Detailed information for compound 1611388

Basic information

Technical information
  • TDR Targets ID: 1611388
  • Name: [5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hyd roxymethyl)oxolan-3-yl]phosphonic acid
  • MW: 308.182 | Formula: C9H13N2O8P
  • H donors: 5 H acceptors: 7 LogP: -3.45 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(C(C1P(=O)(O)O)O)n1ccc(=O)[nH]c1=O
  • InChi: 1S/C9H13N2O8P/c12-3-4-7(20(16,17)18)6(14)8(19-4)11-2-1-5(13)10-9(11)15/h1-2,4,6-8,12,14H,3H2,(H,10,13,15)(H2,16,17,18)
  • InChiKey: GLFLOZNLDYSPKW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl]phosphonic acid
  • [5-(2,4-dioxo-1-pyrimidinyl)-4-hydroxy-2-(hydroxymethyl)-3-tetrahydrofuranyl]phosphonic acid
  • [5-(2,4-diketopyrimidin-1-yl)-4-hydroxy-2-methylol-tetrahydrofuran-3-yl]phosphonic acid
  • NSC677989
  • NSC677990
  • NCI60_027875
  • NCI60_027873

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0742 0.191 0.191
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0197 0.0265 0.0247
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3423 1 1
Loa Loa (eye worm) hypothetical protein 0.0356 0.0747 0.0731
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0315 0.0622 0.0606
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0116 0.0023 0.0005
Echinococcus multilocularis 0.0231 0.0369 0.0352
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0293 0.0556 0.0556
Echinococcus multilocularis serine protein kinase ATM 0.0666 0.1682 0.1667
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3423 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0293 0.0556 0.0556
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0116 0.0023 0.0005
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1229 0.3379 0.3367
Trichomonas vaginalis PIKK family atypical protein kinase 0.1177 0.3222 0.3222
Trichomonas vaginalis PIKK family atypical protein kinase 0.2046 0.5847 0.5847
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1229 0.3379 0.3367
Leishmania major phosphatidylinositol 4-kinase, putative 0.0231 0.0369 0.0352
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1229 0.3379 0.3367
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0666 0.1682 0.1667
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3423 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1177 0.3222 0.3222
Mycobacterium tuberculosis Conserved hypothetical protein 0.0231 0.0369 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2731 0.7914 0.7914
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0666 0.1682 0.1667
Trichomonas vaginalis conserved hypothetical protein 0.051 0.1212 0.1212
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1229 0.3379 0.3367
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0252 0.0431 0.0414
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1229 0.3379 0.3367
Leishmania major hypothetical protein, conserved 0.0325 0.0653 0.0636
Plasmodium vivax hypothetical protein 0.0231 0.0369 0.851
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0293 0.0556 0.0539
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0666 0.1682 0.1667
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0428 0.0962 0.0946
Trichomonas vaginalis PIKK family atypical protein kinase 0.2731 0.7914 0.7914
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0231 0.0369 0.0352
Onchocerca volvulus 0.0231 0.0369 0.5
Toxoplasma gondii FATC domain-containing protein 0.0666 0.1682 0.1871
Schistosoma mansoni hypothetical protein 0.0231 0.0369 0.0352
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0231 0.0369 0.0352
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0252 0.0431 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.7387 0.7387
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0231 0.0369 0.0352
Entamoeba histolytica hypothetical protein 0.0386 0.0838 0.0821
Trichomonas vaginalis PIKK family atypical protein kinase 0.3423 1 1
Loa Loa (eye worm) hypothetical protein 0.0666 0.1682 0.1667
Trichomonas vaginalis PIKK family atypical protein kinase 0.1868 0.5309 0.5309
Giardia lamblia Hypothetical protein 0.0231 0.0369 0.0352
Trichomonas vaginalis conserved hypothetical protein 0.0435 0.0984 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.1865 0.53 0.53
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.0055 0.0038
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0386 0.0838 0.0821
Loa Loa (eye worm) hypothetical protein 0.0435 0.0984 0.0968
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0293 0.0556 0.0539
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0115 0.0018 0.0018
Plasmodium vivax hypothetical protein, conserved 0.0231 0.0369 0.851
Trichomonas vaginalis PIKK family atypical protein kinase 0.2043 0.5835 0.5835
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0231 0.0369 0.0352
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0428 0.0962 0.0946
Trypanosoma cruzi target of rapamycin kinase 3 0.2734 0.7922 0.7918
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0252 0.0431 0.0431
Loa Loa (eye worm) phosphatidylinositol 3 0.0565 0.1376 0.1361
Trichomonas vaginalis PIKK family atypical protein kinase 0.2046 0.5847 0.5847
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0252 0.0431 0.0414
Schistosoma mansoni hypothetical protein 0.051 0.1212 0.1196
Trichomonas vaginalis PIKK family atypical protein kinase 0.2912 0.846 0.846
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0231 0.0369 0.0352
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0252 0.0431 0.0414
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0252 0.0431 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3423 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0252 0.0431 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.1188 0.3256 0.3256
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0252 0.0431 0.0431
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0428 0.0962 0.0962
Loa Loa (eye worm) phosphatidylinositol kinase 0.0231 0.0369 0.0352
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0356 0.0747 0.0731
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1611 0.4534 0.4524
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0431 0.0414
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.2731 0.7914 0.7914
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.7387 0.7387
Trichomonas vaginalis PIKK family atypical protein kinase 0.1868 0.5309 0.5309
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0496 0.1169 0.1153
Leishmania major phosphatidylinositol 3-kinase, putative 0.0252 0.0431 0.0414
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.0369 0.0352
Loa Loa (eye worm) phosphatidylinositol 3 0.3423 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0293 0.0556 0.0556
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0231 0.0369 0.851
Echinococcus granulosus serine protein kinase ATM 0.0666 0.1682 0.1667
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.1682 0.1682
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0606 0.1501 0.1486
Trichomonas vaginalis PIKK family atypical protein kinase 0.2731 0.7914 0.7914
Trichomonas vaginalis PIKK family atypical protein kinase 0.1868 0.5309 0.5309
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0293 0.0556 0.0539
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0431 0.0414
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0231 0.0369 0.851
Loa Loa (eye worm) phosphatidylinositol 3 0.1188 0.3256 0.3244
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0666 0.1682 0.1667
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.092 0.2447 0.2447
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0252 0.0431 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.2043 0.5835 0.5835
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0231 0.0369 0.0369
Schistosoma mansoni voltage-gated potassium channel 0.0127 0.0055 0.0038
Leishmania major phosphatidylinositol 3-kinase, putative 0.1177 0.3222 0.321
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0364 0.0771 0.0771
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0231 0.0369 0.0369
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0252 0.0431 0.0088
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0116 0.0023 0.0005
Loa Loa (eye worm) hypothetical protein 0.0689 0.175 0.1735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0435 0.0984 0.0984
Trichomonas vaginalis PIKK family atypical protein kinase 0.2221 0.6373 0.6373
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.051 0.1212 0.1196
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3423 1 1
Entamoeba histolytica protein kinase rad3, putative 0.0666 0.1682 0.1667
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1188 0.3256 0.3244
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0293 0.0556 0.0539
Giardia lamblia GTOR 0.3423 1 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0273 0.0494 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1177 0.3222 0.3222
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0677 0.1716 0.1701
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.051 0.1212 0.1196
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0252 0.0431 0.0431
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1433 0.3996 0.3985
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0231 0.0369 0.0352
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0364 0.0771 0.0771
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3423 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0252 0.0431 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0293 0.0556 0.0539
Loa Loa (eye worm) phosphatidylinositol 3 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.1177 0.3222 0.3222
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3423 1 1
Loa Loa (eye worm) hypothetical protein 0.0231 0.0369 0.0352
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0431 0.0414
Brugia malayi FAT domain containing protein 0.051 0.1212 0.1196
Mycobacterium leprae conserved hypothetical protein 0.0231 0.0369 0.5
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0356 0.0747 0.0731
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0115 0.0018 0.0018
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0323 0.0646 0.063
Entamoeba histolytica hypothetical protein 0.0231 0.0369 0.0352
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0428 0.0962 0.0962
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0116 0.0023 0.0005
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0666 0.1682 0.1667
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0435 0.0984 0.0968
Echinococcus multilocularis Zinc finger, PHD finger 0.0252 0.0431 0.0414
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0252 0.0431 0.0414
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0115 0.0018 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.7387 0.7387
Trichomonas vaginalis PIKK family atypical protein kinase 0.0666 0.1682 0.1682
Entamoeba histolytica hypothetical protein 0.0231 0.0369 0.0352
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0666 0.1682 0.1667
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0231 0.0369 0.0352
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0666 0.1682 0.1667
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1188 0.3256 0.3244
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0231 0.0369 0.0352
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1177 0.3222 0.321
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0496 0.1169 0.1153
Leishmania major hypothetical protein, unknown function 0.0231 0.0369 0.0352
Trichomonas vaginalis fk506-binding protein, putative 0.0115 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1868 0.5309 0.5309
Leishmania major phosphatidylinositol kinase related protein, putative 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.2731 0.7914 0.7914
Trichomonas vaginalis PIKK family atypical protein kinase 0.3423 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.1865 0.53 0.53
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0231 0.0369 0.0352
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0428 0.0962 0.0946
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0231 0.0369 0.851
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0677 0.1716 0.1716
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0115 0.0018 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0742 0.191 0.2195
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3423 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0231 0.0369 0.0352
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0606 0.1501 0.1486
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3423 1 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3423 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0231 0.0369 0.851
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0293 0.0556 0.0539
Onchocerca volvulus 0.0231 0.0369 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0356 0.0747 0.0731
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0231 0.0369 0.0352
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.7387 0.7387
Trichomonas vaginalis PIKK family atypical protein kinase 0.2296 0.6601 0.6601
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.7387 0.7387
Trichomonas vaginalis immunophilin, putative 0.0115 0.0018 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0666 0.1682 0.1667
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0606 0.1501 0.1486
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2734 0.7922 0.7918
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0231 0.0369 0.0352
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0231 0.0369 0.0352
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.7387 0.7387
Trichomonas vaginalis PIKK family atypical protein kinase 0.2046 0.5847 0.5847
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0231 0.0369 0.0352
Toxoplasma gondii target of rapamycin (TOR), putative 0.2557 0.7387 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1865 0.53 0.53
Entamoeba histolytica hypothetical protein 0.0231 0.0369 0.0352
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0252 0.0431 0.0414
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.0369 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.3423 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0231 0.0369 0.0369
Schistosoma mansoni fkbp-rapamycin associated protein 0.0666 0.1682 0.1667
Trichomonas vaginalis PIKK family atypical protein kinase 0.2557 0.7387 0.7387
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0252 0.0431 0.0414
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1229 0.3379 0.3367
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0252 0.0431 0.0088
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0252 0.0431 0.0414
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0231 0.0369 0.0352
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0428 0.0962 0.0946
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0178 0.021 0.0192
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0231 0.0369 0.851
Loa Loa (eye worm) hypothetical protein 0.051 0.1212 0.1196
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0428 0.0962 0.0962
Giardia lamblia Phosphatidylinositol 4-kinase 0.0231 0.0369 0.0352
Entamoeba histolytica hypothetical protein 0.0666 0.1682 0.1667
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3423 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2734 0.7922 0.7918
Loa Loa (eye worm) hypothetical protein 0.0742 0.191 0.1895

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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