Detailed information for compound 1612281

Basic information

Technical information
  • TDR Targets ID: 1612281
  • Name: TimTec1_004922
  • MW: 244.332 | Formula: C15H20N2O
  • H donors: 1 H acceptors: 1 LogP: 1.02 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1C2CN3CC1(CN(C2)CC3)c1ccccc1
  • InChi: 1S/C15H20N2O/c18-14-12-8-16-6-7-17(9-12)11-15(14,10-16)13-4-2-1-3-5-13/h1-5,12,14,18H,6-11H2
  • InChiKey: MNRUFFKCDYALGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NCI60_028482
  • 1-Phenyl-3,6-diazatricyclo[4.3.1.1~3,8~]undecan-9-ol
  • AIDS-148184
  • AIDS148184
  • NSC679574
  • Oprea1_876132
  • 1-Phenyl-3,6-diazahomoadamantan-9-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0017 0.0458 0.0458
Echinococcus multilocularis SWI:SNF matrix associated 0.0258 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0092 0.3412 0.9368
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0092 0.3412 0.939
Brugia malayi SWIB/MDM2 domain containing protein 0.0258 1 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0458 0.0458
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0126 0.0347
Leishmania major cathepsin L-like protease 0.0066 0.238 0.6054
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0458 0.0336
Onchocerca volvulus 0.0017 0.0458 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Schistosoma mansoni hypothetical protein 0.0092 0.3412 0.3412
Leishmania major cathepsin L-like protease 0.0066 0.238 0.6054
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0092 0.3412 0.3412
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.9435 0.9428
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2362 0.2362
Plasmodium vivax hypothetical protein, conserved 0.0258 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0458 0.0336
Schistosoma mansoni kinase 0.0049 0.1735 0.1735
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0458 0.0336
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0092 0.3412 0.9368
Echinococcus granulosus zinc finger protein Ran binding 0.0092 0.3412 0.3327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Onchocerca volvulus 0.0092 0.3412 0.3255
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0458 0.126
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3633 0.3552
Brugia malayi Cathepsin L-like precursor 0.0017 0.0458 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Trypanosoma brucei hypothetical protein, conserved 0.0092 0.3412 0.9368
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Chlamydia trachomatis DNA topoisomerase I 0.0258 1 0.5
Plasmodium vivax vivapain-3 0.0009 0.0126 0.0126
Onchocerca volvulus 0.0017 0.0458 0.0232
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0458 0.0458
Onchocerca volvulus 0.0017 0.0458 0.0232
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0458 0.0458
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0458 0.0946
Brugia malayi brahma associated protein 60 kDa 0.0258 1 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0993 0.0993
Onchocerca volvulus 0.0017 0.0458 0.0232
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0126 0.0126
Loa Loa (eye worm) ctsf protein 0.0017 0.0458 0.0458
Trypanosoma brucei hypothetical protein, conserved 0.0092 0.3412 0.9368
Onchocerca volvulus 0.005 0.1744 0.1549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Schistosoma mansoni fusion 0.0092 0.3412 0.3412
Echinococcus granulosus ring and YY1 binding protein 0.0092 0.3412 0.3327
Schistosoma mansoni hypothetical protein 0.0258 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0458 0.0336
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.3633 0.3482
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0458 0.0336
Echinococcus granulosus SWI:SNF matrix associated 0.0258 1 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.1822 0.5016
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0458 0.0946
Schistosoma mansoni hypothetical protein 0.005 0.1744 0.1744
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0993 0.0993
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.1744 0.1744
Echinococcus multilocularis cysteine protease 0.0017 0.0458 0.0336
Schistosoma mansoni hypothetical protein 0.0258 1 1
Brugia malayi hypothetical protein 0.0244 0.9435 0.9435
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0993 0.0993
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0092 0.3412 0.3412
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.3412 0.939
Echinococcus multilocularis SWI:SNF matrix associated 0.0258 1 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.3412 0.3412
Trypanosoma cruzi WLM domain containing protein, putative 0.0092 0.3412 0.939
Loa Loa (eye worm) hypothetical protein 0.0012 0.0232 0.0232
Plasmodium vivax vivapain-1 0.0009 0.0126 0.0126
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.2362 0.2362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0092 0.3412 0.3412
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.3633 0.3633
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2362 0.2362
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0949 0.0833
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2362 0.2362
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0258 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3633 0.3552
Brugia malayi Cathepsin L-like precursor 0.0017 0.0458 0.0458
Toxoplasma gondii ran binding protein 0.0092 0.3412 0.3095
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0092 0.3412 0.3412
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0126 0.0126
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0993 0.0561
Echinococcus multilocularis cysteine protease 0.0017 0.0458 0.0336
Onchocerca volvulus 0.0258 1 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0092 0.3412 0.939
Plasmodium vivax vivapain-2 0.0017 0.0458 0.0458
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0009 0.0126 0.0347
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0258 1 1
Leishmania major hypothetical protein, conserved 0.0092 0.3412 0.9302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Plasmodium vivax vivapain-2 0.0017 0.0458 0.0458
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.238 0.6552
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.238 0.6552
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Schistosoma mansoni survival motor neuron protein 0.005 0.1744 0.1744
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0092 0.3412 0.939
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0126 0.0126
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0126 0.0126
Brugia malayi Pre-SET motif family protein 0.0215 0.8277 0.8277
Leishmania major hypothetical protein, conserved 0.0092 0.3412 0.9302
Onchocerca volvulus 0.0017 0.0458 0.0232
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0092 0.3412 0.3095
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0092 0.3412 0.3327
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.2362 0.2362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Giardia lamblia Kinase, PLK 0.0097 0.3633 0.5
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0993 0.0878
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.3633 0.3633
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1684 0.1578
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.8277 0.8277
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0458 0.0336
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3633 0.3552
Echinococcus multilocularis zinc finger protein Ran binding 0.0092 0.3412 0.3327
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2362 0.2362
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.3633 0.3552
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0092 0.3412 0.3412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Loa Loa (eye worm) brahma associated protein 0.0258 1 1
Schistosoma mansoni hypothetical protein 0.0258 1 1
Onchocerca volvulus 0.0092 0.3412 0.3255
Echinococcus multilocularis tar DNA binding protein 0.0065 0.2362 0.2264
Loa Loa (eye worm) TAR-binding protein 0.0065 0.2362 0.2362
Echinococcus multilocularis ring and YY1 binding protein 0.0092 0.3412 0.3327
Trichomonas vaginalis conserved hypothetical protein 0.0258 1 1
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0258 1 1
Trypanosoma cruzi cysteine peptidase, putative 0.0009 0.0126 0.0347
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0458 0.0458
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0458 0.0232
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3633 0.3552
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0092 0.3412 0.939
Trichomonas vaginalis set domain proteins, putative 0.0244 0.9452 0.9445
Loa Loa (eye worm) hypothetical protein 0.0012 0.0232 0.0232
Trypanosoma brucei polo-like protein kinase 0.0097 0.3633 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0458 0.0336
Schistosoma mansoni zinc finger protein 0.0092 0.3412 0.3412
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0092 0.3412 0.3327
Schistosoma mansoni TRABID protein (C64 family) 0.0092 0.3412 0.3412
Echinococcus granulosus cathepsin l1 0.0017 0.0458 0.0336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Onchocerca volvulus 0.0017 0.0458 0.0232
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0092 0.3412 0.3255
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0232 0.0107
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0458 0.0232
Brugia malayi cathepsin L-like precursor 0.0012 0.0232 0.0232
Schistosoma mansoni brg-1 associated factor 0.0258 1 1
Brugia malayi Cathepsin L-like precursor 0.0012 0.0232 0.0232
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.3633 1
Chlamydia trachomatis SWIB complex protein 0.0258 1 0.5
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0258 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3633 0.3552
Loa Loa (eye worm) hypothetical protein 0.0012 0.0232 0.0232
Schistosoma mansoni RNA binding protein 0.0092 0.3412 0.3412
Loa Loa (eye worm) hypothetical protein 0.0092 0.3412 0.3412
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0092 0.3412 0.3327
Brugia malayi Cathepsin L-like precursor 0.0012 0.0232 0.0232
Trypanosoma cruzi cysteine proteinase, putative 0.0009 0.0126 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Loa Loa (eye worm) cysteine protease 0.0017 0.0458 0.0458
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1684 0.1578
Leishmania major cathepsin L-like protease 0.0066 0.238 0.6054
Trypanosoma cruzi cysteine protease, putative 0.0009 0.0126 0.0347
Onchocerca volvulus 0.0092 0.3412 0.3255
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3633 0.3552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Onchocerca volvulus 0.0244 0.9452 0.9439
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0458 0.0336
Loa Loa (eye worm) RNA binding protein 0.0065 0.2362 0.2362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Loa Loa (eye worm) hypothetical protein 0.0092 0.3412 0.3412
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Loa Loa (eye worm) hypothetical protein 0.0244 0.9435 0.9435
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Onchocerca volvulus 0.0017 0.0458 0.0232
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.3633 0.3552
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0993 0.0878
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0092 0.3412 0.3412
Loa Loa (eye worm) fibroinase 0.0017 0.0458 0.0458
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0458 0.0336
Leishmania major hypothetical protein, conserved 0.0092 0.3412 0.9302
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.3412 0.939
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.238 0.6552
Leishmania major hypothetical protein, conserved 0.0092 0.3412 0.9302
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Entamoeba histolytica cysteine protease, putative 0.0017 0.0458 0.0946
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0993 0.0993
Echinococcus multilocularis SWI:SNF matrix associated 0.0258 1 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0258 1 1
Brugia malayi RNA binding protein 0.0065 0.2362 0.2362
Echinococcus granulosus tar DNA binding protein 0.0065 0.2362 0.2264
Onchocerca volvulus 0.0031 0.0993 0.078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0993 0.0878
Brugia malayi TAR-binding protein 0.0065 0.2362 0.2362
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0232 0.0107
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0258 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Schistosoma mansoni tar DNA-binding protein 0.0065 0.2362 0.2362
Brugia malayi YY1-associated factor 2 0.0092 0.3412 0.3412
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0458 0.0336
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.238 0.6552
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.3412 0.939
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.3633 1
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0458 0.0232
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0258 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0258 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0458 0.0336
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0092 0.3412 0.939
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0458 0.0336
Echinococcus granulosus cathepsin l1 0.0012 0.0232 0.0107
Trypanosoma cruzi WLM domain containing protein, putative 0.0092 0.3412 0.939
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.9435 0.9428
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.3633 0.3633
Loa Loa (eye worm) hypothetical protein 0.0017 0.0458 0.0458
Echinococcus granulosus Zinc finger RanBP2 type 0.0092 0.3412 0.3327
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.3633 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.3633 0.3552
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0232 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0458 0.0336
Leishmania major hypothetical protein, conserved 0.0092 0.3412 0.9302
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0458 0.0458
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0092 0.3412 0.3327
Plasmodium vivax unspecified product 0.0009 0.0126 0.0126
Plasmodium vivax SET domain protein, putative 0.0031 0.0993 0.0993
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.238 0.6427
Brugia malayi Cathepsin L-like precursor 0.0017 0.0458 0.0458
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.3633 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0993 0.0993
Brugia malayi Cathepsin L-like precursor 0.0017 0.0458 0.0458
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0993 0.0993
Onchocerca volvulus 0.0092 0.3412 0.3255
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.2154 0.5929
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0232 0.0301

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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