Detailed information for compound 1610232

Basic information

Technical information
  • TDR Targets ID: 1610232
  • Name: 3-[(3-chlorophenyl)sulfamoyl]-N-[(5-methylfur an-2-yl)methylideneamino]benzamide
  • MW: 417.866 | Formula: C19H16ClN3O4S
  • H donors: 2 H acceptors: 3 LogP: 3.78 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)NS(=O)(=O)c1cccc(c1)C(=O)N/N=C/c1ccc(o1)C
  • InChi: 1S/C19H16ClN3O4S/c1-13-8-9-17(27-13)12-21-22-19(24)14-4-2-7-18(10-14)28(25,26)23-16-6-3-5-15(20)11-16/h2-12,23H,1H3,(H,22,24)/b21-12+
  • InChiKey: QZUQQKKIZKXEFM-CIAFOILYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(3-chlorophenyl)sulfamoyl]-N-[(5-methyl-2-furyl)methyleneamino]benzamide
  • MLS000393518
  • SMR000241353
  • T5249094

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens snurportin 1 No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens RAN, member RAS oncogene family No references
Homo sapiens karyopherin (importin) beta 1 No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Importin subunit beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium parvum GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Neospora caninum GTP-binding nuclear protein Ran, related Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma congolense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis importin beta-1, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei gambiense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium knowlesi GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium parvum importin/karyopherin Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Plasmodium yoelii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania infantum GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania donovani importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium yoelii importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium berghei importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva GTP-binding nuclear protein ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trichomonas vaginalis ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania mexicana importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) nucleolar RNA-associated protein alpha Get druggable targets OG5_131808 All targets in OG5_131808
Trypanosoma brucei importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania major GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii HEAT repeat-containing protein Get druggable targets OG5_127843 All targets in OG5_127843
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania braziliensis GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Cryptosporidium hominis GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Snurportin-1, putative Get druggable targets OG5_131808 All targets in OG5_131808
Echinococcus multilocularis GTP binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum ko:K07936 GTP-binding nuclear protein Ran, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania braziliensis importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium knowlesi importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Neospora caninum hypothetical protein Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis importin subunit beta 1 Get druggable targets OG5_127843 All targets in OG5_127843
Cryptosporidium hominis importin-beta2 Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi RNA, U transporter 1 Get druggable targets OG5_131808 All targets in OG5_131808
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi Importin beta-1 subunit Get druggable targets OG5_127843 All targets in OG5_127843
Brugia malayi GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Babesia bovis GTP-binding nuclear protein Ran Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni ran Get druggable targets OG5_127514 All targets in OG5_127514
Babesia bovis importin beta subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Candida albicans Ran, Ras family GTP-binding protein Get druggable targets OG5_127514 All targets in OG5_127514
Giardia lamblia GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica Ran family GTPase Get druggable targets OG5_127514 All targets in OG5_127514
Leishmania mexicana GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma mansoni hypothetical protein Get druggable targets OG5_131808 All targets in OG5_131808
Leishmania donovani GTP-binding protein, putative Get druggable targets OG5_127514 All targets in OG5_127514
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 Get druggable targets OG5_127514 All targets in OG5_127514
Candida albicans karyopherin-beta Get druggable targets OG5_127843 All targets in OG5_127843
Schistosoma mansoni importin beta-1 Get druggable targets OG5_127843 All targets in OG5_127843
Leishmania infantum importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma congolense GTP-binding nuclear protein rtb2, putative Get druggable targets OG5_127514 All targets in OG5_127514
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative Get druggable targets OG5_127514 All targets in OG5_127514
Schistosoma japonicum Importin subunit beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus multilocularis snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
Plasmodium vivax importin-beta 2, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trichomonas vaginalis Importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Trypanosoma brucei gambiense importin beta-1 subunit, putative Get druggable targets OG5_127843 All targets in OG5_127843
Plasmodium falciparum importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Theileria parva importin beta, putative Get druggable targets OG5_127843 All targets in OG5_127843
Echinococcus granulosus snurportin 1 Get druggable targets OG5_131808 All targets in OG5_131808
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis PAK box P21 Rho binding 0.0221 0.0831 0.0904
Schistosoma mansoni hypothetical protein 0.0043 0.0129 0.038
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0069 0.0134
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3259 0.3561
Brugia malayi P21-Rho-binding domain containing protein 0.0216 0.0814 0.0809
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0129 0.0135
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0059 0.0058
Brugia malayi Protein kinase domain 0.0221 0.0831 0.0826
Onchocerca volvulus 0.0012 0.0005 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0216 0.0814 0.2486
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0069 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0005 0.5
Schistosoma mansoni ran 0.0026 0.0059 0.0163
Schistosoma mansoni hypothetical protein 0.0216 0.0814 0.2486
Entamoeba histolytica protein kinase, putative 0.0221 0.0831 1
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0095 0.0098
Schistosoma mansoni tyrosine kinase 0.0216 0.0814 0.2486
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0095 1
Echinococcus granulosus PAK box P21 Rho binding 0.0216 0.0814 0.0885
Trichomonas vaginalis STE family protein kinase 0.0221 0.0831 1
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0914
Brugia malayi hypothetical protein 0.0043 0.0129 0.0124
Trichomonas vaginalis conserved hypothetical protein 0.0216 0.0814 0.9781
Giardia lamblia Kinase, STE STE20 0.0221 0.0831 1
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0216 0.0814 0.2486
Schistosoma mansoni hypothetical protein 0.0372 0.143 0.4378
Entamoeba histolytica protein kinase, putative 0.0221 0.0831 1
Echinococcus granulosus snurportin 1 0.0372 0.143 0.1559
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.2318 0.9143 1
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3259 1
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3259 0.3561
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.2535 1 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0059 0.0058
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0069 0.0134
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0914
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.2318 0.9143 1
Echinococcus multilocularis snurportin 1 0.0372 0.143 0.1559
Entamoeba histolytica protein kinase, putative 0.0221 0.0831 1
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0221 0.0831 0.0904
Brugia malayi P21-Rho-binding domain containing protein 0.0216 0.0814 0.0809
Entamoeba histolytica p21-activated kinase 0.0221 0.0831 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0095 1
Brugia malayi WH1 domain containing protein 0.0216 0.0814 0.0809
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0914
Schistosoma mansoni hypothetical protein 0.0216 0.0814 0.2486
Entamoeba histolytica hypothetical protein 0.0043 0.0129 0.0914
Schistosoma mansoni ran 0.0026 0.0059 0.0163
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.0053
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0095 1
Trichomonas vaginalis STE family protein kinase 0.0221 0.0831 1
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0005 0.5
Entamoeba histolytica hypothetical protein 0.0216 0.0814 0.9781
Echinococcus multilocularis PAK box P21 Rho binding 0.0216 0.0814 0.0885
Entamoeba histolytica hypothetical protein 0.0216 0.0814 0.9781
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0129 0.038
Plasmodium falciparum importin beta, putative 0.0035 0.0095 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.143 0.1425
Plasmodium vivax importin-beta 2, putative 0.0035 0.0095 1
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0221 0.0831 0.0904
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0129 0.0135
Trichomonas vaginalis STE family protein kinase 0.0221 0.0831 1
Trichomonas vaginalis STE family protein kinase 0.0221 0.0831 1
Schistosoma mansoni protein kinase 0.0221 0.0831 0.2538
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0221 0.0831 0.0904
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0005 0.5
Schistosoma mansoni protein kinase 0.0216 0.0814 0.2486
Trichomonas vaginalis STE family protein kinase 0.0221 0.0831 1
Schistosoma mansoni hypothetical protein 0.0216 0.0814 0.2486
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0216 0.0814 0.0885
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0221 0.0831 0.0904
Loa Loa (eye worm) hypothetical protein 0.0216 0.0814 0.0809
Brugia malayi RNA, U transporter 1 0.0099 0.0349 0.0344
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0216 0.0814 0.0885
Leishmania major importin beta-1 subunit, putative 0.0028 0.0069 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0026 0.0059 0.6165
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0069 0.0134
Echinococcus granulosus importin subunit beta 1 0.0035 0.0095 0.0098
Loa Loa (eye worm) hypothetical protein 0.0035 0.0095 0.009
Schistosoma mansoni importin beta-1 0.0035 0.0095 0.0275
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0216 0.0814 0.0885
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0221 0.0831 0.0904
Entamoeba histolytica hypothetical protein 0.0028 0.0069 0.0134
Schistosoma mansoni protein kinase 0.0221 0.0831 0.2538
Entamoeba histolytica protein kinase, putative 0.0221 0.0831 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0059 0.0053
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0216 0.0814 0.0809
Schistosoma mansoni protein kinase 0.0221 0.0831 0.2538
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0221 0.0831 0.0904
Brugia malayi Importin beta-1 subunit 0.0035 0.0095 0.009

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 82.05 uM PUBCHEM_BIOASSAY: AlphaScreen confirmatory assay for validation of inhibitors of SUMOylation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2006, AID2011, AID2069, AID2614, AID2658] ChEMBL. No reference
Potency (functional) 0.0731 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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