TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 381.447 | Formula: C21H24FN5O
H donors: 1 H acceptors: 3 LogP: 3.46 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Fc1cccc(c1)n1ncc2c1CC(C)(C)CC2NC(=O)c1cc(n(n1)C)C
InChi: 1S/C21H24FN5O/c1-13-8-17(25-26(13)4)20(28)24-18-10-21(2,3)11-19-16(18)12-23-27(19)15-7-5-6-14(22)9-15/h5-9,12,18H,10-11H2,1-4H3,(H,24,28)
InChiKey: RKCCYHPULNJLHC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	Starlite/ChEMBL	No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	snurportin 1		No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase	Get druggable targets OG5_128068	All targets in OG5_128068
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase	Get druggable targets OG5_128068	All targets in OG5_128068
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria	Get druggable targets OG5_128068	All targets in OG5_128068
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	Get druggable targets OG5_128068	All targets in OG5_128068
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Mycobacterium tuberculosis	Probable aminotransferase	Get druggable targets OG5_128068	All targets in OG5_128068
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	Get druggable targets OG5_128068	All targets in OG5_128068
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria	Get druggable targets OG5_128068	All targets in OG5_128068
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	acetylornithine aminotransferase, putative	Get druggable targets OG5_128068	All targets in OG5_128068
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Mycobacterium ulcerans	hypothetical protein	Get druggable targets OG5_128068	All targets in OG5_128068
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	Get druggable targets OG5_128068	All targets in OG5_128068
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Mycobacterium leprae	Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	437 aa	397 aa	28.5 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	importin beta, putative	0.0035	0.0394	0.9419
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0009	0	0.0001
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0079	0.1076	0.1074
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0026	0.0252	0.0451
Trypanosoma brucei	trypanothione reductase	0.0036	0.0415	1
Loa Loa (eye worm)	glutathione reductase	0.0036	0.0415	0.0742
Echinococcus multilocularis	microtubule associated protein 2	0.066	1	1
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0083	0.1127	0.4094
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0218	0.4763
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0079	0.1076	0.2866
Brugia malayi	Thioredoxin reductase	0.0036	0.0415	0.1105
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0052	0.0333
Echinococcus granulosus	snurportin 1	0.0372	0.5568	0.5567
Schistosoma mansoni	hypothetical protein	0.0079	0.1076	0.1058
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.001	0.002	0.0018
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0252	0.5681
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0026	0.0252	0.5532
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0307	0.0287
Brugia malayi	RNA, U transporter 1	0.0099	0.138	0.3676
Loa Loa (eye worm)	hypothetical protein	0.0079	0.1076	0.193
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.001	0.002	0.0018
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0394	0.5716
Echinococcus granulosus	single minded 2	0.0033	0.0372	0.037
Brugia malayi	hypothetical protein	0.0151	0.2184	0.5819
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0026	0.026	0.0562
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0422	0.0421
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0052	0.0333
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.0079	0.1076	0.1074
Mycobacterium ulcerans	glutaminase	0.0254	0.3753	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0027	0.0268	0.0479
Trypanosoma cruzi	PAB1-binding protein , putative	0.0023	0.0218	0.4763
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0026	0.026	0.0692
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0052	0.0333
Brugia malayi	Importin beta-1 subunit	0.0035	0.0394	0.1049
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0218	0.4582
Mycobacterium tuberculosis	Probable aminotransferase	0.0184	0.2678	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0307	0.0305
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0026	0.026	0.0793
Mycobacterium leprae	Probable Acetylornithine aminotransferase ArgD	0.0026	0.026	0.0836
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0026	0.026	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0218	0.0389
Loa Loa (eye worm)	hypoxia-induced factor 1	0.014	0.2004	0.3597
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	0.5568	1
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0184	0.2678	0.7106
Schistosoma mansoni	cpg binding protein	0.0028	0.0291	0.0272
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0052	0.0333
Trypanosoma brucei	PAB1-binding protein , putative	0.0023	0.0218	0.4582
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0079	0.1076	0.1058
Echinococcus multilocularis	cpg binding protein	0.0028	0.0291	0.029
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0083	0.1127	0.4122
Mycobacterium tuberculosis	Probable dehydrogenase	0.0083	0.1127	0.4094
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0013	0.0052	0.0333
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0026	0.0252	1
Schistosoma mansoni	hypothetical protein	0.0379	0.5686	0.5677
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0026	0.0252	0.5532
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0092	0.1268	0.4658
Plasmodium vivax	ataxin-2 like protein, putative	0.0023	0.0218	0.4582
Onchocerca volvulus		0.0033	0.0372	0.1006
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0052	0.0137
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0184	0.2678	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0394	0.9419
Mycobacterium tuberculosis	Probable oxidoreductase	0.0092	0.1268	0.4633
Brugia malayi	glutaminase DH11.1	0.0254	0.3753	1
Schistosoma mansoni	aryl hydrocarbon receptor	0.0045	0.0552	0.0533
Trypanosoma cruzi	trypanothione reductase, putative	0.0036	0.0415	1
Schistosoma mansoni	microtubule-associated protein tau	0.066	1	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0307	0.0305
Mycobacterium ulcerans	putative regulatory protein	0.0033	0.0372	0.0865
Brugia malayi	glutathione reductase	0.0036	0.0415	0.1105
Schistosoma mansoni	apoptosis regulator bax	0.0079	0.1076	0.1058
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0083	0.1127	0.4094
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0052	0.0032
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0394	0.9419
Leishmania major	GTP-binding protein, putative	0.0026	0.0252	0.5681
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0052	0.0333
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0026	0.026	0.3478
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0012	0.0039	0.0037
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0293	0.0683
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0052	0.005
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0293	0.6747
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0052	0.0333
Trichomonas vaginalis	ran, putative	0.0026	0.0252	0.0575
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0307	0.0287
Plasmodium vivax	glutathione reductase, putative	0.0036	0.0415	1
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0026	0.0252	0.5532
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0026	0.026	0.0562
Loa Loa (eye worm)	glutaminase 2	0.0254	0.3753	0.674
Echinococcus multilocularis	Aryl hydrocarbon receptor nuclear	0.0012	0.0039	0.0037
Onchocerca volvulus		0.0027	0.0268	0.0692
Plasmodium falciparum	ataxin-2 like protein, putative	0.0023	0.0218	0.4582
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0293	0.0683
Echinococcus multilocularis	snurportin 1	0.0372	0.5568	0.5567
Echinococcus granulosus	dnaJ subfamily B	0.0379	0.5686	0.5685
Plasmodium falciparum	glutathione reductase	0.0036	0.0415	1
Brugia malayi	hypothetical protein	0.0023	0.0218	0.0581
Echinococcus multilocularis	dnaJ subfamily B	0.0379	0.5686	0.5685
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0293	0.0683
Plasmodium falciparum	ornithine aminotransferase	0.0026	0.026	0.5731
Loa Loa (eye worm)	apoptosis regulator protein	0.0079	0.1076	0.193
Schistosoma mansoni	ran	0.0026	0.0252	0.0233
Echinococcus multilocularis	Aminotransferase class III	0.0026	0.026	0.0258
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.02	0.2926	0.5254
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.0079	0.1076	0.1074
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0058	0.0743	0.0724
Echinococcus multilocularis	ornithine aminotransferase	0.0026	0.026	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0394	0.0704
Schistosoma mansoni	hypothetical protein	0.0079	0.1076	0.1058
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0092	0.1268	0.4633
Onchocerca volvulus		0.0227	0.3349	1
Toxoplasma gondii	thioredoxin reductase	0.0036	0.0415	0.6068
Entamoeba histolytica	hypothetical protein	0.0028	0.0293	1
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0394	0.0392
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0052	0.005
Trichomonas vaginalis	set domain proteins, putative	0.0227	0.3349	0.8911
Plasmodium vivax	SET domain protein, putative	0.0029	0.0307	0.7019
Brugia malayi	hypoxia-induced factor 1	0.014	0.2004	0.5339
Echinococcus granulosus	Aminotransferase class III	0.0026	0.026	0.0258
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0026	0.026	1
Onchocerca volvulus		0.0029	0.0307	0.0808
Mycobacterium ulcerans	hypothetical protein	0.0184	0.2678	0.7096
Loa Loa (eye worm)	thioredoxin reductase	0.0036	0.0415	0.0742
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0307	0.0287
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0307	0.4259
Loa Loa (eye worm)	glutaminase	0.0254	0.3753	0.674
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0307	0.0305
Schistosoma mansoni	cpg binding protein	0.0027	0.0268	0.0249
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0052	0.0333
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0026	0.0252	0.3357
Echinococcus granulosus	ornithine aminotransferase	0.0026	0.026	0.0258
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0052	0.0333
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0026	0.026	0.0793
Schistosoma mansoni	cpg binding protein	0.0028	0.0291	0.0272
Echinococcus granulosus	cpg binding protein	0.0028	0.0291	0.029
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0307	0.0548
Echinococcus multilocularis	ornithine aminotransferase	0.0026	0.026	0.0258
Schistosoma mansoni	ran	0.0026	0.0252	0.0233
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0307	0.0287
Echinococcus granulosus	aryl hydrocarbon receptor	0.0012	0.0039	0.0037
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0009	0	0.0001
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0079	0.1076	0.1074
Mycobacterium leprae	Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM	0.0026	0.026	0.0836
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0281	0.028
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0092	0.1268	0.4633
Echinococcus multilocularis	transfer RNA-Lys	0.0033	0.0372	0.037
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0026	0.026	0.0793
Schistosoma mansoni	single-minded	0.0045	0.0552	0.0533
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0052	0.0333
Brugia malayi	Pre-SET motif family protein	0.0029	0.0307	0.0817
Mycobacterium tuberculosis	Probable reductase	0.0083	0.1127	0.4094
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0052	0.0034
Mycobacterium leprae	PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)	0.0026	0.026	0.0836
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0184	0.2678	0.7096
Echinococcus granulosus	Aryl hydrocarbon receptor nuclear	0.0012	0.0039	0.0037
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0083	0.1127	0.4094
Plasmodium vivax	thioredoxin reductase, putative	0.0036	0.0415	1
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0394	0.0392
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0026	0.0252	0.0251
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0026	0.026	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0052	0.0567
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0026	0.0252	0.0673
Schistosoma mansoni	hypothetical protein	0.0372	0.5568	0.5559
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0026	0.026	0.0562
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0052	0.065	1
Trichomonas vaginalis	glutaminase, putative	0.0254	0.3753	1
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0026	0.026	0.024
Schistosoma mansoni	glutaminase	0.0254	0.3753	0.3741
Brugia malayi	bHLH-PAS transcription factor	0.0033	0.0372	0.0991
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0026	0.026	0.0793
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0052	0.0333
Schistosoma mansoni	importin beta-1	0.0035	0.0394	0.0374
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0293	0.6747
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.0052	0.0333
Plasmodium falciparum	thioredoxin reductase	0.0036	0.0415	1
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0052	0.0034
Brugia malayi	PAS domain containing protein	0.0045	0.0552	0.1471
Brugia malayi	CXXC zinc finger family protein	0.0027	0.0268	0.0714
Plasmodium vivax	ornithine aminotransferase, putative	0.0026	0.026	0.5731
Leishmania major	trypanothione reductase	0.0036	0.0415	1
Brugia malayi	hypothetical protein	0.0015	0.0091	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0151	0.2184	0.3921
Toxoplasma gondii	LsmAD domain-containing protein	0.0023	0.0218	0.2781
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0039	0.0067
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0422	0.0421
Treponema pallidum	NADH oxidase	0.0013	0.0052	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0083	0.1127	0.4094
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0012	0.0039	0.0067
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0036	0.0415	0.1383
Mycobacterium ulcerans	L-lysine aminotransferase	0.0026	0.026	0.0562
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0026	0.026	0.0562
Brugia malayi	Pre-SET motif family protein	0.02	0.2926	0.7797
Leishmania major	hypothetical protein, conserved	0.0023	0.0218	0.4763
Schistosoma mansoni	hypothetical protein	0.0079	0.1076	0.1058
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0026	0.0252	0.0251
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0013	0.0052	0.0333
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0026	0.0252	0.5681
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0394	0.9419
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0184	0.2678	1

Activities

Activity type	Activity value	Assay description	Source	Reference
AC50 (functional)	2.72 uM	PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.581 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1888357

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1585568