TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 347.414 | Formula: C20H21N5O
H donors: 2 H acceptors: 3 LogP: 3.43 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1[nH]c2c(n1CC1CCCCC1)nc(cn2)c1ccc2c(c1)cc[nH]2
InChi: 1S/C20H21N5O/c26-20-24-18-19(25(20)12-13-4-2-1-3-5-13)23-17(11-22-18)14-6-7-16-15(10-14)8-9-21-16/h6-11,13,21H,1-5,12H2,(H,22,24,26)
InChiKey: QGZGXGGLQSWROG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	mechanistic target of rapamycin (serine/threonine kinase)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upstream TOR2 CDS (CaP19.1905)	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	frameshifted from upsteam TOR2 CDS (CaP19.9461)	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Neospora caninum	Phosphatidylinositol 3-kinase tor2, related	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3 kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Candida albicans	similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania braziliensis	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	ko:K07203 FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Toxoplasma gondii	target of rapamycin (TOR), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania mexicana	phosphatidylinositol 3-kinase (tor2)-like protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Giardia lamblia	GTOR	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania donovani	Phosphatidylinositol 3-kinase tor1	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma brucei gambiense	phosphatidylinositol 3-kinase tor, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania major	target of rapamycin (TOR) kinase 2, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	Get druggable targets OG5_127212	All targets in OG5_127212
Schistosoma japonicum	FKBP12-rapamycin complex-associated protein, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Loa Loa (eye worm)	phosphatidylinositol 3	Get druggable targets OG5_127212	All targets in OG5_127212
Leishmania infantum	target of rapamycin (TOR) kinase 1, putative	Get druggable targets OG5_127212	All targets in OG5_127212
Trypanosoma congolense	Phosphatidylinositol 3-kinase tor2	Get druggable targets OG5_127212	All targets in OG5_127212

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.005	0.0033
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0054	0.0168	0.4446
Brugia malayi	Carboxylesterase family protein	0.0059	0.0193	0.014
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0082	0.0314	0.0261
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0082	0.0314	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0059	0.0193	0.0347
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0082	0.0314	0.0261
Trichomonas vaginalis	glycogen phosphorylase, putative	0.089	0.4577	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0193	0.014
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0196	0.0917	0.0868
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0082	0.0314	0.0261
Loa Loa (eye worm)	acetylcholinesterase 1	0.035	0.1728	0.1683
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0314	0.0261
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0196	0.0917	0.0868
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Echinococcus granulosus	glycogen phosphorylase	0.089	0.4577	0.4548
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0094	0.0129
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0067	0.0069
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Echinococcus granulosus	neuroligin	0.0059	0.0193	0.014
Brugia malayi	carbohydrate phosphorylase	0.089	0.4577	0.4548
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0082	0.0314	0.0261
Echinococcus granulosus	BC026374 protein S09 family	0.0059	0.0193	0.014
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0314	0.0261
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Echinococcus multilocularis	neuroligin	0.0059	0.0193	0.014
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Onchocerca volvulus	Glycogen phosphorylase homolog	0.089	0.4577	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0082	0.0314	0.0261
Echinococcus granulosus	Glycosyl transferase family 35	0.089	0.4577	0.4548
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0036	0.0001
Trichomonas vaginalis	rotamase, putative	0.0032	0.005	0.0032
Schistosoma mansoni	protein tyrosine phosphatase	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0109	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0193	0.014
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0059	0.0193	0.014
Echinococcus multilocularis	para nitrobenzyl esterase	0.0059	0.0193	0.014
Entamoeba histolytica	glycogen phosphorylase, putative	0.089	0.4577	1
Brugia malayi	hypothetical protein	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	phosphatidylinositol 3	0.0054	0.0168	0.0114
Brugia malayi	Protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0094	0.0129
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Brugia malayi	hypothetical protein	0.0082	0.0314	0.0261
Giardia lamblia	Glycogen phosphorylase	0.089	0.4577	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Echinococcus granulosus	carboxylesterase 5A	0.035	0.1728	0.1683
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0094	0.0129
Echinococcus multilocularis	acetylcholinesterase	0.035	0.1728	0.1683
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0145	0.0091
Schistosoma mansoni	glycogen phosphorylase	0.089	0.4577	0.4548
Echinococcus multilocularis	geminin	0.0196	0.0918	0.0868
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0054	0.0168	0.0114
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0059	0.0193	0.014
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0082	0.0314	0.0261
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Giardia lamblia	Protein tyrosine phosphatase	0.0082	0.0314	0.0333
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0196	0.0917	0.0868
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0168	0.0291
Brugia malayi	hypothetical protein	0.0082	0.0314	0.0261
Echinococcus multilocularis	glycogen phosphorylase	0.089	0.4577	0.4548
Onchocerca volvulus		0.0082	0.0314	0.0276
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0082	0.0314	0.0261
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0043	0.0109	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0082	0.0314	0.0583
Chlamydia trachomatis	glycogen phosphorylase	0.089	0.4577	0.5
Onchocerca volvulus		0.0082	0.0314	0.0276
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0082	0.0314	0.0261
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0059	0.0193	0.014
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0059	0.0193	0.014
Loa Loa (eye worm)	carboxylesterase	0.0059	0.0193	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0052	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0109	0.0162
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0094	0.0129
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0082	0.0314	0.0261
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0082	0.0314	0.0261
Loa Loa (eye worm)	glycogen phosphorylase	0.089	0.4577	0.4548
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0082	0.0314	0.0261
Loa Loa (eye worm)	carboxylesterase	0.0059	0.0193	0.014
Entamoeba histolytica	glycogen phosphorylase, putative	0.0385	0.1912	0.4112
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0193	0.014
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1917	1	1
Echinococcus granulosus	para nitrobenzyl esterase	0.0059	0.0193	0.014
Toxoplasma gondii	target of rapamycin (TOR), putative	0.004	0.0094	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1917	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0168	0.0291
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0109	0.0162
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0193	0.014
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0043	0.0109	0.2235
Brugia malayi	hypothetical protein	0.0059	0.0193	0.014
Schistosoma mansoni	gliotactin	0.0059	0.0193	0.014
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0145	0.0091
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0082	0.0314	0.0261
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Echinococcus granulosus	acetylcholinesterase	0.035	0.1728	0.1683
Schistosoma mansoni	glycogen phosphorylase	0.089	0.4577	0.4548
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0196	0.0917	0.0868
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	hypothetical protein	0.035	0.1728	0.1683
Brugia malayi	hypothetical protein	0.0082	0.0314	0.0261
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0054	0.0168	0.1571
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0094	0.0129
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0082	0.0314	0.0261
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0145	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0036	0.0001
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Echinococcus granulosus	acetylcholinesterase	0.035	0.1728	0.1683
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0054	0.0168	0.4446
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0059	0.0193	0.014
Trichomonas vaginalis	rotamase, putative	0.0033	0.0054	0.0041
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Brugia malayi	Carboxylesterase family protein	0.0059	0.0193	0.014
Schistosoma mansoni	acetylcholinesterase	0.0059	0.0193	0.014
Onchocerca volvulus	4.1 G protein, putative homolog	0.0082	0.0314	0.0276
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0094	0.0129
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0145	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Echinococcus multilocularis		0.0082	0.0314	0.0261
Schistosoma mansoni	hypothetical protein	0.0224	0.1066	0.1017
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0196	0.0917	0.0868
Echinococcus multilocularis	carboxylesterase 5A	0.035	0.1728	0.1683
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0054	0.0168	0.4446
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0082	0.0314	0.0261
Brugia malayi	Carboxylesterase family protein	0.035	0.1728	0.1683
Onchocerca volvulus		0.0082	0.0314	0.0276
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0052	0.0037
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0082	0.0314	0.0261
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0224	0.1061	0.1013
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.004	0.0094	0.0129
Schistosoma mansoni	hypothetical protein	0.0196	0.0918	0.0868
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.0145	0.0091
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.0052	0.0037
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0054	0.0168	0.4446
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0082	0.0314	0.2947
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0046	0.0126	0.0198
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0054	0.0168	0.0114
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0036	0.0001
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0054	0.0168	0.0114
Brugia malayi	hypothetical protein	0.0082	0.0314	0.0261
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0059	0.0193	0.014
Loa Loa (eye worm)	carboxylesterase	0.035	0.1728	0.1683
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0193	0.014
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1917	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.0145	0.0091
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0385	0.1912	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0193	0.014
Onchocerca volvulus		0.0082	0.0314	0.0276
Trichomonas vaginalis	glycogen phosphorylase, putative	0.089	0.4577	1
Echinococcus granulosus	geminin	0.0196	0.0918	0.0868
Onchocerca volvulus		0.0082	0.0314	0.0276
Trypanosoma brucei	RNA helicase, putative	0.0224	0.1066	1
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.0032	0.005	0.047
Schistosoma mansoni	glycogen phosphorylase	0.0385	0.1912	0.1867
Brugia malayi	Protein-tyrosine phosphatase 1	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0054	0.0168	0.0291
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0314	0.0261
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0082	0.0314	0.0261
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0082	0.0314	0.0261
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0082	0.0314	0.0261
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0082	0.0314	0.0583
Trichomonas vaginalis	pten, drome, putative	0.0082	0.0314	0.0614
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0082	0.0314	0.0261
Schistosoma mansoni	protein tyrosine phosphatase	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0109	0.0162
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0054	0.0168	0.0259
Leishmania major	tyrosine specific protein phosphatase, putative	0.0082	0.0314	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Echinococcus granulosus	glycogen phosphorylase	0.089	0.4577	0.4548
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Echinococcus multilocularis	hypothetical protein	0.0082	0.0314	0.0261
Brugia malayi	Carboxylesterase family protein	0.0059	0.0193	0.014
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Schistosoma mansoni	hypothetical protein	0.0196	0.0918	0.0868
Onchocerca volvulus		0.0082	0.0314	0.0276
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.0145	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0082	0.0314	1
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0082	0.0314	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Onchocerca volvulus		0.0082	0.0314	0.0276
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0054	0.0168	0.1571
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0073	0.0083
Schistosoma mansoni	protein tyrosine phosphatase	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.035	0.1728	0.1683
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.0145	0.0091
Echinococcus multilocularis	glycogen phosphorylase	0.089	0.4577	0.4548
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0082	0.0314	0.0261
Trypanosoma cruzi	target of rapamycin kinase 3	0.0043	0.0109	0.2235
Brugia malayi	Carboxylesterase family protein	0.0059	0.0193	0.014
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0082	0.0314	0.0583
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0385	0.1912	1
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0082	0.0314	0.0261
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0054	0.0168	0.0259
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1917	1	1
Schistosoma mansoni	intracisternal A-particle retropepsin (A02 family)	0.123	0.6373	0.6353
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0032	0.005	0.0033
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.0145	0.0091
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0196	0.0917	0.0868
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Entamoeba histolytica	glycogen phosphorylase, putative	0.0385	0.1912	0.4112
Echinococcus multilocularis	acetylcholinesterase	0.035	0.1728	0.1683
Entamoeba histolytica	glycogen phosphorylase, putative	0.089	0.4577	1
Onchocerca volvulus		0.0082	0.0314	0.0276
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0196	0.0917	0.0868
Echinococcus multilocularis	Glycosyl transferase, family 35	0.089	0.4577	0.4548
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Schistosoma mansoni	pcd6 interacting protein-related	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0193	0.014
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0054	0.0168	0.0114
Onchocerca volvulus		0.0082	0.0314	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Loa Loa (eye worm)	hypothetical protein	0.035	0.1728	0.1683
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0082	0.0314	0.0261
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0059	0.0193	0.0347
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0054	0.0041
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0026	0.0016	0.0155
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0082	0.0314	1
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Entamoeba histolytica	glycogenphosphorylase, putative	0.0385	0.1912	0.4112
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0059	0.0193	0.014
Brugia malayi	Carboxylesterase family protein	0.035	0.1728	0.1683
Schistosoma mansoni	BC026374 protein (S09 family)	0.0059	0.0193	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0043	0.0109	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0314	0.0261
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0082	0.0314	0.0261
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0082	0.0314	0.0261
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0082	0.0314	0.0261
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0036	0.0001

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.063 uM	Inhibition of mTOR	ChEMBL.	21978683
IC50 (binding)	> 30 uM	Inhibition of PI3Kalpha	ChEMBL.	21978683

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1946267

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1599521