TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 208.214 | Formula: C10H12N2O3
H donors: 1 H acceptors: 3 LogP: 0.99 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)CCc1cccnc1/C=N/O
InChi: 1S/C10H12N2O3/c1-15-10(13)5-4-8-3-2-6-11-9(8)7-12-14/h2-3,6-7,14H,4-5H2,1H3/b12-7+
InChiKey: ZVKJUCMSBNXTGF-KPKJPENVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0965	0.7368	0.7368
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0084	0.0391	0.0347
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0084	0.0391	0.0242
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0084	0.0391	0.0242
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.019	0.123	0.1214
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.1033	0.7907	0.7874
Schistosoma mansoni	immunophilin	0.0046	0.0095	0.0049
Toxoplasma gondii	FATC domain-containing protein	0.0245	0.1671	0.1835
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0054	0.0153	0.0108
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0084	0.0391	0.0373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0965	0.7368	0.7368
Trichomonas vaginalis	PIKK family atypical protein kinase	0.087	0.6618	0.6618
Schistosoma mansoni	hypothetical protein	0.019	0.123	0.119
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0084	0.0391	0.0242
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.1297	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0273	0.1893	0.1893
Loa Loa (eye worm)	FKBP5 protein	0.0054	0.0153	0.0135
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0245	0.1671	0.1655
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0084	0.0391	0.0373
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0084	0.0391	0.0242
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0084	0.0391	0.0373
Onchocerca volvulus		0.0084	0.0391	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.0391	0.0391
Leishmania major	phosphatidylinositol kinase, putative	0.0084	0.0391	0.0242
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0084	0.0391	0.0391
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.1297	1	1
Giardia lamblia	GTOR	0.1297	1	1
Echinococcus granulosus	serine protein kinase ATM	0.0245	0.1671	0.1655
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0084	0.0391	0.0373
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0084	0.0391	0.0373
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0162	0.1009	0.0868
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	0.0242
Schistosoma mansoni	immunophilin	0.0054	0.0153	0.0108
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0084	0.0391	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0095	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0273	0.1893	0.1878
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.1033	0.7907	0.7874
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.1297	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0699	0.5266	0.5266
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0084	0.0391	0.0347
Leishmania major	hypothetical protein, unknown function	0.0084	0.0391	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0775	0.5866	0.5866
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0965	0.7368	0.7368
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0965	0.7368	0.7368
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	0.0242
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0084	0.0391	0.0242
Plasmodium vivax	hypothetical protein, conserved	0.0084	0.0391	1
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0084	0.0391	1
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0084	0.0391	1
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0435	0.3173	0.3067
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0245	0.1671	0.1633
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0965	0.7368	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0084	0.0391	0.0242
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.0391	0.0373
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0084	0.0391	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1297	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0162	0.1009	0.1009
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.0391	0.0373
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0084	0.0391	0.0242
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.1297	1	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0435	0.3173	0.3067
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0084	0.0391	0.0242
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0539	0.3995	0.3901
Leishmania major	hypothetical protein, conserved	0.0084	0.0391	0.0242
Mycobacterium leprae	conserved hypothetical protein	0.0084	0.0391	0.5
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0084	0.0391	0.0347
Trichomonas vaginalis	conserved hypothetical protein	0.019	0.123	0.123
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0435	0.3173	0.316
Entamoeba histolytica	hypothetical protein	0.0245	0.1671	0.1541
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0084	0.0391	0.0242
Loa Loa (eye worm)	phosphatidylinositol 3	0.0084	0.0391	0.0373
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0084	0.0391	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.1297	1	1
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0435	0.3173	0.316
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0084	0.0391	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0435	0.3173	0.3173
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0245	0.1671	0.1541
Entamoeba histolytica	hypothetical protein	0.0084	0.0391	0.0242
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0084	0.0391	0.0373
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0245	0.1671	0.1655
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0084	0.0391	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0699	0.5266	0.5266
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1297	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1032	0.7898	0.7898
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0084	0.0391	0.0391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.07	0.5275	0.5275
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0054	0.0153	0.0135
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0084	0.0391	0.0391
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0084	0.0391	0.0391
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0245	0.1671	0.1541
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0054	0.0153	0.0135
Loa Loa (eye worm)	phosphatidylinositol 3	0.0084	0.0391	0.0373
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0084	0.0391	0.0373
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0084	0.0391	0.0391
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0054	0.0153	0.5
Trichomonas vaginalis	fk506-binding protein, putative	0.0054	0.0153	0.0153
Loa Loa (eye worm)	phosphatidylinositol 3	0.0084	0.0391	0.0373
Entamoeba histolytica	protein kinase rad3, putative	0.0245	0.1671	0.1541
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0965	0.7368	0.7368
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0054	0.0153	0.0135
Plasmodium vivax	hypothetical protein	0.0084	0.0391	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.0391	0.0373
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0084	0.0391	0.0391
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0245	0.1671	0.1655
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0245	0.1671	0.1671
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	0.0242
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0084	0.0391	0.0347
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	0.0242
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.1297	1	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0084	0.0391	0.0391
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.0391	0.0373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0965	0.7368	0.7368
Trichomonas vaginalis	PIKK family atypical protein kinase	0.07	0.5275	0.5275
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0084	0.0391	0.0373
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0084	0.0391	0.0373
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0245	0.1671	0.1655
Loa Loa (eye worm)	phosphatidylinositol 3	0.0435	0.3173	0.316
Echinococcus multilocularis	fk506 binding protein	0.0054	0.0153	0.0135
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0084	0.0391	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.07	0.5275	0.5275
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.019	0.123	0.1214
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0084	0.0391	0.0373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1032	0.7898	0.7898
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.0391	0.0373
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0435	0.3173	0.3067
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0084	0.0391	0.0373
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.1297	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	0.0242
Schistosoma mansoni	hypothetical protein	0.0084	0.0391	0.0347
Giardia lamblia	Hypothetical protein	0.0084	0.0391	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1107	0.8498	0.8498
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1032	0.7898	0.7898
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0084	0.0391	0.0242
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0084	0.0391	0.0242
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0613	0.4586	0.4502
Loa Loa (eye worm)	phosphatidylinositol 3	0.0084	0.0391	0.0373
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0084	0.0391	0.0242
Echinococcus multilocularis	Zinc finger, PHD finger	0.0084	0.0391	0.0373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0435	0.3173	0.3173
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0084	0.0391	0.0391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0245	0.1671	0.1671
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.1297	1	1
Onchocerca volvulus		0.0084	0.0391	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1297	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0084	0.0391	0.0373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0767	0.5805	0.5805
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0084	0.0391	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0348	0.2484	0.2484
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0046	0.0095	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0162	0.1009	0.0991
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0842	0.6396	0.6396
Loa Loa (eye worm)	hypothetical protein	0.0264	0.1822	0.1806
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0084	0.0391	0.0373
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0054	0.0153	0.0135
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0084	0.0391	0.0242
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0084	0.0391	0.0242
Echinococcus multilocularis		0.0084	0.0391	0.0373
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0435	0.3173	0.3173
Trichomonas vaginalis	immunophilin, putative	0.0054	0.0153	0.0153
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0245	0.1671	0.1633
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1032	0.7898	0.7898
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0084	0.0391	0.0242
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0435	0.3173	0.3067
Loa Loa (eye worm)	phosphatidylinositol 3	0.1297	1	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0245	0.1671	0.1541
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0435	0.3173	0.3067
Entamoeba histolytica	hypothetical protein	0.0084	0.0391	0.0242
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0435	0.3173	0.3173
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0084	0.0391	0.0391
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	1
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0435	0.3173	0.3142
Loa Loa (eye worm)	hypothetical protein	0.019	0.123	0.1214
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0084	0.0391	1
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0054	0.0153	0.5
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0391	0.0373
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0084	0.0391	0.5
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.1297	1	1
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0054	0.0153	0.0153
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0273	0.1893	0.2153
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0435	0.3173	0.3067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0775	0.5866	0.5866
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0435	0.3173	0.316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0435	0.3173	0.3173
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0054	0.0153	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0084	0.0391	0.0391
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.1297	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0245	0.1671	0.1671
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0084	0.0391	0.0391
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0084	0.0391	0.0347
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0767	0.5805	0.5805
Entamoeba histolytica	hypothetical protein	0.0084	0.0391	0.0242
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0054	0.0153	0.0135
Loa Loa (eye worm)	phosphatidylinositol 3	0.0084	0.0391	0.0373
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0084	0.0391	0.0391
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0084	0.0391	0.0373
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0054	0.0153	0.0153
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0699	0.5266	0.5266
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0084	0.0391	0.0242
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.1009	0.1009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0775	0.5866	0.5866
Brugia malayi	FAT domain containing protein	0.019	0.123	0.1214
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0084	0.0391	0.0347
Trypanosoma cruzi	target of rapamycin kinase 3	0.1033	0.7907	0.7874
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0084	0.0391	0.0373
Entamoeba histolytica	hypothetical protein	0.0084	0.0391	0.0242
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0084	0.0391	0.0242
Loa Loa (eye worm)	hypothetical protein	0.0245	0.1671	0.1655
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0084	0.0391	0.0373
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0084	0.0391	0.0242
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1032	0.7898	0.7898
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0391	0.0373
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0084	0.0391	0.0391
Echinococcus multilocularis	serine protein kinase ATM	0.0245	0.1671	0.1655
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0084	0.0391	0.0347
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0084	0.0391	0.0391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.07	0.5275	0.5275
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0245	0.1671	0.1541
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.1297	1	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0965	0.7368	0.7368
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0084	0.0391	0.0373
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0046	0.0095	0.0076
Schistosoma mansoni	immunophilin	0.0054	0.0153	0.0108
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0084	0.0391	0.0242

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1974683

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1611402