Detailed information for compound 1611385

Basic information

Technical information
  • TDR Targets ID: 1611385
  • Name: 4-amino-2-(dicyanomethylidene)-N-[(4-methoxyp henyl)methylideneamino]-3-phenyl-1,3-thiazole -5-carboxamide
  • MW: 416.456 | Formula: C21H16N6O2S
  • H donors: 2 H acceptors: 3 LogP: 3.5 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC(=c1sc(c(n1c1ccccc1)N)C(=O)N/N=C/c1ccc(cc1)OC)C#N
  • InChi: 1S/C21H16N6O2S/c1-29-17-9-7-14(8-10-17)13-25-26-20(28)18-19(24)27(16-5-3-2-4-6-16)21(30-18)15(11-22)12-23/h2-10,13H,24H2,1H3,(H,26,28)/b25-13+
  • InChiKey: CZBOETRWWZXDQN-DHRITJCHSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-amino-2-(dicyanomethylene)-N-[(4-methoxyphenyl)methyleneamino]-3-phenyl-thiazole-5-carboxamide
  • 4-amino-2-(dicyanomethylene)-N-[(4-methoxyphenyl)methyleneamino]-3-phenyl-5-thiazolecarboxamide
  • 4-amino-2-(dicyanomethylene)-N-[(4-methoxybenzylidene)amino]-3-phenyl-thiazole-5-carboxamide
  • 4-Amino-2-(dicyanomethylene)-N'-(4-methoxybenzylidene)-3-phenyl-2,3-dihydro-1,3-thiazole-5-carbohydrazide
  • AIDS-140340
  • AIDS140340
  • NSC652027
  • NCI60_018187

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0436 0.0732 0.072
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0117 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0305 0.0436 0.0423
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0401 0.0653 0.0641
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0119 0.0018 0.0005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0511 0.0901 0.0901
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0881 0.1733 0.1722
Loa Loa (eye worm) hypothetical protein 0.0576 0.1047 0.1036
Echinococcus multilocularis Zinc finger, PHD finger 0.0326 0.0484 0.0472
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0326 0.0484 0.0472
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0117 0.0013 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3398 0.74 0.74
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0881 0.1733 0.1722
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0881 0.1733 0.1722
Entamoeba histolytica hypothetical protein 0.0305 0.0436 0.0423
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0881 0.1733 0.1733
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1569 0.3282 0.3273
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0305 0.0436 0.0423
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1557 0.3256 0.3247
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0583 0.1063 0.1051
Leishmania major hypothetical protein, unknown function 0.0305 0.0436 0.0423
Trichomonas vaginalis fk506-binding protein, putative 0.0117 0.0013 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.3631 0.7924 0.7924
Leishmania major phosphatidylinositol kinase related protein, putative 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.5332 0.5332
Trichomonas vaginalis PIKK family atypical protein kinase 0.4553 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2476 0.5324 0.5324
Leishmania major phosphatidylinositol kinase, putative 0.0305 0.0436 0.0423
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.1557 0.3256 0.3256
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0893 0.1759 0.1749
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0326 0.0484 0.0484
Trichomonas vaginalis conserved hypothetical protein 0.0676 0.1272 0.1272
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0305 0.0436 0.0423
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0445 0.0751 0.0751
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1903 0.4034 0.4027
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.4553 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0326 0.0484 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.037 0.0582 0.057
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.1557 0.3256 0.3256
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.4553 1 1
Loa Loa (eye worm) hypothetical protein 0.0305 0.0436 0.0423
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0326 0.0484 0.0472
Loa Loa (eye worm) phosphatidylinositol 3 0.0656 0.1226 0.1214
Mycobacterium leprae conserved hypothetical protein 0.0305 0.0436 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.3398 0.74 0.74
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0305 0.0436 0.0423
Toxoplasma gondii target of rapamycin (TOR), putative 0.3398 0.74 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2722 0.5877 0.5877
Trichomonas vaginalis PIKK family atypical protein kinase 0.2476 0.5324 0.5324
Entamoeba histolytica hypothetical protein 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0436 0.0436
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0326 0.0484 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.4553 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3398 0.74 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.0305 0.0436 0.0436
Toxoplasma gondii FATC domain-containing protein 0.0881 0.1733 0.1863
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1612 0.3379 0.337
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0326 0.0484 0.0472
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0326 0.0484 0.0472
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0326 0.0484 0.0069
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0305 0.0436 0.0423
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0511 0.0901 0.0889
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0188 0.0172 0.0159
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0305 0.0436 0.8975
Brugia malayi FAT domain containing protein 0.0676 0.1272 0.1261
Giardia lamblia Phosphatidylinositol 4-kinase 0.0305 0.0436 0.0423
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0511 0.0901 0.0901
Entamoeba histolytica hypothetical protein 0.0881 0.1733 0.1722
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.4553 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3635 0.7932 0.7929
Loa Loa (eye worm) hypothetical protein 0.0981 0.1958 0.1948
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0511 0.0901 0.0889
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0305 0.0436 0.8975
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0893 0.1759 0.1759
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0117 0.0013 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0981 0.1958 0.2186
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.4553 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0305 0.0436 0.0423
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0699 0.1323 0.1312
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.4553 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.4553 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0305 0.0436 0.8975
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.037 0.0582 0.057
Onchocerca volvulus 0.0305 0.0436 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0436 0.0732 0.072
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0305 0.0436 0.0423
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.3398 0.74 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.3055 0.6626 0.6626
Trichomonas vaginalis PIKK family atypical protein kinase 0.3398 0.74 0.74
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0305 0.0436 0.0423
Trichomonas vaginalis immunophilin, putative 0.0117 0.0013 0.0013
Schistosoma mansoni fkbp-rapamycin associated protein 0.0881 0.1733 0.1722
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0699 0.1323 0.1312
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3635 0.7932 0.7929
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0305 0.0436 0.0423
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.037 0.0582 0.057
Echinococcus multilocularis serine protein kinase ATM 0.0881 0.1733 0.1722
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0511 0.0901 0.0889
Trichomonas vaginalis PIKK family atypical protein kinase 0.3631 0.7924 0.7924
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0305 0.0436 0.0423
Onchocerca volvulus 0.0305 0.0436 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0881 0.1733 0.1722
Schistosoma mansoni hypothetical protein 0.0305 0.0436 0.0423
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0305 0.0436 0.0423
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0326 0.0484 0.0472
Entamoeba histolytica hypothetical protein 0.0468 0.0803 0.0791
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.3398 0.74 0.74
Trichomonas vaginalis PIKK family atypical protein kinase 0.4553 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0881 0.1733 0.1722
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.5332 0.5332
Giardia lamblia Hypothetical protein 0.0305 0.0436 0.0423
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0576 0.1047 0.1036
Trichomonas vaginalis PIKK family atypical protein kinase 0.2476 0.5324 0.5324
Schistosoma mansoni voltage-gated potassium channel 0.013 0.0042 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0576 0.1047 0.1047
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0468 0.0803 0.0791
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.037 0.0582 0.057
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0117 0.0013 0.0013
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0305 0.0436 0.0423
Plasmodium vivax hypothetical protein, conserved 0.0305 0.0436 0.8975
Trichomonas vaginalis PIKK family atypical protein kinase 0.2712 0.5856 0.5856
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0511 0.0901 0.0889
Trypanosoma cruzi target of rapamycin kinase 3 0.3635 0.7932 0.7929
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0326 0.0484 0.0484
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0676 0.1272 0.1261
Trichomonas vaginalis PIKK family atypical protein kinase 0.2722 0.5877 0.5877
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0326 0.0484 0.0472
Loa Loa (eye worm) hypothetical protein 0.0676 0.1272 0.1261
Trichomonas vaginalis conserved hypothetical protein 0.0981 0.1958 0.1958
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0207 0.0215 0.0202
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.4553 1 1
Loa Loa (eye worm) hypothetical protein 0.0436 0.0732 0.072
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0119 0.0018 0.0005
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0393 0.0634 0.0622
Echinococcus multilocularis 0.0305 0.0436 0.0423
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.037 0.0582 0.0582
Loa Loa (eye worm) hypothetical protein 0.0881 0.1733 0.1722
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.4553 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.037 0.0582 0.0582
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0119 0.0018 0.0005
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1612 0.3379 0.337
Trichomonas vaginalis PIKK family atypical protein kinase 0.1557 0.3256 0.3256
Trichomonas vaginalis PIKK family atypical protein kinase 0.2722 0.5877 0.5877
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1612 0.3379 0.337
Leishmania major phosphatidylinositol 4-kinase, putative 0.0305 0.0436 0.0423
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1612 0.3379 0.337
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0881 0.1733 0.1722
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.4553 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1557 0.3256 0.3256
Mycobacterium tuberculosis Conserved hypothetical protein 0.0305 0.0436 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.3631 0.7924 0.7924
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0881 0.1733 0.1722
Schistosoma mansoni hypothetical protein 0.0676 0.1272 0.1261
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1612 0.3379 0.337
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0326 0.0484 0.0472
Plasmodium vivax hypothetical protein 0.0305 0.0436 0.8975
Leishmania major hypothetical protein, conserved 0.0403 0.0658 0.0646
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1612 0.3379 0.337
Trichomonas vaginalis PIKK family atypical protein kinase 0.1223 0.2504 0.2504
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0326 0.0484 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.2712 0.5856 0.5856
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0305 0.0436 0.0436
Schistosoma mansoni voltage-gated potassium channel 0.013 0.0042 0.0029
Leishmania major phosphatidylinositol 3-kinase, putative 0.1557 0.3256 0.3247
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0445 0.0751 0.0751
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0326 0.0484 0.0069
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0305 0.0436 0.0436
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0119 0.0018 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0576 0.1047 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.2955 0.6401 0.6401
Loa Loa (eye worm) hypothetical protein 0.0919 0.1818 0.1807
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0676 0.1272 0.1261
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.4553 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0881 0.1733 0.1722
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1569 0.3282 0.3273
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.037 0.0582 0.057
Giardia lamblia GTOR 0.4553 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0348 0.0534 0.0521
Trichomonas vaginalis PIKK family atypical protein kinase 0.3877 0.8478 0.8478
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0305 0.0436 0.0423
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0326 0.0484 0.0472
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0326 0.0484 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.4553 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0326 0.0484 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.1569 0.3282 0.3282
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0326 0.0484 0.0484
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0511 0.0901 0.0901
Loa Loa (eye worm) phosphatidylinositol kinase 0.0305 0.0436 0.0423
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0436 0.0732 0.072
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2146 0.458 0.4573
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0326 0.0484 0.0472
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.3631 0.7924 0.7924
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0583 0.1063 0.1051
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.5332 0.5332
Trichomonas vaginalis PIKK family atypical protein kinase 0.3398 0.74 0.74
Leishmania major phosphatidylinositol 3-kinase, putative 0.0326 0.0484 0.0472
Loa Loa (eye worm) phosphatidylinositol 3 0.4553 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.0436 0.0423
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.037 0.0582 0.0582
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0305 0.0436 0.8975
Echinococcus granulosus serine protein kinase ATM 0.0881 0.1733 0.1722
Loa Loa (eye worm) phosphatidylinositol 3 0.0305 0.0436 0.0423
Trichomonas vaginalis PIKK family atypical protein kinase 0.0881 0.1733 0.1733
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0326 0.0484 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.3631 0.7924 0.7924
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.037 0.0582 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.248 0.5332 0.5332
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0699 0.1323 0.1312
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0305 0.0436 0.8975
Loa Loa (eye worm) phosphatidylinositol 3 0.1569 0.3282 0.3273
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0881 0.1733 0.1722
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0305 0.0436 0.0423

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.406 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.318 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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