TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 417.54 | Formula: C27H31NO3
H donors: 2 H acceptors: 1 LogP: 5.53 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1OCCNC[C@H]1CCC([C@@H]1O)(c1ccccc1)c1ccccc1
InChi: 1S/C27H31NO3/c1-30-24-14-8-9-15-25(24)31-19-18-28-20-21-16-17-27(26(21)29,22-10-4-2-5-11-22)23-12-6-3-7-13-23/h2-15,21,26,28-29H,16-20H2,1H3/t21-,26-/m1/s1
InChiKey: LGNZQRMYJQAMTQ-QFQXNSOFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1396	0.2524	0.2524
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0367	0.0501	0.0489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3094	0.5862	0.5862
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0346	0.0459	0.0459
Schistosoma mansoni	voltage-gated potassium channel	0.0132	0.0037	0.0025
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1773	0.3265	0.3257
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0484	0.073	0.073
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0121	0.0016	0.0003
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0367	0.0501	0.006
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0346	0.0459	0.0459
Loa Loa (eye worm)	hypothetical protein	0.105	0.1843	0.1833
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3374	0.6412	0.6412
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0657	0.1069	0.1069
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0735	0.1223	0.1212
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.5199	1	1
Entamoeba histolytica	protein kinase rad3, putative	0.1003	0.175	0.174
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1785	0.3288	0.3279
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.041	0.0585	0.0573
Giardia lamblia	GTOR	0.5199	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0389	0.0543	0.0532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4428	0.8485	0.8485
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0346	0.0459	0.0447
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0367	0.0501	0.0489
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0367	0.0501	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0367	0.0501	0.0489
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.5199	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1785	0.3288	0.3288
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0367	0.0501	0.0501
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.055	0.0859	0.0859
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0346	0.0459	0.0447
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0476	0.0714	0.0703
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0367	0.0501	0.0489
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2451	0.4597	0.4591
Loa Loa (eye worm)	phosphatidylinositol 3	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4144	0.7927	0.7927
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0657	0.1069	0.1059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3878	0.7403	0.7403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2828	0.5338	0.5338
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0367	0.0501	0.0489
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.041	0.0585	0.0585
Loa Loa (eye worm)	phosphatidylinositol 3	0.5199	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0346	0.0459	0.0447
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0346	0.0459	0.915
Echinococcus granulosus	serine protein kinase ATM	0.1003	0.175	0.174
Loa Loa (eye worm)	phosphatidylinositol 3	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1003	0.175	0.175
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2828	0.5338	0.5338
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.041	0.0585	0.0573
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4144	0.7927	0.7927
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0367	0.0501	0.0489
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.077	0.1293	0.1283
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0346	0.0459	0.915
Loa Loa (eye worm)	phosphatidylinositol 3	0.1785	0.3288	0.3279
Echinococcus multilocularis	serine protein kinase ATM	0.1003	0.175	0.174
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0346	0.0459	0.0447
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.041	0.0585	0.0573
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1003	0.175	0.175
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.055	0.0859	0.0848
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4144	0.7927	0.7927
Onchocerca volvulus		0.0346	0.0459	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0346	0.0459	0.0447
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1003	0.175	0.174
Schistosoma mansoni	hypothetical protein	0.0346	0.0459	0.0447
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0346	0.0459	0.0447
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0367	0.0501	0.0489
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3878	0.7403	0.7403
Entamoeba histolytica	hypothetical protein	0.0507	0.0775	0.0764
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5199	1	1
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.1003	0.175	0.174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2828	0.5338	0.5338
Giardia lamblia	Hypothetical protein	0.0346	0.0459	0.0447
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.062	0.0998	0.0987
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2824	0.533	0.533
Schistosoma mansoni	voltage-gated potassium channel	0.0132	0.0037	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0657	0.1069	0.1069
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0507	0.0775	0.0764
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.041	0.0585	0.0573
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0119	0.0012	0.0012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3094	0.5862	0.5862
Plasmodium vivax	hypothetical protein, conserved	0.0346	0.0459	0.915
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0346	0.0459	0.0447
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.055	0.0859	0.0848
Trypanosoma cruzi	target of rapamycin kinase 3	0.4148	0.7935	0.7932
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0367	0.0501	0.0501
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3108	0.5888	0.5888
Loa Loa (eye worm)	hypothetical protein	0.077	0.1293	0.1283
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0735	0.1223	0.1212
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0367	0.0501	0.0489
Trichomonas vaginalis	conserved hypothetical protein	0.1117	0.1974	0.1974
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.5199	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0204	0.0179	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0476	0.0714	0.0703
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0121	0.0016	0.0003
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0433	0.063	0.0618
Echinococcus multilocularis		0.0346	0.0459	0.0447
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.041	0.0585	0.0585
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1003	0.175	0.174
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.5199	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.041	0.0585	0.0585
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0121	0.0016	0.0003
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1827	0.3371	0.3363
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3108	0.5888	0.5888
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1773	0.3265	0.3265
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1827	0.3371	0.3363
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1827	0.3371	0.3363
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0346	0.0459	0.0447
Toxoplasma gondii	FATC domain-containing protein	0.1003	0.175	0.1859
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.5199	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1773	0.3265	0.3265
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0346	0.0459	0.5
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.1003	0.175	0.174
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4144	0.7927	0.7927
Brugia malayi	FAT domain containing protein	0.077	0.1293	0.1283
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1827	0.3371	0.3363
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0367	0.0501	0.0489
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1827	0.3371	0.3363
Plasmodium vivax	hypothetical protein	0.0346	0.0459	0.915
Leishmania major	hypothetical protein, conserved	0.0443	0.065	0.0639
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3878	0.7403	0.7403
Toxoplasma gondii	target of rapamycin (TOR), putative	0.3878	0.7403	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3108	0.5888	0.5888
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0346	0.0459	0.0447
Entamoeba histolytica	hypothetical protein	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2824	0.533	0.533
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0346	0.0459	0.0459
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0367	0.0501	0.0489
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5199	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3878	0.7403	0.7403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0346	0.0459	0.0459
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.1003	0.175	0.174
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0367	0.0501	0.0489
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1827	0.3371	0.3363
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0367	0.0501	0.0489
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0367	0.0501	0.006
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0346	0.0459	0.0447
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.055	0.0859	0.0848
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0185	0.0142	0.013
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0346	0.0459	0.915
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0735	0.1223	0.1212
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0346	0.0459	0.0447
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.055	0.0859	0.0859
Entamoeba histolytica	hypothetical protein	0.1003	0.175	0.174
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.5199	1	1
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.4148	0.7935	0.7932
Loa Loa (eye worm)	hypothetical protein	0.1117	0.1974	0.1964
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.055	0.0859	0.0848
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0346	0.0459	0.915
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1014	0.1773	0.1773
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0119	0.0012	0.5
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.1117	0.1974	0.2181
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.5199	1	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0346	0.0459	0.0447
Trichomonas vaginalis	conserved hypothetical protein	0.077	0.1293	0.1293
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.5199	1	1
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.5199	1	1
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0346	0.0459	0.915
Onchocerca volvulus		0.0346	0.0459	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.041	0.0585	0.0573
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0476	0.0714	0.0703
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0346	0.0459	0.0447
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3878	0.7403	0.7403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3878	0.7403	0.7403
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3488	0.6636	0.6636
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0346	0.0459	0.0447
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.1003	0.175	0.174
Trichomonas vaginalis	immunophilin, putative	0.0119	0.0012	0.0012
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.4148	0.7935	0.7932
Schistosoma mansoni	hypothetical protein	0.077	0.1293	0.1283
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0346	0.0459	0.0447
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0476	0.0714	0.0703
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0119	0.0012	0.0012
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0441	0.0646	0.0634
Entamoeba histolytica	hypothetical protein	0.0346	0.0459	0.0447
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0121	0.0016	0.0003
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.055	0.0859	0.0859
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.1003	0.175	0.174
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.062	0.0998	0.0987
Echinococcus multilocularis	Zinc finger, PHD finger	0.0367	0.0501	0.0489
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0367	0.0501	0.0489
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0119	0.0012	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3878	0.7403	0.7403
Schistosoma mansoni	fkbp-rapamycin associated protein	0.1003	0.175	0.174
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.1003	0.175	0.174
Entamoeba histolytica	hypothetical protein	0.0346	0.0459	0.0447
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0346	0.0459	0.0447
Loa Loa (eye worm)	hypothetical protein	0.1003	0.175	0.174
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1785	0.3288	0.3279
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0346	0.0459	0.0447
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1773	0.3265	0.3257
Loa Loa (eye worm)	hypothetical protein	0.0657	0.1069	0.1059
Leishmania major	hypothetical protein, unknown function	0.0346	0.0459	0.0447
Trichomonas vaginalis	fk506-binding protein, putative	0.0119	0.0012	0.0012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4144	0.7927	0.7927
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2828	0.5338	0.5338
Trichomonas vaginalis	PIKK family atypical protein kinase	0.5199	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2824	0.533	0.533
Leishmania major	phosphatidylinositol kinase, putative	0.0346	0.0459	0.0447
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0346	0.0459	0.0447
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.1014	0.1773	0.1763
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1773	0.3265	0.3265
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.077	0.1293	0.1283
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0367	0.0501	0.0501
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.2171	0.4047	0.404
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0346	0.0459	0.0447
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0484	0.073	0.073
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.5199	1	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0367	0.0501	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.041	0.0585	0.0573
Loa Loa (eye worm)	phosphatidylinositol 3	0.0346	0.0459	0.0447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1773	0.3265	0.3265
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.5199	1	1
Loa Loa (eye worm)	hypothetical protein	0.0346	0.0459	0.0447
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0367	0.0501	0.0489
Loa Loa (eye worm)	phosphatidylinositol 3	0.0692	0.1138	0.1128
Mycobacterium leprae	conserved hypothetical protein	0.0346	0.0459	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1962756

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1611398