Detailed information for compound 1611414

Basic information

Technical information
  • TDR Targets ID: 1611414
  • Name: trimethyl-[2-[2-[(1Z)-2-[(4-methylphenyl)amin o]-2-oxo-1-(3-oxoquinoxalin-2-ylidene)ethyl]h ydrazinyl]-2-oxoethyl]azanium chloride
  • MW: 456.925 | Formula: C22H25ClN6O3
  • H donors: 3 H acceptors: 5 LogP: 3.83 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C[N+](C)(C)C)N/N=C(\c1nc2ccccc2nc1O)/C(=O)Nc1ccc(cc1)C.[Cl-]
  • InChi: 1S/C22H24N6O3.ClH/c1-14-9-11-15(12-10-14)23-22(31)20(27-26-18(29)13-28(2,3)4)19-21(30)25-17-8-6-5-7-16(17)24-19;/h5-12H,13H2,1-4H3,(H2-,23,24,25,26,27,29,30,31);1H
  • InChiKey: SMSCXRXOQDLAKR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • trimethyl-[2-oxo-2-[N'-[(1Z)-2-oxo-1-(3-oxoquinoxalin-2-ylidene)-2-(p-tolylamino)ethyl]hydrazino]ethyl]ammonium chloride
  • trimethyl-[2-oxo-2-[N'-[(1Z)-2-oxo-1-(3-oxo-2-quinoxalinylidene)-2-(p-tolylamino)ethyl]hydrazino]ethyl]ammonium chloride
  • [2-keto-2-[N'-[(1Z)-2-keto-1-(3-ketoquinoxalin-2-ylidene)-2-(p-toluidino)ethyl]hydrazino]ethyl]-trimethyl-ammonium chloride
  • trimethyl-[2-[2-[(1Z)-2-[(4-methylphenyl)amino]-2-oxo-1-(3-oxoquinoxalin-2-ylidene)ethyl]hydrazinyl]-2-oxo-ethyl]azanium chloride
  • NSC646787

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0226 0.0524 0.0524
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2437 1 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0479 0.161 0.1589
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0226 0.0524 0.0502
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0894 0.3388 0.3372
Trichomonas vaginalis PIKK family atypical protein kinase 0.1459 0.5807 0.5807
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.3177 0.3177
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0894 0.3388 0.3372
Echinococcus granulosus potassium voltage gated channel subfamily H 0.011 0.0031 0.0007
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0167 0.0274 0.025
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2437 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0533 0.1841 0.1841
Mycobacterium leprae conserved hypothetical protein 0.0167 0.0274 0.5
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.011 0.0031 0.0007
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0246 0.0614 0.0591
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0286 0.0782 0.0759
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0894 0.3388 0.3372
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0418 0.1348 0.1327
Leishmania major hypothetical protein, conserved 0.0256 0.0655 0.0632
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0167 0.0274 0.7513
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0894 0.3388 0.3372
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0186 0.0357 0.0333
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0479 0.161 0.1589
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0167 0.0274 0.025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0894 0.3388 0.3372
Echinococcus granulosus serine protein kinase ATM 0.0479 0.161 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.1947 0.79 0.79
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0167 0.0274 0.0274
Leishmania major phosphatidylinositol 3-kinase, putative 0.0845 0.3177 0.316
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2437 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2437 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.1823 0.7369 1
Loa Loa (eye worm) hypothetical protein 0.0312 0.0894 0.0872
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0167 0.0274 0.025
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0186 0.0357 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0353 0.1071 0.105
Trichomonas vaginalis PIKK family atypical protein kinase 0.1335 0.5277 0.5277
Giardia lamblia Phosphatidylinositol 4-kinase 0.0167 0.0274 0.025
Loa Loa (eye worm) hypothetical protein 0.0479 0.161 0.1589
Schistosoma mansoni hypothetical protein 0.0167 0.0274 0.025
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0167 0.0274 0.0274
Trichomonas vaginalis PIKK family atypical protein kinase 0.1947 0.79 0.79
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0353 0.1071 0.1071
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0226 0.0524 0.0502
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.161 0.1589
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0167 0.0274 0.7513
Leishmania major phosphatidylinositol kinase, putative 0.0167 0.0274 0.025
Entamoeba histolytica protein kinase rad3, putative 0.0479 0.161 0.1589
Trypanosoma cruzi target of rapamycin kinase 3 0.1949 0.7908 0.7903
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0314 0.0903 0.0881
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0186 0.0357 0.0333
Schistosoma mansoni hypothetical protein 0.0366 0.1125 0.1104
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0479 0.161 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.1457 0.5802 0.5802
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0186 0.0357 0.0333
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0312 0.0894 0.0872
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0353 0.1071 0.1071
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.0075 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.1333 0.5269 0.5269
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0167 0.0274 0.025
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0167 0.0274 0.7513
Trichomonas vaginalis PIKK family atypical protein kinase 0.1457 0.5802 0.5802
Trichomonas vaginalis fk506-binding protein, putative 0.0109 0.0024 0.0024
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0226 0.0524 0.0502
Loa Loa (eye worm) hypothetical protein 0.0286 0.0782 0.0759
Loa Loa (eye worm) phosphatidylinositol kinase 0.0167 0.0274 0.025
Trichomonas vaginalis conserved hypothetical protein 0.0312 0.0894 0.0894
Trichomonas vaginalis PIKK family atypical protein kinase 0.1947 0.79 0.79
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0169 0.0282 0.0258
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1146 0.4466 0.4453
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0186 0.0357 0.0333
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0186 0.0357 0.0333
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0186 0.0357 0.0333
Leishmania major phosphatidylinositol kinase related protein, putative 0.0167 0.0274 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.2071 0.8433 0.8433
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0186 0.0357 0.0333
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0855 0.3222 0.3205
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0186 0.0357 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.2437 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0167 0.0274 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.1947 0.79 0.79
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0186 0.0357 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0226 0.0524 0.0524
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0479 0.161 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.1335 0.5277 0.5277
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0167 0.0274 0.025
Entamoeba histolytica hypothetical protein 0.0479 0.161 0.1589
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0855 0.3222 0.3205
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0226 0.0524 0.0502
Loa Loa (eye worm) phosphatidylinositol 3 0.2437 1 1
Echinococcus multilocularis 0.0167 0.0274 0.025
Echinococcus multilocularis Zinc finger, PHD finger 0.0186 0.0357 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.1823 0.7369 0.7369
Trichomonas vaginalis conserved hypothetical protein 0.0366 0.1125 0.1125
Trichomonas vaginalis PIKK family atypical protein kinase 0.1335 0.5277 0.5277
Loa Loa (eye worm) phosphatidylinositol 3 0.0483 0.1627 0.1607
Onchocerca volvulus 0.0167 0.0274 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0489 0.1655 0.1655
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0167 0.0274 0.025
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0293 0.0814 0.0814
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0845 0.3177 0.316
Schistosoma mansoni voltage-gated potassium channel 0.0121 0.0075 0.0051
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0366 0.1125 0.1104
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0353 0.1071 0.1071
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0522 0.1795 0.1775
Trichomonas vaginalis PIKK family atypical protein kinase 0.1581 0.6332 0.6332
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0186 0.0357 0.0357
Loa Loa (eye worm) phosphatidylinositol 3 0.0167 0.0274 0.025
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.011 0.0031 0.0007
Giardia lamblia Hypothetical protein 0.0167 0.0274 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.1457 0.5802 0.5802
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0186 0.0357 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.0655 0.2366 0.2366
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0206 0.0442 0.0419
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2437 1 1
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0489 0.1655 0.1634
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2437 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0226 0.0524 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0855 0.3222 0.3222
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0186 0.0357 0.0357
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2437 1 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0274 0.025
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0226 0.0524 0.0502
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0186 0.0357 0.0333
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0418 0.1348 0.1327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.3177 0.3177
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0522 0.1795 0.1775
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0293 0.0814 0.0814
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0167 0.0274 0.7513
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1023 0.3942 0.3927
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0167 0.0274 0.025
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0186 0.0357 0.0357
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0167 0.0274 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.2437 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.3177 0.3177
Loa Loa (eye worm) hypothetical protein 0.0366 0.1125 0.1104
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0186 0.0357 0.0333
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0353 0.1071 0.105
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0479 0.161 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.1823 0.7369 0.7369
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0024 0.0024
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0186 0.0355 0.0332
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.011 0.0031 0.0007
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0353 0.1071 0.105
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0167 0.0274 0.025
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0254 0.0646 0.0623
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0109 0.0024 0.0024
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0286 0.0782 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.161 0.161
Trichomonas vaginalis PIKK family atypical protein kinase 0.1947 0.79 0.79
Trichomonas vaginalis PIKK family atypical protein kinase 0.1335 0.5277 0.5277
Leishmania major hypothetical protein, unknown function 0.0167 0.0274 0.025
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0109 0.0024 0.5
Leishmania major phosphatidylinositol 4-kinase, putative 0.0167 0.0274 0.025
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0366 0.1125 0.1104
Loa Loa (eye worm) phosphatidylinositol 3 0.0167 0.0274 0.025
Plasmodium vivax hypothetical protein 0.0167 0.0274 0.7513
Trichomonas vaginalis PIKK family atypical protein kinase 0.1333 0.5269 0.5269
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2437 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0855 0.3222 0.3205
Schistosoma mansoni fkbp-rapamycin associated protein 0.0479 0.161 0.1589
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0167 0.0274 0.025
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0167 0.0274 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0479 0.161 0.161
Trichomonas vaginalis PIKK family atypical protein kinase 0.0845 0.3177 0.3177
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0167 0.0274 0.025
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2437 1 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2437 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0286 0.0782 0.0759
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0186 0.0357 0.0117
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0226 0.0524 0.0524
Plasmodium vivax hypothetical protein, conserved 0.0167 0.0274 0.7513
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0522 0.1795 0.1775
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0167 0.0274 0.025
Entamoeba histolytica hypothetical protein 0.0314 0.0903 0.0881
Loa Loa (eye worm) phosphatidylinositol 3 0.0167 0.0274 0.025
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0479 0.161 0.1589
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0167 0.0274 0.025
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2437 1 1
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0109 0.0024 0.5
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0533 0.1841 0.2209
Trichomonas vaginalis immunophilin, putative 0.0109 0.0024 0.0024
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0479 0.161 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.1635 0.6564 0.6564
Trichomonas vaginalis PIKK family atypical protein kinase 0.1823 0.7369 0.7369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.0274 0.0274
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0167 0.0274 0.025
Echinococcus multilocularis serine protein kinase ATM 0.0479 0.161 0.1589
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1949 0.7908 0.7903
Entamoeba histolytica hypothetical protein 0.0167 0.0274 0.025
Entamoeba histolytica hypothetical protein 0.0167 0.0274 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.1823 0.7369 0.7369
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0894 0.3388 0.3372
Leishmania major phosphatidylinositol 3-kinase, putative 0.0186 0.0357 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.1823 0.7369 0.7369
Toxoplasma gondii FATC domain-containing protein 0.0479 0.161 0.1882
Loa Loa (eye worm) phosphatidylinositol 3 0.0167 0.0274 0.025
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0186 0.0357 0.0333
Giardia lamblia GTOR 0.2437 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0167 0.0274 0.0274
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0167 0.0274 0.025
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0186 0.0357 0.0117
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0186 0.0357 0.0333
Trichomonas vaginalis PIKK family atypical protein kinase 0.1823 0.7369 0.7369
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0167 0.0274 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.1333 0.5269 0.5269
Onchocerca volvulus 0.0167 0.0274 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1823 0.7369 0.7369
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.0274 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.1459 0.5807 0.5807
Loa Loa (eye worm) hypothetical protein 0.0533 0.1841 0.1821
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1949 0.7908 0.7903
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2437 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0167 0.0274 0.025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0312 0.0894 0.0894
Entamoeba histolytica hypothetical protein 0.0167 0.0274 0.025
Loa Loa (eye worm) hypothetical protein 0.0488 0.165 0.163
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0353 0.1071 0.105
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0167 0.0274 0.7513
Brugia malayi FAT domain containing protein 0.0366 0.1125 0.1104

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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