Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 10000 nM | Agonist activity at human recombinant adenosine receptor A2b by cAMP assay | ChEMBL. | 24164628 |
Ki (binding) | Binding affinity to human recombinant adenosine A3 receptor | ChEMBL. | 24164628 | |
Ki (binding) | = 22 nM | Binding affinity towards adenosine A2A receptor in rat brain striatum | ChEMBL. | 11170643 |
Ki (binding) | = 58.5 nM | Binding affinity to A2A adenosine receptor | ChEMBL. | 22104008 |
Ki (binding) | = 89 nM | Binding affinity towards adenosine A1 receptor in rat brain cortex | ChEMBL. | 11170643 |
Ki (binding) | = 490 nM | Binding affinity to human recombinant adenosine receptor A2a | ChEMBL. | 24164628 |
Ki (binding) | = 490 nM | Binding affinity to human adenosine A2A receptor | ChEMBL. | 25780876 |
Ki (binding) | = 10000 nM | Binding affinity to human recombinant adenosine A1 receptor | ChEMBL. | 24164628 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
3 literature references were collected for this gene.