi	Cam kinase protein 1	0.0031	0.0597	0.1292
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.2253	0.603
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.1597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.1597
Trypanosoma brucei	glucose transporter 2A	0.0031	0.0606	0.8651
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0031	0.0597	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0152	0.0328
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.003	0.0582	0.126
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0012	0.016	0.0346
Loa Loa (eye worm)	hypothetical protein	0.003	0.0582	0.126
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0382
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0014	0.0201	0.0436
Schistosoma mansoni	glucose transport protein	0.0101	0.2253	0.603
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0436
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0019	0.0318	1
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0539
Plasmodium falciparum	hexose transporter	0.0101	0.2253	0.2253
Entamoeba histolytica	protein kinase, putative	0.0031	0.0597	1
Trypanosoma cruzi	glucose transporter, putative	0.0014	0.0201	0.2874
Giardia lamblia	Hexose transporter	0.0014	0.0201	0.346
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Entamoeba histolytica	protein kinase, putative	0.0031	0.0597	1
Trichomonas vaginalis	glucose transporter, putative	0.0031	0.0606	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Plasmodium vivax	proline--tRNA ligase, putative	0.0035	0.0701	0.0701
Mycobacterium ulcerans	sugar transporter	0.0014	0.0201	0.5052
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0606	0.8651
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0014	0.0201	0.0539
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0523	0.1398
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.003	0.0582	0.1103
Brugia malayi	Major Facilitator Superfamily protein	0.0014	0.0201	0.0436
Schistosoma mansoni	lamin	0.0026	0.0482	0.1289
Schistosoma mansoni	lamin	0.0026	0.0482	0.1289
Loa Loa (eye worm)	hypothetical protein	0.0118	0.2665	0.5767
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0101	0.2253	0.603
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0911	0.2437
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0911	0.2437
Giardia lamblia	Lysyl-tRNA synthetase	0.0023	0.0399	0.6849
Echinococcus multilocularis	lysyl tRNA synthetase	0.0023	0.0399	0.1067
Plasmodium falciparum	proline--tRNA ligase	0.0035	0.0701	0.0701
Echinococcus granulosus	synaptic vesicle 2 protein	0.0014	0.0201	0.0539
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Loa Loa (eye worm)	sugar transporter	0.0014	0.0201	0.0436
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Trichomonas vaginalis	myo-inositol transporter, putative	0.0014	0.0201	0.0382
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Toxoplasma gondii	lysine-tRNA ligase	0.0023	0.0399	0.0603
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0582	0.1557
Leishmania major	hypothetical protein, conserved	0.0014	0.0201	0.2874
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0436
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0014	0.0201	0.6328
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0911	0.1971
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0031	0.0597	0.0903
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.003	0.0582	0.9752
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Giardia lamblia	Prolyl-tRNA synthetase	0.003	0.0582	1
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0119	1
Mycobacterium ulcerans	integral membrane transport protein	0.0014	0.0201	0.5052
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.1597
Trypanosoma cruzi	hexose transporter, putative	0.0014	0.0201	0.2874
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0548	0.1466
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0031	0.0597	0.0597
Leishmania major	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.5689
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.1597
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0031	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0031	0.0597	0.1292
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Trypanosoma brucei	sugar transporter, putative	0.0014	0.0201	0.2874
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0539
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0548	0.1466
Echinococcus multilocularis	calcium dependent protein kinase	0.0029	0.0552	0.1476
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0606	0.8651
Echinococcus granulosus	muscleblind protein	0.0144	0.3279	0.8773
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0606	0.8651
Echinococcus granulosus	intermediate filament protein	0.0026	0.0482	0.1289
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0539
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Echinococcus multilocularis	lamin dm0	0.0026	0.0482	0.1289
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0606	0.1149
Brugia malayi	hypothetical protein	0.0014	0.0201	0.0436
Echinococcus granulosus	General substrate transporter	0.0087	0.1918	0.5131
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0448	0.0969
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0014	0.0201	0.2874
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0539
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0436
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0606	0.8651
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.2253	0.603
Echinococcus granulosus	lamin dm0	0.0026	0.0482	0.1289
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0482	0.1043
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0023	0.0399	0.6849
Schistosoma mansoni	hypothetical protein	0.0164	0.3737	1
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0606	0.8651
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.2253	0.603
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Onchocerca volvulus		0.0229	0.5278	1
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.1597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Plasmodium vivax	lysine--tRNA ligase, putative	0.0023	0.0399	0.0399
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0014	0.0201	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0118	0.2665	0.5767
Brugia malayi	Pre-SET motif family protein	0.0029	0.0548	0.1185
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Echinococcus granulosus	lamin	0.0026	0.0482	0.1289
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.003	0.0582	0.1557
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0014	0.0201	0.5052
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0031	0.0597	0.0597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Chlamydia trachomatis	lysine--tRNA ligase	0.0023	0.0399	1
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0606	0.1149
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0119	0.2978
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0606	0.8651
Plasmodium falciparum	protein kinase 7	0.0285	0.6612	0.6612
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.2253	0.603
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0019	0.0318	1
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0014	0.0201	1
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0548	0.0828
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0382
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0606	0.8651
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3279	0.7095
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0548	0.1466
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.5278	1
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.2253	0.603
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0911	0.2437
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0606	0.8651
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0014	0.0201	0.6328
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0548	0.1466
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0023	0.0399	0.0755
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.1597
Trichomonas vaginalis	CAMK family protein kinase	0.0031	0.0597	0.1131
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Plasmodium vivax	hexose transporter	0.0101	0.2253	0.2253
Brugia malayi	major facilitator superfamily protein	0.0014	0.0201	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0471	0.1018
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Onchocerca volvulus		0.0026	0.0482	0.0552
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0035	0.0701	1
Schistosoma mansoni	glucose transport protein	0.0101	0.2253	0.603
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0101	0.2253	0.603
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.003	0.0582	0.1557
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0201	0.0382
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0031	0.0597	0.0597
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.003	0.0582	0.126
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.003	0.0582	0.1557
Trichomonas vaginalis	sugar transporter, putative	0.0031	0.0606	0.1149
Toxoplasma gondii	transporter, major facilitator family protein	0.0014	0.0201	0.0305
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0014	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Brugia malayi	Sugar transporter family protein	0.0014	0.0201	0.0436
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0014	0.0201	0.0539
Echinococcus multilocularis	geminin	0.0164	0.3737	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0701	1
Brugia malayi	hypothetical protein	0.0118	0.2665	0.5767
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0539
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0429	1	1
Entamoeba histolytica	hypothetical protein	0.0023	0.0399	0.6679
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Toxoplasma gondii	facilitative glucose transporter GT1	0.0101	0.2253	0.3408
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0014	0.0201	0.5052
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0163	0.3724	0.5632
Toxoplasma gondii	sugar transporter ST2	0.0014	0.0201	0.0305
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Brugia malayi	Muscleblind-like protein	0.0144	0.3279	0.7095
Echinococcus granulosus	lysyl tRNA synthetase	0.0023	0.0399	0.1067
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0539
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0701	1
Trypanosoma brucei	glucose transporter, putative	0.0031	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0031	0.0597	0.0903
Trichomonas vaginalis	glucose transporter, putative	0.0014	0.0201	0.0382
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0013	0.0163	0.0436
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0031	0.0597	0.1292
Onchocerca volvulus		0.0026	0.0482	0.0552
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0548	0.1466
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0201	0.4621	1
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Echinococcus multilocularis	musashi	0.0026	0.0482	0.1289
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0482	0.1289
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0119	0.2978
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Schistosoma mansoni	sugar transporter	0.0014	0.0201	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0548	0.1185
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0101	0.2253	0.603
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Trypanosoma brucei	glucose transporter 1E	0.0031	0.0606	0.8651
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Loa Loa (eye worm)	sugar transporter	0.0101	0.2253	0.4877
Echinococcus multilocularis	solute carrier family 22	0.0014	0.0201	0.0539
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Echinococcus granulosus	solute carrier family 22	0.0014	0.0201	0.0539
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0023	0.0399	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0482	0.1043
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0031	0.0597	0.1597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Brugia malayi	lysyl-tRNA synthetase	0.0023	0.0399	0.0863
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0031	0.0606	0.8651
Schistosoma mansoni	protein kinase	0.0031	0.0597	0.1597
Trypanosoma cruzi	hexose transporter, putative	0.0031	0.0606	0.8651
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0031	0.0597	0.8517
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.0196	0.0424
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0399	0.0863
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Schistosoma mansoni	serine/threonine protein kinase	0.0031	0.0597	0.1597
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.003	0.0582	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0031	0.0597	0.0597
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0031	0.0597	0.1597
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0548	0.1466
Toxoplasma gondii	sugar transporter ST1	0.0014	0.0201	0.0305
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0031	0.0597	0.0903
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0201	0.0436
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.002	0.0333	0.0631
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0035	0.0701	1
Echinococcus granulosus	calcium dependent protein kinase	0.0029	0.0552	0.1476
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0911	0.2437
Trichomonas vaginalis	sugar transporter, putative	0.0014	0.0201	0.0382
Plasmodium falciparum	lysine--tRNA ligase	0.0023	0.0399	0.0399
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0911	0.2437

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	5.0119 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1891726

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1582324