Detailed information for compound 1611393

Basic information

Technical information
  • TDR Targets ID: 1611393
  • Name: N,N-diethyl-6-(2-(1-pyridin-4-ylethylidene)hy drazinyl)pyridine-3-sulfonamide
  • MW: 347.435 | Formula: C16H21N5O2S
  • H donors: 1 H acceptors: 4 LogP: 1.84 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(nc1)N/N=C(/c1ccncc1)\C)CC
  • InChi: 1S/C16H21N5O2S/c1-4-21(5-2)24(22,23)15-6-7-16(18-12-15)20-19-13(3)14-8-10-17-11-9-14/h6-12H,4-5H2,1-3H3,(H,18,20)/b19-13+
  • InChiKey: HVNNVTTVHCLYSU-CPNJWEJPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-diethyl-6-((2E)-2-(1-pyridin-4-ylethylidene)hydrazinyl)pyridine-3-sulfonamide
  • N,N-diethyl-6-[N'-[1-(4-pyridyl)ethylidene]hydrazino]pyridine-3-sulfonamide
  • N,N-diethyl-6-[(N'E)-N'-[1-(4-pyridyl)ethylidene]hydrazino]pyridine-3-sulfonamide
  • N,N-diethyl-6-[(N'E)-N'-[1-(4-pyridyl)ethylidene]hydrazino]-3-pyridinesulfonamide
  • N,N-diethyl-6-[N'-[1-(4-pyridyl)ethylidene]hydrazino]-3-pyridinesulfonamide
  • T5339102

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.014 0.0105 0.0105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0468 0.0573 0.0496
Schistosoma mansoni immunophilin 0.0123 0.008 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0891 0.1176 0.1105
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.049 0.0604 0.0528
Echinococcus multilocularis 0.0468 0.0573 0.0519
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7076 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.008 0.0024
Trichomonas vaginalis PIKK family atypical protein kinase 0.2404 0.3335 0.3281
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0534 0.0667 0.0592
Onchocerca volvulus 0.0468 0.0573 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.049 0.0604 0.0046
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7076 1 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2951 0.4116 0.4068
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0468 0.0573 0.0496
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0611 0.0777 0.0702
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.008 0.008
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.049 0.0604 0.0604
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1045 0.1397 0.1348
Trichomonas vaginalis PIKK family atypical protein kinase 0.2404 0.3335 0.3281
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.137 0.1861 0.1795
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0468 0.0573 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.5378 0.5341
Plasmodium vivax hypothetical protein 0.0468 0.0573 0.9403
Giardia lamblia GTOR 0.7076 1 1
Leishmania major phosphatidylinositol kinase, putative 0.0468 0.0573 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.5637 0.7948 0.7932
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5387 0.5349
Echinococcus granulosus muscleblind protein 0.0164 0.0139 0.0084
Leishmania major phosphatidylinositol 4-kinase, putative 0.0468 0.0573 0.0496
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0871 0.1147 0.1097
Leishmania major phosphatidylinositol 3-kinase, putative 0.2404 0.3335 0.3281
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0468 0.0573 0.0496
Loa Loa (eye worm) phosphatidylinositol 3 0.2416 0.3352 0.3352
Toxoplasma gondii FATC domain-containing protein 0.1359 0.1844 0.1853
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0468 0.0573 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.1359 0.1844 0.1778
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0468 0.0573 0.0519
Trichomonas vaginalis PIKK family atypical protein kinase 0.5274 0.743 0.741
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1359 0.1844 0.1778
Echinococcus multilocularis muscleblind protein 0.0164 0.0139 0.0084
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.049 0.0604 0.0528
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.049 0.0604 0.0551
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0752 0.0979 0.0928
Echinococcus multilocularis serine protein kinase ATM 0.1359 0.1844 0.1797
Loa Loa (eye worm) hypothetical protein 0.0106 0.0056 0.0056
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0679 0.0874 0.08
Schistosoma mansoni hypothetical protein 0.0205 0.0197 0.0142
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0566 0.0713 0.0638
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0468 0.0573 0.0519
Brugia malayi Muscleblind-like protein 0.0164 0.0139 0.006
Loa Loa (eye worm) hypothetical protein 0.0164 0.0139 0.0139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0602 0.0764 0.069
Leishmania major phosphatidylinositol kinase related protein, putative 0.0468 0.0573 0.0496
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5643 0.7956 0.794
Loa Loa (eye worm) hypothetical protein 0.1045 0.1397 0.1397
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0161 0.0135 0.0055
Loa Loa (eye worm) hypothetical protein 0.0166 0.0142 0.0142
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1359 0.1844 0.1844
Trichomonas vaginalis PIKK family atypical protein kinase 0.5274 0.743 0.741
Entamoeba histolytica hypothetical protein 0.0468 0.0573 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.4747 0.6677 0.665
Trichomonas vaginalis PIKK family atypical protein kinase 0.5274 0.743 0.741
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0468 0.0573 0.0519
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0468 0.0573 0.0496
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0602 0.0764 0.0712
Loa Loa (eye worm) phosphatidylinositol kinase 0.0468 0.0573 0.0573
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0161 0.0135 0.0079
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0534 0.0667 0.0592
Plasmodium vivax hypothetical protein, conserved 0.0468 0.0573 0.9403
Trichomonas vaginalis PIKK family atypical protein kinase 0.7076 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.7076 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1045 0.1397 0.1348
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0468 0.0573 0.0573
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7076 1 1
Trichomonas vaginalis conserved hypothetical protein 0.1513 0.2064 0.2
Echinococcus multilocularis muscleblind protein 1 0.0164 0.0139 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.137 0.1861 0.1795
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0468 0.0573 0.0496
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0468 0.0573 0.0519
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0679 0.0874 0.0874
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0161 0.0135 0.0079
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0123 0.008 0.008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.1513 0.2064 0.2064
Trypanosoma cruzi target of rapamycin kinase 3 0.5643 0.7956 0.7956
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7076 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0679 0.0874 0.08
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0468 0.0573 0.0519
Entamoeba histolytica hypothetical protein 0.1359 0.1844 0.1778
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0468 0.0573 0.9403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0891 0.1176 0.1105
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.008 0.0024
Echinococcus granulosus geminin 0.0205 0.0197 0.0142
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0679 0.0874 0.08
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0468 0.0573 0.9403
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.049 0.0604 0.0528
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.049 0.0604 0.0528
Leishmania major phosphatidylinositol 3-kinase, putative 0.049 0.0604 0.0528
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.246 0.3415 0.3415
Loa Loa (eye worm) phosphatidylinositol 3 0.0468 0.0573 0.0573
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1359 0.1844 0.1797
Trichomonas vaginalis PIKK family atypical protein kinase 0.5274 0.743 0.741
Loa Loa (eye worm) phosphatidylinositol 3 0.0468 0.0573 0.0573
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7076 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.049 0.0604 0.0528
Entamoeba histolytica hypothetical protein 0.0468 0.0573 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.5378 0.5341
Trichomonas vaginalis PIKK family atypical protein kinase 0.5274 0.743 0.741
Mycobacterium leprae conserved hypothetical protein 0.0468 0.0573 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.4229 0.5939 0.5906
Toxoplasma gondii target of rapamycin (TOR), putative 0.5274 0.743 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0468 0.0573 0.0519
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.246 0.3415 0.3361
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0468 0.0573 0.9403
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0123 0.008 0.5
Leishmania major hypothetical protein, conserved 0.0569 0.0717 0.0641
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.049 0.0604 0.0551
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.246 0.3415 0.3377
Trichomonas vaginalis conserved hypothetical protein 0.1045 0.1397 0.1327
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1359 0.1844 0.1797
Trichomonas vaginalis PIKK family atypical protein kinase 0.5637 0.7948 0.7932
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0123 0.008 0.0024
Onchocerca volvulus 0.0468 0.0573 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2404 0.3335 0.3281
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7076 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1359 0.1844 0.1778
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0468 0.0573 0.0496
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.246 0.3415 0.3415
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.246 0.3415 0.3377
Trichomonas vaginalis PIKK family atypical protein kinase 0.2404 0.3335 0.3281
Trichomonas vaginalis PIKK family atypical protein kinase 0.4229 0.5939 0.5906
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.246 0.3415 0.3377
Schistosoma mansoni voltage-gated potassium channel 0.0176 0.0156 0.01
Schistosoma mansoni immunophilin 0.0123 0.008 0.0024
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0534 0.0667 0.0592
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7076 1 1
Echinococcus granulosus serine protein kinase ATM 0.1359 0.1844 0.1797
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0534 0.0667 0.0667
Mycobacterium tuberculosis Conserved hypothetical protein 0.0468 0.0573 0.5
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0558 0.0701 0.0626
Schistosoma mansoni voltage-gated potassium channel 0.0176 0.0156 0.01
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0602 0.0764 0.0712
Echinococcus multilocularis fk506 binding protein 0.0123 0.008 0.0024
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0211 0.0207 0.0127
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7076 1 1
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0123 0.008 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1513 0.2064 0.2175
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0891 0.1176 0.1176
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.049 0.0604 1
Schistosoma mansoni hypothetical protein 0.1045 0.1397 0.1348
Trichomonas vaginalis PIKK family atypical protein kinase 0.4229 0.5939 0.5906
Schistosoma mansoni phosphatidylinositol 4-kinase 0.049 0.0604 0.0551
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5643 0.7956 0.794
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0679 0.0874 0.08
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0468 0.0573 0.9403
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.015 0.012 0.004
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0468 0.0573 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.4205 0.5905 0.5871
Brugia malayi hypothetical protein 0.0166 0.0142 0.0062
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0534 0.0667 0.0592
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0123 0.008 0.0024
Entamoeba histolytica hypothetical protein 0.0634 0.081 0.0736
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0871 0.1147 0.1097
Schistosoma mansoni hypothetical protein 0.0205 0.0197 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.3836 0.5378 0.5341
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0752 0.0979 0.0928
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5387 0.5349
Entamoeba histolytica hypothetical protein 0.0468 0.0573 0.0496
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1359 0.1844 0.1778
Loa Loa (eye worm) phosphatidylinositol 3 0.7076 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.008 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.5274 0.743 0.741
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0161 0.0135 0.0135
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0634 0.081 0.0736
Giardia lamblia Hypothetical protein 0.0468 0.0573 0.0496
Plasmodium falciparum phosphatidylinositol 3-kinase 0.049 0.0604 1
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0468 0.0573 0.9403
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0468 0.0573 0.0519
Loa Loa (eye worm) hypothetical protein 0.1359 0.1844 0.1844
Schistosoma mansoni hypothetical protein 0.0468 0.0573 0.0519
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.008 0.008
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0468 0.0573 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.5637 0.7948 0.7932
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0679 0.0874 0.08
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0534 0.0667 0.0592
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1359 0.1844 0.1844
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0468 0.0573 0.0573
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1359 0.1844 0.1797
Trichomonas vaginalis PIKK family atypical protein kinase 0.2416 0.3352 0.3298
Giardia lamblia Phosphatidylinositol 4-kinase 0.0468 0.0573 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5387 0.5349
Brugia malayi FAT domain containing protein 0.1045 0.1397 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.5637 0.7948 0.7932
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.049 0.0604 0.0551
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0534 0.0667 0.0592
Schistosoma mansoni fkbp-rapamycin associated protein 0.1359 0.1844 0.1797
Trichomonas vaginalis PIKK family atypical protein kinase 0.1359 0.1844 0.1778
Loa Loa (eye worm) phosphatidylinositol 3 0.0468 0.0573 0.0573
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0468 0.0573 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0468 0.0573 0.0496
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0534 0.0667 0.0592
Trichomonas vaginalis PIKK family atypical protein kinase 0.7076 1 1
Echinococcus multilocularis Zinc finger, PHD finger 0.049 0.0604 0.0551
Trichomonas vaginalis PIKK family atypical protein kinase 0.3842 0.5387 0.5349
Trichomonas vaginalis PIKK family atypical protein kinase 0.5274 0.743 0.741
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0871 0.1147 0.1097
Trichomonas vaginalis PIKK family atypical protein kinase 0.5637 0.7948 0.7932
Loa Loa (eye worm) phosphatidylinositol 3 0.0468 0.0573 0.0573
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3338 0.4668 0.4625
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.049 0.0604 0.0528
Loa Loa (eye worm) hypothetical protein 0.0602 0.0764 0.0764
Loa Loa (eye worm) hypothetical protein 0.0468 0.0573 0.0573
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0679 0.0874 0.0874
Loa Loa (eye worm) hypothetical protein 0.0077 0.0015 0.0015
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.049 0.0604 0.0528
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2416 0.3352 0.3298
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7076 1 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.049 0.0604 0.0604
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.049 0.0604 0.0528
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.049 0.0604 0.0604
Leishmania major hypothetical protein, unknown function 0.0468 0.0573 0.0496
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.015 0.012 0.004
Trichomonas vaginalis PIKK family atypical protein kinase 0.603 0.8509 0.8497
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0512 0.0636 0.056
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7076 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0101 0.0049 0.0049
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0534 0.0667 0.0615
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2416 0.3352 0.3298
Entamoeba histolytica protein kinase rad3, putative 0.1359 0.1844 0.1778
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7076 1 1
Loa Loa (eye worm) hypothetical protein 0.0891 0.1176 0.1176
Loa Loa (eye worm) hypothetical protein 0.1432 0.1949 0.1949
Loa Loa (eye worm) phosphatidylinositol 3 0.0826 0.1084 0.1084
Trichomonas vaginalis PIKK family atypical protein kinase 0.4592 0.6457 0.6428
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0468 0.0573 0.0519
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.049 0.0604 0.0551
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0192 0.0179 0.0099
Loa Loa (eye worm) FKBP5 protein 0.0123 0.008 0.008
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0611 0.0777 0.0702
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2404 0.3335 0.3281
Echinococcus multilocularis geminin 0.0205 0.0197 0.0142
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0468 0.0573 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.4205 0.5905 0.5871
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.049 0.0604 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.19 0.2616 0.2556
Loa Loa (eye worm) hypothetical protein 0.0164 0.0139 0.0139

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

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