TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 415.524 | Formula: C27H29NO3
H donors: 1 H acceptors: 1 LogP: 5.37 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1OCCNCC1CCC(C1=O)(c1ccccc1)c1ccccc1
InChi: 1S/C27H29NO3/c1-30-24-14-8-9-15-25(24)31-19-18-28-20-21-16-17-27(26(21)29,22-10-4-2-5-11-22)23-12-6-3-7-13-23/h2-15,21,28H,16-20H2,1H3
InChiKey: QLQDGQGXEOZRKZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0411	0.0975	0.0975
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0239	0.0423	0.0406
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0239	0.0423	0.0091
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0112	0.0018	0.5
Toxoplasma gondii	FATC domain-containing protein	0.063	0.1675	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2415	0.7385	0.7385
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0341	0.0751	0.0734
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0112	0.0018	0.0018
Entamoeba histolytica	hypothetical protein	0.0219	0.0359	0.0342
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0308	0.0646	0.0629
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0114	0.0024	0.0006
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0411	0.0974	0.0957
Echinococcus granulosus	serine protein kinase ATM	0.063	0.1675	0.1659
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0478	0.1187	0.1171
Leishmania major	hypothetical protein, unknown function	0.0219	0.0359	0.0342
Trichomonas vaginalis	fk506-binding protein, putative	0.0112	0.0018	0.0018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1765	0.5306	0.5306
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.258	0.7912	0.7912
Loa Loa (eye worm)	phosphatidylinositol 3	0.3233	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1763	0.5297	0.5297
Leishmania major	phosphatidylinositol kinase, putative	0.0219	0.0359	0.0342
Loa Loa (eye worm)	phosphatidylinositol 3	0.0219	0.0359	0.0342
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.063	0.1675	0.1659
Entamoeba histolytica	hypothetical protein	0.0219	0.0359	0.0342
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0219	0.0359	0.0342
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.063	0.1675	0.1659
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1123	0.3252	0.3252
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0219	0.0359	0.0342
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1112	0.3218	0.3205
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.3233	1	1
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0239	0.0423	0.0406
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0279	0.0553	0.0535
Onchocerca volvulus		0.0219	0.0359	0.5
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0641	0.1709	0.1694
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1112	0.3218	0.3218
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0239	0.0423	1
Brugia malayi	FAT domain containing protein	0.0482	0.1203	0.1187
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0219	0.0359	0.0342
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.1354	0.399	0.3979
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0349	0.0776	0.0776
Echinococcus multilocularis		0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1112	0.3218	0.3218
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.3233	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0219	0.0359	0.0342
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0239	0.0423	0.0406
Schistosoma mansoni	hypothetical protein	0.0482	0.1203	0.1187
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.3233	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0239	0.0423	0.0406
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2415	0.7385	0.7385
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.063	0.1675	0.1659
Mycobacterium leprae	conserved hypothetical protein	0.0219	0.0359	0.5
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1163	0.338	0.3368
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0239	0.0423	0.0406
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0239	0.0423	0.0406
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0239	0.0423	0.0406
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0219	0.0359	0.0342
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2415	0.7385	0.7385
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1933	0.5842	0.5842
Toxoplasma gondii	target of rapamycin (TOR), putative	0.2415	0.7385	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1763	0.5297	0.5297
Entamoeba histolytica	hypothetical protein	0.0219	0.0359	0.0342
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.3233	1	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.2583	0.792	0.7917
Loa Loa (eye worm)	hypothetical protein	0.0701	0.1903	0.1888
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0411	0.0974	0.0957
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0174	0.0218	0.02
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0482	0.1203	0.1187
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0219	0.0359	0.8425
Entamoeba histolytica	hypothetical protein	0.063	0.1675	0.1659
Loa Loa (eye worm)	hypothetical protein	0.0411	0.0975	0.0958
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0219	0.0359	0.0342
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.3233	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3233	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0219	0.0359	0.8425
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0279	0.0553	0.0553
Loa Loa (eye worm)	phosphatidylinositol 3	0.0219	0.0359	0.0342
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0341	0.0751	0.0734
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0411	0.0974	0.0974
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0219	0.0359	0.8425
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0641	0.1709	0.1709
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0701	0.1903	0.2196
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0112	0.0018	0.5
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.3233	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0219	0.0359	0.0342
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0585	0.1532	0.1516
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2415	0.7385	0.7385
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2169	0.6597	0.6597
Trichomonas vaginalis	immunophilin, putative	0.0112	0.0018	0.0018
Echinococcus multilocularis	serine protein kinase ATM	0.063	0.1675	0.1659
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0585	0.1532	0.1516
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.2583	0.792	0.7917
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0219	0.0359	0.0342
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0219	0.0359	0.0342
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2415	0.7385	0.7385
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0239	0.0423	0.0406
Entamoeba histolytica	hypothetical protein	0.037	0.0845	0.0828
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2415	0.7385	0.7385
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3233	1	1
Schistosoma mansoni	fkbp-rapamycin associated protein	0.063	0.1675	0.1659
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1765	0.5306	0.5306
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0411	0.0974	0.0974
Giardia lamblia	Hypothetical protein	0.0219	0.0359	0.0342
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0279	0.0553	0.0553
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.063	0.1675	0.1659
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0411	0.0974	0.0957
Trichomonas vaginalis	PIKK family atypical protein kinase	0.258	0.7912	0.7912
Onchocerca volvulus		0.0219	0.0359	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0219	0.0359	0.0342
Loa Loa (eye worm)	hypothetical protein	0.063	0.1675	0.1659
Schistosoma mansoni	hypothetical protein	0.0219	0.0359	0.0342
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0219	0.0359	0.0342
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0411	0.0974	0.0957
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.2583	0.792	0.7917
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0239	0.0423	0.0406
Loa Loa (eye worm)	phosphatidylinositol 3	0.0545	0.1402	0.1387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1933	0.5842	0.5842
Trichomonas vaginalis	conserved hypothetical protein	0.0482	0.1203	0.1203
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0239	0.0423	0.0423
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1763	0.5297	0.5297
Schistosoma mansoni	voltage-gated potassium channel	0.0124	0.0057	0.0039
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.037	0.0845	0.0828
Trichomonas vaginalis	conserved hypothetical protein	0.0411	0.0975	0.0975
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0279	0.0553	0.0535
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0112	0.0018	0.0018
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0219	0.0359	0.0342
Plasmodium vivax	hypothetical protein, conserved	0.0219	0.0359	0.8425
Trichomonas vaginalis	PIKK family atypical protein kinase	0.193	0.5833	0.5833
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0279	0.0553	0.0553
Trichomonas vaginalis	PIKK family atypical protein kinase	0.063	0.1675	0.1675
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3233	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0279	0.0553	0.0535
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0114	0.0024	0.0006
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1163	0.338	0.3368
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1933	0.5842	0.5842
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1112	0.3218	0.3205
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1163	0.338	0.3368
Trichomonas vaginalis	conserved hypothetical protein	0.0701	0.1903	0.1903
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.3233	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0192	0.0274	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0341	0.0751	0.0734
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0114	0.0024	0.0006
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0301	0.0622	0.0604
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0219	0.0359	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0482	0.1203	0.1187
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1163	0.338	0.3368
Echinococcus multilocularis	Zinc finger, PHD finger	0.0239	0.0423	0.0406
Plasmodium vivax	hypothetical protein	0.0219	0.0359	0.8425
Leishmania major	hypothetical protein, conserved	0.0311	0.0653	0.0636
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1163	0.338	0.3368
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0219	0.0359	0.0342
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1163	0.338	0.3368
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.063	0.1675	0.1659
Giardia lamblia	GTOR	0.3233	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1112	0.3218	0.3218
Loa Loa (eye worm)	hypothetical protein	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.258	0.7912	0.7912
Trichomonas vaginalis	PIKK family atypical protein kinase	0.063	0.1675	0.1675
Schistosoma mansoni	voltage-gated potassium channel	0.0124	0.0057	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1112	0.3218	0.3218
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0349	0.0776	0.0776
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0114	0.0024	0.0006
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0239	0.0423	0.0423
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0219	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2098	0.6369	0.6369
Loa Loa (eye worm)	hypothetical protein	0.065	0.1739	0.1724
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0411	0.0974	0.0974
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0482	0.1203	0.1187
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0869	0.2439	0.2439
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0239	0.0423	0.0406
Trichomonas vaginalis	PIKK family atypical protein kinase	0.193	0.5833	0.5833
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0219	0.0359	0.0359
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.3233	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0259	0.0489	0.0471
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.3233	1	1
Entamoeba histolytica	protein kinase rad3, putative	0.063	0.1675	0.1659
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0279	0.0553	0.0535
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1123	0.3252	0.324
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0411	0.0975	0.0958
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0219	0.0359	0.0342
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0341	0.0751	0.0734
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0239	0.0423	0.0406
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.1522	0.4527	0.4517
Trichomonas vaginalis	PIKK family atypical protein kinase	0.258	0.7912	0.7912
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0219	0.0359	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2751	0.8457	0.8457
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0219	0.0359	0.0342
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0239	0.0423	0.0406
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0239	0.0423	0.0406
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.3233	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0239	0.0423	0.0423
Loa Loa (eye worm)	phosphatidylinositol 3	0.1123	0.3252	0.324
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0239	0.0423	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1765	0.5306	0.5306
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0585	0.1532	0.1516
Trichomonas vaginalis	PIKK family atypical protein kinase	0.258	0.7912	0.7912
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0279	0.0553	0.0535
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0239	0.0423	0.0091
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0219	0.0359	0.8425
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1123	0.3252	0.324
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.063	0.1675	0.1659
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0219	0.0359	0.0342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1765	0.5306	0.5306
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0478	0.1187	0.1171
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2415	0.7385	0.7385
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0239	0.0423	0.0406
Loa Loa (eye worm)	phosphatidylinositol 3	0.0219	0.0359	0.0342
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.3233	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0279	0.0553	0.0535
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0219	0.0359	0.8425
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0219	0.0359	0.0359
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.063	0.1675	0.1659
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.063	0.1675	0.1659

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1962754

Bibliographic References

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Detailed information for compound 1611396