Detailed information for compound 1598738

Basic information

Technical information
  • TDR Targets ID: 1598738
  • Name: (5E)-5-[(4-bromophenyl)methylidene]-1,3-thiaz olidine-2,4-dione
  • MW: 284.129 | Formula: C10H6BrNO2S
  • H donors: 1 H acceptors: 2 LogP: 2.89 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)S/C/1=C/c1ccc(cc1)Br
  • InChi: 1S/C10H6BrNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)/b8-5+
  • InChiKey: WOJYBXTWFNRUTA-VMPITWQZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (5E)-5-[(4-bromophenyl)methylene]thiazolidine-2,4-dione
  • (5E)-5-(4-bromobenzylidene)thiazolidine-2,4-quinone
  • BIM-0048262.P001
  • 3M-521S
  • 5-(4-Bromo-benzylidene)-thiazolidine-2,4-dione
  • BAS 00253475
  • ZINC01909781

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoamine oxidase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi amine oxidase, flavin-containing family protein monoamine oxidase B 520 aa 462 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0395 0.3351 1
Plasmodium falciparum glutathione reductase 0.0047 0.0202 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0227 0.1045
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.2656 0.7925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.0382
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.019 0.0187
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0044 0.0176 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0241 0.4494
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.075 0.2676
Loa Loa (eye worm) hypothetical protein 0.0071 0.0414 0.1918
Schistosoma mansoni hypothetical protein 0.0034 0.0085 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma brucei protein kinase, putative 0.0051 0.0241 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.019 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0143 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0079 0.0487 0.1445
Schistosoma mansoni inositol monophosphatase 0.0042 0.0153 0.1146
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0151 0.1138 0.3937
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.019 0.0187
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0049 0.0222 0.0277
Leishmania major phosphatidylinositol 3-kinase, putative 0.0079 0.0487 0.1388
Giardia lamblia GTOR 0.0079 0.0487 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.01 0.0096
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.018 0.0527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.0859 0.3067
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0269 0.0792
Plasmodium vivax glutathione reductase, putative 0.0047 0.0202 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.3023 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0044 0.0176 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0222 0.4087
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0079 0.0487 0.0484
Plasmodium falciparum thioredoxin reductase 0.0047 0.0202 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.018 0.0527
Onchocerca volvulus Huntingtin homolog 0.0122 0.0883 1
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0241 0.4494
Entamoeba histolytica hypothetical protein 0.0044 0.0176 0.0705
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0241 0.0237
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0202 0.0928
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.2794 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0202 0.0594
Mycobacterium tuberculosis Conserved hypothetical protein 0.0168 0.1293 0.462
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0153 0.015
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0202 0.0199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.1431
Trypanosoma brucei trypanothione reductase 0.0047 0.0202 0.0198
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0079 0.0487 0.1335
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi Bromodomain containing protein 0.0075 0.0453 0.2111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.019 0.0187
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0241 0.0709
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1138 0.3257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0222 0.4087
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0084 0.0392
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0044 0.0176 0.0517
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0153 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0079 0.0487 1
Schistosoma mansoni hypothetical protein 0.0034 0.0084 0.0619
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0241 0.0681
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0241 0.0681
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0079 0.0487 0.1445
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0241 0.035
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0153 0.0429
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi glutathione reductase 0.0047 0.0202 0.0943
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.01 0.0096
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0241 0.1107
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.0859 0.3067
Schistosoma mansoni hypothetical protein 0.0169 0.1307 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0079 0.0487 0.1445
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0044 0.0176 0.0094
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0044 0.0176 0.0517
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0227 0.1059
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0079 0.0487 0.1445
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0241 0.0709
Brugia malayi hypothetical protein 0.0122 0.0883 0.4113
Brugia malayi Bromodomain containing protein 0.0038 0.0121 0.0564
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Toxoplasma gondii thioredoxin reductase 0.0047 0.0202 0.4113
Entamoeba histolytica protein kinase rad3, putative 0.0044 0.0176 0.0705
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0079 0.0487 0.3709
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0241 0.0237
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0079 0.0487 0.1335
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0079 0.0487 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.3023 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0079 0.0487 0.0484
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.018 0.0108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0883 0.4104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) inositol-1 0.0042 0.0153 0.0698
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0079 0.0487 0.1388
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0034 0.0085 0.0082
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0079 0.0487 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.075 0.2676
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0222 0.1022
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0079 0.0487 0.1335
Echinococcus granulosus geminin 0.0169 0.1307 0.1304
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0049 0.0222 0.4527
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0241 0.0709
Loa Loa (eye worm) hypothetical protein 0.005 0.0227 0.1045
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0034 0.0085 0.0082
Schistosoma mansoni fkbp-rapamycin associated protein 0.0044 0.0176 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1129 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0084 0.0377
Brugia malayi follicle stimulating hormone receptor 0.0262 0.2146 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0151 0.1138 0.3391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Schistosoma mansoni bromodomain containing protein 0.0063 0.0347 0.2635
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0044 0.0176 0.0705
Brugia malayi MAP kinase sur-1 0.0051 0.0241 0.1121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi Inositol-1 0.0042 0.0153 0.0712
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0241 0.0237
Brugia malayi FAT domain containing protein 0.0034 0.0085 0.0397
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0202 0.0713
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.019 0.0871
Schistosoma mansoni inositol monophosphatase 0.0042 0.0153 0.1146
Echinococcus multilocularis geminin 0.0169 0.1307 0.1304
Leishmania major trypanothione reductase 0.0047 0.0202 0.0571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Echinococcus granulosus serine protein kinase ATM 0.0044 0.0176 0.0173
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0079 0.0487 0.1335
Onchocerca volvulus Huntingtin homolog 0.0122 0.0883 1
Brugia malayi Thioredoxin reductase 0.0047 0.0202 0.0943
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0079 0.0487 0.0484
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.075 0.2676
Toxoplasma gondii FATC domain-containing protein 0.0044 0.0176 0.3578
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.075 0.8728
Loa Loa (eye worm) hypothetical protein 0.0038 0.0122 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0176 0.0822
Mycobacterium tuberculosis Probable reductase 0.0108 0.075 0.2676
Mycobacterium ulcerans hypothetical protein 0.0168 0.1293 0.427
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0079 0.0487 0.1388
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0153 0.5
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0113 0.0394
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.075 0.2676
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.075 0.2676
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0029 0.0039 0.0108
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.0487 0.2269
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.0859 0.3067
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0113 0.1284
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0153 0.3091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0176 0.0822
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.018 0.0527
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0227 0.1059
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0241 0.4904
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0318 0.2656 1
Schistosoma mansoni hypothetical protein 0.0169 0.1307 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.0003 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0318 0.2656 0.7925
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0153 0.0447
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0079 0.0487 0.1388
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0241 0.4494
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0044 0.0176 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Leishmania major mitochondrial DNA polymerase beta 0.0318 0.2656 0.7613
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0079 0.0487 0.3709
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Echinococcus multilocularis serine protein kinase ATM 0.0044 0.0176 0.0173
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0315 0.0311
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0153 0.2535
Chlamydia trachomatis protoporphyrinogen oxidase 0.0025 0.0003 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Loa Loa (eye worm) hypothetical protein 0.0122 0.0883 0.4104
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0153 0.0495
Loa Loa (eye worm) hypothetical protein 0.0043 0.016 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0153 0.2535
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0079 0.0487 0.1388
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0153 0.2535
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0079 0.0487 0.1445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.1431
Loa Loa (eye worm) hypothetical protein 0.0029 0.0039 0.0168
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.0859 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0079 0.0487 0.2269
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0241 0.0237
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0202 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0079 0.0487 0.0484
Toxoplasma gondii hypothetical protein 0.0051 0.0239 0.4881
Brugia malayi hypothetical protein 0.0025 0.0003 0.0016
Brugia malayi SWIRM domain containing protein 0.0025 0.0003 0.0016
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0153 0.0447
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0241 0.1819
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0085 0.1025
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0241 0.4494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0315 0.0311
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.0487 0.2257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.2146 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0176 0.0808
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0202 0.0199
Loa Loa (eye worm) glutathione reductase 0.0047 0.0202 0.0928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Leishmania major hypothetical protein, conserved 0.041 0.3488 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.1431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0176 0.3062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0241 0.0709
Loa Loa (eye worm) phosphatidylinositol 3 0.0079 0.0487 0.2257
Trichomonas vaginalis PIKK family atypical protein kinase 0.0079 0.0487 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.019 0.0885
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0079 0.0487 0.1335

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.228 uM Inhibition of human recombinant MAOB using kynuramine as substrate by fluorimetry ChEMBL. 22225638
IC50 (binding) = 43.46 uM Inhibition of human recombinant MAOA using kynuramine as substrate by fluorimetry ChEMBL. 22225638
Inhibition (binding) Competitive inhibition of human recombinant MAOB by Lineweaver-Burk plot analysis ChEMBL. 22225638

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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