Detailed information for compound 1611392

Basic information

Technical information
  • TDR Targets ID: 1611392
  • Name: 8-[4,4-diethoxy-4-(4-fluorophenyl)butyl]-3-me thyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-o ne
  • MW: 483.618 | Formula: C28H38FN3O3
  • H donors: 0 H acceptors: 1 LogP: 4.53 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(c1ccc(cc1)F)(OCC)CCCN1CCC2(CC1)N(CN(C2=O)C)c1ccccc1
  • InChi: 1S/C28H38FN3O3/c1-4-34-28(35-5-2,23-12-14-24(29)15-13-23)16-9-19-31-20-17-27(18-21-31)26(33)30(3)22-32(27)25-10-7-6-8-11-25/h6-8,10-15H,4-5,9,16-22H2,1-3H3
  • InChiKey: FJBKNVOIDNHJQL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 54079-70-8
  • NCI60_022813
  • 8-(4,4-Diethoxy-4-(4-fluorophenyl)butyl)-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one
  • AIDS-144003
  • AIDS144003
  • NSC665873
  • 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(3-(p-fluorobenzoyl)propyl)-3-methyl-1-phenyl-, alpha',alpha'-diethyl acetal
  • 1,3,8-Triazaspiro(4.5)decan-4-one, 8-(4,4-diethoxy-4-(4-fluorophenyl)butyl)-3-methyl-1-phenyl-
  • 8-(4,4-Diethoxy-4-(p-fluorophenyl)butyl)-3-methyl-4-oxo-1-phenyl-1,3,8-triazaspiro(4.5)decane
  • BRN 0597657

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0382 0.0477 0.0467
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1958 0.3274 0.3266
Loa Loa (eye worm) hypothetical protein 0.1107 0.1764 0.1755
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.197 0.3294 0.3287
Entamoeba histolytica hypothetical protein 0.0382 0.0477 0.0467
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1107 0.1764 0.1755
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0382 0.0477 0.0467
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.5751 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3121 0.5336 0.5336
Leishmania major phosphatidylinositol kinase, putative 0.0382 0.0477 0.0467
Trichomonas vaginalis fk506-binding protein, putative 0.0119 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.3126 0.5344 0.5344
Leishmania major phosphatidylinositol kinase related protein, putative 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.4583 0.7929 0.7929
Loa Loa (eye worm) hypothetical protein 0.0725 0.1087 0.1077
Leishmania major hypothetical protein, unknown function 0.0382 0.0477 0.0467
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1107 0.1764 0.1755
Entamoeba histolytica hypothetical protein 0.0382 0.0477 0.0467
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0477 0.0646 0.0636
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0585 0.0838 0.0838
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0121 0.0014 0.0003
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0511 0.0707 0.0697
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0119 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.4289 0.7407 0.7407
Schistosoma mansoni fkbp-rapamycin associated protein 0.1107 0.1764 0.1755
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0403 0.0515 0.0504
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0119 0.0011 0.5
Echinococcus multilocularis Zinc finger, PHD finger 0.0403 0.0515 0.0504
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0656 0.0964 0.0954
Loa Loa (eye worm) phosphatidylinositol 3 0.0727 0.109 0.108
Loa Loa (eye worm) hypothetical protein 0.0382 0.0477 0.0467
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0403 0.0515 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.1958 0.3274 0.3274
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.5751 1 1
Mycobacterium leprae conserved hypothetical protein 0.0382 0.0477 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.24 0.4058 0.4051
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.052 0.0722 0.0722
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.1958 0.3274 0.3274
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1119 0.1784 0.1775
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0851 0.131 0.13
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0403 0.0515 0.0515
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0446 0.0591 0.058
Loa Loa (eye worm) phosphatidylinositol 3 0.0382 0.0477 0.0467
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0403 0.0515 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.5751 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0382 0.0477 0.9257
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.077 0.1166 0.1156
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0585 0.0838 0.0838
Giardia lamblia Phosphatidylinositol 4-kinase 0.0382 0.0477 0.0467
Entamoeba histolytica hypothetical protein 0.1107 0.1764 0.1755
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0185 0.0128 0.0117
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0585 0.0838 0.0828
Loa Loa (eye worm) hypothetical protein 0.1233 0.1987 0.1978
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.5751 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.4588 0.7938 0.7935
Entamoeba histolytica hypothetical protein 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.3121 0.5336 0.5336
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.3437 0.5897 0.5897
Toxoplasma gondii target of rapamycin (TOR), putative 0.4289 0.7407 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4289 0.7407 0.7407
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0382 0.0477 0.0467
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0403 0.0515 0.0504
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0403 0.0515 0.0054
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.4289 0.7407 0.7407
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1107 0.1764 0.1755
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0477 0.0477
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0403 0.0515 0.0504
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2012 0.3369 0.3362
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0403 0.0515 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.5751 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0382 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.4289 0.7407 0.7407
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0382 0.0477 0.0467
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0382 0.0477 0.0467
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0382 0.0477 0.0467
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.4588 0.7938 0.7935
Schistosoma mansoni hypothetical protein 0.0851 0.131 0.13
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1107 0.1764 0.1755
Trichomonas vaginalis immunophilin, putative 0.0119 0.0011 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.4289 0.7407 0.7407
Trichomonas vaginalis PIKK family atypical protein kinase 0.3858 0.6643 0.6643
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0382 0.0477 0.0467
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0382 0.0477 0.0467
Trichomonas vaginalis conserved hypothetical protein 0.0851 0.131 0.131
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1233 0.1987 0.2179
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0119 0.0011 0.5
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.5751 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1119 0.1784 0.1784
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0585 0.0838 0.0828
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0382 0.0477 0.9257
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0382 0.0477 0.0467
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0446 0.0591 0.058
Onchocerca volvulus 0.0382 0.0477 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0511 0.0707 0.0697
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0382 0.0477 0.9257
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.5751 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.5751 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0119 0.0011 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0382 0.0477 0.9257
Trichomonas vaginalis PIKK family atypical protein kinase 0.3421 0.5867 0.5867
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0382 0.0477 0.0467
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0446 0.0591 0.058
Trichomonas vaginalis conserved hypothetical protein 0.0725 0.1087 0.1087
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0543 0.0762 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.3121 0.5336 0.5336
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0034 0.0023
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0403 0.0515 0.0504
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.077 0.1166 0.1156
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0403 0.0515 0.0515
Trichomonas vaginalis PIKK family atypical protein kinase 0.3437 0.5897 0.5897
Loa Loa (eye worm) hypothetical protein 0.0851 0.131 0.13
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0585 0.0838 0.0828
Trypanosoma cruzi target of rapamycin kinase 3 0.4588 0.7938 0.7935
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0382 0.0477 0.0467
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1107 0.1764 0.1755
Schistosoma mansoni hypothetical protein 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.4583 0.7929 0.7929
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0382 0.0477 0.0467
Onchocerca volvulus 0.0382 0.0477 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1107 0.1764 0.1764
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0446 0.0591 0.058
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0585 0.0838 0.0828
Giardia lamblia Hypothetical protein 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.3126 0.5344 0.5344
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0656 0.0964 0.0954
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1107 0.1764 0.1755
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.4289 0.7407 0.7407
Entamoeba histolytica hypothetical protein 0.0543 0.0762 0.0752
Trichomonas vaginalis PIKK family atypical protein kinase 0.5751 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0403 0.0515 0.0504
Mycobacterium tuberculosis Conserved hypothetical protein 0.0382 0.0477 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4583 0.7929 0.7929
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1107 0.1764 0.1755
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.5751 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1958 0.3274 0.3274
Toxoplasma gondii FATC domain-containing protein 0.1107 0.1764 0.1857
Leishmania major phosphatidylinositol 4-kinase, putative 0.0382 0.0477 0.0467
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2012 0.3369 0.3362
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0403 0.0515 0.0504
Plasmodium vivax hypothetical protein 0.0382 0.0477 0.9257
Leishmania major hypothetical protein, conserved 0.0479 0.065 0.0639
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2012 0.3369 0.3362
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2012 0.3369 0.3362
Brugia malayi FAT domain containing protein 0.0851 0.131 0.13
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0469 0.0631 0.0621
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0121 0.0014 0.0003
Echinococcus multilocularis 0.0382 0.0477 0.0467
Loa Loa (eye worm) hypothetical protein 0.0511 0.0707 0.0697
Trichomonas vaginalis conserved hypothetical protein 0.1233 0.1987 0.1987
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.5751 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0204 0.0161 0.015
Trichomonas vaginalis PIKK family atypical protein kinase 0.1958 0.3274 0.3274
Trichomonas vaginalis PIKK family atypical protein kinase 0.3437 0.5897 0.5897
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2012 0.3369 0.3362
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0121 0.0014 0.0003
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2012 0.3369 0.3362
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0446 0.0591 0.0591
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.5751 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0446 0.0591 0.0591
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1107 0.1764 0.1755
Leishmania major phosphatidylinositol 3-related kinase, putative 0.197 0.3294 0.3287
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0446 0.0591 0.058
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.5751 1 1
Entamoeba histolytica protein kinase rad3, putative 0.1107 0.1764 0.1755
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0425 0.0553 0.0543
Giardia lamblia GTOR 0.5751 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3421 0.5867 0.5867
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0382 0.0477 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.1545 0.254 0.254
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0403 0.0515 0.0504
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.077 0.1166 0.1156
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0121 0.0014 0.0003
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0382 0.0477 0.0477
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0403 0.0515 0.0054
Loa Loa (eye worm) hypothetical protein 0.1163 0.1862 0.1854
Trichomonas vaginalis PIKK family atypical protein kinase 0.0725 0.1087 0.1087
Trichomonas vaginalis PIKK family atypical protein kinase 0.3732 0.642 0.642
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.052 0.0722 0.0722
Schistosoma mansoni voltage-gated potassium channel 0.0132 0.0034 0.0023
Leishmania major phosphatidylinositol 3-kinase, putative 0.1958 0.3274 0.3266
Echinococcus granulosus serine protein kinase ATM 0.1107 0.1764 0.1755
Loa Loa (eye worm) phosphatidylinositol 3 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.1107 0.1764 0.1764
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0382 0.0477 0.9257
Leishmania major phosphatidylinositol 3-kinase, putative 0.0403 0.0515 0.0504
Loa Loa (eye worm) phosphatidylinositol 3 0.5751 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0446 0.0591 0.0591
Loa Loa (eye worm) phosphatidylinositol 3 0.0382 0.0477 0.0467
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0725 0.1087 0.1077
Trichomonas vaginalis PIKK family atypical protein kinase 0.3126 0.5344 0.5344
Trichomonas vaginalis PIKK family atypical protein kinase 0.4289 0.7407 0.7407
Echinococcus multilocularis serine protein kinase ATM 0.1107 0.1764 0.1755
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0382 0.0477 0.0467
Loa Loa (eye worm) phosphatidylinositol 3 0.197 0.3294 0.3287
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0446 0.0591 0.058
Trichomonas vaginalis PIKK family atypical protein kinase 0.4583 0.7929 0.7929
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0851 0.131 0.13
Trichomonas vaginalis PIKK family atypical protein kinase 0.3126 0.5344 0.5344
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0403 0.0515 0.0504
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0382 0.0477 0.9257
Trichomonas vaginalis PIKK family atypical protein kinase 0.197 0.3294 0.3294
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0403 0.0515 0.0515
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0403 0.0515 0.0504
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.5751 1 1
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0382 0.0477 0.0467
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0403 0.0515 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0403 0.0515 0.0504
Trichomonas vaginalis PIKK family atypical protein kinase 0.49 0.849 0.849
Loa Loa (eye worm) phosphatidylinositol 3 0.0382 0.0477 0.0467
Trichomonas vaginalis PIKK family atypical protein kinase 0.4583 0.7929 0.7929
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.2712 0.461 0.4604
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0403 0.0515 0.0504
Loa Loa (eye worm) phosphatidylinositol kinase 0.0382 0.0477 0.0467
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0511 0.0707 0.0697
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0585 0.0838 0.0838

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.462 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.424 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.287 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.163 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.154 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.988 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.936 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.885 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.79 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.781 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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