Detailed information for compound 1587020

Basic information

Technical information
  • TDR Targets ID: 1587020
  • Name: 1,3-dimethyl-N-[3-(4-methylpiperidin-1-yl)-3- oxopropyl]-2,4-dioxoquinazoline-6-sulfonamide
  • MW: 422.499 | Formula: C19H26N4O5S
  • H donors: 1 H acceptors: 5 LogP: 0.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC1CCN(CC1)C(=O)CCNS(=O)(=O)c1ccc2c(c1)c(=O)n(c(=O)n2C)C
  • InChi: 1S/C19H26N4O5S/c1-13-7-10-23(11-8-13)17(24)6-9-20-29(27,28)14-4-5-16-15(12-14)18(25)22(3)19(26)21(16)2/h4-5,12-13,20H,6-11H2,1-3H3
  • InChiKey: DABCUQAQZLLOCG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-dimethyl-N-[3-(4-methyl-1-piperidyl)-3-oxo-propyl]-2,4-dioxo-quinazoline-6-sulfonamide
  • 1,3-dimethyl-N-[3-(4-methyl-1-piperidinyl)-3-oxopropyl]-2,4-dioxo-6-quinazolinesulfonamide
  • 2,4-diketo-N-[3-keto-3-(4-methyl-1-piperidyl)propyl]-1,3-dimethyl-quinazoline-6-sulfonamide
  • 1,3-dimethyl-N-[3-(4-methylpiperidin-1-yl)-3-oxo-propyl]-2,4-dioxo-quinazoline-6-sulfonamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0263 0.0758
Echinococcus multilocularis c src tyrosine kinase 0.003 0.006 0.0109
Echinococcus granulosus dual specificity mitogen activated protein 0.0083 0.0435 0.1256
Echinococcus multilocularis geminin 0.0205 0.129 0.2325
Echinococcus granulosus slit 2 protein 0.0028 0.0043 0.0124
Echinococcus multilocularis 0.0141 0.0841 0.1517
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0049 0.0195 0.0562
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0115 0.0654 0.118
Loa Loa (eye worm) hypothetical protein 0.0055 0.0232 0.0191
Brugia malayi Protein kinase domain containing protein 0.0134 0.0791 0.0752
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0236 0.0195
Plasmodium vivax protein kinase Crk2 0.0104 0.0579 0.1423
Brugia malayi Protein kinase domain containing protein 0.0104 0.0579 0.054
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0059 0.0263 0.0473
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0263 0.0473
Echinococcus multilocularis MAM 0.0028 0.0042 0.0075
Brugia malayi Protein kinase domain containing protein 0.0142 0.0845 0.0807
Loa Loa (eye worm) CDC7 protein kinase 0.0134 0.0791 0.0752
Plasmodium vivax glycogen synthase kinase 3, putative 0.0115 0.0654 0.3852
Echinococcus multilocularis cyclin dependent kinase 19 0.0139 0.0828 0.1493
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0161 0.098 0.2828
Giardia lamblia Kinase, CMGC GSK 0.0115 0.0654 0.5349
Schistosoma mansoni protein kinase 0.0196 0.1227 0.3539
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0196 0.1229 0.2215
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0066 0.0309 0.0557
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0073 0.0032
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0142 0.0845 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.0059 0.0263 0.0758
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0115 0.0654 0.0615
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0236 0.0426
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0236 0.0681
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.006 0.0174
Onchocerca volvulus 0.0115 0.0654 0.1789
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0098 0.0535 0.633
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.0964
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0845 0.2438
Onchocerca volvulus 0.047 0.3162 0.9112
Schistosoma mansoni hypothetical protein 0.0205 0.129 0.3721
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0115 0.0654 0.1888
Echinococcus granulosus protein kinase 0.0141 0.0841 0.2427
Brugia malayi Tyrosine-protein kinase abl-1 0.003 0.006 0.0019
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0066 0.0309 0.0268
Echinococcus multilocularis cyclin dependent kinase 0.0104 0.0579 0.1044
Schistosoma mansoni serine/threonine protein kinase 0.0196 0.1229 0.3545
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0083 0.0435 0.0395
Schistosoma mansoni tyrosine kinase 0.0059 0.0263 0.0758
Trypanosoma cruzi cdc2-related kinase 1 0.0104 0.0579 0.6852
Entamoeba histolytica cell division protein kinase 2, putative 0.0104 0.0579 0.2303
Brugia malayi hypothetical protein 0.0055 0.0232 0.0191
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.1543
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0087 0.0458 0.1321
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0055 0.0232 0.0669
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1439 1 1
Giardia lamblia Kinase, CDC7 0.0134 0.0791 0.8683
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0791 0.8683
Echinococcus multilocularis death associated protein kinase 1 0.0808 0.5548 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0104 0.0579 0.6852
Loa Loa (eye worm) TK protein kinase 0.004 0.0125 0.0084
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0579 0.351
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.0545 0.2165
Schistosoma mansoni hypothetical protein 0.0028 0.0042 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0236 0.0681
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.0964
Leishmania major protein kinase A catalytic subunit isoform 1 0.0098 0.0535 0.633
Trypanosoma cruzi cdc2-related kinase 3 0.0104 0.0579 0.6852
Entamoeba histolytica PH domain containing protein kinase, putative 0.0099 0.0545 0.2165
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0579 0.1671
Brugia malayi Protein kinase domain containing protein 0.0066 0.0309 0.0268
Entamoeba histolytica protein kinase domain containing protein 0.0378 0.2515 1
Schistosoma mansoni serine/threonine protein kinase 0.0134 0.0791 0.2282
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0142 0.0845 0.0807
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0055 0.0232 0.2743
Echinococcus granulosus protein tyrosine kinase 0.0258 0.1668 0.4813
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0263 0.0758
Loa Loa (eye worm) AGC/PKA protein kinase 0.0098 0.0535 0.0495
Echinococcus multilocularis tyrosine protein kinase HCK 0.004 0.0125 0.0226
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0142 0.0845 1
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0535 0.1543
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0513 0.3467 1
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.0654 0.2602
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.2515 0.7255
Onchocerca volvulus 0.0134 0.0791 0.2188
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0059 0.0263 0.0473
Schistosoma mansoni protein kinase 0.0141 0.0841 0.2427
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0236 0.0195
Schistosoma mansoni hypothetical protein 0.0055 0.0232 0.0669
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.0964
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0115 0.0654 0.7744
Brugia malayi Temporarily assigned gene name protein 59 0.0055 0.0232 0.0191
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0115 0.0654 0.7744
Echinococcus multilocularis slit 2 protein 0.0028 0.0043 0.0078
Echinococcus multilocularis cyclin dependent kinase 1 0.0104 0.0579 0.1044
Schistosoma mansoni serine/threonine protein kinase 0.0139 0.0828 0.2388
Loa Loa (eye worm) SRC-1 0.0059 0.0263 0.0222
Trypanosoma cruzi cdc2-related kinase 3 0.0104 0.0579 0.6852
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0049 0.0195 0.0351
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0098 0.0535 0.0495
Echinococcus granulosus rho-associated protein kinase 1 0.047 0.3162 0.9123
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0098 0.0535 0.633
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0142 0.0845 1
Giardia lamblia Kinase, CMGC CDK 0.0104 0.0579 0.351
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0059 0.0263 0.0473
Brugia malayi Serine/threonine-protein kinase SULU 0.0196 0.1229 0.1192
Brugia malayi hypothetical protein 0.0196 0.1229 0.1192
Brugia malayi Protein kinase domain containing protein 0.0513 0.3467 0.3439
Loa Loa (eye worm) hypothetical protein 0.0028 0.0043 0.0001
Onchocerca volvulus 0.0134 0.0791 0.2188
Giardia lamblia Kinase, CMGC GSK 0.0115 0.0654 0.5349
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0142 0.0845 1
Schistosoma mansoni tyrosine kinase 0.003 0.006 0.0174
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0098 0.0535 0.633
Schistosoma mansoni rap gtpase-activating protein 0.0055 0.0232 0.0669
Echinococcus granulosus dual specificity protein kinase clk2 0.0142 0.0845 0.2438
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0059 0.0263 0.0473
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0115 0.0654 0.1888
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0236 0.0681
Echinococcus multilocularis cyclin dependent kinase 1 0.0104 0.0579 0.1044
Brugia malayi protein-tyrosine kinase 0.0049 0.0195 0.0154
Echinococcus granulosus cyclin dependent kinase 5 0.0104 0.0579 0.1671
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0142 0.0845 1
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0378 0.2515 0.2484
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0142 0.0845 1
Giardia lamblia Kinase, CMGC CDK 0.0104 0.0579 0.351
Toxoplasma gondii AGC kinase 0.0098 0.0535 0.633
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0098 0.0535 0.633
Loa Loa (eye worm) TK/ALK protein kinase 0.0513 0.3469 0.3441
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0055 0.0232 0.0418
Trypanosoma brucei cdc2-related kinase 1 0.0104 0.0579 0.6852
Schistosoma mansoni serine/threonine protein kinase 0.0513 0.3467 1
Entamoeba histolytica protein kinase, putative 0.0115 0.0654 0.2602
Echinococcus granulosus twitchin 0.0023 0.0008 0.0022
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0535 0.1543
Echinococcus multilocularis dual specificity protein kinase clk2 0.0142 0.0845 0.1523
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0055 0.0232 0.0669
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0513 0.3467 0.3439
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0087 0.0458 0.0825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0236 0.0681
Loa Loa (eye worm) hypothetical protein 0.0055 0.0232 0.0191
Echinococcus granulosus tyrosine protein kinase Lyn 0.007 0.034 0.098
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.0964
Entamoeba histolytica protein kinase, putative 0.004 0.0125 0.0497
Onchocerca volvulus 0.0055 0.0232 0.0555
Trypanosoma brucei cdc2-related kinase 3 0.0104 0.0579 0.6852
Leishmania major protein kinase, putative 0.0142 0.0845 1
Schistosoma mansoni serine/threonine protein kinase 0.047 0.3162 0.9123
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0059 0.0263 0.0473
Echinococcus granulosus Vam6:Vps39 protein 0.0055 0.0232 0.0669
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0083 0.0435 0.515
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0791 0.8683
Loa Loa (eye worm) hypothetical protein 0.0055 0.0232 0.0191
Echinococcus granulosus cyclin dependent kinase 19 0.0139 0.0828 0.2388
Leishmania major protein kinase A catalytic subunit isoform 2 0.0098 0.0535 0.633
Giardia lamblia Kinase, CMGC CLK 0.0142 0.0845 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0098 0.0535 0.633
Echinococcus multilocularis protein tyrosine kinase 0.0258 0.1668 0.3007
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0263 0.0473
Echinococcus granulosus protein kinase shaggy 0.0115 0.0654 0.1888
Leishmania major protein kinase, putative 0.0142 0.0845 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0513 0.3467 1
Trichomonas vaginalis CMGC family protein kinase 0.0134 0.0791 0.8683
Echinococcus multilocularis protein kinase shaggy 0.0115 0.0654 0.118
Echinococcus granulosus tyrosine protein kinase Fyn 0.0059 0.0263 0.0758
Schistosoma mansoni tyrosine kinase 0.0258 0.1668 0.4813
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0579 0.351
Echinococcus granulosus geminin 0.0205 0.129 0.3721
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0055 0.0232 0.0669
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0055 0.0232 0.2743
Schistosoma mansoni tyrosine kinase 0.0059 0.0263 0.0758
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0104 0.0579 0.6852
Toxoplasma gondii AGC kinase 0.0098 0.0535 0.633
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0115 0.0654 0.0615
Brugia malayi SRC-1 0.0059 0.0263 0.0222
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0104 0.0579 0.054
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0309 0.0891
Onchocerca volvulus 0.0459 0.3085 0.8887
Plasmodium vivax serine/threonine kinase-1, putative 0.0142 0.0845 1
Loa Loa (eye worm) TK protein kinase 0.0049 0.0195 0.0154
Trichomonas vaginalis AGC family protein kinase 0.0098 0.0535 0.2434
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0066 0.0309 0.0557
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0066 0.0309 0.0891
Loa Loa (eye worm) gastrulation defective protein 1 0.0128 0.0751 0.0712
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0073 0.0032
Schistosoma mansoni hypothetical protein 0.0205 0.129 0.3721
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0139 0.0828 0.0789
Leishmania major protein kinase A catalytic subunit 0.0098 0.0535 0.633
Schistosoma mansoni vam6/vps39 related 0.0055 0.0232 0.0669
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0142 0.0845 1
Echinococcus multilocularis rho associated protein kinase 0.047 0.3162 0.5701
Entamoeba histolytica cell division protein kinase 2, putative 0.0104 0.0579 0.2303
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0059 0.0263 0.0473
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0236 0.0681
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0104 0.0579 0.1671
Onchocerca volvulus 0.0028 0.0042 0.0000072528
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0066 0.0309 0.0557
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0378 0.2515 0.4533
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0059 0.0263 0.0473
Echinococcus granulosus tyrosine protein kinase HCK 0.004 0.0125 0.0361
Schistosoma mansoni serine/threonine protein kinase 0.0104 0.0579 0.1671
Brugia malayi Protein kinase domain containing protein 0.0514 0.347 0.3442
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0513 0.3467 0.3439
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0196 0.1229 0.3545
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0654 0.5349
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0161 0.098 0.1767
Brugia malayi EGF-like domain containing protein 0.0028 0.0043 0.0001
Loa Loa (eye worm) TK/FAK protein kinase 0.0261 0.1689 0.1654
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0083 0.0435 0.0395
Echinococcus multilocularis cyclin dependent kinase 5 0.0104 0.0579 0.1044
Plasmodium falciparum glycogen synthase kinase 3 0.0115 0.0654 0.7744
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0378 0.2515 0.2484
Trichomonas vaginalis CMGC family protein kinase 0.0115 0.0654 0.5349
Onchocerca volvulus 0.0028 0.0042 0.0000072528
Schistosoma mansoni tyrosine kinase 0.0151 0.0912 0.2632
Schistosoma mansoni protein kinase 0.0083 0.0435 0.1256
Plasmodium falciparum protein serine/threonine kinase-1 0.0142 0.0845 1
Echinococcus multilocularis dual specificity mitogen activated protein 0.0083 0.0435 0.0785
Echinococcus multilocularis 0.0131 0.0768 0.1384
Loa Loa (eye worm) AGC/PKA protein kinase 0.0098 0.0535 0.0495
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0104 0.0579 0.054
Trypanosoma brucei protein kinase, putative 0.0115 0.0654 0.7744
Echinococcus granulosus hypothetical protein 0.0131 0.0768 0.2216
Echinococcus granulosus tyrosine kinase 0.0049 0.0195 0.0562
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0535 0.1543
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.1543
Schistosoma mansoni tyrosine kinase 0.003 0.006 0.0174
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0196 0.1229 0.1192
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0098 0.0535 0.633
Loa Loa (eye worm) hypothetical protein 0.0098 0.0535 0.0495
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0098 0.0535 0.633
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0098 0.0535 0.1543
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0104 0.0579 0.6852
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0083 0.0435 0.515
Schistosoma mansoni serine/threonine protein kinase 0.0066 0.0309 0.0891
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0083 0.0435 0.515
Echinococcus multilocularis tyrosine protein kinase Abl 0.003 0.006 0.0109
Loa Loa (eye worm) hypothetical protein 0.0093 0.0502 0.0462
Echinococcus granulosus cyclin dependent kinase 0.0104 0.0579 0.1671
Loa Loa (eye worm) hypothetical protein 0.0475 0.3197 0.3168
Echinococcus granulosus CDC7 cell division cycle 7 0.0134 0.0791 0.2282
Trypanosoma cruzi cdc2-related kinase 1 0.0104 0.0579 0.6852
Plasmodium falciparum protein kinase 5 0.0104 0.0579 0.6852
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0236 0.0426
Loa Loa (eye worm) hypothetical protein 0.0131 0.0768 0.0729
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0513 0.3467 0.3439
Brugia malayi Protein kinase domain containing protein 0.0261 0.1689 0.1654
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0055 0.0232 0.2743
Trichomonas vaginalis CMGC family protein kinase 0.0104 0.0579 0.351
Onchocerca volvulus Slit protein homolog 0.0028 0.0043 0.0004
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0185 0.115 0.3316
Brugia malayi cell division control protein 2 homolog 0.0104 0.0579 0.054
Schistosoma mansoni serine/threonine protein kinase 0.0142 0.0845 0.2438
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0378 0.2515 0.7255
Giardia lamblia Kinase, AGC PKA 0.0098 0.0535 0.2434
Echinococcus granulosus tyrosine protein kinase Src42A 0.0039 0.0118 0.0341
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0059 0.0263 0.0758
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0104 0.0579 0.054
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0098 0.0535 0.633
Echinococcus multilocularis CDC7 cell division cycle 7 0.0134 0.0791 0.1426
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0141 0.0841 0.0803
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0059 0.0263 0.0758
Echinococcus multilocularis tyrosine protein kinase Blk 0.0049 0.0195 0.0351
Brugia malayi probable protein kinase 0.0196 0.1227 0.119
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0513 0.3467 0.6249
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0098 0.0535 0.633
Entamoeba histolytica protein kinase domain containing protein 0.0115 0.0654 0.2602
Brugia malayi Protein kinase domain containing protein 0.0139 0.0828 0.0789
Brugia malayi intracellular kinase 0.0115 0.0654 0.0615
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0066 0.0309 0.0891
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0115 0.0654 0.7744
Loa Loa (eye worm) hypothetical protein 0.0185 0.115 0.1112
Echinococcus granulosus cyclin dependent kinase 1 0.0104 0.0579 0.1671
Echinococcus granulosus tyrosine protein kinase Blk 0.0049 0.0195 0.0562
Trichomonas vaginalis CMGC family protein kinase 0.0142 0.0845 1
Echinococcus granulosus MAM 0.0028 0.0042 0.0121
Schistosoma mansoni hypothetical protein 0.0028 0.0042 0.0121
Schistosoma mansoni protein kinase 0.0066 0.0309 0.0891
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0039 0.0118 0.0213
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0066 0.0309 0.0891
Echinococcus granulosus c src tyrosine kinase 0.003 0.006 0.0174
Echinococcus granulosus tyrosine protein kinase Src42A 0.0059 0.0263 0.0758
Echinococcus multilocularis tyrosine protein kinase Srms 0.0049 0.0195 0.0351

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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