Detailed information for compound 1611403

Basic information

Technical information
  • TDR Targets ID: 1611403
  • Name: phenyl-(2,2,4,4-tetraoxo-1,5,2,4-dioxadithiep an-3-yl)methanone
  • MW: 306.312 | Formula: C10H10O7S2
  • H donors: 0 H acceptors: 5 LogP: 0.39 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1S(=O)(=O)OCCOS1(=O)=O)c1ccccc1
  • InChi: 1S/C10H10O7S2/c11-9(8-4-2-1-3-5-8)10-18(12,13)16-6-7-17-19(10,14)15/h1-5,10H,6-7H2
  • InChiKey: YHZXTNMSOFRFSU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • phenyl-(2,2,4,4-tetraketo-1,5,2,4-dioxadithiepan-3-yl)methanone
  • AIDS-139331
  • AIDS139331
  • NSC648302
  • Phenyl(2,2,4,4-tetraoxido-1,5,2,4-dioxadithiepan-3-yl)methanone
  • NCI60_016745

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.7333 0.7333
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0055 0.0262 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0462 0.5211 0.5211
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0856 1 1
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0055 0.0262 0.0262
Leishmania major phosphatidylinositol 3-kinase, putative 0.0055 0.0262 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0262 0.0234
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0055 0.0262 0.0194
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0162 0.1559 0.1535
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.1559 0.1559
Echinococcus multilocularis fk506 binding protein 0.0053 0.0232 0.0203
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0055 0.0262 0.0234
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0125 0.1112 0.1087
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0055 0.0262 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0681 0.7879 0.7828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0462 0.5211 0.5211
Loa Loa (eye worm) phosphatidylinositol 3 0.0287 0.3081 0.3061
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0055 0.0262 0.0234
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0162 0.1559 0.1535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0731 0.8478 0.8478
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0055 0.0262 0.0031
Schistosoma mansoni hypothetical protein 0.0055 0.0262 0.0194
Giardia lamblia Hypothetical protein 0.0055 0.0262 0.0031
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0856 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0055 0.0262 0.0234
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0262 0.0234
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0287 0.3081 0.2917
Echinococcus multilocularis Zinc finger, PHD finger 0.0055 0.0262 0.0234
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0262 0.0234
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0055 0.0262 0.0031
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0405 0.4513 0.4383
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0055 0.0262 0.0031
Leishmania major phosphatidylinositol 4-kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0681 0.787 0.787
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.1559 0.1559
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0856 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.3081 0.3081
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0055 0.0262 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0856 1 1
Onchocerca volvulus 0.0055 0.0262 0.5
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0143 0.0115
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0055 0.0262 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.023 0.2383 0.2383
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0262 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.5749 0.5749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.3081 0.3081
Trichomonas vaginalis immunophilin, putative 0.0053 0.0232 0.0232
Echinococcus multilocularis 0.0055 0.0262 0.0234
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0055 0.0262 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0555 0.6348 0.6348
Loa Loa (eye worm) hypothetical protein 0.0174 0.1712 0.1688
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0055 0.0262 0.0031
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0053 0.0232 0.0203
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0055 0.0262 0.0031
Loa Loa (eye worm) hypothetical protein 0.0107 0.0888 0.0861
Leishmania major phosphatidylinositol 3-kinase, putative 0.0287 0.3081 0.2917
Entamoeba histolytica hypothetical protein 0.0055 0.0262 0.0031
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0162 0.1559 0.1359
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0287 0.3081 0.2917
Loa Loa (eye worm) phosphatidylinositol 3 0.0856 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0162 0.1559 0.15
Trichomonas vaginalis PIKK family atypical protein kinase 0.0681 0.787 0.787
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0055 0.0262 0.0031
Loa Loa (eye worm) hypothetical protein 0.0125 0.1112 0.1087
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0287 0.3081 0.3033
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.3081 0.3081
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0055 0.0262 0.0262
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0055 0.0262 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0856 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0232 0.0232
Toxoplasma gondii non-specific serine/threonine protein kinase 0.018 0.1784 0.2153
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0262 0.5
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0055 0.0262 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0262 0.0234
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0053 0.0232 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0162 0.1559 0.1559
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0055 0.0262 0.0262
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0856 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0262 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.3081 0.3081
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0053 0.0232 0.0203
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0287 0.3081 0.2917
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0287 0.3081 0.3061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.581 0.581
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0053 0.0232 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0461 0.5203 0.5203
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0055 0.0262 0.0234
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0055 0.0262 0.0262
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0262 0.0234
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0055 0.0262 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0506 0.5749 0.5749
Entamoeba histolytica hypothetical protein 0.0055 0.0262 0.0031
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0053 0.0232 0.0203
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0681 0.7879 0.7828
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0055 0.0262 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.581 0.581
Brugia malayi FAT domain containing protein 0.0125 0.1112 0.1087
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0055 0.0262 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0888 0.0888
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0055 0.0262 0.0031
Loa Loa (eye worm) hypothetical protein 0.0055 0.0262 0.0234
Echinococcus multilocularis serine protein kinase ATM 0.0162 0.1559 0.1535
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0055 0.0262 0.0262
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0055 0.0262 0.0031
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0055 0.0262 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0681 0.787 0.787
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0055 0.0262 0.0031
Loa Loa (eye worm) hypothetical protein 0.0162 0.1559 0.1535
Entamoeba histolytica hypothetical protein 0.0055 0.0262 0.0031
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0055 0.0262 0.0031
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0856 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0055 0.0262 0.0234
Schistosoma mansoni immunophilin 0.0053 0.0232 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.7333 0.7333
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0045 0.0143 0.0115
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0162 0.1559 0.1359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0462 0.5211 0.5211
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0055 0.0262 0.0262
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0055 0.0262 0.0194
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0055 0.0262 0.0194
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.7333 0.7333
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0055 0.0262 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.7333 0.7333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0574 0.6573 0.6573
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0053 0.0232 0.0164
Toxoplasma gondii FATC domain-containing protein 0.0162 0.1559 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0681 0.787 0.787
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0125 0.1112 0.1087
Schistosoma mansoni immunophilin 0.0045 0.0143 0.0075
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0055 0.0262 0.0031
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0055 0.0262 0.0234
Leishmania major phosphatidylinositol kinase related protein, putative 0.0055 0.0262 0.0031
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0055 0.0262 0.0234
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0162 0.1559 0.1535
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0856 1 1
Loa Loa (eye worm) FKBP5 protein 0.0053 0.0232 0.0203
Trichomonas vaginalis conserved hypothetical protein 0.018 0.1784 0.1784
Schistosoma mansoni hypothetical protein 0.0125 0.1112 0.1051
Giardia lamblia Phosphatidylinositol 4-kinase 0.0055 0.0262 0.0031
Giardia lamblia GTOR 0.0856 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0856 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0055 0.0262 0.0262
Onchocerca volvulus 0.0055 0.0262 0.5
Leishmania major phosphatidylinositol kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0262 0.0262
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0055 0.0262 0.0234
Schistosoma mansoni immunophilin 0.0053 0.0232 0.0164
Loa Loa (eye worm) phosphatidylinositol kinase 0.0055 0.0262 0.0234
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0055 0.0262 0.0234
Echinococcus granulosus serine protein kinase ATM 0.0162 0.1559 0.1535
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0107 0.0888 0.0671
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0681 0.787 0.787
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0856 1 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1784 0.176
Loa Loa (eye worm) hypothetical protein 0.0045 0.0143 0.0115
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.7333 0.7333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.7333 0.7333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.581 0.581
Leishmania major hypothetical protein, unknown function 0.0055 0.0262 0.0031
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0055 0.0262 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0461 0.5203 0.5203
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0856 1 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0055 0.0262 0.0031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0262 0.0234
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0287 0.3081 0.2917
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0055 0.0262 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0055 0.0262 0.0031
Toxoplasma gondii target of rapamycin (TOR), putative 0.0636 0.7333 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0162 0.1559 0.15
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0055 0.0262 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0262 1
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0055 0.0262 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0856 1 1
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0287 0.3081 0.2917
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0262 0.0234
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0107 0.0888 0.0888
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0055 0.0262 0.0031
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0055 0.0262 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.1112 0.1112
Entamoeba histolytica hypothetical protein 0.0162 0.1559 0.1359
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0287 0.3081 0.3061
Mycobacterium leprae conserved hypothetical protein 0.0055 0.0262 0.5
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0355 0.3914 0.377
Leishmania major hypothetical protein, conserved 0.0055 0.0262 0.0031
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0856 1 1
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0055 0.0262 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0055 0.0262 0.0031
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0262 0.0234
Entamoeba histolytica hypothetical protein 0.0055 0.0262 0.0031
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0055 0.0262 0.0234
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0162 0.1559 0.1535
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.3081 0.3081
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0162 0.1559 0.1359
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0287 0.3081 0.3061
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0055 0.0262 0.0262
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0055 0.0262 0.0262
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0055 0.0262 0.0262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0462 0.5211 0.5211
Trypanosoma cruzi target of rapamycin kinase 3 0.0681 0.7879 0.7828
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0232 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.0461 0.5203 0.5203
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0856 1 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0055 0.0262 0.0031
Trichomonas vaginalis fk506-binding protein, putative 0.0053 0.0232 0.0232
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0053 0.0232 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0262 0.0234
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0053 0.0232 0.0203
Loa Loa (eye worm) phosphatidylinositol 3 0.0055 0.0262 0.0234
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0055 0.0262 0.0262
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0055 0.0262 0.0234
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0162 0.1559 0.1359
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0055 0.0262 0.0262
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0055 0.0262 0.0234
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0053 0.0232 0.0203
Plasmodium vivax hypothetical protein 0.0055 0.0262 1
Entamoeba histolytica protein kinase rad3, putative 0.0162 0.1559 0.1359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0636 0.7333 0.7333

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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